Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure

Toxicology and Applied Pharmacology

Volumn 250, Issue 1, 2011, Pages 1-9

  Fujimura, Masatake ^a   Usuki, Fusako ^a   Kawamura, Miwako ^b   Izumo, Shuji ^b  

^a NATIONAL INSTITUTE FOR MINAMATA DISEASE   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Apoptotic cell death; Axonal degeneration; Cultured cortical neuron; Dorsal spinal nerve root; Methylmercury; Rho ROCK pathway

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; DRINKING WATER; FASUDIL; METHYLMERCURY; RAC1 PROTEIN; RHO ASSOCIATED COILED COIL FORMING PROTEIN KINASE; RHO KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BRAIN CELL; CELL DEATH; CONTROLLED STUDY; DORSAL ROOT; DOWN REGULATION; DRUG INHIBITION; IN VITRO STUDY; IN VIVO STUDY; INTOXICATION; METHYLMERCURY INTOXICATION; NERVE CELL DEGENERATION; NERVE FIBER DEGENERATION; NERVE GROWTH; NERVOUS SYSTEM; NONHUMAN; ONCOGENE RAS; RAT; SENSORY SYSTEM; SPINAL CORD; SPINAL ROOT;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; BOTULINUM TOXINS; DOWN-REGULATION; MALE; METHYLMERCURY COMPOUNDS; NERVE DEGENERATION; NEURONS; PROTEIN KINASE INHIBITORS; RAC1 GTP-BINDING PROTEIN; RATS; RATS, WISTAR; RHO-ASSOCIATED KINASES;

RATTUS;

EID: 78649636704     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.09.011     Document Type: Article

References (39)

