-
1
-
-
0024399028
-
a1-Antichymotrypsin is present together with the β-protein in monkey brain amyloid deposits
-
Abraham, C., Selkoe, D., Potter, H., Price, D., and Cork, L. (1989). a1-Antichymotrypsin is present together with the β-protein in monkey brain amyloid deposits. Neuroscience 32, 715-720. doi: 10.1016/0306-4522(89)90292-3
-
(1989)
Neuroscience
, vol.32
, pp. 715-720
-
-
Abraham, C.1
Selkoe, D.2
Potter, H.3
Price, D.4
Cork, L.5
-
2
-
-
0035543191
-
Reactive astrocytes and a1-antichymotrypsin in Alzheimer's disease
-
Abraham, C. R. (2001). Reactive astrocytes and a1-antichymotrypsin in Alzheimer's disease. Neurobiol. Aging 22, 931-936. doi: 10.1016/S0197-4580(01)00302-5
-
(2001)
Neurobiol. Aging
, vol.22
, pp. 931-936
-
-
Abraham, C.R.1
-
3
-
-
24044503374
-
Expression of scavenger receptors in glial cells
-
Alarcon, R., Fuenzalida, C., Santibanez, M., and von Bernhardi, R. (2005). Expression of scavenger receptors in glial cells. Comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound beta-amyloid. J. Biol. Chem. 280, 30406-30415. doi: 10.1074/jbc.M414686200
-
(2005)
Comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound beta-amyloid. J. Biol. Chem.
, vol.280
, pp. 30406-30415
-
-
Alarcon, R.1
Fuenzalida, C.2
Santibanez, M.3
von Bernhardi, R.4
-
4
-
-
64549116740
-
Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain
-
Azevedo, F. A., Carvalho, L. R., Grinberg, L. T., Farfel, J. M., Ferretti, R. E., Leite, R. E., et al. (2009). Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain. J. Comp. Neurol. 513, 532-541. doi: 10.1002/cne.21974
-
(2009)
J. Comp. Neurol.
, vol.513
, pp. 532-541
-
-
Azevedo, F.A.1
Carvalho, L.R.2
Grinberg, L.T.3
Farfel, J.M.4
Ferretti, R.E.5
Leite, R.E.6
-
5
-
-
0037107177
-
Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy
-
Bacskai, B. J., Kajdasz, S. T., McLellan, M. E., Games, D., Seubert, P., Schenk, D., et al. (2002). Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy. J. Neurosci. 22, 7873-7878.
-
(2002)
J. Neurosci.
, vol.22
, pp. 7873-7878
-
-
Bacskai, B.J.1
Kajdasz, S.T.2
McLellan, M.E.3
Games, D.4
Seubert, P.5
Schenk, D.6
-
6
-
-
0037387147
-
A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation
-
Bamberger, M. E., Harris, M. E., McDonald, D. R., Husemann, J., and Landreth, G. E. (2003). A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation. J. Neurosci. 23, 2665-2674.
-
(2003)
J. Neurosci.
, vol.23
, pp. 2665-2674
-
-
Bamberger, M.E.1
Harris, M.E.2
McDonald, D.R.3
Husemann, J.4
Landreth, G.E.5
-
7
-
-
0033835996
-
Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
-
Bard, F., Cannon, C., Barbour, R., Burke, R., Games, D., Grajeda, H., et al. (2000). Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med. 6, 916-919. doi: 10.1038/78682
-
(2000)
Nat. Med.
, vol.6
, pp. 916-919
-
-
Bard, F.1
Cannon, C.2
Barbour, R.3
Burke, R.4
Games, D.5
Grajeda, H.6
-
8
-
-
67349093525
-
Clearance mechanisms of Alzheimer's amyloid-β peptide: implications for therapeutic design and diagnostic tests
-
Bates, K., Verdile, G., Li, Q., Ames, D., Hudson, P., Masters, C., et al. (2009). Clearance mechanisms of Alzheimer's amyloid-β peptide: implications for therapeutic design and diagnostic tests. Mol. Psychiatry 14, 469-486. doi: 10.1038/mp.2008.96
-
(2009)
Mol. Psychiatry
, vol.14
, pp. 469-486
-
-
Bates, K.1
Verdile, G.2
Li, Q.3
Ames, D.4
Hudson, P.5
Masters, C.6
-
9
-
-
39149099122
-
Regional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitary
-
Bernstein, H., Lendeckel, U., Bukowska, A., Ansorge, S., Ernst, T., Stauch, R., et al. (2008). Regional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitary. J. Chem. Neuroanat. 35, 216-224. doi: 10.1016/j.jchemneu.2007.12.001
-
(2008)
J. Chem. Neuroanat.
, vol.35
, pp. 216-224
-
-
Bernstein, H.1
Lendeckel, U.2
Bukowska, A.3
Ansorge, S.4
Ernst, T.5
Stauch, R.6
-
10
-
-
84896699997
-
Modulation of inflammation in transgenic models of Alzheimer's disease
-
Birch, A. M., Katsouri, L., and Sastre, M. (2014). Modulation of inflammation in transgenic models of Alzheimer's disease. J. Neuroinflammation 11:25. doi: 10.1186/1742-2094-11-25
-
(2014)
J. Neuroinflammation
, vol.11
, pp. 25
-
-
Birch, A.M.1
Katsouri, L.2
Sastre, M.3
-
11
-
-
84904460208
-
Accumulation of intraneuronal Amyloid-β is common in normal brain
-
Blair, J. A., Siedlak, S. L., Wolfram, J. A., Nunomura, A., Castellani, R. J., Ferreira, S. T., et al. (2014). Accumulation of intraneuronal Amyloid-β is common in normal brain. Curr. Alzheimer Res. 11, 317-324. doi: 10.2174/1567205011666140302200902
-
(2014)
Curr. Alzheimer Res.
, vol.11
, pp. 317-324
-
-
Blair, J.A.1
Siedlak, S.L.2
Wolfram, J.A.3
Nunomura, A.4
Castellani, R.J.5
Ferreira, S.T.6
-
12
-
-
52949101715
-
Involvement of formyl-peptide-receptor-like-1 and phospholipase D in the internalization, and signal transduction of amyloid beta 1-42 in glial cells
-
Brandenburg, L., Konrad, M., Wruck, C., Koch, T., Pufe, T., and Lucius, R. (2008). Involvement of formyl-peptide-receptor-like-1 and phospholipase D in the internalization, and signal transduction of amyloid beta 1-42 in glial cells. Neuroscience 156, 266-276. doi: 10.1016/j.neuroscience.2008.07.042
-
(2008)
Neuroscience
, vol.156
, pp. 266-276
-
-
Brandenburg, L.1
Konrad, M.2
Wruck, C.3
Koch, T.4
Pufe, T.5
Lucius, R.6
-
13
-
-
77950644914
-
Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells
-
Brandenburg, L., Konrad, M., Wruck, C. J., Koch, T., Lucius, R., and Pufe, T. (2010). Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells. J. Neurochem. 113, 749-760. doi: 10.1111/j.1471-4159.2010.06637.x
-
(2010)
J. Neurochem.
, vol.113
, pp. 749-760
-
-
Brandenburg, L.1
Konrad, M.2
Wruck, C.J.3
Koch, T.4
Lucius, R.5
Pufe, T.6
-
14
-
-
79551627051
-
The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis
-
Braun, B. J., Slowik, A., Leib, S. L., Lucius, R., Varoga, D., Wruck, C. J., et al. (2011). The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis. J. Neuroinflammation 8:11. doi: 10.1186/1742-2094-8-11
-
(2011)
J. Neuroinflammation
, vol.8
, pp. 11
-
-
Braun, B.J.1
Slowik, A.2
Leib, S.L.3
Lucius, R.4
Varoga, D.5
Wruck, C.J.6
-
15
-
-
40149099870
-
Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology
-
Carare, R., Bernardes-Silva, M., Newman, T., Page, A., Nicoll, J., Perry, V., et al. (2008). Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology. Neuropathol. Appl. Neurobiol. 34, 131-144. doi: 10.1111/j.1365-2990.2007.00926.x
-
(2008)
Neuropathol. Appl. Neurobiol.
