Acute exposure to methylmercury causes Ca2+ dysregulation and neuronal death in rat cerebellar granule cells through an M3 muscarinic receptor-linked pathway

Toxicological Sciences

Volumn 80, Issue 1, 2004, Pages 60-68

  Limke, Tobi L ^a   Bearss, Jeremy J ^a   Atchison, William D ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Ca2+ mediated cell death; Cerebellum; Inositol 14,5 triphosphate receptor; Methylmercury; Muscarinic receptor; Neurotoxicity

Indexed keywords

4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; ATROPINE; BETHANECHOL; CALCIUM ION; DIHYDRO BETA ERYTHROIDINE; FURA 2; INOSITOL 1,3,4 TRISPHOSPHATE; METHYLMERCURY; MUSCARINIC M3 RECEPTOR; MUSCARINIC M3 RECEPTOR ANTAGONIST; THAPSIGARGIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOASSAY; BRAIN NERVE CELL; CALCIUM CELL LEVEL; CALCIUM DEPLETION; CALCIUM TRANSPORT; CELL DEATH; CELL VIABILITY; CEREBELLUM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; ENVIRONMENTAL EXPOSURE; FEMALE; GENE ACTIVATION; GRANULE CELL; IN VITRO STUDY; MALE; MICROFLUOROMETRY; NEUROTOXICITY; NONHUMAN; PROTEIN FUNCTION; RAT; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; SMOOTH ENDOPLASMIC RETICULUM;

ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; ENVIRONMENTAL POLLUTANTS; FEMALE; MALE; METHYLMERCURY COMPOUNDS; NEURONS; PHOSPHOLIPASE C; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MUSCARINIC M3; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL;

EID: 3242812890     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh131     Document Type: Article

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