-
1
-
-
0342906187
-
Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
-
Lucchinetti, C. et al. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann. Neurol. 47, 707-717 (2000).
-
(2000)
Ann. Neurol.
, vol.47
, pp. 707-717
-
-
Lucchinetti, C.1
-
2
-
-
0034765063
-
Immunopathology of secondary-progressive multiple sclerosis
-
Prineas, J. W. et al. Immunopathology of secondary-progressive multiple sclerosis. Ann. Neurol. 50, 646-657 (2001).
-
(2001)
Ann. Neurol.
, vol.50
, pp. 646-657
-
-
Prineas, J.W.1
-
3
-
-
77957931759
-
Activated microglia mediate axoglial disruption that contributes to axonal injury in multiple sclerosis
-
Howell, O. W. et al. Activated microglia mediate axoglial disruption that contributes to axonal injury in multiple sclerosis. J. Neuropathol. Exp. Neurol. 69, 1017-1033 (2010).
-
(2010)
J. Neuropathol. Exp. Neurol.
, vol.69
, pp. 1017-1033
-
-
Howell, O.W.1
-
4
-
-
84905391675
-
Interactions between microglia and T cells in multiple sclerosis pathobiology
-
Strachan-Whaley, M., Rivest, S. & Yong, V. W. Interactions between microglia and T cells in multiple sclerosis pathobiology. J. Interferon Cytokine Res. 34, 615-622 (2014).
-
(2014)
J. Interferon Cytokine Res.
, vol.34
, pp. 615-622
-
-
Strachan-Whaley, M.1
Rivest, S.2
Yong, V.W.3
-
5
-
-
76249095169
-
Development of monocytes, macrophages, and dendritic cells
-
Geissmann, F. et al. Development of monocytes, macrophages, and dendritic cells. Science 327, 656-661 (2010).
-
(2010)
Science
, vol.327
, pp. 656-661
-
-
Geissmann, F.1
-
6
-
-
78149360132
-
Fate mapping analysis reveals that adult microglia derive from primitive macrophages
-
Ginhoux, F. et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330, 841-845 (2010).
-
(2010)
Science
, vol.330
, pp. 841-845
-
-
Ginhoux, F.1
-
7
-
-
84906317107
-
Microglia: Unique and common features with other tissue macrophages
-
Prinz, M., Tay, T. L., Wolf, Y. & Jung, S. Microglia: unique and common features with other tissue macrophages. Acta Neuropathol. 128, 319-331 (2014).
-
(2014)
Acta Neuropathol.
, vol.128
, pp. 319-331
-
-
Prinz, M.1
Tay, T.L.2
Wolf, Y.3
Jung, S.4
-
8
-
-
84875892857
-
Microglia emerge from erythromyeloid precursors via Pu.1-And Irf8-dependent pathways
-
Kierdorf, K. et al. Microglia emerge from erythromyeloid precursors via Pu.1-And Irf8-dependent pathways. Nat. Neurosci. 16, 273-280 (2013).
-
(2013)
Nat. Neurosci.
, vol.16
, pp. 273-280
-
-
Kierdorf, K.1
-
9
-
-
84859508307
-
A lineage of myeloid cells independent of Myb and hematopoietic stem cells
-
Schulz, C. et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science 336, 86-90 (2012).
-
(2012)
Science
, vol.336
, pp. 86-90
-
-
Schulz, C.1
-
10
-
-
84925465211
-
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
-
Gomez Perdiguero, E. et al. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature 518, 547-551 (2015).
-
(2015)
Nature
, vol.518
, pp. 547-551
-
-
Gomez Perdiguero, E.1
-
11
-
-
80053233055
-
Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
-
Prinz, M., Priller, J., Sisodia, S. S. & Ransohoff, R. M. Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nat. Neurosci. 14, 1227-1235 (2011).
-
(2011)
Nat. Neurosci.
, vol.14
, pp. 1227-1235
-
-
Prinz, M.1
Priller, J.2
Sisodia, S.S.3
Ransohoff, R.M.4
-
12
-
-
28544446111
-
Monocyte and macrophage heterogeneity
-
Gordon, S. & Taylor, P. R. Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 5, 953-964 (2005).
-
(2005)
Nat. Rev. Immunol.
, vol.5
, pp. 953-964
-
-
Gordon, S.1
Taylor, P.R.2
-
13
-
-
0037220123
-
Interferon-γ switches monocyte differentiation from dendritic cells to macrophages
-
Delneste, Y. et al. Interferon-γ switches monocyte differentiation from dendritic cells to macrophages. Blood 101, 143-150 (2003).
-
(2003)
Blood
, vol.101
, pp. 143-150
-
-
Delneste, Y.1
-
14
-
-
77957221743
-
The impact of the extracellular matrix on inflammation
-
Sorokin, L. The impact of the extracellular matrix on inflammation. Nat. Rev. Immunol. 10, 712-723 (2010).
-
(2010)
Nat. Rev. Immunol.
, vol.10
, pp. 712-723
-
-
Sorokin, L.1
-
15
-
-
84878863196
-
Extracellular matrix metalloproteinase inducer shows active perivascular cuffs in multiple sclerosis
-
Agrawal, S. M. et al. Extracellular matrix metalloproteinase inducer shows active perivascular cuffs in multiple sclerosis. Brain 136, 1760-1777 (2013).
-
(2013)
Brain
, vol.136
, pp. 1760-1777
-
-
Agrawal, S.M.1
-
16
-
-
0032193213
-
Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice
-
Tran, E. H., Hoekstra, K., van Rooijen, N., Dijkstra, C. D. & Owens, T. Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice. J. Immunol. 161, 3767-3775 (1998).
-
(1998)
J. Immunol.
, vol.161
, pp. 3767-3775
-
-
Tran, E.H.1
Hoekstra, K.2
Van Rooijen, N.3
Dijkstra, C.D.4
Owens, T.5
-
17
-
-
77953268611
-
Alternative activation of macrophages: Mechanism and functions
-
Gordon, S. & Martinez, F. O. Alternative activation of macrophages: mechanism and functions. Immunity 32, 593-604 (2010).
-
(2010)
Immunity
, vol.32
, pp. 593-604
-
-
Gordon, S.1
Martinez, F.O.2
-
18
-
-
84904394690
-
Macrophage activation and polarization: Nomenclature and experimental guidelines
-
Murray, P. J. et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity 41, 14-20 (2014).
-
(2014)
Immunity
, vol.41
, pp. 14-20
-
-
Murray, P.J.1
-
19
-
-
84894102230
-
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation
-
Xue, J. et al. Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity 40, 274-288 (2014).
-
(2014)
Immunity
, vol.40
, pp. 274-288
-
-
Xue, J.1
-
20
-
-
84897556094
-
The M1 and M2 paradigm of macrophage activation: Time for reassessment
-
Martinez, F. O. & Gordon, S. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep. 6, 13 (2014).
-
(2014)
F1000Prime Rep.
, vol.6
, pp. 13
-
-
Martinez, F.O.1
Gordon, S.2
-
21
-
-
78651515693
-
EMMPRIN: A novel regulator of leukocyte transmigration into the CNS in multiple sclerosis and experimental autoimmune encephalomyelitis
-
Agrawal, S. M., Silva, C., Tourtellotte, W. W. & Yong, V. W. EMMPRIN: a novel regulator of leukocyte transmigration into the CNS in multiple sclerosis and experimental autoimmune encephalomyelitis. J. Neurosci. 31, 669-677 (2011).