, vol.34
, pp. 131-144
-
-
Carare, R.1
Bernardes-Silva, M.2
Newman, T.3
Page, A.4
Nicoll, J.5
Perry, V.6
-
16
-
-
84877353475
-
Extracellular chaperones prevent Aβ 42-induced toxicity in rat brains
-
Cascella, R., Conti, S., Tatini, F., Evangelisti, E., Scartabelli, T., Casamenti, F., et al. (2013). Extracellular chaperones prevent Aβ 42-induced toxicity in rat brains. Biochim. Biophys. Acta 1832, 1217-1226. doi: 10.1016/j.bbadis.2013.04.012
-
(2013)
Biochim. Biophys. Acta
, vol.1832
, pp. 1217-1226
-
-
Cascella, R.1
Conti, S.2
Tatini, F.3
Evangelisti, E.4
Scartabelli, T.5
Casamenti, F.6
-
17
-
-
84907898151
-
Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome
-
Cho, M., Cho, K., Kang, H., Jeon, E., Kim, H., Kwon, H., et al. (2014). Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome. Autophagy 10, 1761-1775. doi: 10.4161/auto.29647
-
(2014)
Autophagy
, vol.10
, pp. 1761-1775
-
-
Cho, M.1
Cho, K.2
Kang, H.3
Jeon, E.4
Kim, H.5
Kwon, H.6
-
18
-
-
0036141148
-
CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to β-amyloid fibrils
-
Coraci, I. S., Husemann, J., Berman, J. W., Hulette, C., Dufour, J. H., Campanella, G. K., et al. (2002). CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to β-amyloid fibrils. Am. J. Pathol. 160, 101-112. doi: 10.1016/S0002-9440(10)64354-4
-
(2002)
Am. J. Pathol.
, vol.160
, pp. 101-112
-
-
Coraci, I.S.1
Husemann, J.2
Berman, J.W.3
Hulette, C.4
Dufour, J.H.5
Campanella, G.K.6
-
19
-
-
84862777666
-
ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models
-
Cramer, P. E., Cirrito, J. R., Wesson, D. W., Lee, C. Y., Karlo, J. C., Zinn, A. E., et al. (2012). ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models. Science 335, 1503-1506. doi: 10.1126/science.1217697
-
(2012)
Science
, vol.335
, pp. 1503-1506
-
-
Cramer, P.E.1
Cirrito, J.R.2
Wesson, D.W.3
Lee, C.Y.4
Karlo, J.C.5
Zinn, A.E.6
-
20
-
-
2942586336
-
Blood-brain barrier damage induces release of alpha2-macroglobulin
-
Cucullo, L., Marchi, N., Marroni, M., Fazio, V., Namura, S., and Janigro, D. (2003). Blood-brain barrier damage induces release of alpha2-macroglobulin. Mol. Cell. Proteomics 2, 234-241. doi: 10.1074/mcp.M200077-MCP200
-
(2003)
Mol. Cell. Proteomics
, vol.2
, pp. 234-241
-
-
Cucullo, L.1
Marchi, N.2
Marroni, M.3
Fazio, V.4
Namura, S.5
Janigro, D.6
-
21
-
-
65649105035
-
Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease
-
Deane, R., Bell, R. D., Sagare, A., and Zlokovic, B. V. (2009). Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease. CNS Neurol. Disord. Drug Targets 8, 16-30. doi: 10.2174/187152709787601867
-
(2009)
CNS Neurol. Disord. Drug Targets
, vol.8
, pp. 16-30
-
-
Deane, R.1
Bell, R.D.2
Sagare, A.3
Zlokovic, B.V.4
-
22
-
-
84897935089
-
Microglia receptors and their implications in the response to amyloid beta for Alzheimer's disease pathogenesis
-
Doens, D., and Fernández, P. L. (2014). Microglia receptors and their implications in the response to amyloid beta for Alzheimer's disease pathogenesis. J. Neuroinflammation 11:48. doi: 10.1186/1742-2094-11-48
-
(2014)
J. Neuroinflammation
, vol.11
, pp. 48
-
-
Doens, D.1
Fernández, P.L.2
-
23
-
-
0035816707
-
Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme
-
Eckman, E. A., Reed, D. K., and Eckman, C. B. (2001). Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme. J. Biol. Chem. 276, 24540-24548. doi: 10.1074/jbc.M007579200
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 24540-24548
-
-
Eckman, E.A.1
Reed, D.K.2
Eckman, C.B.3
-
24
-
-
0037462769
-
Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme
-
Eckman, E. A., Watson, M., Marlow, L., Sambamurti, K., and Eckman, C. B. (2003). Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme. J. Biol. Chem. 278, 2081-2084. doi: 10.1074/jbc.C200642200
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 2081-2084
-
-
Eckman, E.A.1
Watson, M.2
Marlow, L.3
Sambamurti, K.4
Eckman, C.B.5
-
25
-
-
0038204838
-
CD36 mediates the innate host response to beta-amyloid
-
El Khoury, J. B., Moore, K. J., Means, T. K., Leung, J., Terada, K., Toft, M., et al. (2003). CD36 mediates the innate host response to beta-amyloid. J. Exp. Med. 197, 1657-1666. doi: 10.1084/jem.20021546
-
(2003)
J. Exp. Med.
, vol.197
, pp. 1657-1666
-
-
El Khoury, J.B.1
Moore, K.J.2
Means, T.K.3
Leung, J.4
Terada, K.5
Toft, M.6
-
26
-
-
79551481336
-
γ-Secretase component presenilin is important for microglia β-amyloid clearance
-
Farfara, D., Trudler, D., Segev-Amzaleg, N., Galron, R., Stein, R., and Frenkel, D. (2011). γ-Secretase component presenilin is important for microglia β-amyloid clearance. Ann. Neurol. 69, 170-180. doi: 10.1002/ana.22191
-
(2011)
Ann. Neurol.
, vol.69
, pp. 170-180
-
-
Farfara, D.1
Trudler, D.2
Segev-Amzaleg, N.3
Galron, R.4
Stein, R.5
Frenkel, D.6
-
27
-
-
0037390039
-
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo
-
Farris, W., Mansourian, S., Chang, Y., Lindsley, L., Eckman, E. A., Frosch, M. P., et al. (2003). Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc. Natl. Acad. Sci. U.S.A. 100, 4162-4167. doi: 10.1073/pnas.0230450100
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 4162-4167
-
-
Farris, W.1
Mansourian, S.2
Chang, Y.3
Lindsley, L.4
Eckman, E.A.5
Frosch, M.P.6
-
28
-
-
34547240466
-
Effects of hypoxia and oxidative stress on expression of neprilysin in human neuroblastoma cells and rat cortical neurones and astrocytes
-
Fisk, L., Nalivaeva, N. N., Boyle, J. P., Peers, C. S., and Turner, A. J. (2007). Effects of hypoxia and oxidative stress on expression of neprilysin in human neuroblastoma cells and rat cortical neurones and astrocytes. Neurochem. Res. 32, 1741-1748. doi: 10.1007/s11064-007-9349-2
-
(2007)
Neurochem. Res.
, vol.32
, pp. 1741-1748
-
-
Fisk, L.1
Nalivaeva, N.N.2
Boyle, J.P.3
Peers, C.S.4
Turner, A.J.5
-
29
-
-
84862809855
-
Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia
-
Fu, H., Liu, B., Frost, J. L., Hong, S., Jin, M., Ostaszewski, B., et al. (2012). Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia. Glia 60, 993-1003. doi: 10.1002/glia.22331
-
(2012)
Glia
, vol.60
, pp. 993-1003
-
-
Fu, H.1
Liu, B.2
Frost, J.L.3
Hong, S.4
Jin, M.5
Ostaszewski, B.6
-
30
-
-
19044378626
-
Aβ-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Aβ pathology
-
Fukami, S., Watanabe, K., Iwata, N., Haraoka, J., Lu, B., Gerard, N. P., et al. (2002). Aβ-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Aβ pathology. Neurosci. Res. 43, 39-56. doi: 10.1016/S0168-0102(02)00015-9
-
(2002)
Neurosci. Res.
