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Volumn 256, Issue 1-2, 2013, Pages 13-18

Fingolimod phosphate promotes the neuroprotective effects of microglia

Author keywords

Fingolimod; Microglia; Neuroprotection; Neurotrophic factor; Pro inflammatory cytokine

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYTOKINE; FINGOLIMOD; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; SPHINGOSINE 1 PHOSPHATE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84875367110     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2012.12.005     Document Type: Article
Times cited : (199)

References (47)
  • 1
    • 79955042876 scopus 로고    scopus 로고
    • Antigen presentation in EAE: role of microglia, macrophages and dendritic cells
    • Almolda B., Gonzalez B., Castellano B. Antigen presentation in EAE: role of microglia, macrophages and dendritic cells. Front. Biosci. 2011, 16:1157-1171.
    • (2011) Front. Biosci. , vol.16 , pp. 1157-1171
    • Almolda, B.1    Gonzalez, B.2    Castellano, B.3
  • 2
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
    • Block M.L., Zecca L., Hong J.S. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci. 2007, 8:57-69.
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.S.3
  • 4
    • 70849086174 scopus 로고    scopus 로고
    • FTY720 (fingolimod) in multiple sclerosis: therapeutic effects in the immune and the central nervous system
    • Brinkmann V. FTY720 (fingolimod) in multiple sclerosis: therapeutic effects in the immune and the central nervous system. Br. J. Pharmacol. 2009, 158:1173-1182.
    • (2009) Br. J. Pharmacol. , vol.158 , pp. 1173-1182
    • Brinkmann, V.1
  • 6
    • 78650881166 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate and immune regulation: trafficking and beyond
    • Chi H. Sphingosine-1-phosphate and immune regulation: trafficking and beyond. Trends Pharmacol. Sci. 2011, 32:16-24.
    • (2011) Trends Pharmacol. Sci. , vol.32 , pp. 16-24
    • Chi, H.1
  • 7
    • 77951073508 scopus 로고    scopus 로고
    • Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis
    • Chun J., Hartung H.P. Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis. Clin. Neuropharmacol. 2010, 33:91-101.
    • (2010) Clin. Neuropharmacol. , vol.33 , pp. 91-101
    • Chun, J.1    Hartung, H.P.2
  • 9
    • 79955455801 scopus 로고    scopus 로고
    • Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis
    • Cohen J.A., Chun J. Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis. Ann. Neurol. 2011, 69:759-777.
    • (2011) Ann. Neurol. , vol.69 , pp. 759-777
    • Cohen, J.A.1    Chun, J.2
  • 11
    • 35348970884 scopus 로고    scopus 로고
    • Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis
    • Foster C.A., Howard L.M., Schweitzer A., Persohn E., Hiestand P.C., Balatoni B., Reuschel R., Beerli C., Schwartz M., Billich A. Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis. J. Pharmacol. Exp. Ther. 2007, 323:469-475.
    • (2007) J. Pharmacol. Exp. Ther. , vol.323 , pp. 469-475
    • Foster, C.A.1    Howard, L.M.2    Schweitzer, A.3    Persohn, E.4    Hiestand, P.C.5    Balatoni, B.6    Reuschel, R.7    Beerli, C.8    Schwartz, M.9    Billich, A.10
  • 12
    • 79954842538 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors block nuclear factor-kappaB-dependent transcription by interfering with RNA polymerase II recruitment
    • Furumai R., Ito A., Ogawa K., Maeda S., Saito A., Nishino N., Horinouchi S., Yoshida M. Histone deacetylase inhibitors block nuclear factor-kappaB-dependent transcription by interfering with RNA polymerase II recruitment. Cancer Sci. 2011, 102:1081-1087.