-
(2011)
J. Neurosci.
, vol.31
, pp. 669-677
-
-
Agrawal, S.M.1
Silva, C.2
Tourtellotte, W.W.3
Yong, V.W.4
-
22
-
-
19744380563
-
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
-
Nimmerjahn, A., Kirchhoff, F. & Helmchen, F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308, 1314-1318 (2005).
-
(2005)
Science
, vol.308
, pp. 1314-1318
-
-
Nimmerjahn, A.1
Kirchhoff, F.2
Helmchen, F.3
-
23
-
-
80255129718
-
The yin and yang of microglia
-
Czeh, M., Gressens, P. & Kaindl, A. M. The yin and yang of microglia. Dev. Neurosci. 33, 199-209 (2011).
-
(2011)
Dev. Neurosci.
, vol.33
, pp. 199-209
-
-
Czeh, M.1
Gressens, P.2
Kaindl, A.M.3
-
24
-
-
80355143546
-
Microglial cell origin and phenotypes in health and disease
-
Saijo, K. & Glass, C. K. Microglial cell origin and phenotypes in health and disease. Nat. Rev. Immunol. 11, 775-787 (2011).
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 775-787
-
-
Saijo, K.1
Glass, C.K.2
-
25
-
-
84880162763
-
The benefits and detriments of macrophages/microglia in models of multiple sclerosis
-
Rawji, K. S. & Yong, V. W. The benefits and detriments of macrophages/microglia in models of multiple sclerosis. Clin. Dev. Immunol. 2013, 948976 (2013).
-
(2013)
Clin. Dev. Immunol.
, vol.2013
, pp. 948976
-
-
Rawji, K.S.1
Yong, V.W.2
-
26
-
-
84923238571
-
Microglia: Multitasking specialists of the brain
-
Casano, A. M. & Peri, F. Microglia: multitasking specialists of the brain. Dev. Cell 32, 469-477 (2015).
-
(2015)
Dev. Cell
, vol.32
, pp. 469-477
-
-
Casano, A.M.1
Peri, F.2
-
27
-
-
79953059788
-
Plasmacytoid dendritic cells: Recent progress and open questions
-
Reizis, B., Bunin, A., Ghosh, H. S., Lewis, K. L. & Sisirak, V. Plasmacytoid dendritic cells: recent progress and open questions. Annu. Rev. Immunol. 29, 163-183 (2011).
-
(2011)
Annu. Rev. Immunol.
, vol.29
, pp. 163-183
-
-
Reizis, B.1
Bunin, A.2
Ghosh, H.S.3
Lewis, K.L.4
Sisirak, V.5
-
28
-
-
34249049841
-
Antigen presentation in the CNS by myeloid dendritic cells drives progression of relapsing experimental autoimmune encephalomyelitis
-
Miller, S. D., McMahon, E. J., Schreiner, B. & Bailey, S. L. Antigen presentation in the CNS by myeloid dendritic cells drives progression of relapsing experimental autoimmune encephalomyelitis. Ann. N. Y. Acad. Sci. 1103, 179-191 (2007).
-
(2007)
Ann. N. Y. Acad. Sci.
, vol.1103
, pp. 179-191
-
-
Miller, S.D.1
McMahon, E.J.2
Schreiner, B.3
Bailey, S.L.4
-
29
-
-
84957436679
-
PDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammation
-
Duraes, F. V. et al. pDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammation. J. Autoimmun. 67, 8-18 (2016).
-
(2016)
J. Autoimmun.
, vol.67
, pp. 8-18
-
-
Duraes, F.V.1
-
30
-
-
65149093082
-
+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease
-
+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease. Blood 113, 3190-3197 (2009).
-
(2009)
Blood
, vol.113
, pp. 3190-3197
-
-
King, I.L.1
Dickendesher, T.L.2
Segal, B.M.3
-
31
-
-
71549167047
-
hi monocytes are crucial for the effector phase of autoimmunity in the central nervous system
-
hi monocytes are crucial for the effector phase of autoimmunity in the central nervous system. Brain 132, 2487-2500 (2009).
-
(2009)
Brain
, vol.132
, pp. 2487-2500
-
-
Mildner, A.1
-
32
-
-
84864117759
-
Kinetics of proinflammatory monocytes in a model of multiple sclerosis and its perturbation by laquinimod
-
Mishra, M. K., Wang, J., Silva, C., Mack, M. & Yong, V. W. Kinetics of proinflammatory monocytes in a model of multiple sclerosis and its perturbation by laquinimod. Am. J. Pathol. 181, 642-651 (2012).
-
(2012)
Am. J. Pathol.
, vol.181
, pp. 642-651
-
-
Mishra, M.K.1
Wang, J.2
Silva, C.3
MacK, M.4
Yong, V.W.5
-
33
-
-
80052246111
-
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
-
Ajami, B., Bennett, J. L., Krieger, C., McNagny, K. M. & Rossi, F. M. Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool. Nat. Neurosci. 14, 1142-1149 (2011).
-
(2011)
Nat. Neurosci.
, vol.14
, pp. 1142-1149
-
-
Ajami, B.1
Bennett, J.L.2
Krieger, C.3
McNagny, K.M.4
Rossi, F.M.5
-
34
-
-
33645869560
-
Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis
-
Agrawal, S. et al. Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis. J. Exp. Med. 203, 1007-1019 (2006).
-
(2006)
J. Exp. Med.
, vol.203
, pp. 1007-1019
-
-
Agrawal, S.1
-
35
-
-
0035405886
-
Metalloproteinases in biology and pathology of the nervous system
-
Yong, V. W., Power, C., Forsyth, P. & Edwards, D. R. Metalloproteinases in biology and pathology of the nervous system. Nat. Rev. Neurosci. 2, 502-511 (2001).
-
(2001)
Nat. Rev. Neurosci.
, vol.2
, pp. 502-511
-
-
Yong, V.W.1
Power, C.2
Forsyth, P.3
Edwards, D.R.4
-
36
-
-
33847723000
-
Metalloproteinases are enriched in microglia compared with leukocytes and they regulate cytokine levels in activated microglia
-
Nuttall, R. K. et al. Metalloproteinases are enriched in microglia compared with leukocytes and they regulate cytokine levels in activated microglia. Glia 55, 516-526 (2007).
-
(2007)
Glia
, vol.55
, pp. 516-526
-
-
Nuttall, R.K.1
-
37
-
-
0019468319
-
The effects of macrophage depletion on the clinical and pathologic expression of experimental allergic encephalomyelitis
-
Brosnan, C. F., Bornstein, M. B. & Bloom, B. R. The effects of macrophage depletion on the clinical and pathologic expression of experimental allergic encephalomyelitis. J. Immunol. 126, 614-620 (1981).
-
(1981)
J. Immunol.
, vol.126
, pp. 614-620
-
-
Brosnan, C.F.1
Bornstein, M.B.2
Bloom, B.R.3
-
38
-
-
0025015655
-
Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages
-
Huitinga, I., van Rooijen, N., de Groot, C. J., Uitdehaag, B. M. & Dijkstra, C. D. Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages. J. Exp. Med. 172, 1025-1033 (1990).
-
(1990)
J. Exp. Med.
, vol.172
, pp. 1025-1033
-
-
Huitinga, I.1
Van Rooijen, N.2
De Groot, C.J.3
Uitdehaag, B.M.4
Dijkstra, C.D.5
-
39
-
-
0029451821
-
The role of macrophages, perivascular cells, and microglial cells in the pathogenesis of experimental autoimmune encephalomyelitis
-
Bauer, J. et al. The role of macrophages, perivascular cells, and microglial cells in the pathogenesis of experimental autoimmune encephalomyelitis. Glia 15, 437-446 (1995).
