Microglial cell activation and proliferation precedes the onset of CNS autoimmunity

Journal of Neuroscience Research

Volumn 81, Issue 3, 2005, Pages 374-389

  Ponomarev, Eugene D ^a   Shriver, Leah P ^a,b   Maresz, Katarzyna ^a   Dittel, Bonnie N ^a,b  

^a BLOOD RESEARCH INSTITUTE   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Dendritic cells; EAE MS; Microglia; Monocytes macrophages; Neuroimmunology

Indexed keywords

CD40 ANTIGEN; CD45 ANTIGEN; CD86 ANTIGEN; GLYCOPROTEIN P 15095; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; BONE MARROW; BONE MARROW CELL; CELL ACTIVATION; CELL PROLIFERATION; CELL SELECTION; CENTRAL NERVOUS SYSTEM; CHIMERA; CONTROLLED STUDY; DENDRITIC CELL; FLOW CYTOMETRY; IMMUNOFLUORESCENCE; LEUKOCYTE; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; MICROGLIA; MONOCYTE; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD; AUTOIMMUNITY; BONE MARROW; BROMODEOXYURIDINE; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GREEN FLUORESCENT PROTEINS; HISTOCOMPATIBILITY ANTIGENS CLASS I; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; MYELIN BASIC PROTEINS; RECEPTORS, ANTIGEN, T-CELL; TIME FACTORS; UP-REGULATION; WHOLE-BODY IRRADIATION;

EID: 25444484079     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.20488     Document Type: Article

References (34)

