Modulation of autoimmune demyelination by laquinimod via induction of brain-derived neurotrophic factor

American Journal of Pathology

Volumn 180, Issue 1, 2012, Pages 267-274

  Thöne, Jan ^a   Ellrichmann, Gisa ^a   Seubert, Silvia ^a   Peruga, Isabella ^a   Lee, De Hyung ^a   Conrad, Rebecca ^b   Hayardeny, Liat ^c   Comi, Giancarlo ^d   Wiese, Stefan ^b   Linker, Ralf A ^a   Gold, Ralf ^a  

^a ST JOSEF HOSPITAL   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c TEVA PHARMACEUTICALS   (Israel)

^d VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; INTERLEUKIN 10; INTERLEUKIN 6; LAQUINIMOD;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; DRUG TARGETING; EXPERIMENTAL STUDY; HUMAN; IMMUNOMODULATION; MOUSE; NEUROPROTECTION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; TH1 CELL; TH2 CELL; TH3 CELL;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CYTOKINES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MICE; MICE, INBRED C57BL; MONOCYTES; MULTIPLE SCLEROSIS; NEUROPROTECTIVE AGENTS; QUINOLONES;

EID: 83555174399     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.09.037     Document Type: Article

References (30)

1. J. Thöne, R. Gold Laquinimod: a promising oral medication for the treatment of relapsing-remitting multiple sclerosis Expert Opin Drug Metab Toxicol 7 2011 365 370
2. J.S. Yang, L.Y. Xu, B.G. Xiao, G. Hedlund, H. Link Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-beta in Lewis rats J Neuroimmunol 156 2004 3 9 (Pubitemid 39310510)
3. C.A. Brunmark, A. Runström, L. Ohlsson, B. Sparre, T. Brodin, M. Aström, G. Hedlund The new orally active immunoregulator laquinimod (ABR-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitis J Neuroimmunol 130 2002 163 172 (Pubitemid 35240003)
4. C. Wegner, C. Stadelmann, R. Pförtner, E. Raymond, S. Feigelson, R. Alon, B. Timan, L. Hayardeny, W. Brck Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demylination and acute axonal damage in mice with experimental autoimmune encephalomyelitis J Neuroimmunol 227 2010 133 143
5. L.P. Zou, N. Abbas, I. Volkmann, I. Nennesmo, M. Levi, B. Wahren, B. Winblad, G. Hedlund, J. Zhu Suppression of experimental autoimmune neuritis by ABR-215062 is associated with altered Th1/Th2 balance and inhibited migration of inflammatory cells into the peripheral nerve tissue Neuropharmacology 42 2002 731 739 (Pubitemid 34457755)
6. M. Kerschensteiner, E. Gallmeier, L. Behrens, L. Leal, T. Misgeld, W.E. Klinkert, R. Kolbeck, E. Hoppe, R.L. Oropeza-Wekerle, I. Bartke, C. Stadelmann, H. Lassmann, H. Wekerle, R. Hohlfeld Activated human T cells B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J Exp Med 189 1999 865 887
7. D. Azoulay, N. Urshansky, A. Karni Low and dysregulated BDNF secretion from immune cells of MS patients is related to reduced neuroprotection J Neuroimmunol 195 2008 186 193
8. L. De Santi, P. Annunziata, E. Sessa, P. Bramanti Brain-derived neurotrophic factor and TrkB receptor in experimental autoimmune encephalomyelitis and multiple sclerosis J Neurol Sci 287 2009 17 26
9. R. Aharoni, R. Eilam, H. Domev, G. Labunskay, M. Sela, R. Arnon The immunomodulator glatiramer acetate augments the expression of neurotrophic factors in brains of experimental autoimmune encephalomyelitis mice Proc Natl Acad Sci USA 102 2005 19045 19050 (Pubitemid 43049563)
10. T. Ziemssen, T. Kmpfel, W.E. Klinkert, O. Neuhaus, R. Hohlfeld Glatiramer acetatespecific T-helper 1 and 2type cell lines produce BDNF: implications for multiple sclerosis therapy Brain derived neurotrophic factor Brain 125 2002 2381 2391 (Pubitemid 35303499)
11. R.A. Linker, R. Gold, F. Lhder Function of neurotrophic factors beyond the nervous system: inflammation and autoimmune demyelination Crit Rev Immunol 29 2009 43 68
12. R.A. Linker, D.H. Lee, S. Demir, S. Wiese, N. Kruse, I. Siglienti, E. Gerhardt, H. Neumann, M. Sendtner, F. Lhder, R. Gold Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis Brain 133 2010 2248 2263