-
(1995)
Glia
, vol.15
, pp. 437-446
-
-
Bauer, J.1
-
40
-
-
84880184615
-
Reduction of microglial activity in a model of multiple sclerosis by dipyridamole
-
Sloka, S., Metz, L. M., Hader, W., Starreveld, Y. & Yong, V. W. Reduction of microglial activity in a model of multiple sclerosis by dipyridamole. J. Neuroinflamm. 10, 89 (2013).
-
(2013)
J. Neuroinflamm.
, vol.10
, pp. 89
-
-
Sloka, S.1
Metz, L.M.2
Hader, W.3
Starreveld, Y.4
Yong, V.W.5
-
41
-
-
78650996588
-
Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration
-
Mikita, J. et al. Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration. Mult. Scler. 17, 2-15 (2011).
-
(2011)
Mult. Scler.
, vol.17
, pp. 2-15
-
-
Mikita, J.1
-
42
-
-
34547699396
-
Type II monocytes modulate T cell-mediated central nervous system autoimmune disease
-
Weber, M. S. et al. Type II monocytes modulate T cell-mediated central nervous system autoimmune disease. Nat. Med. 13, 935-943 (2007).
-
(2007)
Nat. Med.
, vol.13
, pp. 935-943
-
-
Weber, M.S.1
-
43
-
-
0030970058
-
Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis
-
Benveniste, E. N. Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis. J. Mol. Med. (Berl.) 75, 165-173 (1997).
-
(1997)
J. Mol. Med. (Berl.)
, vol.75
, pp. 165-173
-
-
Benveniste, E.N.1
-
44
-
-
84941242991
-
IFN-γ ameliorates autoimmune encephalomyelitis by limiting myelin lipid peroxidation
-
Sosa, R. A., Murphey, C., Robinson, R. R. & Forsthuber, T. G. IFN-γ ameliorates autoimmune encephalomyelitis by limiting myelin lipid peroxidation. Proc. Natl Acad. Sci. USA 112, E5038-E5047 (2015).
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. E5038-E5047
-
-
Sosa, R.A.1
Murphey, C.2
Robinson, R.R.3
Forsthuber, T.G.4
-
45
-
-
79953761792
-
A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis
-
Nikic, I. et al. A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat. Med. 17, 495-499 (2011).
-
(2011)
Nat. Med.
, vol.17
, pp. 495-499
-
-
Nikic, I.1
-
46
-
-
84947611521
-
Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation
-
Mossakowski, A. A. et al. Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation. Acta Neuropathol. 130, 799-814 (2015).
-
(2015)
Acta Neuropathol.
, vol.130
, pp. 799-814
-
-
Mossakowski, A.A.1
-
47
-
-
78650170203
-
Radical changes in multiple sclerosis pathogenesis
-
van Horssen, J., Witte, M. E., Schreibelt, G. & de Vries, H. E. Radical changes in multiple sclerosis pathogenesis. Biochim. Biophys. Acta 1812, 141-150 (2011).
-
(2011)
Biochim. Biophys. Acta
, vol.1812
, pp. 141-150
-
-
Van Horssen, J.1
Witte, M.E.2
Schreibelt, G.3
De Vries, H.E.4
-
48
-
-
84905116959
-
Differential roles of microglia and monocytes in the inflamed central nervous system
-
Yamasaki, R. et al. Differential roles of microglia and monocytes in the inflamed central nervous system. J. Exp. Med. 211, 1533-1549 (2014).
-
(2014)
J. Exp. Med.
, vol.211
, pp. 1533-1549
-
-
Yamasaki, R.1
-
49
-
-
0022975160
-
Prazosin treatment during the effector stage of disease suppresses experimental autoimmune encephalomyelitis in the Lewis rat
-
Brosnan, C. F., Sacks, H. J., Goldschmidt, R. C., Goldmuntz, E. A. & Norton, W. T. Prazosin treatment during the effector stage of disease suppresses experimental autoimmune encephalomyelitis in the Lewis rat. J. Immunol. 137, 3451-3456 (1986).
-
(1986)
J. Immunol.
, vol.137
, pp. 3451-3456
-
-
Brosnan, C.F.1
Sacks, H.J.2
Goldschmidt, R.C.3
Goldmuntz, E.A.4
Norton, W.T.5
-
50
-
-
84947768583
-
Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation
-
Shaked, I. et al. Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation. Nat. Immunol. 16, 1228-1234 (2015).
-
(2015)
Nat. Immunol.
, vol.16
, pp. 1228-1234
-
-
Shaked, I.1
-
51
-
-
25444484079
-
Microglial cell activation and proliferation precedes the onset of CNS autoimmunity
-
Ponomarev, E. D., Shriver, L. P., Maresz, K. & Dittel, B. N. Microglial cell activation and proliferation precedes the onset of CNS autoimmunity. J. Neurosci. Res. 81, 374-389 (2005).
-
(2005)
J. Neurosci. Res.
, vol.81
, pp. 374-389
-
-
Ponomarev, E.D.1
Shriver, L.P.2
Maresz, K.3
Dittel, B.N.4
-
52
-
-
35649010838
-
Persistent activation of microglia is associated with neuronal dysfunction of callosal projecting pathways and multiple sclerosis-like lesions in relapsing-remitting experimental autoimmune encephalomyelitis
-
Rasmussen, S. et al. Persistent activation of microglia is associated with neuronal dysfunction of callosal projecting pathways and multiple sclerosis-like lesions in relapsing-remitting experimental autoimmune encephalomyelitis. Brain 130, 2816-2829 (2007).
-
(2007)
Brain
, vol.130
, pp. 2816-2829
-
-
Rasmussen, S.1
-
53
-
-
33746354022
-
Tumor necrosis factor-α induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner
-
Takeuchi, H. et al. Tumor necrosis factor-α induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. J. Biol. Chem. 281, 21362-21368 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 21362-21368
-
-
Takeuchi, H.1
-
54
-
-
0032524997
-
Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 cell activation
-
Aloisi, F., Ria, F., Penna, G. & Adorini, L. Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 cell activation. J. Immunol. 160, 4671-4680 (1998).
-
(1998)
J. Immunol.
, vol.160
, pp. 4671-4680
-
-
Aloisi, F.1
Ria, F.2
Penna, G.3
Adorini, L.4
-
55
-
-
0033370612
-
Relative efficiency of microglia, astrocytes, dendritic cells and B cells in naive CD4+ T cell priming and Th1/Th2 cell restimulation
-
Aloisi, F. et al. Relative efficiency of microglia, astrocytes, dendritic cells and B cells in naive CD4+ T cell priming and Th1/Th2 cell restimulation. Eur. J. Immunol. 29, 2705-2714 (1999).
-
(1999)
Eur. J. Immunol.
, vol.29
, pp. 2705-2714
-
-
Aloisi, F.1
-
56
-
-
84870815173
-
Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation
-
Davalos, D. et al. Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation. Nat. Commun. 3, 1227 (2012).
-
(2012)
Nat. Commun.
, vol.3
, pp. 1227
-
-
Davalos, D.1
-
57
-
-
20044376483
-
Experimental autoimmune encephalomyelitis repressed by microglial paralysis
-
Heppner, F. L. et al. Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat. Med. 11, 146-152 (2005).
-
(2005)
Nat. Med.
, vol.11
, pp. 146-152
-
-
Heppner, F.L.1
-
58
-
-
84886953273
-
A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation
-
Goldmann, T. et al. A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation. Nat. Neurosci. 16, 1618-1626 (2013).
