Translocation of apoptosis-inducing factor in cerebellar granule cells exposed to neurotoxic agents inducing oxidative stress

European Journal of Neuroscience

Volumn 16, Issue 10, 2002, Pages 2013-2016

  Fonfria E ^a,b   Dare E ^a   Benelli, M ^a   Sunol C ^b   Ceccatelli, Sandra ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b INST D INVESTIGACIONS B   (Spain)

Author keywords

Chromatin rearrangement; Hydrogen peroxide; Methylmercury; Rat

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE; COLCHICINE; DNA FRAGMENT; HYDROGEN PEROXIDE; METHYLMERCURY; NEUROTOXIN; FLAVOPROTEIN; MEMBRANE PROTEIN; METHYLMERCURIC HYDROXIDE; METHYLMERCURY DERIVATIVE; OXIDIZING AGENT; PDCD8 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA CLEAVAGE; DNA DEGRADATION; ENZYME ACTIVATION; GRANULE CELL; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; ANIMAL; CELL NUCLEUS; CEREBELLUM; CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECT; GRANULOCYTE; METABOLISM; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

ANIMALS; APOPTOSIS; APOPTOSIS INDUCING FACTOR; CELL CULTURE TECHNIQUES; CELL NUCLEUS; CEREBELLUM; DNA FRAGMENTATION; FLAVOPROTEINS; GRANULOCYTES; HYDROGEN PEROXIDE; MEMBRANE PROTEINS; METHYLMERCURY COMPOUNDS; MITOCHONDRIA; OXIDANTS; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0036836070     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2002.02269.x     Document Type: Article

References (26)