, vol.43
, pp. 39-56
-
-
Fukami, S.1
Watanabe, K.2
Iwata, N.3
Haraoka, J.4
Lu, B.5
Gerard, N.P.6
-
31
-
-
33644863605
-
Astrocyte-specific expression of the alpha1-antichymotrypsin, and glial fibrillary acidic protein genes requires activator protein-1
-
Gopalan, S. M., Wilczynska, K. M., Konik, B. S., Bryan, L., and Kordula, T. (2006a). Astrocyte-specific expression of the alpha1-antichymotrypsin, and glial fibrillary acidic protein genes requires activator protein-1. J. Biol. Chem. 281, 1956-1963. doi: 10.1074/jbc.M510935200
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 1956-1963
-
-
Gopalan, S.M.1
Wilczynska, K.M.2
Konik, B.S.3
Bryan, L.4
Kordula, T.5
-
32
-
-
33744957534
-
Nuclear factor-1-X regulates astrocyte-specific expression of the alpha1-antichymotrypsin, and glial fibrillary acidic protein genes
-
Gopalan, S. M., Wilczynska, K. M., Konik, B. S., Bryan, L., and Kordula, T. (2006b). Nuclear factor-1-X regulates astrocyte-specific expression of the alpha1-antichymotrypsin, and glial fibrillary acidic protein genes. J. Biol. Chem. 281, 13126-13133. doi: 10.1074/jbc.M601194200
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 13126-13133
-
-
Gopalan, S.M.1
Wilczynska, K.M.2
Konik, B.S.3
Bryan, L.4
Kordula, T.5
-
33
-
-
61449250853
-
Astrocytes are very sensitive to develop innate immune responses to lipid-carried short interfering RNA
-
Gorina, R., Santalucia, T., Petegnief, V., Ejarque-Ortiz, A., Saura, J., and Planas, A. M. (2009). Astrocytes are very sensitive to develop innate immune responses to lipid-carried short interfering RNA. Glia 57, 93-107. doi: 10.1002/glia.20738
-
(2009)
Glia
, vol.57
, pp. 93-107
-
-
Gorina, R.1
Santalucia, T.2
Petegnief, V.3
Ejarque-Ortiz, A.4
Saura, J.5
Planas, A.M.6
-
34
-
-
25144501662
-
Intraneuronal Aβ accumulation, and origin of plaques in Alzheimer's disease
-
Gouras, G. K., Almeida, C. G., and Takahashi, R. H. (2005). Intraneuronal Aβ accumulation, and origin of plaques in Alzheimer's disease. Neurobiol. Aging 26, 1235-1244. doi: 10.1016/j.neurobiolaging.2005.05.022
-
(2005)
Neurobiol. Aging
, vol.26
, pp. 1235-1244
-
-
Gouras, G.K.1
Almeida, C.G.2
Takahashi, R.H.3
-
35
-
-
47849085872
-
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
-
Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., et al. (2008). The NALP3 inflammasome is involved in the innate immune response to amyloid-β. Nat. Immunol. 9, 857-865. doi: 10.1038/ni.1636
-
(2008)
Nat. Immunol.
, vol.9
, pp. 857-865
-
-
Halle, A.1
Hornung, V.2
Petzold, G.C.3
Stewart, C.R.4
Monks, B.G.5
Reinheckel, T.6
-
36
-
-
70349558522
-
Genome-wide association study identifies variants at CLU, and PICALM associated with Alzheimer's disease
-
Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., et al. (2009). Genome-wide association study identifies variants at CLU, and PICALM associated with Alzheimer's disease. Nat. Genet. 41, 1088-1093. doi: 10.1038/ng.440
-
(2009)
Nat. Genet.
, vol.41
, pp. 1088-1093
-
-
Harold, D.1
Abraham, R.2
Hollingworth, P.3
Sims, R.4
Gerrish, A.5
Hamshere, M.L.6
-
37
-
-
0942287189
-
Astroglial regulation of apolipoprotein E expression in neuronal cells
-
Harris, F. M., Tesseur, I., Brecht, W. J., Xu, Q., Mullendorff, K., Chang, S., et al. (2004). Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease. J. Biol. Chem. 279, 3862-3868. doi: 10.1074/jbc.M309475200
-
(2004)
Implications for Alzheimer's disease. J. Biol. Chem.
, vol.279
, pp. 3862-3868
-
-
Harris, F.M.1
Tesseur, I.2
Brecht, W.J.3
Xu, Q.4
Mullendorff, K.5
Chang, S.6
-
38
-
-
51149120624
-
Microglial dysfunction, and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
-
Hickman, S. E., Allison, E. K., and El Khoury, J. (2008). Microglial dysfunction, and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J. Neurosci. 28, 8354-8360. doi: 10.1523/JNEUROSCI.0616-08.2008
-
(2008)
J. Neurosci.
, vol.28
, pp. 8354-8360
-
-
Hickman, S.E.1
Allison, E.K.2
El Khoury, J.3
-
39
-
-
0036260892
-
Increased expression of the amyloid precursor β-secretase in Alzheimer's disease
-
Holsinger, R., McLean, C. A., Beyreuther, K., Masters, C. L., and Evin, G. (2002). Increased expression of the amyloid precursor β-secretase in Alzheimer's disease. Ann. Neurol. 51, 783-786. doi: 10.1002/ana.10208
-
(2002)
Ann. Neurol.
, vol.51
, pp. 783-786
-
-
Holsinger, R.1
McLean, C.A.2
Beyreuther, K.3
Masters, C.L.4
Evin, G.5
-
40
-
-
84894292228
-
Relationship between amyloid-beta, and the ubiquitin-proteasome system in Alzheimer's disease
-
Hong, L., Huang, H., and Jiang, Z. (2014). Relationship between amyloid-beta, and the ubiquitin-proteasome system in Alzheimer's disease. Neurol. Res. 36, 276-282. doi: 10.1179/1743132813Y.0000000288
-
(2014)
Neurol. Res.
, vol.36
, pp. 276-282
-
-
Hong, L.1
Huang, H.2
Jiang, Z.3
-
41
-
-
0035930538
-
Angiotensin-converting enzyme degrades Alzheimer amyloid β-peptide (Aβ); retards
-
Hu, J., Igarashi, A., Kamata, M., and Nakagawa, H. (2001). Angiotensin-converting enzyme degrades Alzheimer amyloid β-peptide (Aβ); retards. (Aβ) aggregation, deposition, fibril formation; and inhibits cytotoxicity. J. Biol. Chem. 276, 47863-47868. doi: 10.1074/jbc.M104068200
-
(2001)
(Aβ) aggregation, deposition, fibril formation; and inhibits cytotoxicity. J. Biol. Chem.
, vol.276
, pp. 47863-47868
-
-
Hu, J.1
Igarashi, A.2
Kamata, M.3
Nakagawa, H.4
-
42
-
-
0036847848
-
Scavenger receptors in neurobiology, and neuropathology: their role on microglia, and other cells of the nervous system
-
Husemann, J., Loike, J. D., Anankov, R., Febbraio, M., and Silverstein, S. C. (2002). Scavenger receptors in neurobiology, and neuropathology: their role on microglia, and other cells of the nervous system. Glia 40, 195-205. doi: 10.1002/glia.10148
-
(2002)
Glia
, vol.40
, pp. 195-205
-
-
Husemann, J.1
Loike, J.D.2
Anankov, R.3
Febbraio, M.4
Silverstein, S.C.5
-
43
-
-
84919402659
-
Water influx into cerebrospinal fluid is significantly reduced in senile plaque bearing transgenic mice, supporting beta-amyloid clearance hypothesis of Alzheimer's disease
-
Igarashi, H., Suzuki, Y., Kwee, I. L., and Nakada, T. (2014). Water influx into cerebrospinal fluid is significantly reduced in senile plaque bearing transgenic mice, supporting beta-amyloid clearance hypothesis of Alzheimer's disease. Neurol. Res. 36, 1094-1098. doi: 10.1179/1743132814Y.0000000434
-
(2014)
Neurol. Res.