1. Alliot F, Lecain E, Grima B, Pessac B. 1991. Microglial progenitors with a high proliferative potential in the embryonic and adult mouse brain. Proc Natl Acad Sci USA 88:1541-1545.
2. Aloisi F. 2001. Immune function of microglia. Glia 36:165-179.
3. Bauer J, Huitinga I, Zhao W, Lassmann H, Hickey WF, Dijkstra CD. 1995. The role of macrophages, perivascular cells, and microglial cells in the pathogenesis of experimental autoimmune encephalomyelitis. Glia 15:437-446.
4. Carson MJ. 2002. Microglia as liaisons between the immune and central nervous systems: functional implications for multiple sclerosis. Glia 40: 218-231.
5. Carson MJ, Reilly CR, Sutcliffe JG, Lo D. 1998. Mature microglia resemble immature antigen-presenting cells. Glia 22:72-85.
6. Dittel BN, Merchant RM, Janeway CA Jr. 1999. Evidence for Fas-dependent and Fas-independent mechanisms in the pathogenesis of experimental autoimmune encephalomyelitis. J Immunol 162:6392-6400.
7. Fischer HG, Reichmann G. 2001. Brain dendritic cells and macrophages/microglia in central nervous system inflammation. J Immunol 166:2717-2726.
8. Flugel A, Bradl M, Kreutzberg GW, Graeber MB. 2001. Transformation of donor-derived bone marrow precursors into host microglia during autoimmune CNS inflammation and during the retrograde response to axotomy. J Neurosci Res 66:74-82.
9. Ford AL, Foulcher E, Lemckert FA, Sedgwick JD. 1996. Microglia induce CD4 T lymphocyte final effector function and death. J Exp Med 184:1737-1745.
10. Geissmann F, Jung S, Littman DR. 2003. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19: 71-82.
11. Gordon S. 2003. Alternative activation of macrophages. Nat Rev Immunol 3:23-35.
12. Hickey WF, Kimura H. 1988. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 239: 290-292.
13. Hickey WF, Vass K, Lassmann H. 1992. Bone marrow-derived elements in the central nervous system: an immunohistochemical and ultrastructural survey of rat chimeras. J Neuropathol Exp Neurol 51:246-256.
14. Kennedy DW, Abkowitz JL. 1997. Kinetics of central nervous system microglial and macrophage engraftment: analysis using a transgenic bone marrow transplantation model. Blood 90:986-993.
15. Lawson LJ, Perry VH, Gordon S. 1992. Turnover of resident microglia in the normal adult mouse brain. Neuroscience 48:405-415.
16. Lee SC, Liu W, Roth P, Dickson DW, Berman JW, Brosnan CF. 1993. Macrophage colony-stimulating factor in human fetal astrocytes and microglia. Differential regulation by cytokines and lipopolysaccharide, and modulation of class II MHC on microglia. J Immunol 150:594-604.
17. Matsumoto Y, Fujiwara M. 1987. Absence of donor-type major histocompatibility complex class I antigen-bearing microglia in the rat central nervous system of radiation bone marrow chimeras. J Neuroimmunol 17:71-82.
18. Matyszak MK, Denis-Donini S, Citterio S, Longhi R, Granucci F, Ricciardi-Castagnoli P. 1999. Microglia induce myelin basic protein-specific T cell anergy or T cell activation, according to their state of activation. Eur J Immunol 29:3063-3076.
19. Mosser DM. 2003. The many faces of macrophage activation. J Leukoc Biol 73:209-212.
20. Nelson PT, Soma LA, Lavi E. 2002. Microglia in diseases of the central nervous system. Ann Med 34:491-500.
21. Neumann H, Misgeld T, Matsumuro K, Wekerle H. 1998. Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor. Proc Natl Acad Sci USA 95:5779-5784.
22. Ponomarev EB, Novikova M, Yassai M, Szczepanik M, Gorski J, Dittel BN. 2004. γδ cell regulation of IFN-γ production by CNS infiltrating encephalitogenic T cells: correlation with recovery from experimental autoimmune encephalomyelitis. J Immunol 173:1587-1595.
23. Priller J, Flugel A, Wehner T, Boentert M, Haas CA, Prinz M, Fernandez-Klett F, Prass K, Bechmann I, de Boer BA, Frotscher M, Kreutzberg GW, Persons DA, Dirnagl U. 2001. Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment. Nat Med 7:1356-1361.
24. Rinner WA, Bauer J, Schmidts M, Lassmann H, Hickey WF. 1995. Resident microglia and hematogenous macrophages as phagocytes in adoptively transferred experimental autoimmune encephalomyelitis: an investigation using rat radiation bone marrow chimeras. Glia 14:257-266.
25. Santambrogio L, Belyanskaya SL, Fischer FR, Cipriani B, Brosnan CF, Ricciardi-Castagnoli P, Stern LJ, Strominger JL, Riese R. 2001. Developmental plasticity of CNS microglia. Proc Natl Acad Sci USA 98: 6295-6300.
26. Schilling M, Besselmann M, Leonhard C, Mueller M, Ringelstein EB, Kiefer R. 2003. Microglial activation precedes and predominates over macrophage infiltration in transient focal cerebral ischemia: a study in green fluorescent protein transgenic bone marrow chimeric mice. Exp Neurol 183:25-33.
27. Schroeter M, Jander S, Witte OW, Stoll G. 1999. Heterogeneity of the microglial response in photochemically induced focal ischemia of the rat cerebral cortex. Neuroscience 89:1367-1377.
28. Sedgwick JD, Schwender S, Imrich H, Dorries R, Butcher GW, ter Meulen V. 1991. Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system. Proc Natl Acad Sci USA 88:7438-7442.
29. Serafini B, Columba-Cabezas S, Di Rosa F, Aloisi F. 2000. Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis. Am J Pathol 157: 1991-2002.
30. Stein M, Keshav S, Harris N, Gordon S. 1992. Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J Exp Med 176:287-292.
31. Steinman RM, Hawiger D, Nussenzweig MC. 2003. Tolerogenic dendritic cells. Annu Rev Immunol 21:685-711.
32. Suter T, Biollaz G, Gatto D, Bernasconi L, Herren T, Reith W, Fontana A. 2003. The brain as an immune privileged site: dendritic cells of the central nervous system inhibit T cell activation. Eur J Immunol 33: 2998-3006.
33. Ulvestad E, Williams K, Bjerkvig R, Tiekotter K, Antel J, Matre R. 1994. Human microglial cells have phenotypic and functional characteristics in common with both macrophages and dendritic antigen-presenting cells. J Leukoc Biol 56:732-740.
34. Wong FS, Dittel BN, Janeway CA Jr. 1999. Transgenes and knockout mutations in animal models of type 1 diabetes and multiple sclerosis. Immunol Rev 169:93-104.