Methylmercury: Recent advances in the understanding of its neurotoxicity

Therapeutic Drug Monitoring

Volumn 27, Issue 3, 2005, Pages 278-283

  Aschner, Michael ^a   Syversen, Tore ^b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLMERCURY; REACTIVE OXYGEN METABOLITE;

ADULT; APOPTOSIS; ASTROCYTE; BRAIN DEVELOPMENT; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CENTRAL NERVOUS SYSTEM; ENVIRONMENTAL EXPOSURE; HUMAN; INNERVATION; LONG TERM EXPOSURE; NERVE CELL LESION; NERVOUS SYSTEM DEVELOPMENT; NEUROTOXICITY; OXIDATIVE STRESS; PRIORITY JOURNAL; SHORT SURVEY;

AGE FACTORS; ANIMALS; BRAIN; GLUTAMIC ACID; HUMANS; METHYLMERCURY COMPOUNDS; REACTIVE OXYGEN SPECIES; SULFHYDRYL COMPOUNDS;

EID: 20044385396     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ftd.0000160275.85450.32     Document Type: Short Survey

References (92)

1. Takeuchi T, Eto N, Eto K. Neuropathology of childhood cases of methylmercury poisoning (Minamata disease) with prolonged symptoms, with particular reference to the decortication syndrome. Neurotoxicology. 1979;1:1-20.
2. Bakir F, Damluji SF, Amin-Zaki L, et al. Methylmercury poisoning in Iraq. Science. 1973;181:23-41.
3. Kjellstrom T, Kennedy P, Wallis S, et al. 1989. Physical and mental development of children with prenatal exposure to mercury from fish. Stage II: Interviews and psychological tests at age 6. Solna, Sweden: National Swedish Environmental Protection Board Report 3642, 1989.
4. Grandjean P, Weihe P, White RF, et al. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol. 1997;19:417-428.
5. Grandjean P, Budiz-Jorgensen E, White RF, et al. Methylmercury exposure biomarkers as indicators of neurotoxicity in children aged 7 years. Am J Epidemiol. 1999;150:301-305.
6. Grandjean P, White RF, Weihe P, et al. Neurotoxic risk caused by stable and variable exposure to methylmercury from seafood. Ambul Pediatr. 2003;3:18-23.
7. Cordier S, Garel M, Mandereau L, et al. Neurodevelopmental investigations among methylmercury-exposed children in French Guiana. Environ Res. 2002;89:1-11.
8. Steuerwald U, Weihe P, Jorgensen PJ, et al. Maternal seafood diet, methylmercury exposure, and neonatal neurologic function. J Pediatr. 2000;136:599-605.
9. Faustmann EM, Ponce RA, Ou YC, et al. Investigations of methylmercury-induced alterations in neurogenesis. Environ Health Perspect. 2002; 110(Suppl. 5):859-864.
10. Myers GJ, Davidson PW, Shamlaye CF, et al. Effects of prenatal methylmercury exposure from a high fish diet on developmental milestones in the Seychelles Child Development Study. Neurotoxicology. 1997;18:819-829.
11. Davidson PW, Myers GJ, Cox C, et al. Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment: outcomes at 66 months of age in the Seychelles child development study. JAMA. 1998;280:701-707.
12. Huang LS, Cox C, Wilding GE, et al. Using measurement error models to assess effects of prenatal and postnatal methylmercury exposure in the Seychelles Child Development Study. Environ Res. 2003;93:115-122.
13. Huang LS, Cox C, Myers GJ, et al. Exploring nonlinear association between prenatal methylmercury exposure from fish consumption and child development: evaluation of the Seychelles Child Development Study nine-year data using semiparametric additive models. Environ Res. 2005;97:100-108.
14. Hughes WH. A physicochemical rationale for the biological activity of mercury and its compound. Ann N Y Acad Sci. 1957;65:454-460.
15. Carry AJ, Malone SF. The chemistry of mercury in biological systems. In Nriagu JO, ed. The Biogeochemistry of Mercury in the Environment. New York: Elsevier/North Holland, 1979, pp 433-459.
16. Naganuma A, Imura N. Methylmercury binds to a low molecular weight substance in rabbit and human erythrocytes. Toxicol Appl Pharmacol. 1979;47:613-616.
17. Rabenstein DL, Fairhurst MT. Nuclear magnetic resonance studies of the solution chemistry of metal complexes. J Am Chem Soc. 1975;97: 2086-2092.