, vol.36
, pp. 1094-1098
-
-
Igarashi, H.1
Suzuki, Y.2
Kwee, I.L.3
Nakada, T.4
-
44
-
-
84879671420
-
Is there a cerebral lymphatic system?
-
Iliff, J. J., and Nedergaard, M. (2013). Is there a cerebral lymphatic system? Stroke 44, S93-S95. doi: 10.1161/STROKEAHA.112.678698
-
(2013)
Stroke
, vol.44
, pp. S93-S95
-
-
Iliff, J.J.1
Nedergaard, M.2
-
45
-
-
28744458578
-
CpG-containing oligodeoxynucleotide promotes microglial cell uptake of amyloid beta 1-42 peptide by up-regulating the expression of the G-protein-coupled receptor mFPR2
-
Iribarren, P., Chen, K., Hu, J., Gong, W., Cho, E. H., Lockett, S., et al. (2005). CpG-containing oligodeoxynucleotide promotes microglial cell uptake of amyloid beta 1-42 peptide by up-regulating the expression of the G-protein-coupled receptor mFPR2. FASEB J. 19, 2032-2034. doi: 10.1096/fj.05-4578fje
-
(2005)
FASEB J.
, vol.19
, pp. 2032-2034
-
-
Iribarren, P.1
Chen, K.2
Hu, J.3
Gong, W.4
Cho, E.H.5
Lockett, S.6
-
46
-
-
0035877610
-
Subcellular compartment, and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2
-
Iwata, H., Tomita, T., Maruyama, K., and Iwatsubo, T. (2001). Subcellular compartment, and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2. J. Biol. Chem. 276, 21678-21685. doi: 10.1074/jbc.M007989200
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 21678-21685
-
-
Iwata, H.1
Tomita, T.2
Maruyama, K.3
Iwatsubo, T.4
-
47
-
-
84905721968
-
The ubiquitin proteasome system in glia, and its role in neurodegenerative diseases
-
Jansen, A. H., Reits, E. A., and Hol, E. M. (2014). The ubiquitin proteasome system in glia, and its role in neurodegenerative diseases. Front. Mol. Neurosci. 7:73. doi: 10.3389/fnmol.2014.00073
-
(2014)
Front. Mol. Neurosci.
, vol.7
, pp. 73
-
-
Jansen, A.H.1
Reits, E.A.2
Hol, E.M.3
-
48
-
-
84874650512
-
Amyloid-β-induced astrocytic phagocytosis is mediated by CD36, CD47, and RAGE
-
Jones, R. S., Minogue, A. M., Connor, T. J., and Lynch, M. A. (2013). Amyloid-β-induced astrocytic phagocytosis is mediated by CD36, CD47, and RAGE. J. Neuroimmune Pharmacol. 8, 301-311. doi: 10.1007/s11481-012-9427-3
-
(2013)
J. Neuroimmune Pharmacol.
, vol.8
, pp. 301-311
-
-
Jones, R.S.1
Minogue, A.M.2
Connor, T.J.3
Lynch, M.A.4
-
49
-
-
84896726518
-
ApoE, and Aβ in Alzheimer's disease: accidental encounters or partners?
-
Kanekiyo, T., Xu, H., and Bu, G. (2014). ApoE, and Aβ in Alzheimer's disease: accidental encounters or partners? Neuron 81, 740-754. doi: 10.1016/j.neuron.2014.01.045
-
(2014)
Neuron
, vol.81
, pp. 740-754
-
-
Kanekiyo, T.1
Xu, H.2
Bu, G.3
-
50
-
-
34248512598
-
Aβ upregulates, and colocalizes with LGI3 in cultured rat astrocytes
-
Kimura, N., Ishii, Y., Suzaki, S., Negishi, T., Kyuwa, S., and Yoshikawa, Y. (2007). Aβ upregulates, and colocalizes with LGI3 in cultured rat astrocytes. Cell Mol. Neurobiol. 27, 335-350. doi: 10.1007/s10571-006-9127-8
-
(2007)
Cell Mol. Neurobiol.
, vol.27
, pp. 335-350
-
-
Kimura, N.1
Ishii, Y.2
Suzaki, S.3
Negishi, T.4
Kyuwa, S.5
Yoshikawa, Y.6
-
51
-
-
84904479732
-
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
-
243ra86
-
Kleinberger, G., Yamanishi, Y., Suarez-Calvet, M., Czirr, E., Lohmann, E., Cuyvers, E., et al. (2014). TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci. Transl. Med. 6:243ra86. doi: 10.1126/scitranslmed.3009093
-
(2014)
Sci. Transl. Med.
, vol.6
-
-
Kleinberger, G.1
Yamanishi, Y.2
Suarez-Calvet, M.3
Czirr, E.4
Lohmann, E.5
Cuyvers, E.6
-
52
-
-
33846316333
-
The TREM receptor family, and signal integration
-
Klesney-Tait, J., Turnbull, I. R., and Colonna, M. (2006). The TREM receptor family, and signal integration. Nat. Immunol. 7:1266-1273. doi: 10.1038/ni1411
-
(2006)
Nat. Immunol.
, vol.7
, pp. 1266-1273
-
-
Klesney-Tait, J.1
Turnbull, I.R.2
Colonna, M.3
-
53
-
-
3142781310
-
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides
-
Koistinaho, M., Lin, S., Wu, X., Esterman, M., Koger, D., Hanson, J., et al. (2004). Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides. Nat. Med. 10, 719-726. doi: 10.1038/nm1058
-
(2004)
Nat. Med.
, vol.10
, pp. 719-726
-
-
Koistinaho, M.1
Lin, S.2
Wu, X.3
Esterman, M.4
Koger, D.5
Hanson, J.6
-
54
-
-
0035864169
-
Amyloid β42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1
-
Le, Y., Gong, W., Tiffany, H. L., Tumanov, A., Nedospasov, S., Shen, W., et al. (2001). Amyloid β42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1. J. Neurosci. 21.
-
(2001)
J. Neurosci.
, pp. 21
-
-
Le, Y.1
Gong, W.2
Tiffany, H.L.3
Tumanov, A.4
Nedospasov, S.5
Shen, W.6
-
55
-
-
0036839229
-
Formyl-peptide receptors revisited
-
Le, Y., Murphy, P. M., and Wang, J. M. (2002). Formyl-peptide receptors revisited. Trends Immunol. 23, 541-548. doi: 10.1016/S1471-4906(02)02316-5
-
(2002)
Trends Immunol.
, vol.23
, pp. 541-548
-
-
Le, Y.1
Murphy, P.M.2
Wang, J.M.3
-
56
-
-
77956955758
-
The role of microglia in amyloid clearance from the AD brain
-
Lee, C. D., and Landreth, G. E. (2010). The role of microglia in amyloid clearance from the AD brain. J. Neural. Transm. 117, 949-960. doi: 10.1007/s00702-010-0433-4
-
(2010)
J. Neural. Transm.
, vol.117
, pp. 949-960
-
-
Lee, C.D.1
Landreth, G.E.2
-
57
-
-
84949671101
-
Metallothionein-3 modulates the amyloid β endocytosis of astrocytes through its effects on actin polymerization
-
Lee, S., Seo, B., and Koh, J. (2015). Metallothionein-3 modulates the amyloid β endocytosis of astrocytes through its effects on actin polymerization. Mol. Brain. 8:84. doi: 10.1186/s13041-015-0173-3
-
(2015)
Mol. Brain.
, vol.8
, pp. 84
-
-
Lee, S.1
Seo, B.2
Koh, J.3
-
58
-
-
0346101885
-
Enhanced proteolysis of β-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
-
Leissring, M. A., Farris, W., Chang, A. Y., Walsh, D. M., Wu, X., Sun, X., et al. (2003). Enhanced proteolysis of β-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron 40, 1087-1093. doi: 10.1016/S0896-6273(03)00787-6
-
(2003)
Neuron
, vol.40
, pp. 1087-1093
-
-
Leissring, M.A.1
Farris, W.2
Chang, A.Y.3
Walsh, D.M.4
Wu, X.5
Sun, X.6
-
59
-
-
84886908979
-
P2Y4 receptor-mediated pinocytosis contributes to amyloid beta-induced self-uptake by microglia
-
Li, H. Q., Chen, C., Dou, Y., Wu, H. J., Liu, Y. J., Lou, H. F., et al. (2013). P2Y4 receptor-mediated pinocytosis contributes to amyloid beta-induced self-uptake by microglia. Mol. Cell Biol. 33, 4282-4293. doi: 10.1128/MCB.00544-13
-
(2013)
Mol. Cell Biol.