    • (2011) Cancer Sci. , vol.102 , pp. 1081-1087
    • Furumai, R.1    Ito, A.2    Ogawa, K.3    Maeda, S.4    Saito, A.5    Nishino, N.6    Horinouchi, S.7    Yoshida, M.8
  • 13
    • 84866095781 scopus 로고    scopus 로고
    • Fingolimod (FTY720) inhibits neuroinflammation and attenuates spontaneous convulsions in lithium-pilocarpine induced status epilepticus in rat model
    • Gao F., Liu Y., Li X., Wang Y., Wei D., Jiang W. Fingolimod (FTY720) inhibits neuroinflammation and attenuates spontaneous convulsions in lithium-pilocarpine induced status epilepticus in rat model. Pharmacol. Biochem. Behav. 2012, 103:187-196.
    • (2012) Pharmacol. Biochem. Behav. , vol.103 , pp. 187-196
    • Gao, F.1    Liu, Y.2    Li, X.3    Wang, Y.4    Wei, D.5    Jiang, W.6
  • 15
    • 77950363010 scopus 로고    scopus 로고
    • Mechanisms underlying inflammation in neurodegeneration
    • Glass C.K., Saijo K., Winner B., Marchetto M.C., Gage F.H. Mechanisms underlying inflammation in neurodegeneration. Cell 2010, 140:918-934.
    • (2010) Cell , vol.140 , pp. 918-934
    • Glass, C.K.1    Saijo, K.2    Winner, B.3    Marchetto, M.C.4    Gage, F.H.5
  • 16
    • 79957800283 scopus 로고    scopus 로고
    • Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists
    • Guerrero M., Urbano M., Velaparthi S., Zhao J., Schaeffer M.T., Brown S., Rosen H., Roberts E. Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorg. Med. Chem. Lett. 2011, 21:3632-3636.
    • (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 3632-3636
    • Guerrero, M.1    Urbano, M.2    Velaparthi, S.3    Zhao, J.4    Schaeffer, M.T.5    Brown, S.6    Rosen, H.7    Roberts, E.8
  • 17
    • 58149216131 scopus 로고    scopus 로고
    • Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic
    • Jimenez S., Baglietto-Vargas D., Caballero C., Moreno-Gonzalez I., Torres M., Sanchez-Varo R., Ruano D., Vizuete M., Gutierrez A., Vitorica J. Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic. J. Neurosci. 2008, 28:11650-11661.
    • (2008) J. Neurosci. , vol.28 , pp. 11650-11661
    • Jimenez, S.1    Baglietto-Vargas, D.2    Caballero, C.3    Moreno-Gonzalez, I.4    Torres, M.5    Sanchez-Varo, R.6    Ruano, D.7    Vizuete, M.8    Gutierrez, A.9    Vitorica, J.10
  • 18
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: a sensor for pathological events in the CNS
    • Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996, 19:312-318.
    • (1996) Trends Neurosci. , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 19
    • 78449244305 scopus 로고    scopus 로고
    • Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (fingolimod) in multiple sclerosis
    • Lee C.W., Choi J.W., Chun J. Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (fingolimod) in multiple sclerosis. Arch. Pharm. Res. 2010, 33:1567-1574.
    • (2010) Arch. Pharm. Res. , vol.33 , pp. 1567-1574
    • Lee, C.W.1    Choi, J.W.2    Chun, J.3
  • 24
    • 1242284201 scopus 로고    scopus 로고
    • Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia
    • Mizuno T., Kurotani T., Komatsu Y., Kawanokuchi J., Kato H., Mitsuma N., Suzumura A. Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia. Neuropharmacology 2004, 46:404-411.
    • (2004) Neuropharmacology , vol.46 , pp. 404-411
    • Mizuno, T.1    Kurotani, T.2    Komatsu, Y.3    Kawanokuchi, J.4    Kato, H.5    Mitsuma, N.6    Suzumura, A.7
  • 25
    • 64849090408 scopus 로고    scopus 로고
    • Microglia-aging: roles of microglial lysosome- and mitochondria-derived reactive oxygen species in brain aging
    • Nakanishi H., Wu Z. Microglia-aging: roles of microglial lysosome- and mitochondria-derived reactive oxygen species in brain aging. Behav. Brain Res. 2009, 201:1-7.
