Multiple sclerosis is associated with high levels of circulating dendritic cells secreting pro-inflammatory cytokines

Journal of Neuroimmunology

Volumn 99, Issue 1, 1999, Pages 82-90

  Huang, Yu Min ^a   Xiao, Bao Guo ^a   Özenci, Volkan ^a   Kouwenhoven, Mathilde ^a   Teleshova, Natalia ^a   Fredrikson, Sten ^a   Link, Hans ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Dendritic cells; ELISPOT; Interferon ; Interferon ; Multiple sclerosis

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; AUTOLOGOUS MIXED LYMPHOCYTE REACTION; CELL MIGRATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; LYMPHOID ORGAN; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ADULT; AGED; ANIMALS; AUTOIMMUNE DISEASES; CYTOKINES; DENDRITIC CELLS; FEMALE; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-6; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; MALE; MICE; MIDDLE AGED; MULTIPLE SCLEROSIS; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032828862     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(99)00106-X     Document Type: Article

References (48)

1. Alvaro-Gracia J.M., Zvaifler N.J., Firestein G.S. Cytokines in chronic inflammatory arthritis: IV. Granulocyte/macrophage colony-stimulating factor-mediated induction of class II MHC antigen on human monocytes: a possible role in rheumatoid arthritis. J. Exp. Med. 170:1989;865-875.
2. Ashkenazi A., Dixit V.M. Death receptor: signaling and modulation. Science. 281:1998;1305-1308.
3. Banchereau J., Steinman R.M. Dendritic cells and the control of immunity. Nature. 392:1998;245-252.
4. Caux C., Dezutter-Dambuyant C., Schmitt D., Banchereau J. GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells. Nature. 360:1992;258-261.
5. Clark, G.J., Hart, D.N.J., 1999. Phenotypic characterization of dendritic cells. In: Lotze, M.T., Thomson, A.W. (Eds.), Dendritic Cells. Academic Press, San Diego, pp. 555-577.
6. Cumberbatch M., Dearman R.J., Kimber I. Constitutive and inducible expression of interleukin-6 by Langerhans cells and lymph node dendritic cells. Immunology. 87:1996;513-518.
7. Gluckman J.C., Canque B., Chapuis F., Rosenzwajg M. In vitro generation of human dendritic cells and cell therapy. Cytokines, Cell. Mol. Ther. 3:1997;187-196.
8. Hohlfeld R. Neurological autoimmune disease and the trimolecular complex of T-lymphocytes. Ann. Neurol. 25:1989;531-538.
9. Hope J.C., Cumberbatch M., Fielding I., Dearman R.J., Kimber I., Hopkins S.J. Identification of dendritic cells as a major source of interleukin-6 in draining lymph nodes following skin sensitization of mice. Immunology. 86:1995;441-447.
10. Huang Y.M., Xiao B.G., Westerlund I., Link H. Phenotypic and functional properties of dendritic cells isolated from human peripheral blood in comparison with mononuclear cells and T cells. Scand. J. Immunol. 49:1999;177-183.
11. Krasteva M., Kehren J., Horand F., Akiba H., Choquet G., Ducluzeau M.T., Tedone R., Garrigue J.L., Kaiserlian D., Nicolas J.F. Dual role of dendritic cells in the induction and down-regulation of antigen-specific cutaneous inflammation. J. Immunol. 160:1998;1181-1190.
12. Link H. The cytokine storm in multiple sclerosis. Mult. Scler. 4:1998;12-15.
13. Link H., Olsson O., Sun J., Wang W.Z., Andersson G., Ekre H.P., Brenner T., Abramsky O., Olsson T. Acetylcholine receptor-reactive T and B cells in myasthenia gravis and controls. J. Clin. Invest. 87:1991;2191-2195.
