Leptin inhibits amyloid β-protein degradation through decrease of neprilysin expression in primary cultured astrocytes

Biochemical and Biophysical Research Communications

Volumn 445, Issue 1, 2014, Pages 214-217

  Yamamoto, Naoki ^a,b   Tanida, Mamoru ^b,c   Ono, Yoko ^b   Kasahara, Rika ^b   Fujii, Yuko ^b   Ohora, Kentaro ^b   Suzuki, Kenji ^b   Sobue, Kazuya ^d  

^a HOKURIKU UNIVERSITY   (Japan)

^b RITSUMEIKAN UNIVERSITY   (Japan)

^c KANAZAWA MEDICAL UNIVERSITY   (Japan)

^d NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

Alzheimer's disease; Amyloid protein; Leptin; Neprilysin

Indexed keywords

AMYLOID BETA PROTEIN; INSULINASE; LEPTIN; MEMBRANE METALLOENDOPEPTIDASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; ARTICLE; ASTROCYTE; CONTROLLED STUDY; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT;

RATTUS;

ALZHEIMER'S DISEASE; AMYLOID Β-PROTEIN; LEPTIN; NEPRILYSIN;

AMYLOID BETA-PEPTIDES; ANIMALS; ASTROCYTES; BLOTTING, WESTERN; BUTADIENES; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INSULYSIN; LEPTIN; NEPRILYSIN; NITRILES; PROTEOLYSIS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84896715400     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.01.168     Document Type: Article

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