    • (2009) Behav. Brain Res. , vol.201 , pp. 1-7
    • Nakanishi, H.1    Wu, Z.2
  • 29
    • 58149141584 scopus 로고    scopus 로고
    • Neuroprotective and toxic changes in microglia in neurodegenerative disease
    • Sawada M. Neuroprotective and toxic changes in microglia in neurodegenerative disease. Parkinsonism Relat. Disord. 2009, 15(Suppl. 1):S39-S41.
    • (2009) Parkinsonism Relat. Disord. , vol.15 , Issue.SUPPL. 1
    • Sawada, M.1
  • 30
    • 33646243562 scopus 로고    scopus 로고
    • Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice
    • Seabrook T.J., Jiang L., Maier M., Lemere C.A. Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice. Glia 2006, 53:776-782.
    • (2006) Glia , vol.53 , pp. 776-782
    • Seabrook, T.J.1    Jiang, L.2    Maier, M.3    Lemere, C.A.4
  • 31
    • 80054885633 scopus 로고    scopus 로고
    • Role of glial cells in innate immunity and their role in CNS demyelination
    • Sriram S. Role of glial cells in innate immunity and their role in CNS demyelination. J. Neuroimmunol. 2011, 239:13-20.
    • (2011) J. Neuroimmunol. , vol.239 , pp. 13-20
    • Sriram, S.1
  • 32
    • 1542376941 scopus 로고    scopus 로고
    • Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury
    • Stirling D.P., Khodarahmi K., Liu J., McPhail L.T., McBride C.B., Steeves J.D., Ramer M.S., Tetzlaff W. Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury. J. Neurosci. 2004, 24:2182-2190.
    • (2004) J. Neurosci. , vol.24 , pp. 2182-2190
    • Stirling, D.P.1    Khodarahmi, K.2    Liu, J.3    McPhail, L.T.4    McBride, C.B.5    Steeves, J.D.6    Ramer, M.S.7    Tetzlaff, W.8
  • 33
    • 0023252003 scopus 로고
    • MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: induction of Ia antigen expression by gamma-interferon
    • Suzumura A., Mezitis S.G., Gonatas N.K., Silberberg D.H. MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: induction of Ia antigen expression by gamma-interferon. J. Neuroimmunol. 1987, 15:263-278.
    • (1987) J. Neuroimmunol. , vol.15 , pp. 263-278
    • Suzumura, A.1    Mezitis, S.G.2    Gonatas, N.K.3    Silberberg, D.H.4
  • 34
    • 77956322561 scopus 로고    scopus 로고
    • Neurotoxicity by microglia: mechanisms and potential therapeutic strategy
    • Takeuchi H. Neurotoxicity by microglia: mechanisms and potential therapeutic strategy. Clin. Exp. Neuroimmunol. 2010, 1:12-21.
    • (2010) Clin. Exp. Neuroimmunol. , vol.1 , pp. 12-21
    • Takeuchi, H.1
  • 35
    • 33746354022 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner
    • Takeuchi H., Jin S., Wang J., Zhang G., Kawanokuchi J., Kuno R., Sonobe Y., Mizuno T., Suzumura A. Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. J. Biol. Chem. 2006, 281:21362-21368.
    • (2006) J. Biol. Chem. , vol.281 , pp. 21362-21368
    • Takeuchi, H.1    Jin, S.2    Wang, J.3    Zhang, G.4    Kawanokuchi, J.5    Kuno, R.6    Sonobe, Y.7    Mizuno, T.8    Suzumura, A.9
  • 36
    • 0037184999 scopus 로고    scopus 로고
    • Mitochondrial localization of mutant superoxide dismutase 1 triggers caspase-dependent cell death in a cellular model of familial amyotrophic lateral sclerosis
    • Takeuchi H., Kobayashi Y., Ishigaki S., Doyu M., Sobue G. Mitochondrial localization of mutant superoxide dismutase 1 triggers caspase-dependent cell death in a cellular model of familial amyotrophic lateral sclerosis. J. Biol. Chem. 2002, 277:50966-50972.