18. Thomas DJ, Smith CJ. Effects of coadministered low molecular weight thiol compounds on short term distribution of methylmercury in the rat. Toxicol Appl Pharmacol. 1979;62:104-110.
19. Omata S, Sakimura K, Ishii T, et al. Chemical nature of a methylmercury complex with a low molecular weight in the liver cytosol of rats exposed to methylmercury chloride. Biochem Pharmacol. 1978;27:333-335.
20. Refsvik T, Norseth T. Methyl mercuric compounds in rat bile. Acta Pharmacol Toxicol. 1975;36:67-78.
21. Clarkson TW, Magos L, Myers GJ. The toxicology of mercury-current exposures and clinical manifestations. N Engl J Med. 2003;349: 1731-1737.
22. Myers GJ, Davidson PW, Shamlaye CF. A review of methylmercury and child development. Neurotoxicology. 1998;19:313-328.
23. Harada M. Minamata disease-methylmercury poisoning in Japan caused by environmental pollution. Crit Rev Toxicol. 1995;25:1-24.
24. Inskip MJ, Piotrowski JK. Review of the health-effects of methylmercury. Appl Toxicol. 1985;5:113-133.
25. Choi BH. The effects of methylmercury on the developing brain. Prog Neurobiol. 1989;32:447-470.
26. Kumimoto M, Suzuki T. Migration of granule neurons in cerebellar organotypic cultures is impared by methylmercury. Neurosci Lett. 1997; 226:183-186.
27. Miura K, Koide N, Himeno S, et al. The involvement of microtubular disruption in methylmercury-induced apoptosis in neuronal and non-neuronal cell lines. Toxicol Appl Pharmacol. 1999;160:279-288.
28. Miura K, Himeno S, Koide N, et al. Effects of methylmercury and inorganic mercury on the growth of nerve fibers in cultured chick dorsal root ganglia. Health Sci. 2000;46:182-186.
29. Nagashima K, Fujii Y, Tsukamoto T, et al. Apoptotic process of cerebellar degeneration in experimental methylmercury infoxication of rats. Acta Neuropathol (Berl). 1996;91:72-77.
30. Nagashima K. A review of experimental methylmercury toxicity in rats: neuropathology and evidence for apoptosis. Toxicol Pathol. 1997;25: 624-631.
31. Axtell CD, Cox C, Myers GJ, et al. Association between methylmercury exposure from fish consumption and child development at five and a half years of age in the Seychelles Child Development Study: an evaluation of nonlinear relationships. Environ Res. 2000;84:71-80.
32. Rice DC. Identification of functional domains affected by developmental exposure to methylmercury: Faroe Islands and related studies. Neurotoxicology. 2000;21:1039-1044.
33. Myers GJ, Davidson PW, Cox C, et al. Prenatal methylmercury exposure from ocean fish consumption in the Seychelles child development study. Lancet. 2003;361:1686-1692.
34. Charleston JS, Bolender RP, Mottet NK, et al. Increases in the number of reactive glia in the visual cortex of Macaca fascicularis following subclinical long-term methyl mercury exposure. Toxicol Appl Pharmacol. 1994;129:196-206.
35. Charleston JS, Body RL, Bolander RP, et al. Changes in the number of astrocytes and microglia in the thalamus of the monkey Macaca fascicularis following long-term subclinical methylmercury exposure. Neurotoxicology. 1996;17:127-138.
36. Garman RH, Weiss B, Evans HL. Alkylmercurial encephalopathy in the monkey: a histopathologic and autoradiographic study. Acta Neuropathol (Berl). 1975;32:61-74.
37. Aschner M, Du YL, Gannon M, et al. Methylmercury-induced alterations in excitatory amino acid transport in rat primary astrocytic cultures. Brain Res. 1993;602:181-186.
38. Aschner M. Methylmercury in astrocytes-what possible significance? Neurotoxicology. 1996;17:93-106.
39. Aschner M, Yao CP, Allen JW, et al. Methylmercury alters glutamate transport in astrocytes. Neurochem Int. 2000;37:199-206.
40. 3H-D-aspartate transporter in cultured astrocytes is reversed by the antioxidant catalase. Brain Res. 2001;902:92-100.
41. 2 and methylmercury in astrocytes: selectivity and reversibility. J Neurochem. 1989;53:1228-1237.
42. Juarez BI, Martinez ML, Montante M, et al. Methylmercury increases glutamate extracellular levels in frontal cortex of awake rats. Neurotoxicol Teratol. 2002;24:767-771.