13. G. Comi, A. Pulizzi, M. Rovaris, O. Abramsky, T. Arbizu, A. Boiko, R. Gold, E. Havrdova, S. Komoly, K. Selmaj, B. Sharrack, M. Filippi LAQ/5062 Study Group Effect of laquinimod on MRI-monitored disease activity in patients with relapsingremitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study Lancet 371 2008 2085 2092 (Pubitemid 351842581)
14. S. Wiese, T. Herrmann, C. Drepper, S. Jablonka, N. Funk, A. Klausmeyer, M.L. Rogers, R. Rush, M. Sendtner Isolation and enrichment of embryonic mouse motoneurons from the lumbar spinal cord of individual mouse embryos Nat Protoc 5 2010 31 38
15. R.A. Linker, M. Murer, S. Gaupp, R. Martini, B. Holtmann, R. Giess, P. Rieckmann, H. Lassmann, K.V. Toyka, M. Sendtner, R. Gold CNTF is a major protective factor in demyelinating CNS disease: a neurotrophic cytokine as modulator in neuroinflammation Nat Med 8 2002 620 624 (Pubitemid 34633441)
16. J. Stegbauer, D.H. Lee, S. Seubert, G. Ellrichmann, A. Manzel, H. Kvakan, D.N. Muller, S. Gaupp, L.C. Rump, R. Gold, R.A. Linker Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system Proc Natl Acad Sci USA 106 2009 14942 14947
17. V.K. Kuchroo, M.P. Das, J.A. Brown, A.M. Ranger, S.S. Zamvil, R.A. Sobel, H.L. Weiner, N. Nabavi, L.H. Glimcher B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy Cell 80 1995 707 718
18. A.M. Ranger, M.P. Das, V.K. Kuchroo, L.H. Glimcher B7-2 (CD86) is essential for the development of IL-4-producing T cells Int Immunol 8 1996 1549 1560 (Pubitemid 26341095)
19. M. Sendtner, B. Holtmann, R. Kolbeck, H. Thoenen, Y.A. Barde Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section Nature 360 1992 757 759 (Pubitemid 23012276)
20. Q. Yan, J. Elliott, W.D. Snider Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death Nature 360 1992 753 755 (Pubitemid 23012274)
21. C. Gravel, R. Götz, A. Lorrain, M. Sendtner Adenoviral gene transfer of ciliary neurotrophic factor and brain-derived neurotrophic factor leads to long-term survival of axotomized motor neurons Nat Med 3 1997 765 769
22. D.M. McTigue, P.J. Horner, B.T. Stokes, F.H. Gage Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord J Neurosci 18 1998 5354 5365 (Pubitemid 28311952)
23. R.A. Linker, B.C. Kieseier, R. Gold Identification and development of new therapeutics in multiple sclerosis Trends Pharmacol Sci 29 2008 558 565
24. G. Comi, O. Abramsky, T. Arbizu, A. Boyko, R. Gold, E. Havrdová, S. Komoly, K. Selmaj, B. Sharrack, M. Filippi LAQ/5063 Study Group Oral laquinimod in patients with relapsing-remitting multiple sclerosis: 36-week double-blind active extension of the multi-centre, randomized, double-blind, parallel-group placebo-controlled study Mult Scler 16 2010 1360 1366
25. M. Caggiula, A.P. Batocchi, G. Frisullo, F. Angelucci, A.K. Patanella, C. Sancricca, V. Nociti, P.A. Tonali, M. Mirabella Neurotrophic factors and clinical recovery in relapsingremitting multiple sclerosis Scand J Immunol 62 2005 176 182 (Pubitemid 41176501)
26. M.S. Weber, T. Prod'homme, S. Youssef, S.E. Dunn, C.D. Rundle, L. Lee, J.C. Patarroyo, O. Stve, R.A. Sobel, L. Steinman, S.S. Zamvil Type II monocytes modulate T cellmediated central nervous system autoimmune disease Nat Med 13 2007 935 943 (Pubitemid 47222047)
27. J.A. Vega, O. Garcia-Suarez, J. Hannestad, M. Perez-Perez, A. Germana Neurotrophins and the immune system J Anat 203 2003 1 19 (Pubitemid 36889240)
28. A.Y. Wen, K.M. Sakamoto, L.S. Miller The role of the transcription factor CREB in immune function J Immunol 185 2010 6413 6419
29. I. Sánchez-Muoz, F. Sánchez-Franco, M. Vallejo, A. Fernández, N. Palacios, M. Fernández, M. Sánchez-Grande, L. Cacicedo Regulation of somatostatin gene expression by brain derived neurotrophic factor in fetal rat cerebrocortical cells Brain Res 1375 2011 28 40
30. A. London, E. Itskovich, I. Benhar, V. Kalchenko, M. Mack, S. Jung, M. Schwartz Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages J Exp Med 208 2011 23 39