Interferon β induces mature dendritic cell apoptosis through caspase-11/caspase-3 activation

Blood

Volumn 114, Issue 7, 2009, Pages 1344-1354

  Yen, Jui Hung ^a   Ganea, Doina ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CASPASE 11; CASPASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PROSTAGLANDIN E2; STAT1 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; CASP11 PROTEIN, MOUSE; CASP3 PROTEIN, MOUSE; CASPASE; STAT1 PROTEIN, MOUSE;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; DRUG MECHANISM; ENZYME ACTIVATION; HOMEOSTASIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPLEEN CELL; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; BONE MARROW CELL; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; INFLAMMATION; METABOLISM; MOUSE MUTANT; MULTIPLE SCLEROSIS; SPLEEN;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; DENDRITIC CELLS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HOMEOSTASIS; HUMANS; INFLAMMATION; INTERFERON-BETA; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MULTIPLE SCLEROSIS; MYELOID CELLS; NF-KAPPA B; SPLEEN; STAT1 TRANSCRIPTION FACTOR;

EID: 70349323428     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-12-196592     Document Type: Article

References (50)

1. Weinstock-Guttman B, Ramanathan M, Zivadinov R. Interferon-beta treatment for relapsing multiple sclerosis. Expert Opin Biol Ther. 2008;8:1435-1447.
2. Markowitz CE. Interferon-beta: mechanism of action and dosing issues. Neurology. 2007;68:S8-11.
3. Coccia EM. IFN regulation and functions in myeloid dendritic cells. Cytokine Growth Factor Rev. 2008;19:21-32. (Pubitemid 351200061)
4. Blanco P, Palucka AK, Pascual V, Banchereau J. Dendritic cells and cytokines in human inflammatory and autoimmune diseases. Cytokine Growth Factor Rev. 2008;19:41-52.
5. Lande R, Gafa V, Serafini B, et al. Plasmacytoid dendritic cells in multiple sclerosis: intracerebral recruitment and impaired maturation in response to interferon-beta. J Neuropathol Exp Neurol. 2008;67:388-401. (Pubitemid 351653532)
6. Bertho N, Blancheteau VM, Setterblad N, et al. MHC class II-mediated apoptosis of mature dendritic cells proceeds by activation of the protein kinase C-delta isoenzyme. Int Immunol. 2002;14:935-942. (Pubitemid 34906083)
7. Chen M, Wang YH, Wang Y, et al. Dendritic cell apoptosis in the maintenance of immune tolerance. Science. 2006;311:1160-1164. (Pubitemid 43305956)
8. Dubois SP, Waldmann TA, Muller JR. Survival adjustment of mature dendritic cells by IL-15. Proc Natl Acad Sci U S A. 2005;102:8662-8667. (Pubitemid 40862792)
9. Gamero AM, Potla R, Wegrzyn J, et al. Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells. J Biol Chem. 2006;281:16238-16244. (Pubitemid 43916639)
10. Jung DY, Lee H, Jung BY, et al. TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker. J Immunol. 2005;174:6467-6476. (Pubitemid 40663842)
11. Khvalevsky E, Rivkin L, Rachmilewitz J, Galun E, Giladi H. TLR3 signaling in a hepatoma cell line is skewed towards apoptosis. J Cell Biochem. 2007;100:1301-1312. (Pubitemid 46480411)
12. van Koetsveld PM, Vitale G, de Herder WW, et al. Potent inhibitory effects of type I interferons on human adrenocortical carcinoma cell growth. J Clin Endocrinol Metab. 2006;91:4537-4543. (Pubitemid 44833436)
13. Kim HS, Lee MS. STAT1 as a key modulator of cell death. Cell Signal. 2007;19:454-465.
14. Kang SJ, Wang S, Hara H, et al. Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions. J Cell Biol. 2000;149:613-622. (Pubitemid 30252395)