-
(2013)
Nat. Neurosci.
, vol.16
, pp. 1618-1626
-
-
Goldmann, T.1
-
59
-
-
44949248404
-
Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: A new mechanism of CNS immune privilege
-
Neumann, J. et al. Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: a new mechanism of CNS immune privilege. J. Neurosci. 28, 5965-5975 (2008).
-
(2008)
J. Neurosci.
, vol.28
, pp. 5965-5975
-
-
Neumann, J.1
-
60
-
-
84919455244
-
Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain
-
Chen, Z. et al. Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain. Nat. Commun. 5, 4486 (2014).
-
(2014)
Nat. Commun.
, vol.5
, pp. 4486
-
-
Chen, Z.1
-
61
-
-
0031002545
-
Axonal damage in acute multiple sclerosis lesions
-
Ferguson, B., Matyszak, M. K., Esiri, M. M. & Perry, V. H. Axonal damage in acute multiple sclerosis lesions. Brain 120, 393-399 (1997).
-
(1997)
Brain
, vol.120
, pp. 393-399
-
-
Ferguson, B.1
Matyszak, M.K.2
Esiri, M.M.3
Perry, V.H.4
-
62
-
-
84866117533
-
Increased PK11195 PET binding in the cortex of patients with MS correlates with disability
-
Politis, M. et al. Increased PK11195 PET binding in the cortex of patients with MS correlates with disability. Neurology 79, 523-530 (2012).
-
(2012)
Neurology
, vol.79
, pp. 523-530
-
-
Politis, M.1
-
63
-
-
27644552194
-
Cortical demyelination and diffuse white matter injury in multiple sclerosis
-
Kutzelnigg, A. et al. Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain 128, 2705-2712 (2005).
-
(2005)
Brain
, vol.128
, pp. 2705-2712
-
-
Kutzelnigg, A.1
-
64
-
-
79961000152
-
Preactive multiple sclerosis lesions offer novel clues for neuroprotective therapeutic strategies
-
van Noort, J. M. et al. Preactive multiple sclerosis lesions offer novel clues for neuroprotective therapeutic strategies. CNS Neurol. Disord. Drug Targets 10, 68-81 (2011).
-
(2011)
CNS Neurol. Disord. Drug Targets
, vol.10
, pp. 68-81
-
-
Van Noort, J.M.1
-
65
-
-
84874446407
-
Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status
-
Vogel, D. Y. et al. Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status. J. Neuroinflamm. 10, 35 (2013).
-
(2013)
J. Neuroinflamm.
, vol.10
, pp. 35
-
-
Vogel, D.Y.1
-
66
-
-
84867537711
-
Heterogeneity of cortical lesions in multiple sclerosis: Clinical and pathologic implications
-
Kooi, E. J., Strijbis, E. M., van der Valk, P. & Geurts, J. J. Heterogeneity of cortical lesions in multiple sclerosis: clinical and pathologic implications. Neurology 79, 1369-1376 (2012).
-
(2012)
Neurology
, vol.79
, pp. 1369-1376
-
-
Kooi, E.J.1
Strijbis, E.M.2
Van Der Valk, P.3
Geurts, J.J.4
-
67
-
-
84876670276
-
Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons
-
Singh, S. et al. Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons. Acta Neuropathol. 125, 595-608 (2013).
-
(2013)
Acta Neuropathol.
, vol.125
, pp. 595-608
-
-
Singh, S.1
-
68
-
-
84920283093
-
Activation status of human microglia is dependent on lesion formation stage and remyelination in multiple sclerosis
-
Peferoen, L. A. et al. Activation status of human microglia is dependent on lesion formation stage and remyelination in multiple sclerosis. J. Neuropathol. Exp. Neurol. 74, 48-63 (2015).
-
(2015)
J. Neuropathol. Exp. Neurol.
, vol.74
, pp. 48-63
-
-
Peferoen, L.A.1
-
69
-
-
0035205622
-
Monocytes in multiple sclerosis: Phenotype and cytokine profile
-
Kouwenhoven, M., Teleshova, N., Ozenci, V., Press, R. & Link, H. Monocytes in multiple sclerosis: phenotype and cytokine profile. J. Neuroimmunol. 112, 197-205 (2001).
-
(2001)
J. Neuroimmunol.
, vol.112
, pp. 197-205
-
-
Kouwenhoven, M.1
Teleshova, N.2
Ozenci, V.3
Press, R.4
Link, H.5
-
70
-
-
0032828862
-
Multiple sclerosis is associated with high levels of circulating dendritic cells secreting pro-inflammatory cytokines
-
Huang, Y. M. et al. Multiple sclerosis is associated with high levels of circulating dendritic cells secreting pro-inflammatory cytokines. J. Neuroimmunol. 99, 82-90 (1999).
-
(1999)
J. Neuroimmunol.
, vol.99
, pp. 82-90
-
-
Huang, Y.M.1
-
71
-
-
0035801768
-
+ monocytes in the blood correlates with the presence of active MRI lesions in MS
-
+ monocytes in the blood correlates with the presence of active MRI lesions in MS. J. Neuroimmunol. 119, 145-149 (2001).
-
(2001)
J. Neuroimmunol.
, vol.119
, pp. 145-149
-
-
Makhlouf, K.1
Weiner, H.L.2
Khoury, S.J.3
-
72
-
-
84958582142
-
+ monocytes in immune surveillance of the central nervous system
-
+ monocytes in immune surveillance of the central nervous system. J. Immunol. 196, 1558-1567 (2016).
-
(2016)
J. Immunol.
, vol.196
, pp. 1558-1567
-
-
Waschbisch, A.1
-
73
-
-
65649096159
-
Localizing central nervous system immune surveillance: Meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis
-
Kivisakk, P. et al. Localizing central nervous system immune surveillance: meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis. Ann. Neurol. 65, 457-469 (2009).
-
(2009)
Ann. Neurol.
, vol.65
, pp. 457-469
-
-
Kivisakk, P.1
-
74
-
-
84941735780
-
+ monocytes and licenses autoimmunity
-
+ monocytes and licenses autoimmunity. Immunity 43, 502-514 (2015).
-
(2015)
Immunity
, vol.43
, pp. 502-514
-
-
Croxford, A.L.1
-
75
-
-
84875244645
-
Communication between pathogenic T cells and myeloid cells in neuroinflammatory disease
-
Codarri, L., Greter, M. & Becher, B. Communication between pathogenic T cells and myeloid cells in neuroinflammatory disease. Trends Immunol. 34, 114-119 (2013).
-
(2013)
Trends Immunol.
, vol.34
, pp. 114-119
-
-
Codarri, L.1
Greter, M.2
Becher, B.3
-
76
-
-
33846018916
-
GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis
-
Ponomarev, E. D. et al. GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis. J. Immunol. 178, 39-48 (2007).
-
(2007)
J. Immunol.
, vol.178
, pp. 39-48
-
-
Ponomarev, E.D.1
-
77
-
-
79956116032
-
RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
-
Codarri, L. et al. RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat. Immunol. 12, 560-567 (2011).
-
(2011)
Nat. Immunol.
, vol.12
, pp. 560-567
-
-
Codarri, L.1
-
78
-
-
79956152607
-
H17 cells is dependent on IL-1-And IL-23-induced production of the cytokine GM-CSF
-
H17 cells is dependent on IL-1-And IL-23-induced production of the cytokine GM-CSF. Nat. Immunol. 12, 568-575 (2011).
-
(2011)
Nat. Immunol.
