Activation status of human microglia is dependent on lesion formation stage and remyelination in multiple sclerosis

Journal of Neuropathology and Experimental Neurology

Volumn 74, Issue 1, 2015, Pages 48-63

  Peferoen, Laura A N ^a   Vogel, Daphne Y S ^a   Ummenthum, Kimberley ^a   Breur, Marjolein ^a   Heijnen, Priscilla D A M ^a   Gerritsen, Wouter H ^a   Peferoen Baert, Regina M B ^a   Van Der Valk, Paul ^a   Dijkstra, Christine D ^a   Amor, Sandra ^a,b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Anti inflammatory; Innate immune system; Microglia; Multiple sclerosis; Pathology; Polarization; Proinflammatory

Indexed keywords

BIOLOGICAL MARKER; CD209 ANTIGEN; CD40 ANTIGEN; CD47 ANTIGEN; CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR7; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MACROPHAGE DERIVED CHEMOKINE; MANNOSE RECEPTOR; CYTOKINE; HLA ANTIGEN CLASS 2; LEUKOCYTE ANTIGEN; MESSENGER RNA; PROTEOLIPID PROTEIN; TRANSCRIPTOME;

ADULT; AGED; ARTICLE; BRAIN REGION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFLAMMATION; MALE; MICROENVIRONMENT; MICROGLIA; MIDDLE AGED; MULTIPLE SCLEROSIS; NERVE CELL PLASTICITY; PROTEIN EXPRESSION; REMYELINIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE REPAIR; VERY ELDERLY; WHITE MATTER; BRAIN; CELL CULTURE; CELL DIFFERENTIATION; FLOW CYTOMETRY; GENETICS; MACROPHAGE; METABOLISM; NONPARAMETRIC TEST; PATHOLOGY; PHYSIOLOGY;

AGED; AGED, 80 AND OVER; ANTIGENS, CD; BRAIN; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOKINES; FEMALE; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; MACROPHAGES; MALE; MICROGLIA; MIDDLE AGED; MULTIPLE SCLEROSIS; MYELIN PROTEOLIPID PROTEIN; RNA, MESSENGER; STATISTICS, NONPARAMETRIC; TRANSCRIPTOME;

EID: 84920283093     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0000000000000149     Document Type: Article

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