    • (2002) J. Biol. Chem. , vol.277 , pp. 50966-50972
    • Takeuchi, H.1    Kobayashi, Y.2    Ishigaki, S.3    Doyu, M.4    Sobue, G.5
  • 37
    • 15444363122 scopus 로고    scopus 로고
    • Neuritic beading induced by activated microglia is an early feature of neuronal dysfunction toward neuronal death by inhibition of mitochondrial respiration and axonal transport
    • Takeuchi H., Mizuno T., Zhang G., Wang J., Kawanokuchi J., Kuno R., Suzumura A. Neuritic beading induced by activated microglia is an early feature of neuronal dysfunction toward neuronal death by inhibition of mitochondrial respiration and axonal transport. J. Biol. Chem. 2005, 280:10444-10454.
    • (2005) J. Biol. Chem. , vol.280 , pp. 10444-10454
    • Takeuchi, H.1    Mizuno, T.2    Zhang, G.3    Wang, J.4    Kawanokuchi, J.5    Kuno, R.6    Suzumura, A.7
  • 38
    • 33645081959 scopus 로고    scopus 로고
    • Interferon-gamma induces microglial-activation-induced cell death: a hypothetical mechanism of relapse and remission in multiple sclerosis
    • Takeuchi H., Wang J., Kawanokuchi J., Mitsuma N., Mizuno T., Suzumura A. Interferon-gamma induces microglial-activation-induced cell death: a hypothetical mechanism of relapse and remission in multiple sclerosis. Neurobiol. Dis. 2006, 22:33-39.
    • (2006) Neurobiol. Dis. , vol.22 , pp. 33-39
    • Takeuchi, H.1    Wang, J.2    Kawanokuchi, J.3    Mitsuma, N.4    Mizuno, T.5    Suzumura, A.6
  • 39
    • 27744464859 scopus 로고    scopus 로고
    • The microglial "activation" continuum: from innate to adaptive responses
    • Town T., Nikolic V., Tan J. The microglial "activation" continuum: from innate to adaptive responses. J. Neuroinflammation 2005, 2:24.
    • (2005) J. Neuroinflammation , vol.2 , pp. 24
    • Town, T.1    Nikolic, V.2    Tan, J.3
  • 41
    • 0036522967 scopus 로고    scopus 로고
    • Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
    • Wu D.C., Jackson-Lewis V., Vila M., Tieu K., Teismann P., Vadseth C., Choi D.K., Ischiropoulos H., Przedborski S. Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J. Neurosci. 2002, 22:1763-1771.
    • (2002) J. Neurosci. , vol.22 , pp. 1763-1771
    • Wu, D.C.1    Jackson-Lewis, V.2    Vila, M.3    Tieu, K.4    Teismann, P.5    Vadseth, C.6    Choi, D.K.7    Ischiropoulos, H.8    Przedborski, S.9
  • 43
    • 56349167984 scopus 로고    scopus 로고
    • Age-dependent responses of glial cells and leptomeninges during systemic inflammation
    • Wu Z., Tokuda Y., Zhang X.W., Nakanishi H. Age-dependent responses of glial cells and leptomeninges during systemic inflammation. Neurobiol. Dis. 2008, 32:543-551.
    • (2008) Neurobiol. Dis. , vol.32 , pp. 543-551
    • Wu, Z.1    Tokuda, Y.2    Zhang, X.W.3    Nakanishi, H.4
  • 44
    • 78650994912 scopus 로고    scopus 로고
    • Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge
    • Wynne A.M., Henry C.J., Huang Y., Cleland A., Godbout J.P. Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge. Brain Behav. Immun. 2010, 24:1190-1201.
    • (2010) Brain Behav. Immun. , vol.24 , pp. 1190-1201
    • Wynne, A.M.1    Henry, C.J.2    Huang, Y.3    Cleland, A.4    Godbout, J.P.5


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