14. Link J., Soderstrom M., Olsson T., Höjeberg B., Ljungdahl Å., Link H. Increased transforming growth factor-β, interleukin-4 and interferon-γ in multiple sclerosis. Ann. Neurol. 35:1994;197-203.
15. Luft T., Pang K.C., Thomas E., Hertzog P., Hart D.N., Trapani J., Cebon J. Type I IFNs enhance the terminal differentiation of dendritic cells. J. Immunol. 161:1998;1947-1953.
16. Macatonia S.E., Hosken N.A., Litton M., Vieira P., Hsieh C.S., Culpepper J.A., Wysocka M., Trinchieri G., Murphy K.M., O'Garra A. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J. Immunol. 154:1995;5071-5079.
17. Markowicz S., Engleman E.G. Granulocyte-macrophage colony-stimulating factor promotes differentiation and survival of human peripheral blood dendritic cells in vitro. J. Clin. Invest. 85:1990;955-961.
18. McRae B.L., Semnani R.T., Hayes M.P., van Seventer G.A. Type I IFNs inhibit human dendritic cell IL-12 production and Th1 cell development. J. Immunol. 160:1998;4298-4304.
19. Meierhoff G., Krause S., Andreesen R. Comparative analysis of dendritic cells derived from blood monocytes or CD34+ hematopoietic progenitor cells. Immunobiology. 198:1998;501-513.
20. Navikas V., Link H. Cytokines and the pathogenesis of multiple sclerosis. J. Neurosci. Res. 45:1996;322-333.
21. Navikas V., Link J., Palasik W., Soderstrom M., Fredrikson S., Olsson T., Link H. Increased mRNA expression of IL-10 in mononuclear cells in multiple sclerosis and optic neuritis. Scand. J. Immunol. 41:1995;171-178.
22. Navikas V., He B., Link J., Haglund M., Soderstrom M., Fredrikson S., Ljungdahl A., Hojeberg J., Qiao J., Olsson T., Link H. Augmented expression of tumour necrosis factor-alpha and lymphotoxin in mononuclear cells in multiple sclerosis and optic neuritis. Brain. 119:1996;213-223.
23. Navikas V., Matusevicius D., Soderstrom M., Fredrikson S., Kivisakk P., Ljungdahl A., Hojeberg B., Link H. Increased interleukin-6 mRNA expression in blood and cerebrospinal fluid mononuclear cells in multiple sclerosis. J. Neuroimmunol. 64:1996;63-69.
24. O'Garra A., Hosken N., Macatonia S., Wenner C.A., Murphy K. The role of macrophage- and dendritic cell-derived IL-12 in Th1 phenotype development. Res. Immunol. 146:1995;466-472.
25. Ohshima Y., Delespesse G. T cell-derived IL-4 and dendritic cell-derived IL-12 regulate the lymphokine-producing phenotype of alloantigen-primed naïve human CD4 cells. J. Immunol. 158:1997;629-636.
26. Olsson T. Immunology of multiple sclerosis. Curr. Opin. Neurol. Neurosurg. 5:1992;195-202.
27. Olsson T., Wang W.Z., Höjeberg B., Kostulas V., Jiang Y.P., Andersson G., Ekre H.P., Link H. Autoreactive T lymphocytes in multiple sclerosis determined by antigen induced secretion of interferon-gamma. J. Clin. Invest. 86:1990;981-985.
28. Panitch H.S. Interferons in multiple sclerosis. A review of the evidence. Drugs. 44:1992;946-962.
29. Pfeiffer S., Gooding R.P., Apperley J.E., Goldschmidt H., Samson D. Dendritic cells generated from the blood of patients with multiple myeloma are phenotypically and functionally identical to those similarly produced from healthy donors. Br. J. Haematol. 98:1997;973-982.
30. Poser C.M., Paty D.W., Scheinberg L., McDonald W.I., Davis F.A., Ebers G.C., Johnson K.P., Sibley W.A., Silberberg D.H., Tourtellotte W.W. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann. Neurol. 13:1983;227-231.
31. Rieckmann P., Albrecht M., Kitze B., Weber T., Tumani H., Broocks A., Luer W., Poser S. Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis. Neurology. 44:1994;1523-1526.