, vol.12
, pp. 568-575
-
-
El-Behi, M.1
-
79
-
-
84942516683
-
GM-CSF in neuroinflammation: Licensing myeloid cells for tissue damage
-
Croxford, A. L., Spath, S. & Becher, B. GM-CSF in neuroinflammation: licensing myeloid cells for tissue damage. Trends Immunol. 36, 651-662 (2015).
-
(2015)
Trends Immunol.
, vol.36
, pp. 651-662
-
-
Croxford, A.L.1
Spath, S.2
Becher, B.3
-
80
-
-
84885730321
-
Therapeutic decisions in multiple sclerosis: Moving beyond efficacy
-
Bruck, W. et al. Therapeutic decisions in multiple sclerosis: moving beyond efficacy. JAMA Neurol. 70, 1315-1324 (2013).
-
(2013)
JAMA Neurol.
, vol.70
, pp. 1315-1324
-
-
Bruck, W.1
-
81
-
-
37249048528
-
Pharmacological treatment of early multiple sclerosis
-
Stuve, O. et al. Pharmacological treatment of early multiple sclerosis. Drugs 68, 73-83 (2008).
-
(2008)
Drugs
, vol.68
, pp. 73-83
-
-
Stuve, O.1
-
82
-
-
84957840860
-
Central nervous system myeloid cells as drug targets: Current status and translational challenges
-
Biber, K., Moller, T., Boddeke, E. & Prinz, M. Central nervous system myeloid cells as drug targets: current status and translational challenges. Nat. Rev. Drug Discov. 15, 110-124 (2016).
-
(2016)
Nat. Rev. Drug Discov.
, vol.15
, pp. 110-124
-
-
Biber, K.1
Moller, T.2
Boddeke, E.3
Prinz, M.4
-
83
-
-
74249112995
-
Interferon-beta mechanisms of action in multiple sclerosis
-
Dhib-Jalbut, S. & Marks, S. Interferon-beta mechanisms of action in multiple sclerosis. Neurology 74, S17-S24 (2010).
-
(2010)
Neurology
, vol.74
, pp. S17-S24
-
-
Dhib-Jalbut, S.1
Marks, S.2
-
84
-
-
9644252636
-
Interferon-β up-regulates the expression of co-stimulatory molecules CD80, CD86 and CD40 on monocytes: Significance for treatment of multiple sclerosis
-
Marckmann, S. et al. Interferon-β up-regulates the expression of co-stimulatory molecules CD80, CD86 and CD40 on monocytes: significance for treatment of multiple sclerosis. Clin. Exp. Immunol. 138, 499-506 (2004).
-
(2004)
Clin. Exp. Immunol.
, vol.138
, pp. 499-506
-
-
Marckmann, S.1
-
85
-
-
0035212758
-
Immunomodulatory effects of interferon beta-1a in multiple sclerosis
-
Liu, Z., Pelfrey, C. M., Cotleur, A., Lee, J. C. & Rudick, R. A. Immunomodulatory effects of interferon beta-1a in multiple sclerosis. J. Neuroimmunol. 112, 153-162 (2001).
-
(2001)
J. Neuroimmunol.
, vol.112
, pp. 153-162
-
-
Liu, Z.1
Pelfrey, C.M.2
Cotleur, A.3
Lee, J.C.4
Rudick, R.A.5
-
86
-
-
77950526192
-
IFN-p inhibits human Th17 cell differentiation
-
Ramgolam, V. S., Sha, Y., Jin, J., Zhang, X. & Markovic-Plese, S. IFN-p inhibits human Th17 cell differentiation. J. Immunol. 183, 5418-5427 (2009).
-
(2009)
J. Immunol.
, vol.183
, pp. 5418-5427
-
-
Ramgolam, V.S.1
Sha, Y.2
Jin, J.3
Zhang, X.4
Markovic-Plese, S.5
-
87
-
-
77951634161
-
IFN-p inhibits dendritic cell migration through STAT-1-mediated transcriptional suppression of CCR7 and matrix metalloproteinase 9
-
Yen, J. H., Kong, W. & Ganea, D. IFN-p inhibits dendritic cell migration through STAT-1-mediated transcriptional suppression of CCR7 and matrix metalloproteinase 9. J. Immunol. 184, 3478-3486 (2010).
-
(2010)
J. Immunol.
, vol.184
, pp. 3478-3486
-
-
Yen, J.H.1
Kong, W.2
Ganea, D.3
-
88
-
-
0036789982
-
Modulation of monocytes matrix metalloproteinase-2, MT1-MMP and TIMP-2 by interferon-y and-(3: Implications to multiple sclerosis
-
Galboiz, Y, Shapiro, S., Lahat, N. & Miller, A. Modulation of monocytes matrix metalloproteinase-2, MT1-MMP and TIMP-2 by interferon-y and-(3: implications to multiple sclerosis. J. Neuroimmunol. 131, 191-200 (2002).
-
(2002)
J. Neuroimmunol.
, vol.131
, pp. 191-200
-
-
Galboiz, Y.1
Shapiro, S.2
Lahat, N.3
Miller, A.4
-
89
-
-
4444355857
-
Interferon-p enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: Relevance for the immune modulatory effect in multiple sclerosis
-
Schreiner, B. et al. Interferon-p enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis. J. Neuroimmunol. 155, 172-182 (2004).
-
(2004)
J. Neuroimmunol.
, vol.155
, pp. 172-182
-
-
Schreiner, B.1
-
90
-
-
72649106903
-
A type i interferon signature in monocytes is associated with poor response to interferon-p in multiple sclerosis
-
Comabella, M. et al. A type I interferon signature in monocytes is associated with poor response to interferon-p in multiple sclerosis. Brain 132, 3353-3365 (2009).
-
(2009)
Brain
, vol.132
, pp. 3353-3365
-
-
Comabella, M.1
-
91
-
-
70349323428
-
Interferon (3 induces mature dendritic cell apoptosis through caspase-11/caspase-3 activation
-
Yen, J. H. & Ganea, D. Interferon (3 induces mature dendritic cell apoptosis through caspase-11/caspase-3 activation. Blood 114, 1344-1354 (2009).
-
(2009)
Blood
, vol.114
, pp. 1344-1354
-
-
Yen, J.H.1
Ganea, D.2
-
92
-
-
43049101640
-
The type i IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice
-
Guo, B., Chang, E. Y & Cheng, G. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J. Clin. Invest. 118, 1680-1690 (2008).
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 1680-1690
-
-
Guo, B.1
Chang, E.Y.2
Cheng, G.3
-
93
-
-
43049177588
-
Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system
-
Prinz, M. et al. Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity 28, 675-686 (2008).
-
(2008)
Immunity
, vol.28
, pp. 675-686
-
-
Prinz, M.1
-
94
-
-
0347968011
-
Multiple sclerosis: Expression of CD1a and production of IL-12p70 and IFN-y by blood mononuclear cells in patients on combination therapy with IFN-p and glatiramer acetate compared to monotherapy with IFN-p
-
Hussien, Y., Sanna, A., Soderstrom, M., Link, H. & Huang, Y. M. Multiple sclerosis: expression of CD1a and production of IL-12p70 and IFN-y by blood mononuclear cells in patients on combination therapy with IFN-p and glatiramer acetate compared to monotherapy with IFN-p. Mult. Scler. 10, 16-25 (2004).
-
(2004)
Mult. Scler.
