18β-Glycyrrhetinic acid protects against methotrexate-induced kidney injury by up-regulating the Nrf2/ARE/HO-1 pathway and endogenous antioxidants

Renal Failure

Volumn 38, Issue 9, 2016, Pages 1516-1527

  Abd El Twab, Sanaa M ^a   Hozayen, Walaa G ^a,b   Hussein, Omnia E ^a   Mahmoud, Ayman M ^a  

^a Beni Suef University   (Egypt)

^b BENI SUEF UNIVERSITY   (Egypt)

Author keywords

glycyrrhetinic acid; inflammation; kidney; Methotrexate; oxidative stress

Indexed keywords

CREATININE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; GLYCYRRHETINIC ACID; HEME OXYGENASE 1; MALONALDEHYDE; MESSENGER RNA; METHOTREXATE; NITRIC OXIDE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR; UREA; URIC ACID; 18ALPHA-GLYCYRRHETINIC ACID; ARYLESTERASE; BIOLOGICAL MARKER; CARBOXYLESTERASE; HEME OXYGENASE; HMOX1 PROTEIN, RAT; NFE2L2 PROTEIN, RAT; RNA;

ADULT; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DECAPITATION; HISTOPATHOLOGY; KIDNEY FUNCTION; KIDNEY INJURY; LIPID PEROXIDATION; MALE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; UPREGULATION; UREA BLOOD LEVEL; URIC ACID BLOOD LEVEL; ACUTE KIDNEY INJURY; ANALOGS AND DERIVATIVES; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; GAP JUNCTION; GENETICS; KIDNEY; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WISTAR RAT;

ACUTE KIDNEY INJURY; ANIMALS; BIOMARKERS; CARBOXYLIC ESTER HYDROLASES; DISEASE MODELS, ANIMAL; GAP JUNCTIONS; GLYCYRRHETINIC ACID; HEME OXYGENASE (DECYCLIZING); KIDNEY; LIPID PEROXIDATION; MALE; METHOTREXATE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; UP-REGULATION;

EID: 84981271743     PISSN: 0886022X     EISSN: 15256049     Source Type: Journal    
DOI: 10.1080/0886022X.2016.1216722     Document Type: Article

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