, vol.33
, pp. 4282-4293
-
-
Li, H.Q.1
Chen, C.2
Dou, Y.3
Wu, H.J.4
Liu, Y.J.5
Lou, H.F.6
-
60
-
-
84876050570
-
Relationship between the proteasomal system, and autophagy
-
Lilienbaum, A. (2013). Relationship between the proteasomal system, and autophagy. Int. J. Biochem. Mol. Biol. 4, 1-26.
-
(2013)
Int. J. Biochem. Mol. Biol.
, vol.4
, pp. 1-26
-
-
Lilienbaum, A.1
-
61
-
-
23444448277
-
LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide
-
Liu, Y., Walter, S., Stagi, M., Cherny, D., Letiembre, M., Schulz-Schaeffer, W., et al. (2005). LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide. Brain 128, 1778-1789. doi: 10.1093/brain/awh531
-
(2005)
Brain
, vol.128
, pp. 1778-1789
-
-
Liu, Y.1
Walter, S.2
Stagi, M.3
Cherny, D.4
Letiembre, M.5
Schulz-Schaeffer, W.6
-
62
-
-
0347755563
-
Contribution of cerebral amyloid angiopathy to Alzheimer's disease
-
Love, S. (2004). Contribution of cerebral amyloid angiopathy to Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 75, 1-4.
-
(2004)
J. Neurol. Neurosurg. Psychiatry
, vol.75
, pp. 1-4
-
-
Love, S.1
-
63
-
-
84884185631
-
Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease
-
Lucin, K. M., O'Brien, C. E., Bieri, G., Czirr, E., Mosher, K. I., Abbey, R. J., et al. (2013). Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease. Neuron 79, 873-886. doi: 10.1016/j.neuron.2013.06.046
-
(2013)
Neuron
, vol.79
, pp. 873-886
-
-
Lucin, K.M.1
O'Brien, C.E.2
Bieri, G.3
Czirr, E.4
Mosher, K.I.5
Abbey, R.J.6
-
64
-
-
65249170245
-
Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis
-
Mandrekar, S., Jiang, Q., Lee, C. Y., Koenigsknecht-Talboo, J., Holtzman, D. M., and Landreth, G. E. (2009). Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis. J. Neurosci. 29, 4252-4262. doi: 10.1523/JNEUROSCI.5572-08.2009
-
(2009)
J. Neurosci.
, vol.29
, pp. 4252-4262
-
-
Mandrekar, S.1
Jiang, Q.2
Lee, C.Y.3
Koenigsknecht-Talboo, J.4
Holtzman, D.M.5
Landreth, G.E.6
-
65
-
-
16844363404
-
Tissue plasminogen activator in central nervous system physiology, and pathology
-
Melchor, J. P., and Strickland, S. (2005). Tissue plasminogen activator in central nervous system physiology, and pathology. Thromb. Haemost. 93, 655-660. doi: 10.1160/TH04-12-0838
-
(2005)
Thromb. Haemost.
, vol.93
, pp. 655-660
-
-
Melchor, J.P.1
Strickland, S.2
-
66
-
-
84907222721
-
The cerebrovascular basement membrane: role in the clearance of β-amyloid, and cerebral amyloid angiopathy
-
Morris, A. W., Carare, R. O., Schreiber, S., and Hawkes, C. A. (2014). The cerebrovascular basement membrane: role in the clearance of β-amyloid, and cerebral amyloid angiopathy. Front. Aging Neurosci. 6:251. doi: 10.3389/fnagi.2014.00251
-
(2014)
Front. Aging Neurosci.
, vol.6
, pp. 251
-
-
Morris, A.W.1
Carare, R.O.2
Schreiber, S.3
Hawkes, C.A.4
-
67
-
-
84893736391
-
Apolipoproteins E, and J interfere with amyloid-beta uptake by primary human astrocytes, and microglia in vitro
-
Mulder, S. D., Nielsen, H. M., Blankenstein, M. A., Eikelenboom, P., and Veerhuis, R. (2014). Apolipoproteins E, and J interfere with amyloid-beta uptake by primary human astrocytes, and microglia in vitro. Glia 62, 493-503. doi: 10.1002/glia.22619
-
(2014)
Glia
, vol.62
, pp. 493-503
-
-
Mulder, S.D.1
Nielsen, H.M.2
Blankenstein, M.A.3
Eikelenboom, P.4
Veerhuis, R.5
-
68
-
-
0037427384
-
Astrocytes accumulate Aβ42, and give rise to astrocytic amyloid plaques in Alzheimer disease brains
-
Nagele, R. G., D'Andrea, M. R., Lee, H., Venkataraman, V., and Wang, H. (2003). Astrocytes accumulate Aβ42, and give rise to astrocytic amyloid plaques in Alzheimer disease brains. Brain Res. 971, 197-209. doi: 10.1016/S0006-8993(03)02361-8
-
(2003)
Brain Res.
, vol.971
, pp. 197-209
-
-
Nagele, R.G.1
D'Andrea, M.R.2
Lee, H.3
Venkataraman, V.4
Wang, H.5
-
69
-
-
2342635237
-
Cellular distribution of the endothelin system in the human brain
-
Naidoo, V., Naidoo, S., Mahabeer, R., and Raidoo, D. (2004). Cellular distribution of the endothelin system in the human brain. J. Chem. Neuroanat. 27, 87-98. doi: 10.1016/j.jchemneu.2003.12.002
-
(2004)
J. Chem. Neuroanat.
, vol.27
, pp. 87-98
-
-
Naidoo, V.1
Naidoo, S.2
Mahabeer, R.3
Raidoo, D.4
-
70
-
-
0034619582
-
Endothelin-converting enzymes, and endothelin receptor B messenger RNAs are expressed in different neural cell species, and these messenger RNAs are coordinately induced in neurons, and astrocytes respectively following nerve injury
-
Nakagomi, S., Kiryu-Seo, S., and Kiyama, H. (2000). Endothelin-converting enzymes, and endothelin receptor B messenger RNAs are expressed in different neural cell species, and these messenger RNAs are coordinately induced in neurons, and astrocytes respectively following nerve injury. Neuroscience 101, 441-449. doi: 10.1016/S0306-4522(00)00345-6
-
(2000)
Neuroscience
, vol.101
, pp. 441-449
-
-
Nakagomi, S.1
Kiryu-Seo, S.2
Kiyama, H.3
-
71
-
-
0038348526
-
Microglial functions, and proteases
-
Nakanishi, H. (2003). Microglial functions, and proteases. Mol. Neurobiol. 27, 163-176. doi: 10.1385/MN:27:2:163
-
(2003)
Mol. Neurobiol.
, vol.27
, pp. 163-176
-
-
Nakanishi, H.1
-
72
-
-
84655160768
-
Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease?
-
Nalivaeva, N. N., Beckett, C., Belyaev, N. D., and Turner, A. J. (2012). Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease? J. Neurochem. 120, 167-185. doi: 10.1111/j.1471-4159.2011.07510.x
-
(2012)
J. Neurochem.
, vol.120
, pp. 167-185
-
-
Nalivaeva, N.N.1
Beckett, C.2
Belyaev, N.D.3
Turner, A.J.4
-
73
-
-
38349046973
-
Autophagy, amyloidogenesis, and Alzheimer disease
-
Nixon, R. A. (2007). Autophagy, amyloidogenesis, and Alzheimer disease. J. Cell Sci. 120, 4081-4091. doi: 10.1242/jcs.019265
-
(2007)
J. Cell Sci.
, vol.120
, pp. 4081-4091
-
-
Nixon, R.A.1
-
74
-
-
84929320131
-
LRP1 plays a major role in the amyloid-β clearance in microglia
-
N'Songo, A., Kanekiyo, T., and Bu, G. (2013). LRP1 plays a major role in the amyloid-β clearance in microglia. Mol. Neurodegener. 8:33. doi: 10.1186/1750-1326-8-S1-P33
-
(2013)
Mol. Neurodegener.