, vol.10
, pp. 16-25
-
-
Hussien, Y.1
Sanna, A.2
Soderstrom, M.3
Link, H.4
Huang, Y.M.5
-
95
-
-
0037210372
-
Regulation by interferon p-1a of reactive oxygen metabolites production by lymphocytes and monocytes and serum sulfhydryls in relapsing multiple sclerosis patients
-
Lucas, M. et al. Regulation by interferon p-1a of reactive oxygen metabolites production by lymphocytes and monocytes and serum sulfhydryls in relapsing multiple sclerosis patients. Neurochem. Int. 42, 67-71 (2003).
-
(2003)
Neurochem. Int.
, vol.42
, pp. 67-71
-
-
Lucas, M.1
-
96
-
-
34249021938
-
T Interferon-p regulates cytokines and BDNF: Greater effect in relapsing than in progressive multiple sclerosis
-
Hamamcioglu, K. & Reder, A. T Interferon-p regulates cytokines and BDNF: greater effect in relapsing than in progressive multiple sclerosis. Mult. Scler. 13, 459-470 (2007).
-
(2007)
Mult. Scler.
, vol.13
, pp. 459-470
-
-
Hamamcioglu, K.1
Reder, A.2
-
97
-
-
84920491105
-
Interferon beta and Vitamin D synergize to induce immunoregulatory receptors on peripheral blood monocytes of multiple sclerosis patients
-
Waschbisch, A. et al. Interferon beta and vitamin D synergize to induce immunoregulatory receptors on peripheral blood monocytes of multiple sclerosis patients. PLoS ONE 9, e115488 (2014).
-
(2014)
PLoS ONE
, vol.9
, pp. e115488
-
-
Waschbisch, A.1
-
98
-
-
2942594278
-
Multiple sclerosis: Glatiramer acetate inhibits monocyte reactivity in vitro and in vivo
-
Weber, M. S. et al. Multiple sclerosis: glatiramer acetate inhibits monocyte reactivity in vitro and in vivo. Brain 127, 1370-1378 (2004).
-
(2004)
Brain
, vol.127
, pp. 1370-1378
-
-
Weber, M.S.1
-
99
-
-
2442698974
-
Type 2 monocyte and microglia differentiation mediated by glatiramer acetate therapy in patients with multiple sclerosis
-
Kim, H. J. et al. Type 2 monocyte and microglia differentiation mediated by glatiramer acetate therapy in patients with multiple sclerosis. J. Immunol. 172, 7144-7153 (2004).
-
(2004)
J. Immunol.
, vol.172
, pp. 7144-7153
-
-
Kim, H.J.1
-
100
-
-
84872174912
-
Dendritic cell, monocyte and T cell activation and response to glatiramer acetate in multiple sclerosis
-
Sellebjerg, F et al. Dendritic cell, monocyte and T cell activation and response to glatiramer acetate in multiple sclerosis. Mult. Scler. 19, 179-187 (2013).
-
(2013)
Mult. Scler.
, vol.19
, pp. 179-187
-
-
Sellebjerg, F.1
-
101
-
-
48349088568
-
Reduction of free radicals in multiple sclerosis: Effect of glatiramer acetate (Copaxone)
-
Iarlori, C. et al. Reduction of free radicals in multiple sclerosis: effect of glatiramer acetate (Copaxone). Mult. Scler. 14, 739-748 (2008).
-
(2008)
Mult. Scler.
, vol.14
, pp. 739-748
-
-
Iarlori, C.1
-
102
-
-
79955662810
-
Glatiramer acetate modulates TNF-A and IL-10 secretion in microglia and promotes their phagocytic activity
-
Pul, R. et al. Glatiramer acetate modulates TNF-A and IL-10 secretion in microglia and promotes their phagocytic activity. J. Neuroimmune Pharmacol. 6, 381-388 (2011).
-
(2011)
J. Neuroimmune Pharmacol.
, vol.6
, pp. 381-388
-
-
Pul, R.1
-
103
-
-
84871429821
-
Glatiramer acetate increases phagocytic activity of human monocytes in vitro and in multiple sclerosis patients
-
Pul, R. et al. Glatiramer acetate increases phagocytic activity of human monocytes in vitro and in multiple sclerosis patients. PLoS ONE 7, e51867 (2012).
-
(2012)
PLoS ONE
, vol.7
, pp. e51867
-
-
Pul, R.1
-
104
-
-
63149114677
-
Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1 p in human monocytes and multiple sclerosis
-
Burger, D. et al. Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1 p in human monocytes and multiple sclerosis. Proc. Natl Acad. Sci. USA 106, 4355-4359 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 4355-4359
-
-
Burger, D.1
-
105
-
-
84876337179
-
Modulation of immune function occurs within hours of therapy initiation for multiple sclerosis
-
Ayers, C. L. et al. Modulation of immune function occurs within hours of therapy initiation for multiple sclerosis. Clin. Immunol. 147, 105-119 (2013).
-
(2013)
Clin. Immunol.
, vol.147
, pp. 105-119
-
-
Ayers, C.L.1
-
106
-
-
84862764134
-
Decreased microglial activation in MS patients treated with glatiramer acetate
-
Ratchford, J. N. et al. Decreased microglial activation in MS patients treated with glatiramer acetate. J. Neurol. 259, 1199-1205 (2012).
-
(2012)
J. Neurol.
, vol.259
, pp. 1199-1205
-
-
Ratchford, J.N.1
-
107
-
-
77951073508
-
Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis
-
Chun, J. & Hartung, H. P. Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis. Clin. Neuropharmacol. 33, 91-101 (2010).
-
(2010)
Clin. Neuropharmacol.
, vol.33
, pp. 91-101
-
-
Chun, J.1
Hartung, H.P.2
-
108
-
-
14744287548
-
The immunomodulator FTY720 interferes with effector functions of human monocyte-derived dendritic cells
-
Muller, H. et al. The immunomodulator FTY720 interferes with effector functions of human monocyte-derived dendritic cells. Eur. J. Immunol. 35, 533-545 (2005).
-
(2005)
Eur. J. Immunol.
, vol.35
, pp. 533-545
-
-
Muller, H.1
-
109
-
-
84882750764
-
Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis
-
Awojoodu, A. O. et al. Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis. Proc. Natl Acad. Sci. USA 110, 13785-13790 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 13785-13790
-
-
Awojoodu, A.O.1
-
110
-
-
42549148380
-
Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages
-
Hughes, J. E. et al. Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages. Circ. Res. 102, 950-958 (2008).
-
(2008)
Circ. Res.
, vol.102
, pp. 950-958
-
-
Hughes, J.E.1
-
111
-
-
78650966754
-
Differential responses of human microglia and blood-derived myeloid cells to FTY720
-
Durafourt, B. A. et al. Differential responses of human microglia and blood-derived myeloid cells to FTY720. J. Neuroimmunol. 230, 10-16 (2011).
-
(2011)
J. Neuroimmunol.
, vol.230
, pp. 10-16
-
-
Durafourt, B.A.1
-
112
-
-
84875367110
-
Fingolimod phosphate promotes the neuroprotective effects of microglia
-
Noda, H., Takeuchi, H., Mizuno, T & Suzumura, A. Fingolimod phosphate promotes the neuroprotective effects of microglia. J. Neuroimmunol. 256, 13-18 (2013).
-
(2013)
J. Neuroimmunol.
, vol.256
, pp. 13-18
-
-
Noda, H.1
Takeuchi, H.2
Mizuno, T.3
Suzumura, A.4
-
113
-
-
84886994204
-
3, calcipotriol and FTY720 on the expression of surface molecules and cytolytic activities of human natural killer cells and dendritic cells
-
3, calcipotriol and FTY720 on the expression of surface molecules and cytolytic activities of human natural killer cells and dendritic cells. Toxins (Basel) 5, 1932-1947 (2013).