1. Appenzeller O., Kornfeld M., Atkinson R. Pure axonal neuropathy: nerve xenografts and clinicopathological study of a family with peripheral neuropathy, hereditary ataxia, focal necrotizing encephalopathy, and spongy degeneration of brain. Ann. Neurol. 1990, 7:251-261.
2. Bakir F., Damluji S.F., Amin-Zaki L., Murtadha M., Khalidi A., al-Rawi N.Y., Tikriti S., Dahahir H.I., Clarkson T.W., Smith J.C., Doherty R.A. Methylmercury poisoning in Iraq. Science 1973, 181:230-241.
3. Bertrand J., Winton M.J., Rodriguez-Hernandez N., Campenot R.B., McKerracher L. Application of Rho antagonist to neuronal cell bodies promotes neurite growth in compartmented cultures and regeneration of retinal ganglion cell axons in the optic nerve of adult rats. J. Neurosci. 2005, 25:1113-1121.
4. Chakrabarti S.K., Bai C. Effects of protein-deficient nutrition during rat pregnancy and development on developmental hindlimb crossing due to methylmercury intoxication. Arch. Toxicol. 2000, 74:196-202.
5. Chang L.W. Neurotoxic effects of mercury-a review. Environ. Res. 1977, 14:329-373.
6. Chang J.Y., Tsai P.F. Prevention of methylmercury-induced mitochondrial depolarization, glutathione depletion and cell death by 15-deoxy-delta-12, 14-prostaglandin J(2). Neurotoxicology 2008, 29:10574-11061.
7. Dabies S.P., Reddy H., Caivano M., Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitor. Biochem. J. 2000, 351:95-105.
8. Daré E., Götz M.E., Zhivotovsky B., Manzo L., Ceccatelli S. Antioxidants J811 and 17beta-estradiol protect cerebellar granule cells from methylmercury-induced apoptotic cell death. J. Neurosci. Res. 2000, 62:557-565.
9. Ellis L.C., Rustioni A. A correlative HRP, Golgi, and EM study of the intrinsic organization of the feline dorsal column nuclei. J. Comp. Neurol. 1981, 197:341-367.
10. Eto K. Pathology of Minamata disease. Toxicol. Pathol. 1997, 25:614-623.
11. Eto K., Tokunaga H., Nagashima K., Takeuchi T. An autopsy case of Minamata disease (methylmercury poisoning) pathological viewpoints of peripheral nerves. Toxicol. Pathol. 2002, 30:714-722.
12. Fournier A.E., Takizawa B.T., Strittmatter S.M. Rho kinase inhibition enhances axonal regeneration in the injured CNS. J. Neurosci. 2003, 23:1416-1423.
13. Fujimura M., Usuki F., Sawada M., Rostene W., Godefroy D., Takashima A. Methylmercury exposure downregulates the expression of Racl and leads to neuritic degeneration and ultimately apoptosis in cerebrocortical neurons. Neurotoxicology 2009, 30:16-22.
14. Fujimura M., Usuki F., Sawada M., Takashima A. Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. Neurotoxicology 2009, 30:1000-1007.
15. Gassó S., Cristòfol R.M., Selema G., Rosa R., Rodrígues-Farreé E., Sanfeliu C. Antioxidant compounds and Ca(2+) pathway blockers differently protect against methylmercury and mercuric chloride neurotoxicity. J. Neurosci. Res. 2001, 66:135-145.
16. Giuffrida R., Rustioni A. Dorsal root ganglion neurons projecting to the dorsal root nuclei of rats. J. Comp. Neurol. 1992, 316:206-220.
17. Hara M., Takayasu M., Watanabe K., Noda A., Takagi T., Suzuki Y., Yoshida J. Protein kinase inhibition by fasudil hydrochloride promotes neurological recovery after spinal cord injury in rats. J. Neurosurg. 2000, 93:94-101.
18. Jeong H.G., Cho H.J., Chang I.Y., Yoon S.P., Joen Y.J., Chung M.H., You H.J. Rac1 prevents cisplatin-induced apoptosis through down-regulation of p38 activation in NIH3T3 cells. FEBS Lett. 2002, 518:129-134.
19. Kawasaki S., Watanabe S., Kimura S., Fujita R., Ochiai J., Sasaki K. Regulation of dopamine-induced Na+ current response by small G-protein RhoB or C and phospholipase D in Aplysia neurons. Neurosci. Res. 2008, 60:147-155.
20. Le S.S., Loucks F.A., Udo H., Richardson-Burns S., Phelps R.A., Bouchard R.J., Barth H., Aktories K., Tyler K.L., Kandel E.R., Heidenreich K.A., Linseman D.A. Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons. J. Neurochem. 2005, 94:1025-1039.
21. Lie M., Grover M., Whitlon D.S. Accelerated neurite growth from spinal ganglion neurons exposed to the Rho kinase inhibitor H-1152. Neuroscience 2010, 169:855-862.
22. Lyeth B.G., Jenkins L.W., Hamm R.J., Dixon C.E., Phillips L.L., Clifton G.L., Young H.F., Hayes R.L. Prolonged memory impairment in the absence of hippocampal cell death following traumatic brain injury in the rat. Brain Res. 1990, 526:249-258.
23. Moretto M.B., Funchal C., Santos A.Q., Gottfried C., Boff B., Zeni G., Pureur R.P., Souza D.O., Wufchuk S., Rocha J.B. Ebselen protects glutamate uptake inhibition caused by methyl mercury but does not by Hg2+. Toxicology 2005, 14:57-66.
24. Moretto M.B., Funchal C., Zeni G., Pessoa-Pureur R., Rocha J.B. Selenium compounds prevent the effects of methylmercury on the in vitro phosphorylation of skeletal proteins in cerebral cortex of young rats. Toxicol. Sci. 2005, 85:639-646.
25. Mukai H. The structure and function of PKN, a protein kinase having a catalytic domain homologous to that of PKC. J. Biochem. 2003, 133:17-27.
26. Negishi M., Katoh H. Rho family GTPases as key regulators for neuronal network formation. J. Biochem. (Tokyo) 2002, 132:157-166.
27. Nonaka I. An electron microscopic study on the experimental congenital Minamata disease in the rat. Kumamoto Med. J. 1969, 31:27-40.
28. Park S.T., Lim K.T., Chung Y.T., Kim S.U. Methylmercury-induced neurotoxicity in cerebral neuron culture is blocked by antioxidants and NMDA receptor antagonist. Neurotoxicology 1996, 17:37-45.
29. Peres-Alcala S., Nieto M.A., Barbas J.A. Lsox regulates RhoB expression in the neural tube and promotes generation of the neural crest. Development 2004, 131:4455-4465.
30. Sager P.R., Aschner M., Rodier P.M. Persistent, differential alterations in developing cerebellar cortex of male and female mice after methylmercury exposure. Brain Res. 1984, 314:1-11.
31. Sakamoto M., Ikegami N., Nakano A. Protective effects of Ca2+ channel blockers against methyl mercury toxicity. Pharmacol. Toxicol. 1996, 78:193-199.
32. Schiønning J.D., Møller-Madsen B., Danscher G. Mercury in the dorsal root ganglia of rats treated with inorganic or organic mercury. Environ. Res. 1991, 56:48-56.
33. Su M., Kakita A., Yamada M., Takahashi H., Ikuta F. Degeneration of the synaptic boutons of parallel fibers in rats treated with methylmercury: Chronological observations. Neuropathology 1996, 16:172-177.
34. Takeuchi T. Pathology of Minamata disease With special reference to its pathogenesis. Acta Pathol. Jpn. 1982, 32:73-99.
35. Tanabe K., Bonilla I., Winkles J.A., Strittmatter S.M. Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth. J. Neurosci. 2003, 23:9675-9686.
36. Tomasevic N., Jia Z., Russell A., Fujii T., Hartman J.J., Clancy S., Wang M., Beraud C., Wood K.W., Sakowicz R. Differential regulation of WASP and N-WASP by Cdc42, Rac1, NCK, and PI(4, 5)P2. Biochemistry 2007, 46:3494-3502.
37. Uehata M., Ishizaki T., Satoh H., Ono T., Kawahara T., Morishita T., Tamakawa H., Yamagami K., Inui J., Maekawa M., Narumiya S. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 1997, 389:990-994.
38. Usuki F., Yasutake A., Umehara F., Tokunaga H., Matsumoto M., Eto K., Ishiura S., Higuchi I. In vivo protection of a water-soluble derivative of vitamin E, Trolox, against methylmercury-intoxication in the rat. Neurosci. Lett. 2001, 304:199-203.
39. Wakabayashi K., Kakita A., Sakamoto M., Su M., Iwanaga K., Ikuta F. Variability of brain lesions in rats administered methylmercury at various postnatal development phases. Brain Res. 1995, 705:267-272.