Microtubule: A common target for Parkin and Parkinson's disease toxins

Neuroscientist

Volumn 12, Issue 6, 2006, Pages 469-476

  Feng, Jian ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Dopamine; Microtubules; Parkin; Parkinson's disease; Rotenone; Tubulin

Indexed keywords

ANTIFUNGAL AGENT; ANTIPARASITIC AGENT; BENZIMIDAZOLE; NOCODAZOLE; PARKIN; ROTENONE; TIABENDAZOLE; TOXIN; TUBULIN; UBIQUITIN PROTEIN LIGASE E3;

CELL LOSS; DOPAMINERGIC NERVE CELL; ENZYME ACTIVITY; GENE MUTATION; MICROTUBULE; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; REVIEW;

ANIMALS; HUMANS; MICROTUBULES; MODELS, BIOLOGICAL; NEURONS; PARKINSON DISEASE; PROTEIN BINDING; ROTENONE; TUBULIN; UBIQUITIN-PROTEIN LIGASES;

EID: 33750466222     PISSN: 10738584     EISSN: 10894098     Source Type: Journal    
DOI: 10.1177/1073858406293853     Document Type: Review

References (50)

1. Amos LA. 2005. Tubulin and microtubules. In: Encyclopedia of life sciences. Chichester (UK): Wiley.
2. Baas PW. 2002. Microtubule transport in the axon. Int Rev Cytol 212:41-62.
3. Barker RA. 2006. Continuing trials of GDNF in Parkinson's disease. Lancet Neurol 5:285-6.
4. Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT. 2000. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci 3:1301-6.
5. Brinkley BR, Barham SS, Barranco SC, Fuller GM. 1974. Rotenone inhibition of spindle microtubule assembly in mammalian cells. Exp Cell Res 85:41-6.
6. Burke D, Gasdaska P, Hartwell L. 1989. Dominant effects of tubulin overexpression in saccharomyces-cerevisiae. Mol Cell Biol 9:1049-59.
7. Cappelletti G, Maggioni MG, Maci R. 1999. Influence of MPP+ on the state of tubulin polymerisation in NGF-differentiated PC12 cells. J Neurosci Res 56:28-35.
8. Cappelletti G, Pedrotti B, Maggioni MG, Maci R. 2001. Microtubule assembly is directly affected by MPP(+) in vitro. Cell Biol Int 25:981-4.
9. Cassimeris L, Spittle C. 2001. Regulation of microtubule-associated proteins. Int Rev Cytol 210:163-226.
10. Chance B, Williams GR, Hollunger G. 1963. Inhibition of electron and energy transfer in mitochondria. I. Effects of amytal, thiopental, rotenone, progesterone, and methylene glycol. J Biol Chem 238:418-31.
11. Cleveland DW. 1983. The tubulins: from DNA to RNA to protein and back again. Cell 34:330-2.
12. Cleveland DW. 1989. Autoregulated control of tubulin synthesis in animal cells. Curr Opin Cell Biol 1:10-14.
13. Cole NB, Lippincott-Schwartz J. 1995. Organization of organelles and membrane traffic by microtubules. Curr Opin Cell Biol 7:55-64.
14. Conn PJ, Battaglia G, Marino MJ, Nicoletti F. 2005. Metabotropic glutamate receptors in the basal ganglia motor circuit. Nat Rev Neurosci 6:787-98.
15. Di Monte DA. 2003. The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins? Lancet Neurol 2:531-8.
16. Floor E, Leventhal PS, Wang Y, Meng L, Chen W. 1995. Dynamic storage of dopamine in rat brain synaptic vesicles in vitro. J Neurochem 64:689-99.
17. Hampton RY. 2002. ER-associated degradation in protein quality control and cellular regulation. Curr Opin Cell Biol 14:476-82.
18. Higgins DS, Greenamyre JT. 1996. [H-3]dihydrorotenone binding to NADH: ubiquinone reductase (Complex I) of the electron transport chain: an autoradiographic study. J Neurosci 16:3807-16.
19. Hoffman JC, Vaughn KC. 1994. Mitotic disrupter herbicides act by a single mechanism but vary in efficacy. Protoplasma 179:16-25.
20. Holy J. 1998. Chlorpropham [isopropyl N-(3-chlorophenyl) carbamate] disrupts microtubule organization, cell division, and early development of sea urchin embryos. J Toxicol Environ Health A 54:319-33.
21. Hsuan SL, Klintworth HM, Xia Z. 2006. Basic fibroblast growth factor protects against rotenone-induced dopaminergic cell death through activation of extracellular signal-regulated kinases 1/2 and phosphatidylinositol-3 kinase pathways. J Neurosci 26:4481-91.
22. Huynh DP, Scoles DR, Nguyen D, Pulst SM. 2003. The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI. Hum Mol Genet 12:2587-97.
23. Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R. 2001. An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin Cell 105:891-902.
