-
1
-
-
0037077040
-
Toxic proteins in neurodegenerative disease
-
Taylor, J. P., Hardy, J., and Fischbeck, K. H. (2002) Toxic proteins in neurodegenerative disease Science 296, 1991-1995
-
(2002)
Science
, vol.296
, pp. 1991-1995
-
-
Taylor, J.P.1
Hardy, J.2
Fischbeck, K.H.3
-
2
-
-
0035066332
-
Alzheimers disease: Genes, proteins, and therapy
-
Selkoe, D. J. (2001) Alzheimers disease: Genes, proteins, and therapy Physiol. Rev. 81, 741-766
-
(2001)
Physiol. Rev.
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
3
-
-
0023105114
-
The precursor of Alzheimers disease amyloid A4 protein resembles a cell-surface receptor
-
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., and Muller-Hill, B. (1987) The precursor of Alzheimers disease amyloid A4 protein resembles a cell-surface receptor Nature 325, 733-736
-
(1987)
Nature
, vol.325
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.-G.2
Unterbeck, A.3
Salbaum, J.M.4
Masters, C.L.5
Grzeschik, K.-H.6
Multhaup, G.7
Beyreuther, K.8
Muller-Hill, B.9
-
4
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimers amyloid beta-peptide
-
Haass, C. and Selkoe, D. J. (2007) Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimers amyloid beta-peptide Nat. Rev. Mol. Cell. Biol. 8, 101-112
-
(2007)
Nat. Rev. Mol. Cell. Biol.
, vol.8
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
5
-
-
0027333557
-
Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide
-
Haass, C. and Selkoe, D. J. (1993) Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide Cell 75, 1039-1042
-
(1993)
Cell
, vol.75
, pp. 1039-1042
-
-
Haass, C.1
Selkoe, D.J.2
-
6
-
-
0034644836
-
Regulation of APP cleavage by alpha-, beta- and gamma-secretases
-
Nunan, J. and Small, D. H. (2000) Regulation of APP cleavage by alpha-, beta- and gamma-secretases FEBS Lett. 483, 6-10
-
(2000)
FEBS Lett.
, vol.483
, pp. 6-10
-
-
Nunan, J.1
Small, D.H.2
-
7
-
-
0028267440
-
Normal and abnormal biology of the beta-amyloid precursor protein
-
Selkoe, D. J. (1994) Normal and abnormal biology of the beta-amyloid precursor protein Annu. Rev. Neurosci. 17, 489-517
-
(1994)
Annu. Rev. Neurosci.
, vol.17
, pp. 489-517
-
-
Selkoe, D.J.1
-
8
-
-
1642290835
-
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein
-
Farris, W., Mansourian, S., Leissring, M. A., Eckman, E. A., Bertram, L., Eckman, C. B., Tanzi, R. E., and Selkoe, D. J. (2004) Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein Am. J. Pathol. 164, 1425-1434
-
(2004)
Am. J. Pathol.
, vol.164
, pp. 1425-1434
-
-
Farris, W.1
Mansourian, S.2
Leissring, M.A.3
Eckman, E.A.4
Bertram, L.5
Eckman, C.B.6
Tanzi, R.E.7
Selkoe, D.J.8
-
9
-
-
0035816707
-
Degradation of the Alzheimers amyloid beta peptide by endothelin-converting enzyme
-
Eckman, E. A., Reed, D. K., and Eckman, C. B. (2001) Degradation of the Alzheimers amyloid beta peptide by endothelin-converting enzyme J. Biol. Chem. 276, 24540-24548
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 24540-24548
-
-
Eckman, E.A.1
Reed, D.K.2
Eckman, C.B.3
-
10
-
-
0035877747
-
Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases
-
Shirotani, K., Tsubuki, S., Iwata, N., Takaki, Y., Harigaya, W., Maruyama, K., Kiryu-Seo, S., Kiyama, H., Iwata, H., Tomita, T., Iwatsubo, T., and Saido, T. C. (2001) Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases J. Biol. Chem. 276, 21895-21901
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 21895-21901
-
-
Shirotani, K.1
Tsubuki, S.2
Iwata, N.3
Takaki, Y.4
Harigaya, W.5
Maruyama, K.6
Kiryu-Seo, S.7
Kiyama, H.8
Iwata, H.9
Tomita, T.10
Iwatsubo, T.11
Saido, T.C.12
-
11
-
-
0035659917
-
Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons
-
Hama, E., Shirotani, K., Masumoto, H., Sekine-Aizawa, Y., and Saido, T. C. (2001) Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons J. Biochem. 130, 721-726
-
(2001)
J. Biochem.
, vol.130
, pp. 721-726
-
-
Hama, E.1
Shirotani, K.2
Masumoto, H.3
Sekine-Aizawa, Y.4
Saido, T.C.5
-
12
-
-
50249143450
-
Amyloid beta-degrading cryptidases: Insulin degrading enzyme, presequence peptidase, and neprilysin
-
Malito, E., Hulse, R., and Tang, W. J. (2008) Amyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin Cell. Mol. Life Sci. 65, 2574-2585
-
(2008)
Cell. Mol. Life Sci.
