Antioxidants J811 and 17β-estradiol granule cells from methylmercury-induced apoptotic cell death

Journal of Neuroscience Research

Volumn 62, Issue 4, 2000, Pages 557-565

  Dare E ^a   Gotz M E ^a,b   Zhivotovsky, B ^a   Manzo, L ^c   Ceccatelli, S ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF PAVIA   (Italy)

Author keywords

Apoptosis; Calpain; CGC; Methylmercury; Radical scavengers

Indexed keywords

ANTIOXIDANT; CALPAIN; CASPASE 3; CASPASE INHIBITOR; DNA FRAGMENT; ESTRADIOL; FODRIN; METHYLMERCURY; SCAVENGER; BENZYLOXYCARBONYLVALYL ALANYL ASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; CASP3 PROTEIN, RAT; CASPASE; J811 SCAVESTROGEN; METHYLMERCURY DERIVATIVE; NEUROPROTECTIVE AGENT; NEUROTOXIN; PEPTIDE CHLOROMETHYL KETONE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CHROMATIN CONDENSATION; ENZYME ACTIVITY; GRANULE CELL; INTOXICATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; ANIMAL; CELL CULTURE; CELL SIZE; CEREBELLUM; CYTOLOGY; DRUG EFFECT; DRUG INTERACTION; ENVIRONMENTAL EXPOSURE; FEMALE; METABOLISM; NERVE CELL; NEWBORN; PHYSIOLOGY; PREGNANCY; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; ANIMALS, NEWBORN; ANTIOXIDANTS; APOPTOSIS; CALPAIN; CASPASE 3; CASPASES; CELL SIZE; CELLS, CULTURED; CEREBELLUM; DRUG INTERACTIONS; ENVIRONMENTAL EXPOSURE; ESTRADIOL; FEMALE; FREE RADICAL SCAVENGERS; METHYLMERCURY COMPOUNDS; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 0034668745     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4547(20001115)62:4<557::AID-JNR10>3.0.CO;2-9     Document Type: Article

References (47)

1. Neuroprotection against oxidative stress by estrogens: Structure-activity relationship
2. Early acute necrosis, delayed apoptosis and cytoskeletal breakdown in cultured cerebellar granule neurons exposed to methylmercury
3. Caspase and calpain substrates: Roles in synaptic plasticity and cell death
4. The toxicology of mercury
5. Mercurial-induced alterations in neuronal divalent cation homeostasis
6. Pathology of Minamata disease
7. Modification of methylmercury toxicity and metabolism by selenium and vitamin E: Possible mechanisms
8. Interactions of vitamin E and selenium with mercury and silver
9. Apoptosis in neuronal cells: Role of caspases
10. Dexamethasone pre-treatment interferes with apoptotic death in glioma cells
11. Radical scavenging compound J 811 inhibits hydrogen peroxide-induced death of cerebellar granule cells
12. Altered sensitivity of posttranslationally modified microtubules to methylmercury in differentiating embryonal carcinoma-derived neurons
13. Oxidative stress inhibits calpain activity in situ
14. Redox regulation of the caspases during apoptosis
15. Evidence that noncaspase proteases are required for chromatin degradation during apoptosis
16. Methylmercury induces apoptosis of rat cerebellar neurons in primary culture
17. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
18. Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death
19. An analysis of autopsy brain tissue from infants prenatally exposed to methymercury
20. Deferoxamine inhibits methyl mercury-induced increases in reactive oxygen species formation in rat brain
21. 2+ entry in rat cerebellar granule cells following in vitro exposure to methyl mercury
22. 2+ as a probable contributor to decreased viability in cerebellar granule cells following acute exposure to methylmercury
23. Mechanism of cytotoxicity of methylmercury. With special reference to microtubule disruption
24. Differential toxicity of protease inhibitors in cultures of cerebellar granule neurons
25. Antioxidant properties of steroids
26. The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties
27. A review of experimental methylmercury toxicity in rats: Neuropathology and evidence for apoptosis
28. Apoptotic process of cerebellar degeneration in experimental methylmercury intoxication of rats
29. Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1β-convertingenzyme-like protease(s) in apoptotic cells: Contributory roles of both protease families in neuronal apoptosis
30. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
31. The therapeutic potential of scavestrogens
32. Methylmercury-induced neurotoxicity in cerebral neuron culture is blocked by antioxidants and NMDA receptor antagonists
33. Novel 'scavestrogens' and their radical scavenging effects, iron-chelating, and total antioxidative activities: Δ8,9-dehydro derivatives of 17α-estradiol and 17β-estradiol
34. 2+ and inositol phosphate levels in cultured cerebellar granule neurons
35. Oxidative mechanisms underlying methyl mercury neurotoxicity
36. A rapid, sensitive, and specific method for the determination of protein in dilute solution
37. Preparation of primary cultures of mouse (rat) cerebellar granule cells
38. Low-level methylmercury exposure causes human T-cells to undergo apoptosis: Evidence of mitochondrial dysfunction
39. Induction of apoptosis in human T-cells by methyl mercury: Temporal relationship between mitochondrial dysfunction and loss of reductive reserve
40. Structure and physiological function of calpains
41. Death by a thousand cuts: An ever increasing list of caspase substrates
42. Caspases: Enemies within
43. Phospholipase A2 stimulation by methyl mercury in neuron culture
44. Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation
45. Cell death: The significance of apoptosis
46. Oxidative stress in neurotoxic effects of methyl-mercury poisoning
47. Formation of 50 kbp chromatin fragments in isolated liver nuclei is mediated by protease and endonuclease activation