, vol.8
, pp. 33
-
-
N'Songo, A.1
Kanekiyo, T.2
Bu, G.3
-
75
-
-
51649124533
-
Leucine-rich glioma inactivated 3 is involved in amyloid beta peptide uptake by astrocytes, and endocytosis itself
-
Okabayashi, S., and Kimura, N. (2008). Leucine-rich glioma inactivated 3 is involved in amyloid beta peptide uptake by astrocytes, and endocytosis itself. Neuroreport 19, 1175-1179. doi: 10.1097/WNR.0b013e32830a4cc4
-
(2008)
Neuroreport
, vol.19
, pp. 1175-1179
-
-
Okabayashi, S.1
Kimura, N.2
-
76
-
-
77956393132
-
Involvement of Fc receptors in disorders of the central nervous system
-
Okun, E., Mattson, M. P., and Arumugam, T. V. (2010). Involvement of Fc receptors in disorders of the central nervous system. Neuromolecular Med. 12, 164-178. doi: 10.1007/s12017-009-8099-5
-
(2010)
Neuromolecular Med.
, vol.12
, pp. 164-178
-
-
Okun, E.1
Mattson, M.P.2
Arumugam, T.V.3
-
77
-
-
84874302223
-
Endothelin-converting enzymes degrade intracellular beta-amyloid produced within the endosomal/lysosomal pathway, and autophagosomes
-
Pacheco-Quinto, J., and Eckman, E. A. (2013). Endothelin-converting enzymes degrade intracellular beta-amyloid produced within the endosomal/lysosomal pathway, and autophagosomes. J. Biol. Chem. 288, 5606-5615. doi: 10.1074/jbc.M112.422964
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 5606-5615
-
-
Pacheco-Quinto, J.1
Eckman, E.A.2
-
78
-
-
79959676154
-
Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease
-
Pan, X., Zhu, Y., Lin, N., Zhang, J., Ye, Q., Huang, H., et al. (2011). Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease. Mol. Neurodegener. 6, 1-18. doi: 10.1186/1750-1326-6-45
-
(2011)
Mol. Neurodegener.
, vol.6
, pp. 1-18
-
-
Pan, X.1
Zhu, Y.2
Lin, N.3
Zhang, J.4
Ye, Q.5
Huang, H.6
-
79
-
-
34548562299
-
Formyl peptide receptors on immune, and nonimmune cells: analysis of sequence conservation in FPR genes
-
Panaro, M., Acquafredda, A., Sisto, M., Lisi, S., Calvello, R., Mitolo, C., et al. (2007). Formyl peptide receptors on immune, and nonimmune cells: analysis of sequence conservation in FPR genes. Immunopharmacol. Immunotoxicol. 29, 243-269. doi: 10.1080/08923970701512544
-
(2007)
Immunopharmacol. Immunotoxicol.
, vol.29
, pp. 243-269
-
-
Panaro, M.1
Acquafredda, A.2
Sisto, M.3
Lisi, S.4
Calvello, R.5
Mitolo, C.6
-
80
-
-
0030248270
-
Microglial cells internalize aggregates of the Alzheimer's disease amyloid β-protein via a scavenger receptor
-
Paresce, D. M., Ghosh, R. N., and Maxfield, F. R. (1996). Microglial cells internalize aggregates of the Alzheimer's disease amyloid β-protein via a scavenger receptor. Neuron 17, 553-565. doi: 10.1016/S0896-6273(00)80187-7
-
(1996)
Neuron
, vol.17
, pp. 553-565
-
-
Paresce, D.M.1
Ghosh, R.N.2
Maxfield, F.R.3
-
81
-
-
0027331779
-
Identification of FcγRI, II, and III on normal human brain ramified microglia, and on microglia in senile plaques in Alzheimer's disease
-
Peress, N. S., Fleit, H. B., Perillo, E., Kuljis, R., and Pezzullo, C. (1993). Identification of FcγRI, II, and III on normal human brain ramified microglia, and on microglia in senile plaques in Alzheimer's disease. J. Neuroimmunol. 48, 71-79. doi: 10.1016/0165-5728(93)90060-C
-
(1993)
J. Neuroimmunol.
, vol.48
, pp. 71-79
-
-
Peress, N.S.1
Fleit, H.B.2
Perillo, E.3
Kuljis, R.4
Pezzullo, C.5
-
82
-
-
84956686151
-
Glial alterations from early to late stages in a model of Alzheimer's disease: evidence of autophagy involvement in Aβ internalization
-
Pomilio, C., Pavia, P., Gorojod, R. M., Vinuesa, A., Alaimo, A., Galvan, V., et al. (2016). Glial alterations from early to late stages in a model of Alzheimer's disease: evidence of autophagy involvement in Aβ internalization. Hippocampus 26, 194-210. doi: 10.1002/hipo.22503
-
(2016)
Hippocampus
, vol.26
, pp. 194-210
-
-
Pomilio, C.1
Pavia, P.2
Gorojod, R.M.3
Vinuesa, A.4
Alaimo, A.5
Galvan, V.6
-
83
-
-
70349323417
-
CD14, and toll-like receptors 2, and 4 are required for fibrillar Aβ-stimulated microglial activation
-
Reed-Geaghan, E. G., Savage, J. C., Hise, A. G., and Landreth, G. E. (2009). CD14, and toll-like receptors 2, and 4 are required for fibrillar Aβ-stimulated microglial activation. J. Neurosci. 29, 11982-11992. doi: 10.1523/JNEUROSCI.3158-09.2009
-
(2009)
J. Neurosci.
, vol.29
, pp. 11982-11992
-
-
Reed-Geaghan, E.G.1
Savage, J.C.2
Hise, A.G.3
Landreth, G.E.4
-
84
-
-
45949106077
-
Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42, and delay the cognitive decline in a mouse model of Alzheimer's disease
-
Richard, K. L., Filali, M., Prefontaine, P., and Rivest, S. (2008). Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42, and delay the cognitive decline in a mouse model of Alzheimer's disease. J. Neurosci. 28, 5784-5793. doi: 10.1523/JNEUROSCI.1146-08.2008
-
(2008)
J. Neurosci.
, vol.28
, pp. 5784-5793
-
-
Richard, K.L.1
Filali, M.2
Prefontaine, P.3
Rivest, S.4
-
85
-
-
0027980319
-
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
-
Rock, K. L., Gramm, C., Rothstein, L., Clark, K., Stein, R., Dick, L., et al. (1994). Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78, 761-771. doi: 10.1016/S0092-8674(94)90462-6
-
(1994)
Cell
, vol.78
, pp. 761-771
-
-
Rock, K.L.1
Gramm, C.2
Rothstein, L.3
Clark, K.4
Stein, R.5
Dick, L.6
-
86
-
-
84864755408
-
Proteolytic degradation of amyloid beta-protein
-
Saido, T., and Leissring, M. A. (2012). Proteolytic degradation of amyloid beta-protein. Cold Spring Harb. Perspect. Med. 2:a006379. doi: 10.1101/cshperspect.a006379
-
(2012)
Cold Spring Harb. Perspect. Med.
, vol.2
-
-
Saido, T.1
Leissring, M.A.2
-
87
-
-
84983273186
-
Metal ions in Alzheimer's disease brain
-
Sastre, M., Ritchie, C. W., and Hajji, N. (2015). Metal ions in Alzheimer's disease brain. JSM Alzheimer's Dis. Relat. Dement. 2:1014.
-
(2015)
JSM Alzheimer's Dis. Relat. Dement.
