The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis

Journal of Neuroinflammation

Volumn 8, Issue , 2011, Pages

  Braun, Benedikt J ^a   Slowik, Alexander ^a   Leib, Stephen L ^b   Lucius, Ralph ^c   Varoga, Deike ^d   Wruck, Christoph J ^a   Jansen, Sandra ^a   Podschun, Rainer ^d   Pufe, Thomas ^a   Brandenburg, Lars Ove ^a,c  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b UNIVERSITY OF BERN   (Switzerland)

^c UNIVERSITY OF KIEL   (Germany)

^d UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CATHELIN; CYCLIC AMP; FORMYLPEPTIDE RECEPTOR LIKE 1; INTERLEUKIN 1BETA; MACROPHAGE RECEPTOR WITH COLLAGENOUS STRUCTURE; MITOGEN ACTIVATED PROTEIN KINASE 3; SCAVENGER RECEPTOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CATHELICIDIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE; FORMYLPEPTIDE RECEPTOR; FPR2 PROTEIN, HUMAN; IMMUNOGLOBULIN RECEPTOR; LIPOXIN RECEPTOR; MARCO PROTEIN, HUMAN; MARCO PROTEIN, RAT; MITOGEN ACTIVATED PROTEIN KINASE; OLIGOPEPTIDE; PERTUSSIS TOXIN; TRYPTOPHYL ARGINYL TRYPTOPHYL TRYPTOPHYL TRYPTOPHYL TRYPTOPHANAMIDE; TRYPTOPHYL-ARGINYL-TRYPTOPHYL-TRYPTOPHYL-TRYPTOPHYL-TRYPTOPHANAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BACTERIAL MENINGITIS; CELL ACTIVATION; CONTROLLED STUDY; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; GLIA CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MENINGEAL CELL; MICROGLIA; NEISSERIA MENINGITIDIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STREPTOCOCCUS PNEUMONIAE; SUPERNATANT; ANIMAL; CELL CULTURE; CELL STRAIN HEK293; CYTOLOGY; DRUG EFFECT; GENETICS; GLIA; MENINX; METABOLISM; MICROBIOLOGY; NEWBORN; PATHOGENICITY;

ANIMALS; ANIMALS, NEWBORN; CATHELICIDINS; CELLS, CULTURED; CYCLIC AMP; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEK293 CELLS; HUMANS; INTERLEUKIN-1BETA; MENINGES; MENINGITIS, BACTERIAL; NEISSERIA MENINGITIDIS; NEUROGLIA; OLIGOPEPTIDES; PERTUSSIS TOXIN; RATS; RECEPTORS, FORMYL PEPTIDE; RECEPTORS, IMMUNOLOGIC; RECEPTORS, LIPOXIN; RNA, SMALL INTERFERING; STREPTOCOCCUS PNEUMONIAE;

EID: 79551627051     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-8-11     Document Type: Article

References (34)