43. Miyamoto K, Nakanishi H, Moriguchi S, et al. Involvement of enhanced sensitivity of N-methyl-D-aspartate receptors in vulnerability of developing cortical neurons to methylmercury neurotoxicity. Brain Res. 2001;901:252-258.
44. Miyamoto K, Murao K, Wakamiya J, et al. Protective effect of MK-801 in methylmercury-induced neuronal injury. In: Mercury as a Global Pollutant. 5th International Conference, 1999, p 376.
45. Lafon-Cazal M, Pietri S, Culcasi M, et al. NMDA-dependent superoxide production and neurotoxicity. Nature. 1993;364:535-537.
46. Allen JW, Shanker G, Aschner M. Methylmercury inhibits the in vitro uptake of the glutathione precursor, cystine, in astrocytes, but not in neurons. Brain Res. 2001;894:131-140.
47. Shanker G, Allen JW, Mutkus LA, et al. Methylmercury inhibits cysteine uptake in cultured primary astrocytes, but not in neurons. Brain Res. 2001; 914:159-165.
48. Shanker G, Aschner M. Identification and characterization of uptake systems for cystine and cysteine in cultured astrocytes and neurons: evidence for methylmercury-targeted disruption of astrocytic transport. J Neurosci Res. 2001;66:998-1002.
49. Aschner M, Sonnewald U, Tan KH. Astrocyte modulation of neuropathologic damage. Brain Pathol. 2002;12:476-481.
50. Maret M. Oxidative metal release from metallothionein via zinc-thiol/ disulfide interchange. Proc Natl Acad Sci USA. 1994;91:237-241.
51. Philbert MA, Beiswanger CM, Waters DK, et al. Cellular and regional distribution of reduced glutathione in the nervous system of the rat: histochemical localization by mercury orange and o-phthaldialdehyde-induced histofluorescence. Toxicol Appl Pharmacol. 1991;107:215-227.
52. Dringen R, Pfeiffer B, Hamprecht B. Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione. J Neurosci. 1999;19:562-569.
53. Wang XF, Cynader MS. Astrocytes provide cysteine to neurons by releasing glutathione. J Neurochem. 2000;74:1434-1442.
54. 2 expression in primary cultures of neonatal astrocytes. Brain Res Mol Brain Res. 2002;106: 1-11.
55. Matyja E, Albrecht J. Ultrastructural evidence that mercuric chloride lowers the threshold for glutamate neurotoxicity in an organotypic culture of rat cerebellum. Neurosci Lett. 1993;158:155-158.
56. Oyake Y, Tanaka M, Kubo H, et al. Neuropathological studies on organic mercury poisoning with special reference to the staining and distribution of mercury granules. Shinkei Kenkyu No Shimpo. 1966;10:744-750.
57. Vahter M, Mottet NK, Friberg L, et al. Speciation of mercury in the primate blood and brain following long-term exposure to methyl mercury. Toxicol Appl Pharmacol. 1994;124:221-229.
58. Aschner M, Eberle N, Miller K, et al. Interaction of methylmercury with rat primary astrocyte cultures: effects on rubidium uptake and efflux and induction of swelling. Brain Res. 1990;530:245-250.
59. Brookes N. in vitro evidence for the role of glutamate in the CNS toxicity of mercury. Toxicology. 1992;76:245-256.
60. Kaltschmidt B, Baeuerle PA, Kaltschmidt C. Potential involvement of the transcription factor NF-kappa B in neurological disorders. Mol Aspects Med. 1993;14:171-190.
61. Hunot S, Brugg B, Ricard D, et al. Nuclear translocation of NF-kappa B is increased in dopaminergic neurons of patients with Parkinson disease. Proc Natl Acad Sci USA. 1997;94:7531-7536.
62. Kitamura Y, Shimohama S, Ota T, et al. Alterations of transcription factor NF-kappa B and STAT1 in Alzheimer's disease brains. Neurosci Lett. 1997;237:17-20.
63. Lukiw WJ, Bazan NG. Neuroinflammatory signaling upregulation in Alzheimer's disease. Neurochem Res. 2000;25:1173-1184.
64. Kehrer JP, Smith CV. Free radicals in biology: sources, reactivities, and roles in the etiology of human diseases. In: Frei B, ed. Natural Antioxidants in Human Health and Disease. San Diego: Academic Press, 1994, pp 25-62.
65. Halliwell B. Free radicals and antioxidants: a personal view. Nutr Rev. 1994;52:253-265.