15. Lee J, Hur J, Lee P, et al. Dual role of inflammatory stimuli in activation-induced cell death of mouse microglial cells. Initiation of two separate apoptotic pathways via induction of interferon regulatory factor-1 and caspase-11. J Biol Chem. 2001;276:32956-32965. (Pubitemid 37384746)
16. Suk K, Chang I, Kim YH, et al. Interferon gamma (IFNgamma) and tumor necrosis factor alpha synergism in ME-180 cervical cancer cell apoptosis and necrosis. IFNgamma inhibits cytoprotective NF-kappa B through STAT1/IRF-1 pathways. J Biol Chem. 2001;276:13153-13159. (Pubitemid 37385243)
17. Suk K, Kim S, Kim YH, et al. IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death. J Immunol. 2001;166:4481-4489. (Pubitemid 32233732)
18. Martinon F, Tschopp J. Inflammatory caspases and inflammasomes: master switches of inflammation. Cell Death Differ. 2007;14:10-22. (Pubitemid 44911890)
19. Nadiri A, Wolinski MK, Saleh M. The inflammatory caspases: key players in the host response to pathogenic invasion and sepsis. J Immunol. 2006;177:4239-4245. (Pubitemid 44469748)
20. Bailey SL, Schreiner B, McMahon EJ, Miller SD. CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ T(H)-17 cells in relapsing EAE. Nat Immunol. 2007;8:172-180.
21. Miller SD, McMahon EJ, Schreiner B, Bailey SL. Antigen presentation in the CNS by myeloid dendritic cells drives progression of relapsing experimental autoimmune encephalomyelitis. Ann N Y Acad Sci. 2007;1103:179-191. (Pubitemid 46791123)
22. Stephanou A, Latchman DS. Opposing actions of STAT-1 and STAT-3. Growth Factors. 2005;23:177-182.
23. Kang SJ, Wang S, Kuida K, Yuan J. Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response. Cell Death Differ. 2002;9:1115-1125.
24. Suk K, Kim SY, Kim H. Essential role of caspase-11 in activation-induced cell death of rat astrocytes. J Neurochem. 2002;80:230-238. (Pubitemid 34809368)
25. Schauvliege R, Vanrobaeys J, Schotte P, Beyaert R. Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 1. J Biol Chem. 2002;277:41624-41630. (Pubitemid 35257467)
26. Maher SG, Romero-Weaver AL, Scarzello AJ, Gamero AM. Interferon: cellular executioner or white knight? Curr Med Chem. 2007;14:1279-1289.
27. Luft T, Jefford M, Luetjens P, et al. Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: prostaglandin E(2) regulates the migratory capacity of specific DC subsets. Blood. 2002;100:1362-1372. (Pubitemid 34864293)
28. Scandella E, Men Y, Gillessen S, Forster R, Groettrup M. Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells. Blood. 2002;100:1354-1361. (Pubitemid 34864292)
29. Adorini L. Immunotherapeutic approaches in multiple sclerosis. J Neurol Sci. 2004;223:13-24.
30. Neuhaus O, Archelos JJ, Hartung HP. Immunomodulation in multiple sclerosis: from immunosuppression to neuroprotection. Trends Pharmacol Sci. 2003;24:131-138. (Pubitemid 36293779)
31. Polman CH, Uitdehaag BM. New and emerging treatment options for multiple sclerosis. Lancet Neurol. 2003;2:563-566. (Pubitemid 36994996)
32. Teige I, Treschow A, Teige A, et al. IFN-beta gene deletion leads to augmented and chronic demyelinating experimental autoimmune encephalomyelitis. J Immunol. 2003;170:4776-4784. (Pubitemid 36519987)
33. Floris S, Ruuls SR, Wierinckx A, et al. Interferon-beta directly influences monocyte infiltration into the central nervous system. J Neuroimmunol. 2002;127:69-79. (Pubitemid 34603576)