1. Schut ES, de Gans J, van de Beek D. Community-acquired bacterial meningitis in adults. Pract Neurol 2008, 8:8-23. 10.1136/jnnp.2007.139725, 18230706.
2. Nguyen MD, Julien JP, Rivest S. Innate immunity: the missing link in neuroprotection and neurodegeneration?. Nat Rev Neurosci 2002, 3:216-227. 10.1038/nrn752, 11994753.
3. Mariani MM, Kielian T. Microglia in infectious diseases of the central nervous system. J Neuroimmune Pharmacol 2009, 4:448-461. 10.1007/s11481-009-9170-6, 2847353, 19728102.
4. Bals R. Epithelial antimicrobial peptides in host defense against infection. Respir Res 2000, 1:141-150. 10.1186/rr25, 59560, 11667978.
5. Ganz T. Defensins and host defense. Science 1999, 286:420-421. 10.1126/science.286.5439.420, 10577203.
6. Brandenburg LO, Varoga D, Nicolaeva N, Leib SL, Wilms H, Podschun R, Wruck CJ, Schroder JM, Pufe T, Lucius R. Role of glial cells in the functional expression of LL-37/rat cathelin-related antimicrobial peptide in meningitis. J Neuropathol Exp Neurol 2008, 67:1041-1054. 10.1097/NEN.0b013e31818b4801, 18957897.
7. Brandenburg LO, Varoga D, Nicolaeva N, Leib SL, Podschun R, Wruck CJ, Wilms H, Lucius R, Pufe T. Expression and regulation of antimicrobial peptide rCRAMP after bacterial infection in primary rat meningeal cells. J Neuroimmunol 2009, 217(1-2):55-64. 10.1016/j.jneuroim.2009.10.004, 19879657.
8. Lehrer RI, Ganz T. Cathelicidins: a family of endogenous antimicrobial peptides. Curr Opin Hematol 2002, 9:18-22. 10.1097/00062752-200201000-00004, 11753073.
9. Gallo RL, Kim KJ, Bernfield M, Kozak CA, Zanetti M, Merluzzi L, Gennaro R. Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse. J Biol Chem 1997, 272:13088-13093. 10.1074/jbc.272.20.13088, 9148921.
10. Termen S, Tollin M, Olsson B, Svenberg T, Agerberth B, Gudmundsson GH. Phylogeny, processing and expression of the rat cathelicidin rCRAMP: a model for innate antimicrobial peptides. Cell Mol Life Sci 2003, 60:536-549. 10.1007/s000180300045, 12737313.
11. Romano Carratelli C, Mazzola N, Paolillo R, Sorrentino S, Rizzo A. Toll-like receptor-4 (TLR4) mediates human beta-defensin-2 (HBD-2) induction in response to Chlamydia pneumoniae in mononuclear cells. FEMS Immunol Med Microbiol 2009, 57:116-124. 10.1111/j.1574-695X.2009.00586.x, 19735472.
12. Lai Y, Cogen AL, Radek KA, Park HJ, Macleod DT, Leichtle A, Ryan AF, Di Nardo A, Gallo RL. Activation of TLR2 by a Small Molecule Produced by Staphylococcus epidermidis Increases Antimicrobial Defense against Bacterial Skin Infections. J Invest Dermatol 2010, 130(9):2211-21. 10.1038/jid.2010.123, 2922455, 20463690.
13. Peiser L, De Winther MP, Makepeace K, Hollinshead M, Coull P, Plested J, Kodama T, Moxon ER, Gordon S. The class A macrophage scavenger receptor is a major pattern recognition receptor for Neisseria meningitidis which is independent of lipopolysaccharide and not required for secretory responses. Infect Immun 2002, 70:5346-5354. 10.1128/IAI.70.10.5346-5354.2002, 128305, 12228258.
14. Mukhopadhyay S, Chen Y, Sankala M, Peiser L, Pikkarainen T, Kraal G, Tryggvason K, Gordon S. MARCO, an innate activation marker of macrophages, is a class A scavenger receptor for Neisseria meningitidis. Eur J Immunol 2006, 36:940-949. 10.1002/eji.200535389, 16525990.
15. Arredouani M, Yang Z, Ning Y, Qin G, Soininen R, Tryggvason K, Kobzik L. The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles. J Exp Med 2004, 200:267-272. 10.1084/jem.20040731, 2212010, 15263032.
16. Brandenburg LO, Konrad M, Wruck CJ, Koch T, Lucius R, Pufe T. Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells. J Neurochem 113:749-760. 10.1111/j.1471-4159.2010.06637.x, 20141570.
17. McCarthy KD, de Vellis J. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 1980, 85:890-902. 10.1083/jcb.85.3.890, 2111442, 6248568.
18. Wilms H, Rosenstiel P, Sievers J, Deuschl G, Zecca L, Lucius R. Activation of microglia by human neuromelanin is NF-kappaB dependent and involves p38 mitogen-activated protein kinase: implications for Parkinson's disease. Faseb J 2003, 17:500-502.