, vol.65
, pp. 2574-2585
-
-
Malito, E.1
Hulse, R.2
Tang, W.J.3
-
13
-
-
51449096696
-
A-beta inhibits the proteasome and enhances amyloid and tau accumulation
-
Tseng, B. P., Green, K. N., Chan, J. L., Blurton-Jones, M., and LaFerla, F. M. (2008) A-beta inhibits the proteasome and enhances amyloid and tau accumulation Neurobiol. Aging 29, 1607-1618
-
(2008)
Neurobiol. Aging
, vol.29
, pp. 1607-1618
-
-
Tseng, B.P.1
Green, K.N.2
Chan, J.L.3
Blurton-Jones, M.4
Laferla, F.M.5
-
14
-
-
0031026231
-
Binding of amyloid beta protein to the 20 S proteasome
-
Gregori, L., Hainfeld, J. F., Simon, M. N., and Goldgaber, D. (1997) Binding of amyloid beta protein to the 20 S proteasome J. Biol. Chem. 272, 58-62
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 58-62
-
-
Gregori, L.1
Hainfeld, J.F.2
Simon, M.N.3
Goldgaber, D.4
-
15
-
-
0028979993
-
Amyloid beta-protein inhibits ubiquitin-dependent protein degradation in vitro
-
Gregori, L., Fuchs, C., Figueiredo-Pereira, M. E., Van Nostrand, W. E., and Goldgaber, D. (1995) Amyloid beta-protein inhibits ubiquitin-dependent protein degradation in vitro J. Biol. Chem. 270, 19702-19708
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 19702-19708
-
-
Gregori, L.1
Fuchs, C.2
Figueiredo-Pereira, M.E.3
Van Nostrand, W.E.4
Goldgaber, D.5
-
16
-
-
0029867623
-
Proteasomes: Destruction as a programme
-
Hilt, W. and Wolf, D. H. (1996) Proteasomes: Destruction as a programme Trends Biochem. Sci. 31, 96-102
-
(1996)
Trends Biochem. Sci.
, vol.31
, pp. 96-102
-
-
Hilt, W.1
Wolf, D.H.2
-
17
-
-
0030774890
-
The active sites of the eukaryotic 20 S proteasome and their involvement in subunit precursor processing
-
Heinemeyer, W., Fischer, M., Krimmer, T., Stachon, U., and Wolf, D. H. (1997) The active sites of the eukaryotic 20 S proteasome and their involvement in subunit precursor processing J. Biol. Chem. 272, 25200-25209
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 25200-25209
-
-
Heinemeyer, W.1
Fischer, M.2
Krimmer, T.3
Stachon, U.4
Wolf, D.H.5
-
19
-
-
77958467435
-
-
Since the AΒ peptides likely continue to aggregate over the course of these studies and affect the UV signal of the parent AΒ peptide on the HPLC instrument, quantification of the time-dependent degradation of AΒ(1-42) by the h20S proteasome was not possible using this method of analysis
-
Since the AΒ peptides likely continue to aggregate over the course of these studies and affect the UV signal of the parent AΒ peptide on the HPLC instrument, quantification of the time-dependent degradation of AΒ(1-42) by the h20S proteasome was not possible using this method of analysis.
-
-
-
-
20
-
-
33644808144
-
Solvent-free mass spectrometry fro hydrophobic peptide sequence analysis and protein conformation studies
-
Trimpin, S. and Deinzer, M. (2005) Solvent-free mass spectrometry fro hydrophobic peptide sequence analysis and protein conformation studies Biotechniques 39, 799-805
-
(2005)
Biotechniques
, vol.39
, pp. 799-805
-
-
Trimpin, S.1
Deinzer, M.2
-
21
-
-
0028981219
-
Structure-activity analyses of Β-amyloid peptides: Contributions of the Β25-35 region to aggregation and neurotoxicity
-
Pike, C. J., Walencewicz-Wasserman, A. J., Kosmoski, J., Cribbs, D. H., Glabe, C. G., and Cotman, C. W. (1995) Structure-activity analyses of Β-amyloid peptides: contributions of the Β25-35 region to aggregation and neurotoxicity J. Neurochem. 64, 253
-
(1995)
J. Neurochem.
, vol.64
, pp. 253
-
-
Pike, C.J.1
Walencewicz-Wasserman, A.J.2
Kosmoski, J.3
Cribbs, D.H.4
Glabe, C.G.5
Cotman, C.W.6
-
22
-
-
0038350948
-
Predicting proteasomal cleavage sites: A comparison of available methods
-
Saxova, P., Buus, S., Brunak, S., and Kesmir, C. (2003) Predicting proteasomal cleavage sites: a comparison of available methods Int. Immunol. 15, 781-787
-
(2003)
Int. Immunol.