, vol.2
, pp. 1014
-
-
Sastre, M.1
Ritchie, C.W.2
Hajji, N.3
-
88
-
-
0038810288
-
Microglial apolipoprotein E and astroglial apolipoprotein J expression in vitro: opposite effects of lipopolysaccharide
-
Saura, J., Petegnief, V., Wu, X., Liang, Y., and Paul, S. M. (2003). Microglial apolipoprotein E and astroglial apolipoprotein J expression in vitro: opposite effects of lipopolysaccharide. J. Neurochem. 85, 1455-1467. doi: 10.1046/j.1471-4159.2003.01788.x
-
(2003)
J. Neurochem.
, vol.85
, pp. 1455-1467
-
-
Saura, J.1
Petegnief, V.2
Wu, X.3
Liang, Y.4
Paul, S.M.5
-
89
-
-
84869180626
-
Involvement of formyl peptide receptors in receptor for advanced glycation end products(RAGE)-and amyloid beta 1-42-induced signal transduction in glial cells
-
Slowik, A., Merres, J., Elfgen, A., Jansen, S., Mohr, F., Wruck, C. J., et al. (2012). Involvement of formyl peptide receptors in receptor for advanced glycation end products(RAGE)-and amyloid beta 1-42-induced signal transduction in glial cells. Mol. Neurodegener. 7, 1-18. doi: 10.1186/1750-1326-7-55
-
(2012)
Mol. Neurodegener.
, vol.7
, pp. 1-18
-
-
Slowik, A.1
Merres, J.2
Elfgen, A.3
Jansen, S.4
Mohr, F.5
Wruck, C.J.6
-
90
-
-
84864134469
-
Microglia function in Alzheimer's disease
-
Solito, E., and Sastre, M. (2012). Microglia function in Alzheimer's disease. Front. Pharmacol. 3:14. doi: 10.3389/fphar.2012.00014
-
(2012)
Front. Pharmacol.
, vol.3
, pp. 14
-
-
Solito, E.1
Sastre, M.2
-
91
-
-
84878253079
-
The type 2 diabetes-associated gene ide is required for insulin secretion and suppression of alpha-synuclein levels in beta-cells
-
Steneberg, P., Bernardo, L., Edfalk, S., Lundberg, L., Backlund, F., Ostenson, C. G., et al. (2013). The type 2 diabetes-associated gene ide is required for insulin secretion and suppression of alpha-synuclein levels in beta-cells. Diabetes 62, 2004-2014. doi: 10.2337/db12-1045
-
(2013)
Diabetes
, vol.62
, pp. 2004-2014
-
-
Steneberg, P.1
Bernardo, L.2
Edfalk, S.3
Lundberg, L.4
Backlund, F.5
Ostenson, C.G.6
-
92
-
-
4644310560
-
Role of oxidative modifications in atherosclerosis
-
Stocker, R., and Keaney, J. F. Jr. (2004). Role of oxidative modifications in atherosclerosis. Physiol. Rev. 84, 1381-1478. doi: 10.1152/physrev.00047.2003
-
(2004)
Physiol. Rev.
, vol.84
, pp. 1381-1478
-
-
Stocker, R.1
Keaney, J.F.2
-
93
-
-
33750576993
-
Role of toll-like receptor signalling in Abeta uptake, and clearance
-
Tahara, K., Kim, H. D., Jin, J. J., Maxwell, J. A., Li, L., and Fukuchi, K. (2006). Role of toll-like receptor signalling in Abeta uptake, and clearance. Brain 129, 3006-3019. doi: 10.1093/brain/awl249
-
(2006)
Brain
, vol.129
, pp. 3006-3019
-
-
Tahara, K.1
Kim, H.D.2
Jin, J.J.3
Maxwell, J.A.4
Li, L.5
Fukuchi, K.6
-
94
-
-
78549284024
-
Statins promote the degradation of extracellular amyloid (beta)-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion
-
Tamboli, I. Y., Barth, E., Christian, L., Siepmann, M., Kumar, S., Singh, S., et al. (2010). Statins promote the degradation of extracellular amyloid (beta)-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion. J. Biol. Chem. 285, 37405-37414. doi: 10.1074/jbc.M110.149468
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 37405-37414
-
-
Tamboli, I.Y.1
Barth, E.2
Christian, L.3
Siepmann, M.4
Kumar, S.5
Singh, S.6
-
95
-
-
84958106930
-
Differential roles of M1, and M2 microglia in neurodegenerative diseases
-
Tang, Y., and Le, W. (2016). Differential roles of M1, and M2 microglia in neurodegenerative diseases. Mol. Neurobiol. 53, 1181-1194. doi: 10.1007/s12035-014-9070-5
-
(2016)
Mol. Neurobiol.
, vol.53
, pp. 1181-1194
-
-
Tang, Y.1
Le, W.2
-
96
-
-
84938949776
-
Clearance systems in the brain-implications for Alzheimer disease
-
Tarasoff-Conway, J. M., Carare, R. O., Osorio, R. S., Glodzik, L., Butler, T., Fieremans, E., et al. (2015). Clearance systems in the brain-implications for Alzheimer disease. Nat. Rev. Neurol. 11, 457-470. doi: 10.1038/nrneurol.2015.119
-
(2015)
Nat. Rev. Neurol.
, vol.11
, pp. 457-470
-
-
Tarasoff-Conway, J.M.1
Carare, R.O.2
Osorio, R.S.3
Glodzik, L.4
Butler, T.5
Fieremans, E.6
-
97
-
-
77956802559
-
Toll-like receptors expression, and signaling in glia cells in neuro-amyloidogenic diseases: towards future therapeutic application
-
Trudler, D., Farfara, D., and Frenkel, D. (2010). Toll-like receptors expression, and signaling in glia cells in neuro-amyloidogenic diseases: towards future therapeutic application. Mediators Inflamm. 2010:12. doi: 10.1155/2010/497987
-
(2010)
Mediators Inflamm.
, vol.2010
, pp. 12
-
-
Trudler, D.1
Farfara, D.2
Frenkel, D.3
-
98
-
-
52649157170
-
Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes
-
Utter, S., Tamboli, I. Y., Walter, J., Upadhaya, A. R., Birkenmeier, G., Pietrzik, C. U., et al. (2008). Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes. J. Neuropathol. Exp. Neurol. 67, 842-856. doi: 10.1097/NEN.0b013e3181836a71
-
(2008)
J. Neuropathol. Exp. Neurol.
, vol.67
, pp. 842-856
-
-
Utter, S.1
Tamboli, I.Y.2
Walter, J.3
Upadhaya, A.R.4
Birkenmeier, G.5
Pietrzik, C.U.6
-
99
-
-
67849102209
-
Toll-like receptors in the CNS: implications for neurodegeneration, and repair
-
van Noort, J. M., and Bsibsi, M. (2009). Toll-like receptors in the CNS: implications for neurodegeneration, and repair. Prog. Brain Res. 175, 139-148. doi: 10.1016/S0079-6123(09)17509-X
-
(2009)
Prog. Brain Res.
, vol.175
, pp. 139-148
-
-
van Noort, J.M.1
Bsibsi, M.2
-
100
-
-
84877326649
-
ApoE influences amyloid-beta (Abeta) clearance despite minimal apoE/Abeta association in physiological conditions
-
Verghese, P. B., Castellano, J. M., Garai, K., Wang, Y., Jiang, H., Shah, A., et al. (2013). ApoE influences amyloid-beta (Abeta) clearance despite minimal apoE/Abeta association in physiological conditions. Proc. Natl. Acad. Sci. U.S.A. 110, E1807-E1816. doi: 10.1073/pnas.1220484110
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. E1807-E1816
-
-
Verghese, P.B.1
Castellano, J.M.2
Garai, K.3
Wang, Y.4
Jiang, H.5
Shah, A.6
-
101
-
-
77956583512
-
Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain
-
Wang, S., Wang, R., Chen, L., Bennett, D. A., Dickson, D. W., and Wang, D. (2010). Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain. J. Neurochem. 115, 47-57. doi: 10.1111/j.1471-4159.2010.06899.x
-
(2010)