1. Baker, A., Santos, BD. & Powis, G. (2000) Redox control of caspase-3 activity by thioredoxin and other reduced proteins. Biochem. Biophys. Res. Commun., 268, 78-81.
2. Bidere, N. & Senik, A. (2001) Caspase-independent apoptotic pathways in T lymphocytes: a minireview. Apoptosis, 6, 371-375.
3. Bonfoco, E., Ceccatelli, S., Manzo, L. & Nicotera, P. (1995) Colchicine induces apoptosis in cerebellar granule cells. Exp. Cell Res., 218, 189-200.
4. 2 mediate brain cell apoptosis during meningitis. J. Clin. Invest., 109, 19-27.
5. Castoldi, A.F., Barni, S., Turin, I., Gandini, C. & Manzo, L. (2000) Early acute necrosis, delayed apoptosis and cytoskeletal breakdown in cultured cerebellar granule neurons exposed to methylmercury. J. Neurosci. Res., 59, 775-787.
6. Close, A.H., Guo, T.L. & Shenker, B.J. (1999) Activated human T lymphocytes exhibit reduced susceptibility to methylmercury chloride-induced apoptosis. Toxicol. Sci., 49, 68-77.
7. Darè E., Gorman, A.M., Ahlbom, E., Götz, M.E., Momoi, T. & Ceccatelli, S. (2001) Apoptotic morphology does not always require caspase activity in rat cerebellar granule neurons. Neurotox. Res., 3, 501-514.
8. Darè E., Götz, M.E., Zhivotovsky, B., Manzo, L. & Ceccatelli, S. (2000) Antioxidants JS11 and 17β-estradiol protect cerebellar granule cells from methylmercury-induced apoptotic cell death. J. Neurosci. Res., 62, 557-565.
9. Daugas, E., Nochy, D., Ravagnan, L., Loeffler, M, Susin, S.A., Zamzami, N. & Kroemer, G. (2000) Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis. FEBS Lett., 476, 118-123.
10. 2+ pathway blockers differentially protect against methylmercury and mercuric chloride neurotoxicity. J. Neurosci. Res., 66, 135-145.
11. Gorman, A.M., Bonfoco, E., Zhivotovsky, B., Orrenius, S. & Ceccatelli, S. (1999) Cytochrome c release and caspase-3 activation during colchicine-induced apoptosis of cerebellar granule cells. Eur. J. Neurosci., 11, 1067-1072.
12. Götz, M.E., Ahlbom, E., Zhivotovsky, B., Blum-Degen, D., Oettel, Römer, W., Riederer, P., Orrenius, S. & Ceccatelli, S. (1999) Radical scavenging compound J 811 inhibits hydrogen peroxide-induced death of cerebellar granule cells. J. Neurosci. Res., 56, 420-426.
13. Granville, D.J., Cassidy, B.A., Ruehlmann, D.O., Choy, J.C., Brenner, C., Kroemer, G., van Breemen, C., Margaron, P., Hunt, D.W. & McManus, B.M. (2001) Mitochondrial release of apoptosis-inducing factor and cytochrome c during smooth muscle cell apoptosis. Am. J. Pathol., 159, 305-311.
14. Gupta, S. (2001) Molecular steps of death receptor and mitochondrial pathways of apoptosis. Life Sci., 69, 2957-2964.
15. Hampton, M.B. & Orrenius, S. (1997) Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis. FEBS Lett., 414, 552-556.
16. InSug, O., Datar, S., Koch, C.J., Shapiro, I.M. & Shenker, B.J. (1997) Mercuric compounds inhibit human monocyte function by inducing apoptosis: evidence for formation of reactive oxygen species, development of mitochondrial membrane permeability transition and loss of reductive reserve. Toxicology, 124, 211-224.
17. Joza, N., Susin, S.A., Daugas, E., Stanford, W.L., Cho, S.K., Li, C.Y.J., Sasaki, T., Elia, A.J., Cheng, H.Y.M., Ravagnan, L., Ferri, KF., Zamzami, N., Wakeham, A., Hakem, R., Yoshida, H., Kong, Y.Y., Mak, T.W., Zuniga-Pflucker, J.C., Kroemer, G. & Penninger, J.M. (2001) Essential role of the mitochondrial apoptosis-inducing factor in pro-grammed cell death. Nature, 410, 549-554.
18. Kaufmann, S.H. & Hengartner, M.O. (2001) Programmed cell death: alive and well in the new millennium. Trends Cell Biol., 11, 526-534.
19. Lankiewicz, S., Luetjens, C.M., Bui, N.T., Krohn, A.J., Poppe, M., Cole, G.M., Saido, T.C. & Prehn, J.H.M. (2000) Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death. J. Biol. Chem., 275, 17064-17071.
20. Limke, T.L. & Atchison, W.D. (2002) Acute exposure to methylmercury opens the mitochondrial permeability transition pore in rat cerebellar granule cells. Toxicol. Appl. Pharmacol., 178, 52-61.
21. 2+ as a probable contributor to decreased viability in cerebellar granule cells following acute exposure to methylmercury. Toxicol. Appl. Pharmacol., 150, 98-105.
22. Susin, S.A., Daugas, E., Ravagnan, L., Samejima, K., Zamzami, N., Loeffler, M., Costantini, P., Ferri, K.F., Irinopoulou, T., Prevost, M.C., Brothers, G., Mak, T.W., Penninger, J., Earnshaw, W.C. & Kroemer, G. (2000) Two distinct pathways leading to nuclear apoptosis. J. Exp. Med., 192, 571-580.
23. Susin, S.A., Lorenzo, H.K., Zamzami, N., Marzo, I., Snow, B.E., Brothers, G.M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., Larochette, N., Goodlett, D.R., Aebersold, R., Siderovski, D.P., Penninger, J.M. & Kroemer, G. (1999) Molecular characterization of mitochondrial apoptosis-inducing factor. Nature, 397, 441-446.
24. Takeyama, N., Miki, S., Hirakawa, A. & Tanaka, T. (2002) Role of the mitochondrial permeability transition and cytochrome C release in hydrogen peroxide-induced apoptosis. Exp. Cell Res., 274, 16-24.
25. Whittemore, E.R., Loo, D.T., Watt, J.A. & Cotman, C.W. (1995) A detailed analysis of hydrogen peroxide-induced cell death in primary neuronal culture. Neuroscience, 67, 921-932.
26. Yee, S. & Choi, B.H. (1996) Oxidative stress in neurotoxic effects of methylmercury poisoning. Neurotoxicology, 17, 17-26.