, vol.15
, pp. 781-787
-
-
Saxova, P.1
Buus, S.2
Brunak, S.3
Kesmir, C.4
-
23
-
-
0034607546
-
An algorithm for the prediction of proteasomal cleavages
-
Kuttler, C., Nussbaum, A. K., Dick, T. P., Rammensee, H.-G., Schild, H., and Hadeler, K.-P. (2000) An algorithm for the prediction of proteasomal cleavages J. Mol. Biol. 298, 417-429
-
(2000)
J. Mol. Biol.
, vol.298
, pp. 417-429
-
-
Kuttler, C.1
Nussbaum, A.K.2
Dick, T.P.3
Rammensee, H.-G.4
Schild, H.5
Hadeler, K.-P.6
-
24
-
-
0035074032
-
PAProC: A prediction algorithm for proteasomal cleavages available on the WWW
-
Nussbaum, A. K., Kuttler, C., Hadeler, K.-P., Rammensee, H.-G., and Schild, H. (2001) PAProC: A prediction algorithm for proteasomal cleavages available on the WWW Immunogenetics 53, 87-94
-
(2001)
Immunogenetics
, vol.53
, pp. 87-94
-
-
Nussbaum, A.K.1
Kuttler, C.2
Hadeler, K.-P.3
Rammensee, H.-G.4
Schild, H.5
-
25
-
-
0345291184
-
A theoretical approach towards the identification of cleavage-determining amino acid motifs of the 20s proteasome
-
Holzhutter, H.-G., Frommel, C., and Kloetzel, P.-M. (1999) A theoretical approach towards the identification of cleavage-determining amino acid motifs of the 20s proteasome J. Mol. Biol. 286, 1251-1265
-
(1999)
J. Mol. Biol.
, vol.286
, pp. 1251-1265
-
-
Holzhutter, H.-G.1
Frommel, C.2
Kloetzel, P.-M.3
-
26
-
-
0033849945
-
A kinetic model of vertebrate 20S proteasome accounting for the generation of major proteolytic fragments from oligomeric peptide substrates
-
Holzhutter, H.-G. and Kloetzel, P.-M. (2000) A kinetic model of vertebrate 20S proteasome accounting for the generation of major proteolytic fragments from oligomeric peptide substrates Biophys. J. 1196-1205
-
(2000)
Biophys. J.
, pp. 1196-1205
-
-
Holzhutter, H.-G.1
Kloetzel, P.-M.2
-
27
-
-
0034131044
-
Impaired proteasome function in Alzheimers disease
-
Keller, J. N., Hanni, K. B., and Markesbery, W. R. (2000) Impaired proteasome function in Alzheimers disease J. Neurochem. 75, 436-439
-
(2000)
J. Neurochem.
, vol.75
, pp. 436-439
-
-
Keller, J.N.1
Hanni, K.B.2
Markesbery, W.R.3
-
28
-
-
0037381710
-
Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimers disease
-
Keck, S., Nitsch, R., Grune, T., and Ullrich, O. (2003) Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimers disease J. Neurochem. 85, 115-122
-
(2003)
J. Neurochem.
, vol.85
, pp. 115-122
-
-
Keck, S.1
Nitsch, R.2
Grune, T.3
Ullrich, O.4
-
29
-
-
34250819839
-
Intracellular amyloid-beta in Alzheimers disease
-
LaFerla, F. M., Green, K. N., and Oddo, S. (2007) Intracellular amyloid-beta in Alzheimers disease Nat. Rev. Neurosci. 8, 499-509
-
(2007)
Nat. Rev. Neurosci.
, vol.8
, pp. 499-509
-
-
Laferla, F.M.1
Green, K.N.2
Oddo, S.3
-
30
-
-
33646461282
-
Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system
-
Almeida, C. G., Takahashi, R. H., and Gouras, G. K. (2006) beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system J. Neurosci. 26, 4277-4288
-
(2006)
J. Neurosci.
, vol.26
, pp. 4277-4288
-
-
Almeida, C.G.1
Takahashi, R.H.2
Gouras, G.K.3
-
31
-
-
0037200117
-
Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability
-
Dahlgren, K. N., Manelli, A. M., Stine, W. B., Baker, L. K., Krafft, G. A., and LaDu, M. J. (2002) Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability J. Biol. Chem. 277, 32046-32053
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 32046-32053
-
-
Dahlgren, K.N.1
Manelli, A.M.2
Stine, W.B.3
Baker, L.K.4
Krafft, G.A.5
Ladu, M.J.6
|