34. Harzheim M, Stepien-Mering M, Schroder R, Schmidt S. The expression of microfilament-associated cell-cell contacts in brain endothelial cells is modified by IFN-beta1a (Rebif). J Interferon Cytokine Res. 2004;24:711-716. (Pubitemid 39658234)
35. Dauer M, Pohl K, Obermaier B, et al. Interferonalpha disables dendritic cell precursors: dendritic cells derived from interferon-alpha-treated monocytes are defective in maturation and T-cell stimulation. Immunology. 2003;110:38-47. (Pubitemid 37059670)
36. Santini SM, Di Pucchio T, Lapenta C, Parlato S, Logozzi M, Belardelli F. The natural alliance between type I interferon and dendritic cells and its role in linking innate and adaptive immunity. J Interferon Cytokine Res. 2002;22:1071-1080. (Pubitemid 36051179)
37. Tough DF. Type I interferon as a link between innate and adaptive immunity through dendritic cell stimulation. Leuk Lymphoma. 2004;45:257-264.
38. McRae BL, Beilfuss BA, van Seventer GA. IFN-beta differentially regulates CD40-induced cytokine secretion by human dendritic cells. J Immunol. 2000;164:23-28.
39. Remoli ME, Gafa V, Giacomini E, Severa M, Lande R, Coccia EM. IFN-beta modulates the response to TLR stimulation in human DC: involvement of IFN regulatory factor-1 (IRF-1) in IL-27 gene expression. Eur J Immunol. 2007;37:3499-3508.
40. Yasuda CL, Al-Sabbagh A, Oliveira EC, Diaz-Bardales BM, Garcia AA, Santos LM. Interferon beta modulates experimental autoimmune encephalomyelitis by altering the pattern of cytokine secretion. Immunol Invest. 1999;28:115-126. (Pubitemid 29264192)
41. Coelho LF, Magno de Freitas Almeida G, Mennechet FJ, Blangy A, Uze G. Interferon-alpha and -beta differentially regulate osteoclastogenesis: role of differential induction of chemokine CXCL11 expression. Proc Natl Acad Sci U S A. 2005;102:11917-11922. (Pubitemid 41170825)
42. Gavutis M, Lata S, Lamken P, Muller P, Piehler J. Lateral ligand-receptor interactions on membranes probed by simultaneous fluorescence-interference detection. Biophys J. 2005;88:4289-4302. (Pubitemid 40991139)
43. Jaitin DA, Roisman LC, Jaks E, et al. Inquiring into the differential action of interferons (IFNs): an IFN-alpha2 mutant with enhanced affinity to IFNAR1 is functionally similar to IFN-beta. Mol Cell Biol. 2006;26:1888-1897. (Pubitemid 43297418)
44. Johnson KP. Treatment of multiple sclerosis with various interferons: the cons. Neurology. 1988;38:62-65.
45. Panitch HS, Bever CT, Jr. Clinical trials of interferons in multiple sclerosis: what have we learned? J Neuroimmunol. 1993;46:155-164. (Pubitemid 23284261)
46. Panitch HS, Hirsch RL, Schindler J, Johnson KP. Treatment of multiple sclerosis with gamma interferon: exacerbations associated with activation of the immune system. Neurology. 1987;37:1097-1102. (Pubitemid 17123439)
47. Yeretssian G, Labbe K, Saleh M. Molecular regulation of inflammation and cell death. Cytokine. 2008;43:380-390.
48. Arai H, Furuya T, Yasuda T, Miura M, Mizuno Y, Mochizuki H. Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and expression of caspase-11 in mice. J Biol Chem. 2004;279:51647-51653. (Pubitemid 40017915)
49. Hisahara S, Yuan J, Momoi T, Okano H, Miura M. Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination. J Exp Med. 2001;193:111-122. (Pubitemid 32060702)
50. Sasagawa T, Hlaing M, Akaike T. Synergistic induction of apoptosis in murine hepatoma Hepa1-6 cells by IFN-gamma and TNF-alpha. Biochem Biophys Res Commun. 2000;272:674-680. (Pubitemid 30420697)