Methylmercury exposure downregulates the expression of Racl and leads to neuritic degeneration and ultimately apoptosis in cerebrocortical neurons

NeuroToxicology

Volumn 30, Issue 1, 2009, Pages 16-22

  Fujimura, Masatake ^a   Usuki, Fusako ^a   Sawada, Masumi ^a   Rostene, William ^b,c   Godefroy, David ^b,c   Takashima, Akihiko ^d  

^a NATIONAL INSTITUTE FOR MINAMATA DISEASE   (Japan)

^b HÔPITAL SAINT ANTOINE   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

Cerebrocortical neuronal culture; Methylmercury; Neuritic degeneration; Rac1; Rho family proteins

Indexed keywords

CASPASE 3; METHYLMERCURY; MICROTUBULE ASSOCIATED PROTEIN 2; PROTEIN CDC42; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TAU PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; AXONAL INJURY; BRAIN CORTEX; BRAIN NERVE CELL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; EMBRYO; NERVE CELL CULTURE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; APOPTOSIS; CDC42 GTP-BINDING PROTEIN; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; DENDRITES; DOWN-REGULATION; METHYLMERCURY COMPOUNDS; MICROTUBULE-ASSOCIATED PROTEINS; NEURITES; NEURONS; RAC1 GTP-BINDING PROTEIN; RATS; RATS, SPRAGUE-DAWLEY; RHOA GTP-BINDING PROTEIN; TAU PROTEINS;

RATTUS;

EID: 58749103132     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2008.10.002     Document Type: Article

References (39)