-
(2013)
Toxins (Basel)
, vol.5
, pp. 1932-1947
-
-
Al-Jaderi, Z.1
Maghazachi, A.A.2
-
114
-
-
79959846854
-
Fingolimod modulates microglial activation to augment markers of remyelination
-
Jackson, S. J., Giovannoni, G. & Baker, D. Fingolimod modulates microglial activation to augment markers of remyelination. J. Neuroinflamm. 8, 76 (2011).
-
(2011)
J. Neuroinflamm.
, vol.8
, pp. 76
-
-
Jackson, S.J.1
Giovannoni, G.2
Baker, D.3
-
115
-
-
84875465529
-
Circulating monocytes are reduced by sphingosine-1-phosphate receptor modulators independently of S1P3
-
Lewis, N. D. et al. Circulating monocytes are reduced by sphingosine-1-phosphate receptor modulators independently of S1P3. J. Immunol. 190, 3533-3540 (2013).
-
(2013)
J. Immunol.
, vol.190
, pp. 3533-3540
-
-
Lewis, N.D.1
-
116
-
-
84948144040
-
FTY720 (fingolimod) treatment tips the balance towards less immunogenic antigen-presenting cells in patients with multiple sclerosis
-
Luessi, F et al. FTY720 (fingolimod) treatment tips the balance towards less immunogenic antigen-presenting cells in patients with multiple sclerosis. Mult. Scler 21, 1811-1822 (2015).
-
(2015)
Mult. Scler
, vol.21
, pp. 1811-1822
-
-
Luessi, F.1
-
117
-
-
84981720306
-
Effects of fumarates on circulating and CNS myeloid cells in multiple sclerosis
-
Michell-Robinson, M. A. et al. Effects of fumarates on circulating and CNS myeloid cells in multiple sclerosis. Ann. Clin. Transl. Neurol. 3, 27-41 (2016).
-
(2016)
Ann. Clin. Transl. Neurol.
, vol.3
, pp. 27-41
-
-
Michell-Robinson, M.A.1
-
118
-
-
79952136166
-
Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
-
Linker, R. A. et al. Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 134, 678-692 (2011).
-
(2011)
Brain
, vol.134
, pp. 678-692
-
-
Linker, R.A.1
-
119
-
-
84865009934
-
Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor KB (NF-KB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-Activated kinase 1 (MSK1) signaling
-
Peng, H. et al. Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor KB (NF-KB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-Activated kinase 1 (MSK1) signaling. J. Biol. Chem. 287, 28017-28026 (2012).
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 28017-28026
-
-
Peng, H.1
-
120
-
-
77952301752
-
Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1p, TNF-A and IL-6 in an in-vitro model of brain inflammation
-
Wilms, H. et al. Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1p, TNF-A and IL-6 in an in-vitro model of brain inflammation. J. Neuroinflamm. 7, 30 (2010).
-
(2010)
J. Neuroinflamm.
, vol.7
, pp. 30
-
-
Wilms, H.1
-
121
-
-
81455135889
-
Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: A novel candidate for HIV neuroprotection
-
Cross, S. A. et al. Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection. J. Immunol. 187, 5015-5025 (2011).
-
(2011)
J. Immunol.
, vol.187
, pp. 5015-5025
-
-
Cross, S.A.1
-
122
-
-
33745162188
-
Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltration
-
Schilling, S., Goelz, S., Linker, R., Luehder, F & Gold, R. Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltration. Clin. Exp. Immunol. 145, 101-107 (2006).
-
(2006)
Clin. Exp. Immunol.
, vol.145
, pp. 101-107
-
-
Schilling, S.1
Goelz, S.2
Linker, R.3
Luehder, F.4
Gold, R.5
-
124
-
-
80055106751
-
Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells
-
Ghoreschi, K. et al. Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells. J. Exp. Med. 208, 2291-2303 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, pp. 2291-2303
-
-
Ghoreschi, K.1
-
125
-
-
84876518370
-
Role of oral teriflunomide in the management of multiple sclerosis
-
Tanasescu, R., Evangelou, N. & Constantinescu, C. S. Role of oral teriflunomide in the management of multiple sclerosis. Neuropsychiatr. Dis. Treat. 9, 539-553 (2013).
-
(2013)
Neuropsychiatr. Dis. Treat.
, vol.9
, pp. 539-553
-
-
Tanasescu, R.1
Evangelou, N.2
Constantinescu, C.S.3
-
126
-
-
7644223637
-
Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide-mechanisms independent of pyrimidine depletion
-
Korn, T., Magnus, T., Toyka, K. & Jung, S. Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide-mechanisms independent of pyrimidine depletion. J. Leukoc. Biol. 76, 950-960 (2004).
-
(2004)
J. Leukoc. Biol.
, vol.76
, pp. 950-960
-
-
Korn, T.1
Magnus, T.2
Toyka, K.3
Jung, S.4
-
127
-
-
84899426389
-
Teriflunomide attenuates immunopathological changes in the dark agouti rat model of experimental autoimmune encephalomyelitis
-
Ringheim, G. E. et al. Teriflunomide attenuates immunopathological changes in the dark agouti rat model of experimental autoimmune encephalomyelitis. Front. Neurol. 4, 169 (2013).
-
(2013)
Front. Neurol.
, vol.4
, pp. 169
-
-
Ringheim, G.E.1
-
128
-
-
84888338846
-
The effects of teriflunomide on lymphocyte subpopulations in human peripheral blood mononuclear cells in vitro
-
Li, L. et al. The effects of teriflunomide on lymphocyte subpopulations in human peripheral blood mononuclear cells in vitro. J. Neuroimmunol. 265, 82-90 (2013).
-
(2013)
J. Neuroimmunol.
, vol.265
, pp. 82-90
-
-
Li, L.1
-
129
-
-
84922986271
-
Laquinimod reduces neuroaxonal injury through inhibiting microglial activation
-
Mishra, M. K. et al. Laquinimod reduces neuroaxonal injury through inhibiting microglial activation. Ann. Clin. Transl. Neurol. 1, 409-422 (2014).
-
(2014)
Ann. Clin. Transl. Neurol.
, vol.1
, pp. 409-422
-
-
Mishra, M.K.1
-
130
-
-
84859151160
-
Laquinimod, a quinoline-3-carboxamide, induces type II myeloid cells that modulate central nervous system autoimmunity
-
Schulze-Topphoff, U. et al. Laquinimod, a quinoline-3-carboxamide, induces type II myeloid cells that modulate central nervous system autoimmunity. PLoS ONE 7, e33797 (2012).
-
(2012)
PLoS ONE
, vol.7
, pp. e33797
-
-
Schulze-Topphoff, U.1
-
131
-
-
84876042951
-
Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis
-
Jolivel, V. et al. Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis. Brain 136, 1048-1066 (2013).
-
(2013)
Brain
, vol.136
, pp. 1048-1066
-
-
Jolivel, V.1
-
132
-
-
83555174399
-
Modulation of autoimmune demyelination by laquinimod via induction of brain-derived neurotrophic factor
-
Thone, J. et al. Modulation of autoimmune demyelination by laquinimod via induction of brain-derived neurotrophic factor. Am. J. Pathol. 180, 267-274 (2012).
-
(2012)
Am. J. Pathol.
, vol.180
, pp. 267-274
-
-
Thone, J.1
-
133
-
-
84884814792
-
Assessment of changes in immune measures of multiple sclerosis patients treated with laquinimod
-
Lund, B. T. et al. Assessment of changes in immune measures of multiple sclerosis patients treated with laquinimod. J. Neuroimmunol. 263, 108-115 (2013).