66. Betteridge DJ. What is oxidative stress? Metabolism. 2000;49:3-8.
67. LeBel CP, Ishiropoulos H, Bondy SC. Evaluation of the probe 2′,7′-dichlorofluorescein as an indicator of reactive oxygen species formation and oxidative stress. Chem Res Toxicol. 1992;5:227-231.
68. Bush AI. Metals and neuroscience. Curr Opin Chem Biol. 2000;4:184-191.
69. Sayre LM, Perry G, Smith MA. Redox metals and neurodegenerative disease. Curr Opin Chem Biol. 1999;3:220-225.
70. Davis KL, Martin E, Turko IV, et al. Novel effects of nitric oxide. Annu Rev Pharmacol Toxicol. 2001;41:203-236.
71. Ali SF, LeBel CP, Bondy SC. Reactive oxygen species formation as a biomarker of methylmercury and trimethyltin neurotoxicity. Neurotoxicology. 1992;13:633-648.
72. Sarafian TA. Methylmercury-induced generation of free radicals: Biological implications. Metal Ions Biol Syst. 1999;36:415-444.
73. Park ST, Lim KT, Chung YT, et al. Methylmercury-induced neurotoxicity in cerebral neuron culture is blocked by antioxidants and NMDA receptor antagonists. Neurotoxicology. 1996;17:37-46.
74. Sorg O, Schilter B, Honnegger P, et al. Increased vulnerability of neurons and glial cells to low concentrations of methylmercury in a prooxidant situation. Acta Neuropathol (Berl). 1998;96:621-627.
75. Sarafian TA, Vartavarian L, Kane DJ, et al. bcl-2 expression decreases methylmercury-induced free radical generation and cell killing in a neutral cell line. Toxicol Lett. 1994;74:149-155.
76. 2+ pathway blockers differentially protect against methylmercury and mercuric chloride neurotoxicity. J Neurosci Res. 2001;66:135-145.
77. 2. Biochem Pharmacol. 2001;62:119-128.
78. Dugan LL, Sensi SL, Canzoniero LM, et al. Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-asparate. J Neurosci. 1995;6377-6388.
79. Brawer JR, McCarthy GF, Gornitsky M, et al. Mercuric chloride induces a stress response in cultured astrocytes characterized by mitochondrial uptake of iron. Neurotoxicology. 1998;19:767-776.
80. Atlante A, Calissano P, Bobba A, et al. Glutamate neurotoxicity, oxidative stress and mitochondria. FEBS Lett. 2001;497:1-5.
81. Dykens JA, Stern A, Trenkner E. Mechanism of kainate toxicity to cerebellar neurons in vitro is analogous to reperfusion tissue injury. J Neurochem. 1987;49:1222-1228.
82. Culcasi M, Lafon-Cazal M, Pietri S, et al. Glutamate receptors induce a burst of superoxide via activation of nitric oxide synthase in arginine-depleted neurons. J Biol Chem. 1994;269:12589-12593.
83. Schulz JB, Lindenau J, Seyfried J, et al. Glutathione, oxidative stress and neurodegeneration. Eur J Biochem. 2000;267:4904-4911.
84. Rakic P. Principles of neural migration. Experientia. 1990;46:882-891.
85. Stitt TN, Hatten ME. Antibodies that recognize astrotactin block granule neuron binding to astroglia. Neuron. 1990;5:639-649.
86. Smith GM, Rutishauser U, Silver J, et al. Maturation of astrocytes in vitro alters the extent and molecular basis of neurite outgrowth. Dev Biol. 1990; 138:377-390.
87. Rodier PM, Aschner M, Sager PR. Mitotic arrest in the developing CNS after prenatal exposure to methylmercury. Neurobehav Toxicol Teratol. 1984;6:379-385.
88. Choi BH, Cho KH, Lapham LW. Effects of methylmercury on human fetal neurons and astrocytes in vitro: a time-lapse cinematographic, phase and electron microscopic study. Environ Res. 1981;24:61-74.
89. Choi BH. Effects of prenatal methylmercury poisoning upon growth and development of fetal central nervous system. In Clarkson TW, Nordberg GF, Sager PR, eds. Reproductive and Developmental Toxicity of Metals. New York: Plenum Press, 1983, pp 473-495.
90. Reuhl KR, Chang LW. Effects of methylmercury on the development of the nervous system: a review. Neurotoxicology. 1979;1:21-55.
91. Choi BH. Effects of methylmercury on developing fetal astrocytes, In The Biochemical Pathology of Astrocytes. New York: Alan R. Liss, 1988, pp 219-230.
92. Ball LK, Ball R, Pratt RD. An assessment of thimerosal use in childhood vaccines. Pediatrics. 2001;107:1147-1154.