32. Rissoan M.C., Soumelis V., Kadowaki N., Grouard G., Briere F., de Waal Malefyt R., Liu Y.J. Reciprocal control of T helper cell and dendritic cell differentiation. Science. 283:1999;1183-1186.
33. Romani N., Reider D., Heuer M., Ebner S., Kämpgen E., Eibi B., Niederwieser D., Schuler G. Generation of mature dendritic cells from human blood: an improved method with special regard to clinical applicability. J. Immunol. Meth. 196:1996;137-151.
34. Rönnelid J., Klareskog L. A comparison between ELISPOT methods for the detection of cytokine producing cells: greater sensitivity and specificity using ELISA plates as compared to nitrocellulose membranes. J. Immunol. Meth. 200:1997;17-26.
35. Rudick R.A., Ransohoff R.M., Peppler R., van der Brug Medendorp S., Lehmann P., Alam J. Interferon beta induces interleukin-10 expression: relevance to multiple sclerosis. Ann. Neurol. 40:1996;618-627.
36. Rudick R.A., Goodkin D.E., Jacobs L.D., Cookfair D.L., Herndon R.M., Richert J.R., Salazar A.M., Fischer J.S., Granger C.V., Simon J.H., Alam J.J., Simonian N.A., Campion M.K., Bartoszak D.M., Bourdette D.N., Braiman J., Brownscheidle C.M., Coats M.E., Cohan S.L., Dougherty D.S., Kinkel R.P., Mass M.K., Munschauer F.E., Priore R.L., Whitham R.H. Impact of interferon beta-1a on neurologic disability in relapsing multiple sclerosis. Neurology. 49:1997;358-363.
37. Rudick R.A., Ransohoff R.M., Lee J.C., Peppler R., Yu M., Mathisen P.M., Tuohy V.K. In vivo effects of interferon beta-1a on immunosuppressive cytokines in multiple sclerosis. Neurology. 50:1998;1294-1300.
38. Sharief M.K., Hentges R. Association between tumor necrosis factor-α and disease progression in patients with multiple sclerosis. N. Engl. J. Med. 325:1991;467-472.
39. Soderstrom M., Hillert J., Link J., Navikas V., Fredrikson S., Link H. Expression of IFN-gamma, IL-4, and TGF-beta in multiple sclerosis in relation to HLA-Dw2 phenotype and stage of disease. Mult. Scler. 1:1995;173-180.
40. Steinman R.M. The dendritic cell system, and its role in immunogenicity. Annu. Rev. Immunol. 9:1991;271-296.
41. Steinman R.M., Kaplan G., Witman M.D., Cohn Z.A. Identification of a novel cell type in peripheral lymphoid organs of mice. J. Exp. Med. 149:1979;1-16.
42. Steptoe R.J., Thomson A.W. Dendritic cells and tolerance induction. Clin. Exp. Immunol. 105:1996;397-402.
43. The IFNB Multiple Sclerosis Study Group Interferon beta-1b is effective in relapsing-remitting multiple sclerosis: I. Clinical results of a multicenter, randomised, double-blind, placebo controlled trial. Neurology. 43:1993;655-661.
44. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:1995;251-276.
45. Van Schooten W.C.A., Strang G., Biologica P.V. Properties of dendritic cells: implications to their use in the treatment of cancer. Mol. Med. Today. 3:1997;254-260.
46. Weinstock-Guttman B., Ransohoff R.M., Kinkel R.P., Rudick R.A. The interferons: biological effects, mechanisms of action, and use in multiple sclerosis. Ann. Neurol. 37:1995;7-15.
47. Xiao B.G., Huang Y.M., Xu L.Y., Ishikawa M., Link H. Mechanisms of recovery from experimental allergic encephalomyelitis induced with myelin basic protein peptide 68-86 in Lewis rats: a role for dendritic cells in inducing apoptosis of CD4+ T cells. J. Neuroimmunol. 97:1999;25-36.
48. Zhou L.J., Tedder T.F. A distinct pattern of cytokine gene expression by human CD83+ blood dendritic cells. Blood. 86:1995;3295-3301.