J. Neurochem.
, vol.115
, pp. 47-57
-
-
Wang, S.1
Wang, R.2
Chen, L.3
Bennett, D.A.4
Dickson, D.W.5
Wang, D.6
-
102
-
-
84925464993
-
TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model
-
Wang, Y., Cella, M., Mallinson, K., Ulrich, J. D., Young, K. L., Robinette, M. L., et al. (2015). TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model. Cell 160, 1061-1071. doi: 10.1016/j.cell.2015.01.049
-
(2015)
Cell
, vol.160
, pp. 1061-1071
-
-
Wang, Y.1
Cella, M.2
Mallinson, K.3
Ulrich, J.D.4
Young, K.L.5
Robinette, M.L.6
-
103
-
-
84969286765
-
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
-
Wang, Y., Ulland, T. K., Ulrich, J. D., Song, W., Tzaferis, J. A., Hole, J. T., et al. (2016). TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques. J. Exp. Med. 213, 667-675. doi: 10.1084/jem.20151948
-
(2016)
J. Exp. Med.
, vol.213
, pp. 667-675
-
-
Wang, Y.1
Ulland, T.K.2
Ulrich, J.D.3
Song, W.4
Tzaferis, J.A.5
Hole, J.T.6
-
104
-
-
0037531198
-
Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation
-
Wilcock, D. M., DiCarlo, G., Henderson, D., Jackson, J., Clarke, K., Ugen, K. E., et al. (2003). Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation. J. Neurosci. 23, 3745-3751.
-
(2003)
J. Neurosci.
, vol.23
, pp. 3745-3751
-
-
Wilcock, D.M.1
DiCarlo, G.2
Henderson, D.3
Jackson, J.4
Clarke, K.5
Ugen, K.E.6
-
105
-
-
84880256692
-
Evidence for impaired amyloid beta clearance in Alzheimer's disease
-
Wildsmith, K. R., Holley, M., Savage, J. C., Skerrett, R., and Landreth, G. E. (2013). Evidence for impaired amyloid beta clearance in Alzheimer's disease. Alzheimers Res. Ther. 5:33. doi: 10.1186/alzrt187
-
(2013)
Alzheimers Res. Ther.
, vol.5
, pp. 33
-
-
Wildsmith, K.R.1
Holley, M.2
Savage, J.C.3
Skerrett, R.4
Landreth, G.E.5
-
106
-
-
84896715400
-
Leptin inhibits amyloid β-protein degradation through decrease of neprilysin expression in primary cultured astrocytes
-
Yamamoto, N., Tanida, M., Ono, Y., Kasahara, R., Fujii, Y., Ohora, K., et al. (2014). Leptin inhibits amyloid β-protein degradation through decrease of neprilysin expression in primary cultured astrocytes. Biochem. Biophys. Res. Commun. 445, 214-217. doi: 10.1016/j.bbrc.2014.01.168
-
(2014)
Biochem. Biophys. Res. Commun.
, vol.445
, pp. 214-217
-
-
Yamamoto, N.1
Tanida, M.2
Ono, Y.3
Kasahara, R.4
Fujii, Y.5
Ohora, K.6
-
107
-
-
84884528603
-
Low-density lipoprotein receptor related protein-1 (LRP1)-dependent cell signaling promotes neurotrophic activity in embryonic sensory neurons
-
Yamauchi, K., Yamauchi, T., Mantuano, E., Murakami, K., Henry, K., Takahashi, K., et al. (2013). Low-density lipoprotein receptor related protein-1 (LRP1)-dependent cell signaling promotes neurotrophic activity in embryonic sensory neurons. PLoS ONE 8:e75497. doi: 10.1371/journal.pone.0075497
-
(2013)
PLoS ONE
, vol.8
-
-
Yamauchi, K.1
Yamauchi, T.2
Mantuano, E.3
Murakami, K.4
Henry, K.5
Takahashi, K.6
-
108
-
-
33747680357
-
Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ
-
Yan, P., Hu, X., Song, H., Yin, K., Bateman, R. J., Cirrito, J. R., et al. (2006). Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ. J. Biol. Chem. 281, 24566-24574. doi: 10.1074/jbc.M602440200
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 24566-24574
-
-
Yan, P.1
Hu, X.2
Song, H.3
Yin, K.4
Bateman, R.J.5
Cirrito, J.R.6
-
109
-
-
79954632126
-
Mechanism mediating oligomeric Aβ clearance by naïve primary microglia
-
Yang, C., Shiao, Y., Shie, F., Guo, B., Chen, P., Cho, C., et al. (2011). Mechanism mediating oligomeric Aβ clearance by naïve primary microglia. Neurobiol. Dis. 42, 221-230. doi: 10.1016/j.nbd.2011.01.005
-
(2011)
Neurobiol. Dis.
, vol.42
, pp. 221-230
-
-
Yang, C.1
Shiao, Y.2
Shie, F.3
Guo, B.4
Chen, P.5
Cho, C.6
-
110
-
-
0037236622
-
Elevated β-secretase expression, and enzymatic activity detected in sporadic Alzheimer disease
-
Yang, L., Lindholm, K., Yan, R., Citron, M., Xia, W., Yang, X., et al. (2003). Elevated β-secretase expression, and enzymatic activity detected in sporadic Alzheimer disease. Nat. Med. 9, 3-4. doi: 10.1038/nm0103-3
-
(2003)
Nat. Med.
, vol.9
, pp. 3-4
-
-
Yang, L.1
Lindholm, K.2
Yan, R.3
Citron, M.4
Xia, W.5
Yang, X.6
-
111
-
-
33751112725
-
Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism
-
Yin, K. J., Cirrito, J. R., Yan, P., Hu, X., Xiao, Q., Pan, X., et al. (2006). Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism. J. Neurosci. 26, 10939-10948. doi: 10.1523/JNEUROSCI.2085-06.2006
-
(2006)
J. Neurosci.
, vol.26
, pp. 10939-10948
-
-
Yin, K.J.1
Cirrito, J.R.2
Yan, P.3
Hu, X.4
Xiao, Q.5
Pan, X.6
-
112
-
-
84862670985
-
Mechanisms of amyloid-β peptide clearance: potential therapeutic targets for Alzheimer's disease
-
Yoon, S., and Jo, S. A. (2012). Mechanisms of amyloid-β peptide clearance: potential therapeutic targets for Alzheimer's disease. Biomol. Ther. 20, 245-255. doi: 10.4062/biomolther.2012.20.3.245
-
(2012)
Biomol. Ther.
, vol.20
, pp. 245-255
-
-
Yoon, S.1
Jo, S.A.2
-
113
-
-
77958475033
-
Amyloid-β peptide is a substrate of the human 20S proteasome
-
Zhao, X., and Yang, J. (2010). Amyloid-β peptide is a substrate of the human 20S proteasome. ACS Chem. Neurosci. 1, 655-660. doi: 10.1021/cn100067e
-
(2010)
ACS Chem. Neurosci.
, vol.1
, pp. 655-660
-
-
Zhao, X.1
Yang, J.2
-
114
-
-
34247100646
-
M. Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease
-
Zhao, Z., Xiang, Z., Haroutunian, V., Buxbaum, J. D., Stetka, B., and Pasinetti, G. (2007). M. Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease. Neurobiol. Aging 28, 824-830. doi: 10.1016/j.neurobiolaging.2006.05.001
-
(2007)
Neurobiol. Aging
, vol.28
, pp. 824-830
-
-
Zhao, Z.1
Xiang, Z.2
Haroutunian, V.3
Buxbaum, J.D.4
Stetka, B.5
Pasinetti, G.6
-
115
-
-
0029920929
-
Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone, and in a complex with Alzheimer disease amyloid beta at the blood-brain, and blood-cerebrospinal fluid barriers
-
Zlokovic, B. V., Martel, C. L., Matsubara, E., McComb, J. G., Zheng, G., McCluskey, R. T., et al. (1996). Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone, and in a complex with Alzheimer disease amyloid beta at the blood-brain, and blood-cerebrospinal fluid barriers. Proc. Natl. Acad. Sci. U.S.A. 93, 4229-4234. doi: 10.1073/pnas.93.9.4229
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 4229-4234
-
-
Zlokovic, B.V.1
Martel, C.L.2
Matsubara, E.3
McComb, J.G.4
Zheng, G.5
McCluskey, R.T.6
|