19. Brandenburg LO, Seyferth S, Wruck CJ, Koch T, Rosenstiel P, Lucius R, Pufe T. Involvement of Phospholipase D 1 and 2 in the subcellular localization and activity of formyl-peptide-receptors in the human colonic cell line HT29. Mol Membr Biol 2009, 26:371-383. 10.1080/09687680903188340, 19707939.
20. Brandenburg LO, Koch T, Sievers J, Lucius R. Internalization of PrP106-126 by the formyl-peptide-receptor-like-1 in glial cells. J Neurochem 2007, 101:718-728. 10.1111/j.1471-4159.2006.04351.x, 17448144.
21. Leib SL, Kim YS, Black SM, Tureen JH, Tauber MG. Inducible nitric oxide synthase and the effect of aminoguanidine in experimental neonatal meningitis. J Infect Dis 1998, 177:692-700. 10.1086/514226, 9498449.
22. Bramanti V, Tomassoni D, Avitabile M, Amenta F, Avola R. Biomarkers of glial cell proliferation and differentiation in culture. Front Biosci (Schol Ed) 2:558-570.
23. Alarcon R, Fuenzalida C, Santibanez M, von Bernhardi R. Expression of scavenger receptors in glial cells. Comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound beta-amyloid. J Biol Chem 2005, 280:30406-30415. 10.1074/jbc.M414686200, 15987691.
24. Pluddemann A, Mukhopadhyay S, Sankala M, Savino S, Pizza M, Rappuoli R, Tryggvason K, Gordon S. SR-A, MARCO and TLRs differentially recognise selected surface proteins from Neisseria meningitidis: an example of fine specificity in microbial ligand recognition by innate immune receptors. J Innate Immun 2009, 1:153-163. 10.1159/000155227, 20375573.
25. Kivisakk P, Imitola J, Rasmussen S, Elyaman W, Zhu B, Ransohoff RM, Khoury SJ. Localizing central nervous system immune surveillance: meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis. Ann Neurol 2009, 65:457-469. 10.1002/ana.21379, 18496841.
26. Marasco WA, Phan SH, Krutzsch H, Showell HJ, Feltner DE, Nairn R, Becker EL, Ward PA. Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli. J Biol Chem 1984, 259:5430-5439.
27. Klein M, Obermaier B, Angele B, Pfister HW, Wagner H, Koedel U, Kirschning CJ. Innate immunity to pneumococcal infection of the central nervous system depends on toll-like receptor (TLR) 2 and TLR4. J Infect Dis 2008, 198:1028-1036. 10.1086/591626, 18700834.
28. Liu X, Chauhan VS, Young AB, Marriott I. NOD2 mediates inflammatory responses of primary murine glia to Streptococcus pneumoniae. Glia 58:839-847.
29. Mogensen TH, Paludan SR, Kilian M, Ostergaard L. Live Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis activate the inflammatory response through Toll-like receptors 2, 4, and 9 in species-specific patterns. J Leukoc Biol 2006, 80:267-277. 10.1189/jlb.1105626, 16731773.
30. Bergman P, Johansson L, Wan H, Jones A, Gallo RL, Gudmundsson GH, Hokfelt T, Jonsson AB, Agerberth B. Induction of the antimicrobial peptide CRAMP in the blood-brain barrier and meninges after meningococcal infection. Infect Immun 2006, 74:6982-6991. 10.1128/IAI.01043-06, 1698100, 17030578.
31. Cruse G, Fernandes VE, de Salort J, Pankhania D, Marinas MS, Brewin H, Andrew PW, Bradding P, Kadioglu A. Human lung mast cells mediate pneumococcal cell death in response to activation by pneumolysin. J Immunol 184:7108-7115. 10.4049/jimmunol.0900802, 20483738.
32. Brandenburg LO, Jansen S, Wruck CJ, Lucius R, Pufe T. Antimicrobial peptide rCRAMP induced glial cell activation through P2Y receptor signalling pathways. Mol Immunol 47:1905-1913. 10.1016/j.molimm.2010.03.012, 20392497.
33. Edmond K, Clark A, Korczak VS, Sanderson C, Griffiths UK, Rudan I. Global and regional risk of disabling sequelae from bacterial meningitis: a systematic review and meta-analysis. Lancet Infect Dis 10:317-328. 10.1016/S1473-3099(10)70048-7, 20417414.
34. Ramakrishnan M, Ulland AJ, Steinhardt LC, Moisi JC, Were F, Levine OS. Sequelae due to bacterial meningitis among African children: a systematic literature review. BMC Med 2009, 7:47. 10.1186/1741-7015-7-47, 2759956, 19751516.