Immunomodulatory effects of interferon beta-1a in multiple sclerosis

Journal of Neuroimmunology

Volumn 112, Issue 1-2, 2001, Pages 153-162

  Liu, Zhugong ^a   Pelfrey, Clara M ^a   Cotleur, Anne ^a   Lee, Jar Chi ^a   Rudick, Richard A ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Co stimulatory molecules; IFN beta; IL 10; Multiple sclerosis

Indexed keywords

B7 ANTIGEN; BETA1A INTERFERON; CD28 ANTIGEN; CD40 ANTIGEN; GAMMA INTERFERON; GLYCOPROTEIN GP 39; INTERLEUKIN 10;

ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOREGULATION; MONONUCLEAR CELL; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; RECURRENT DISEASE; T LYMPHOCYTE;

ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, CD86; CD40 LIGAND; CELLS, CULTURED; HUMANS; INTERFERON-BETA; INTERLEUKIN-10; LEUKOCYTES, MONONUCLEAR; MEMBRANE GLYCOPROTEINS; MULTIPLE SCLEROSIS;

EID: 0035212758     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(00)00403-3     Document Type: Article

References (33)

1. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. The IFNB Multiple Sclerosis Study Group
2. Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis, PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group
3. Adenovirus-mediated transfer of viral IL-10 gene inhibits murine collagen-induced arthritis
4. Immunologic therapy of multiple sclerosis
5. Converging and diverging properties of human interleukin-4 and interleukin-10
6. CD40 ligand (CD154) triggers short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis
7. Decreased interleukin-10 and increased interleukin-12p40 mRNA are associated with disease activity and characterize different disease stages in multiple sclerosis
8. Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
9. The immunobiology of multiple sclerosis: An autoimmune disease of the central nervous system
10. Patterns of cytokine secretion by autoreactive proteolipid protein-specific T cell clones during the course of multiple sclerosis
11. Autoreactivity to myelin antigens: Myelin/oligodendrocyte glycoprotein is a prevalent autoantigen
12. Increased CD80(+) B cells in active multiple sclerosis and reversal by interferon beta-1b therapy
13. Cytokine profile of myelin basic protein-reactive T cells in multiple sclerosis and healthy individuals
14. Therapeutic strategies in multiple sclerosis I. Immunotherapy
15. Identification of an epitope derived from human proteolipid protein that can induce autoreactive CD8+ cytotoxic T lymphocytes restricted by HLA-A3: Evidence for cross-reactivity with an environmental microorganism
16. Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis
17. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
18. Magnetic resonance imaging results of the PRISMS trial: A randomized, double-blind, placebo-controlled study of interferon-beta1a in relapsing-remitting multiple sclerosis. Prevention of relapses and disability by interferon-beta1a subcutaneously in multiple sclerosis
19. IFN-beta differentially regulates CD40-induced cytokine secretion by human dendritic cells
20. Type I IFNs inhibit human dendritic cell IL-12 production and Th1 cell development
21. The role of IL-10 in crossregulation of TH1 and TH2 responses
22. Interleukin-10 inhibits the capacity of synovial macrophages to function as antigen-presenting cells
23. Cellular responses to interferons and other cytokines: The JAK-STAT paradigm
24. Recombinant interferon-beta blocks proliferation but enhances interleukin-10 secretion by activated human T-cells
25. Biologic effects of interferons: Relevance to multiple sclerosis
26. In vivo effects of interferon beta-1a on immunosuppressive cytokines in multiple sclerosis
27. Interferon beta induces interleukin-10 expression: Relevance to multiple sclerosis
28. Suppression by IL-10 and IL-4 of cytokine production induced by two-way autologous mixed lymphocyte reaction
29. Interferons and their role in inflammation
30. Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes. IL-10 and IL-4 suppress cytokine synthesis by different mechanisms
31. Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis
32. Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions
33. Interferon-beta inhibits progression of relapsing-remitting experimental autoimmune encephalomyelitis