24. Jiang H, Jiang Q, Feng J. 2004. Parkin increases dopamine uptake by enhancing the cell surface expression of dopamine transporter. J Biol Chem 279:54380-6.
25. Jiang Q, Yan Z, Feng J. 2006a. Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons. J Biol Chem 281:29391-400.
26. Jiang Q, Yan Z, Feng J. 2006b. Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism. J Neurosci 26:4318-28.
27. Jordan MA, Wilson L. 2004. Microtubules as a target for anticancer drugs. Nat Rev Cancer 4:253-65.
28. Kirik D, Georgievska B, Bjorklund A. 2004. Localized striatal delivery of GDNF as a treatment for Parkinson disease. Nat Neurosci 7:105-10.
29. Kiso T, Fujita K, Ping X, Tanaka T, Taniguchi M. 2004. Screening for microtubule-disrupting antifungal agents by using a mitotic-arrest mutant of Aspergillus nidulans and novel action of phenylalanine derivatives accompanying tubulin loss. Antimicrob Agents Chemother 48:1739-48.
30. Lacey E, Gill JH. 1994. Biochemistry of benzimidazole resistance. Acta Trop 56:245-62.
31. Langston JW. 2002. Parkinson's disease: current and future challenges. Neurotoxicology 23:443-50.
32. Lewis SA, Tian GL, Cowan NJ. 1997. The alpha- and beta-tubulin folding pathways. Trends Cell Biol 7:479-84.
33. Li H, DeRosier DJ, Nicholson WV, Nogales E, Downing KH. 2002. Microtubule structure at 8 A resolution. Structure 10:1317-28.
34. Liu Y, Edwards RH. 1997. The role of vesicular transport proteins in synaptic transmission and neural degeneration. Annu Rev Neurosci 20:125-56.
35. Macinnes N, Messenger MJ, Duty S. 2004. Activation of group III metabotropic glutamate receptors in selected regions of the basal ganglia alleviates akinesia in the reserpine-treated rat. Br J Pharmacol 141:15-22.
36. Marshall LE, Himes RH. 1978. Rotenone inhibition of tubulin self-assembly. Biochim Biophys Acta 543:590-4.
37. Martin N, Jaubert J, Gounon P, Salido E, Haase G, Szatanik M, and others. 2002. A missense mutation in Tbce causes progressive motor neuronopathy in mice. Nat Genet 32:443-7.
38. Moore DJ, West AB, Dawson VL, Dawson TM. 2005. Molecular pathophysiology of Parkinson's disease. Annu Rev Neurosci 28:57-87.
39. Ren Y, Liu W, Jiang H, Jiang Q, Feng J. 2005. Selective vulnerability of dopaminergic neurons to microtubule depolymerization. J Biol Chem 280:34105-12.
40. Ren Y, Zhao JH, Feng J. 2003. Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation. J Neurosci 23:3316-24.
41. Rosso SB, Caceres AO, de Duffard AM, Duffard RO, Quiroga S. 2000. 2,4-Dichlorophenoxyacetic acid disrupts the cytoskeleton and disorganizes the Golgi apparatus of cultured neurons. Toxicol Sci 56:133-40.
42. Takeshige K, Minakami S. 1979. NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH-ubiquinone reductase preparation. Biochem J 180:129-35.
43. Tanner CM, Ottman R, Goldman SM, Ellenberg J, Chan P, Mayeux R, Langston JW. 1999. Parkinson disease in twins: an etiologic study. JAMA 281:341-6.
44. Tsai B, Ye Y, Rapoport TA. 2002. Retro-translocation of proteins from the endoplasmic reticulum into the cytosol. Nat Rev Mol Cell Biol 3:246-55.
45. Valenti O, Marino MJ, Wittmann M, Lis E, DiLella AG, Kinney GG, and others. 2003. Group III metabotropic glutamate receptor-mediated modulation of the striatopallidal synapse. J Neurosci 23:7218-26.
46. Vogelstein B, Kinzler KW. 2004. Cancer genes and the pathways they control. Nat Med 10:789-99.
47. Wang Y, Tian G, Cowan NJ, Cabral F. 2006. Mutations affecting beta-tubulin folding and degradation. J Biol Chem 281:13628-35.
48. Yang F, Jiang Q, Zhao J, Ren Y, Sutton MD, Feng J. 2005. Parkin stabilizes microtubules through strong binding mediated by three independent domains. J Biol Chem 280:17154-62.
49. Zeng L, Baird WV. 1999. Inheritance of resistance to anti-microtubule dinitroaniline herbicides in an "intermediate" resistant biotype of Eleusine indica (Poaceae). Am J Bot 86:940.
50. Zhang Y, Gao J, Chung KK, Huang H, Dawson VL, Dawson TM. 2000. Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. Proc Natl Acad Sci U S A 97:13354-59.