Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling

Journal of Biological Chemistry

Volumn 287, Issue 33, 2012, Pages 28017-28026

  Peng, Haiyan ^a   Guerau de Arellano, Mireia ^a   Mehta, Veela B ^a   Yang, Yuhong ^a   Huss, David J ^a,b   Papenfuss, Tracey L ^a   Lovett Racke, Amy E ^a   Racke, Michael K ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b BIOGEN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DIFFERENTIATION; CHROMATIN ENVIRONMENT; CLASS II; CLINICAL EFFICACY; CLINICAL OBSERVATION; CLINICAL TRIAL; CYTOKINE PRODUCTION; DENDRITIC CELLS; DIMETHYL FUMARATE; EXTRACELLULAR SIGNAL-REGULATED KINASE; MITOGENS; MOLECULAR MECHANISM; MULTIPLE SCLEROSIS; NUCLEAR FACTORS; SIGNALING PATHWAYS; STRESS-ACTIVATED KINASE; T CELLS; T-CELL RESPONSE; TRANSCRIPTIONAL ACTIVITY;

AMINO ACIDS; CELLS; ENZYME ACTIVITY; PATIENT TREATMENT; PHOSPHORYLATION; SIGNALING;

IMMUNOLOGY;

B7 ANTIGEN; CD86 ANTIGEN; FUMARIC ACID DIMETHYL ESTER; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; SERINE; STRESS ACTIVATED PROTEIN KINASE 1; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL NUCLEUS; CHROMATIN; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME REGULATION; IMMUNE RESPONSE; INHIBITION KINETICS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH17 CELL;

ANIMALS; ANTIGENS, CD80; ANTIGENS, CD86; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; FUMARATES; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-12; INTERLEUKIN-6; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; TH1 CELLS; TH17 CELLS; TRANSCRIPTION FACTOR RELA;

EID: 84865009934     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.383380     Document Type: Article

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