Involvement of enhanced sensitivity of N-methyl-D-aspartate receptors in vulnerability of developing cortical neurons to methylmercury neurotoxicity

Brain Research

Volumn 901, Issue 1-2, 2001, Pages 252-258

  Miyamoto, Ken ichiro ^a   Nakanishi, Hiroshi ^b   Moriguchi, Shigeki ^b   Fukuyama, Naoto ^c   Eto, Komyo ^a   Wakamiya, Junji ^a   Murao, Koji ^a   Arimura, Kimiyoshi ^d   Osame, Mitsuhiro ^d  

^a NATIONAL INSTITUTE FOR MINAMATA DISEASE   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c TOKAI UNIVERSITY   (Japan)

^d KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Methylmercury; Microglia; NMDA receptor; Occipital cortex; Peroxynitrite; Rat

Indexed keywords

METHYLMERCURY; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; DISEASE PREDISPOSITION; DISEASE SEVERITY; JAPAN; MERCURIALISM; MINAMATA DISEASE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; ANTIGENS, CD; ANTIGENS, CD147; ANTIGENS, NEOPLASM; ANTIGENS, SURFACE; AVIAN PROTEINS; BLOOD PROTEINS; CEREBRAL CORTEX; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; GLUTAMIC ACID; MEMBRANE GLYCOPROTEINS; MERCURY POISONING, NERVOUS SYSTEM; METHYLMERCURY COMPOUNDS; NERVE DEGENERATION; NEURONS; NITRATES; QUINOXALINES; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; TYROSINE;

EID: 0035906526     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02281-8     Document Type: Article

References (25)

1. Intra-uterine methylmercury poisonong in Iraq
2. Methylmercury in astrocytes - What possible significance?
3. + and amino acid transport and metallothionein (MT) induction
4. Apparent hydroxyl radical production by peroxynitrite: Implication for endothelial injury from nitric oxide and superoxide
5. Methylmercury developmental neurotoxicity: A comparison of effects in humans and animals
6. Early acute necrosis, delayed apoptosis and cytoskeletal breakdown in cultured cerebellar granule neurons exposed to methylmercury
7. Astrocytes as mediators of methylmercury neurotoxicity: Effects on d-aspartate and serotonin uptake
8. Congenital Minamata disease: Intrauterine methylmercury poisoning
9. Physiological and pathophysiological roles of excitatory amino acids during central nervous system development
10. Neurotoxicity of N-methyl-D-aspartate is markedly enhanced in developing rat central nervous system
11. Functional change of NMDA receptors related to enhancement of susceptibility to neurotoxicity in the developing pontine nucleus
12. Involvement of caspase-3-like and lysosomal proteases in methylmercury-induced apoptosis of primary cultured rat cerebral microglia
13. Glutamate release from microglia via glutamate transporter is enhanced by amyloid-β peptide
14. Methylmercury-induced neurotoxicity in cerebral neuron culture is blocked by antioxidants and NMDA receptor antagonists
15. Effects of methylmercury on the development of the nervous system: A review
16. Comparison of mercury accumulation among the brain, liver and kidney and the brain regions of rats administered methylmercury in various phases of postnatal development
17. Widespread neuronal degeneration in rats following oral administration of methylmercury during the postnatal developing phase: A model of fetal-type minamata disease
18. Serum and depolarizing agents cause acute neurotoxicity in cultured cerebellar granule cells: Role of glutamate receptor responsive to N-methyl-D-aspartate
19. Inflammation and NO(X)-induced nitration: Assay for 3-nitrotyrosine by HPLC with electrochemical detection
20. Differential changes in rat brain nitric oxide synthase in vivo and in vitro by methylmercury
21. A rapid method for acid hydrolysis of protein with a mixture of trifluoroacetic acid and hydrochloric acid
22. Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite. Evidence for hydroxyl radical production from peroxynitrite
23. Variability of brain regions in rats administered methylmercury at various postnatal developmental phases
24. Mercury distribution in cortical areas and fiber systems of the neonatal and maternal adult cereberum after exposure of pregnant squirrel monkeys to mercury vapor
25. Expression of NMDA-receptor dependent long-term potentiation in the neostriatal neurons in an in vitro slice after ethanol withdrawal of the rat