1. Aschner M. Changes in axonally transported proteins in the mature and developing rat nervous system during early stages of methyl mercury exposure. Pharmacol Toxicol 60 (1987) 81-85
2. Bakir F., Damluji S.F., Amin-Zaki L., Murtadha M., Khalidi A., al-Rawi N.Y., et al. Methylmercury poisoning in Iraq. Science 181 (1973) 230-241
3. Banker G.A., and Cowan W.M. Rat hippocampal neurons in dispersed cell culture. Brain Res 126 (1997) 397-425
4. Belletti S., Orlandini G., Vettori M.V., Mutti A., Uggeri J., Scandroglio R., et al. Time course assessment of methylmercury effects on C6 glioma cells: submicromolar concentrations induce oxidative DNA damage and apoptosis. J Neurosci Res 70 (2002) 703-711
5. Brewer G.J. Serum-free B27/Neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus. J Neurosci Res 42 (1995) 674-683
6. Castoldi A.F., Marni S., Turin I., Gandini C., and Manzo L. Early acute necrosis, delayed apoptosis and cytoskeletal breakdown in cultured cerebellar granule neurons exposed to methylmercury. J Neurosci Res 59 (2000) 775-787
7. Daré E., Go{combining double acute accent}tz M.E., Zhivotovsky B., Manzo L., and Ceccatelli S. Antioxidants J811 and 17beta-estradiol protect cerebellar granule cells from methylmercury-induced apoptotic cell death. J Neurosci Res 62 (2000) 557-565
8. Daré E., Gorman A.M., Ahlbom E., Go{combining double acute accent}tz M., Momoi T., and Ceccatelli S. Apoptotic morphology does not always require caspase activity in rat cerebellar granule neurons. Neurotox Res 3 (2001) 501-514
9. Dickson T.C., and Vickers J.C. The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease. Neuroscience 105 (2001) 99-107
10. Eto K., Takizawa Y., Akagi H., Haraguchi K., Asano S., Takahata N., et al. Differential diagnosis between organic and inorganic mercury poisoning in human cases-the pathologic point of view. Toxicol Pathol 27 (1999) 664-671
11. Fronfría E., Daré E., Benelli M., Suñol C., and Ceccatelli S. Translocation of apoptosis-inducing factor in cerebellar granule cells exposed to neurotoxic agents inducing oxidative stress. Eur J Neurosci 16 (2002) 2013-2016
12. Fuhrmann S., Kirsch M., Wewetzer K., and Hofmann H.D. Use of cell ELISA for the screening of neurotrophic activities on minor cell population in retinal monolayer cultures. J Neurosci Methods 75 (1997) 199-205
13. Go{combining double acute accent}tz M.E., Koutsilieri E., Riederer P., Ceccatelli S., and Daré E. Methylmercury induces neurite degeneration in primary culture of mouse dopaminergic mesencephalic cells. J Neural Transm 109 (2002) 597-605
14. Hakoshima T., Shimizu T., and Maesaki R. Structural basis of the Rho GTPase signaling. J Biochem 134 (2003) 327-331
15. Heidemann S.R., Lamourex P., and Atchison W.D. Inhibition of axonal morphogenesis by nonlethal, submicromolar concentration of methylmercury. Toxicol Appl Pharmacol 174 (2001) 49-59
16. InSug O., Datar S., Koch C.J., Shapiro I.M., and Shenker B.J. Mercuric compounds inhibit human monocyte function by inducing apoptosis: evidence for formation of reactive oxygen species, development of mitochondrial membrane permeability transition and loss of reductive reserve. Toxicology 124 (1997) 211-224
17. Iwata M., Muneoka K.T., Shirayama Y., Yamamoto A., and Kawahara R. A study of a dendritic marker, microtubule-associated protein 2 (MAP-2), in rats neonatally treated neurosteroids, pregnenolone and dehydroepiandrosterone (DHEA). Neurosci Lett 386 (2005) 145-149
18. Jackson M., Gentleman S., Lennox G., Ward L., Gray T., Randall K., et al. The cortical neuritic pathology of Huntington's disease. Neuropathol Appl Neurobiol 21 (1995) 18-26
19. Jeong H.G., Cho H.J., Chang I.Y., Yoon S.P., Joen Y.J., Chung M.H., et al. Rac1 prevents cisplatin-induced apoptosis through down-regulation of p38 activation in NIH3T3 cells. FEBS Lett 518 (2002) 129-134
20. Kosik K.S., and Finch E.A. MAP2 and Tau segregate into dendritic and axonal domains after the elaboration of morphologically distinct neurites: an immunocytochemical study of cultured rat cerebrum. J Neurosci 7 (1987) 3142-3153
21. Kouroku Y., Urase K., Fujita E., Isahara K., Ohsawa Y., Uchiyama Y., et al. Detection of activated caspase-3 by a cleavage site-directed antiserum during naturally occurring DRG neurons apoptosis. Biochem Biophys Res Commun 247 (1998) 780-784
22. Kunimoto M. Methylmercury induces apoptosis of rat cerebellar neurons in primary culture. Biochem Biophys Res Commun 204 (1994) 310-317
23. Le S.S., Loucks F.A., Udo H., Richardson-Burns S., Phelps R.A., Bouchard R.J., et al. Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons. J Neurochem 94 (2005) 1025-1039
24. 2+ dysregulation and neuronal death in rat cerebellar granule cells through an M3 muscarinic receptor-linked pathway. Toxicol Sci 80 (2004) 60-68
25. Mattila P.M., Rinne J.O., Helenius H., and Ro{combining double acute accent}yttä M. Neutritic degeneration in the hippocampus and amygdala in Parkinson's disease in relation to Alzheimer pathology. Acta Neuropathol 98 (1999) 157-164
26. Miura K., Inokawa M., and Imura N. Effects of methylmercury and some metal ions on microtubule networks in mouse glioma cells and in vitro tubulin polymerization. Toxicol Appl Pharmacol 73 (1984) 218-231
27. Negishi M., and Katoh H. Rho family GTPases as key regulators for neuronal network formation. J Biochem 132 (2002) 157-166
28. Nishioku T., Takai N., Miyamoto K., Murao K., Hara C., Yamamoto K., et al. Involvement of caspase 3-like protease in methylmercury-induced apoptosis of primary cultured rat cerebral microglia. Brain Res 871 (2000) 160-164
29. Sakaue M., Okazaki M., and Hara S. Very low levels of methylmercury induce cell death of cultured rat cerebellar neurons via calpain activation. Toxicology 213 (2005) 97-106
30. 2+ and inositol phosphate levels in cultured cerebellar granule neurons. Oxidative mechanisms underlying methyl mercury neurotoxicity. J. Neurochem 61 (1993) 648-657
31. Shanker G., Aschner J.L., Syversen T., and Aschner M. Free radical formation in cerebral cortical astrocytes in culture induced by methylmercury. Brain Res Mol 128 (2004) 48-57
32. Shenker B.J., Guo T.L., and Shapiro I.M. Mercury-induced apoptosis in human lymphoid cells: evidence that the apoptotic pathway is mercurial species dependent. Environ Res 84 (2000) 88-99
33. Takeuchi T. Pathology of Minamata disease. With special reference to its pathogenesis. Acta Pathol Jpn 32 (1982) 73-99
34. Tamm C., Duckworth J., Hermanson O., and Ceccatelli S. High susceptibility of neural stem cells to methylmercury toxicity: effects on cell survival and neuronal differentiation. J Neurochem 97 (2006) 69-78
35. Tanabe K., Bonilla I., Winkles J.A., and Strittmatter S.M. Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrows. J Neurosci 23 (2003) 9675-9686
36. Tomasevic N., Jia Z., Russell A., Fujii T., Hartman J.J., Clancy S., et al. Differential regulation of WASP and N-WASP by Cdc42, Rac1, NCK, and PI(4,5)P2. Biochemistry 46 (2007) 3494-3502
37. Usuki F., Fujita E., and Sasagawa N. Methylmercury activates ASK1/JNK signaling pathways, leading to apoptosis due to both mitochondria- and endoplasmic reticulum (ER)-generated processes in myogenic cell lines. Neurotoxicology 29 (2008) 22-30
38. Vendrell I., Carrascal M., Vilaró M.T., Abián J., Rodrígues-Farré E., and Suñol C. Cell viability and proteomic analysis in cultured neurons exposed to methylmercury. Hum Exp Toxicol 26 (2007) 263-272
39. Wilke R.A., Kolbert C.P., Rahimi R.A., and Windebank A.J. Methylmercury induces apoptosis in cultured rat dorsal root ganglion neurons. Neurotoxicology 24 (2003) 369-378