-
(2013)
J. Neuroimmunol.
, vol.263
, pp. 108-115
-
-
Lund, B.T.1
-
134
-
-
84878638136
-
Drugs in development for relapsing multiple sclerosis
-
Ali, R., Nicholas, R. S. & Muraro, P. A. Drugs in development for relapsing multiple sclerosis. Drugs 73, 625-650 (2013).
-
(2013)
Drugs
, vol.73
, pp. 625-650
-
-
Ali, R.1
Nicholas, R.S.2
Muraro, P.A.3
-
135
-
-
84859512094
-
Natalizumab treatment perturbs memory-And marginal zone-like B-cell homing in secondary lymphoid organs in multiple sclerosis
-
Planas, R., Jelcic, I., Schippling, S., Martin, R. & Sospedra, M. Natalizumab treatment perturbs memory-And marginal zone-like B-cell homing in secondary lymphoid organs in multiple sclerosis. Eur. J. Immunol. 42, 790-798 (2012).
-
(2012)
Eur. J. Immunol.
, vol.42
, pp. 790-798
-
-
Planas, R.1
Jelcic, I.2
Schippling, S.3
Martin, R.4
Sospedra, M.5
-
136
-
-
84908608431
-
Mode of action and clinical studies with alemtuzumab
-
Jones, J. L. & Coles, A. J. Mode of action and clinical studies with alemtuzumab. Exp. Neurol. 262, 37-43 (2014).
-
(2014)
Exp. Neurol.
, vol.262
, pp. 37-43
-
-
Jones, J.L.1
Coles, A.J.2
-
137
-
-
31544467633
-
The window of therapeutic opportunity in multiple sclerosis: Evidence from monoclonal antibody therapy
-
Coles, A. J. et al. The window of therapeutic opportunity in multiple sclerosis: evidence from monoclonal antibody therapy. J. Neurol. 253, 98-108 (2006).
-
(2006)
J. Neurol.
, vol.253
, pp. 98-108
-
-
Coles, A.J.1
-
138
-
-
78649931912
-
The potential role of B cell-targeted therapies in multiple sclerosis
-
Boster, A., Ankeny, D. P. & Racke, M. K. The potential role of B cell-targeted therapies in multiple sclerosis. Drugs 70, 2343-2356 (2010).
-
(2010)
Drugs
, vol.70
, pp. 2343-2356
-
-
Boster, A.1
Ankeny, D.P.2
Racke, M.K.3
-
139
-
-
84945538148
-
Proinflammatory GM-CSF-producing B cells in multiple sclerosis and B cell depletion therapy
-
Li, R. et al. Proinflammatory GM-CSF-producing B cells in multiple sclerosis and B cell depletion therapy. Sci. Transl. Med. 7, 310ra166 (2015).
-
(2015)
Sci. Transl. Med.
, vol.7
, pp. 310ra166
-
-
Li, R.1
-
140
-
-
67650345281
-
Ocrelizumab: A step forward in the evolution of B-cell therapy
-
Kausar, F. et al. Ocrelizumab: a step forward in the evolution of B-cell therapy. Expert. Opin. Biol. Ther. 9, 889-895 (2009).
-
(2009)
Expert. Opin. Biol. Ther.
, vol.9
, pp. 889-895
-
-
Kausar, F.1
-
141
-
-
84055197914
-
Mechanisms of glucocorticoids in the control of neuroinflammation
-
Schweingruber, N., Reichardt, S. D., Luhder, F. & Reichardt, H. M. Mechanisms of glucocorticoids in the control of neuroinflammation. J. Neuroendocrinol. 24, 174-182 (2012).
-
(2012)
J. Neuroendocrinol.
, vol.24
, pp. 174-182
-
-
Schweingruber, N.1
Reichardt, S.D.2
Luhder, F.3
Reichardt, H.M.4
-
142
-
-
0030715244
-
Glucocorticoid modulation of human monocyte/macrophage function: Control of TNF-α secretion
-
Joyce, D. A., Steer, J. H. & Abraham, L. J. Glucocorticoid modulation of human monocyte/macrophage function: control of TNF-α secretion. Inflamm. Res. 46, 447-451 (1997).
-
(1997)
Inflamm. Res.
, vol.46
, pp. 447-451
-
-
Joyce, D.A.1
Steer, J.H.2
Abraham, L.J.3
-
143
-
-
0018657510
-
Mechanisms of glucocorticoid action on immune processes
-
Parrillo, J. E. & Fauci, A. S. Mechanisms of glucocorticoid action on immune processes. Annu. Rev. Pharmacol. Toxicol. 19, 179-201 (1979).
-
(1979)
Annu. Rev. Pharmacol. Toxicol.
, vol.19
, pp. 179-201
-
-
Parrillo, J.E.1
Fauci, A.S.2
-
145
-
-
80054764032
-
Liposomal encapsulation of glucocorticoids alters their mode of action in the treatment of experimental autoimmune encephalomyelitis
-
Schweingruber, N. et al. Liposomal encapsulation of glucocorticoids alters their mode of action in the treatment of experimental autoimmune encephalomyelitis. J. Immunol. 187, 4310-4318 (2011).
-
(2011)
J. Immunol.
, vol.187
, pp. 4310-4318
-
-
Schweingruber, N.1
-
146
-
-
84906935393
-
Glutathione PEGylated liposomal methylprednisolone (2B3-201) attenuates CNS inflammation and degeneration in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
-
Lee, D. H. et al. Glutathione PEGylated liposomal methylprednisolone (2B3-201) attenuates CNS inflammation and degeneration in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis. J. Neuroimmunol. 274, 96-101 (2014).
-
(2014)
J. Neuroimmunol.
, vol.274
, pp. 96-101
-
-
Lee, D.H.1
-
147
-
-
34547841656
-
Glucocorticoid treatment reduces T-bet and pSTAT1 expression in mononuclear cells from relapsing remitting multiple sclerosis patients
-
Frisullo, G. et al. Glucocorticoid treatment reduces T-bet and pSTAT1 expression in mononuclear cells from relapsing remitting multiple sclerosis patients. Clin. Immunol. 124, 284-293 (2007).
-
(2007)
Clin. Immunol.
, vol.124
, pp. 284-293
-
-
Frisullo, G.1
-
148
-
-
60149091269
-
Changes in circulating dendritic cells and B-cells in patients with multiple sclerosis relapse during corticosteroid therapy
-
Krystyna, M. S. et al. Changes in circulating dendritic cells and B-cells in patients with multiple sclerosis relapse during corticosteroid therapy. J. Neuroimmunol. 207, 107-110 (2009).
-
(2009)
J. Neuroimmunol.
, vol.207
, pp. 107-110
-
-
Krystyna, M.S.1
-
149
-
-
0032524790
-
Glucocorticoids increase IL-10 expression in multiple sclerosis patients with acute relapse
-
Gayo, A. et al. Glucocorticoids increase IL-10 expression in multiple sclerosis patients with acute relapse. J. Neuroimmunol. 85, 122-130 (1998).
-
(1998)
J. Neuroimmunol.
, vol.85
, pp. 122-130
-
-
Gayo, A.1
-
150
-
-
77956302879
-
Inflammation in neurological disorders: A help or a hindrance?
-
Wee Yong, V. Inflammation in neurological disorders: a help or a hindrance? Neuroscientist 16, 408-420 (2010).
-
(2010)
Neuroscientist
, vol.16
, pp. 408-420
-
-
Wee Yong, V.1
|