Effect of the systemic use of methotrexate on the oxidative stress and paraoxonase enzyme in psoriasis patients

Archives of Dermatological Research

Volumn 305, Issue 6, 2013, Pages 495-500

  Kılıc, Sevgi ^a   Emre, Selma ^b   Metin, Ahmet ^b   Isıkoglu, Semra ^b   Erel, Ozcan ^b  

^a Clinical Microbiology Laboratory   (Turkey)

^b YILDIRIM BEYAZIT UNIVERSITY   (Turkey)

Author keywords

Methotrexate; Oxidative stress; Paraoxonase; Psoriasis; Total antioxidant status; Total oxidant status

Indexed keywords

ALANINE AMINOTRANSFERASE; ARYLDIALKYLPHOSPHATASE; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; METHOTREXATE;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANALYTICAL PARAMETERS; ARTHRALGIA; ARTICLE; BIOCHEMISTRY; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG WITHDRAWAL; DYSPEPSIA; EDEMA; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FEMALE; HEMATEMESIS; HEMOGLOBIN BLOOD LEVEL; HUMAN; LIPOPROTEIN BLOOD LEVEL; LIVER FUNCTION TEST; LONGITUDINAL STUDY; MALE; OXIDATIVE STRESS; OXIDATIVE STRESS INDEX; PRIORITY JOURNAL; PROSPECTIVE STUDY; PSORIASIS; PSORIASIS AREA AND SEVERITY INDEX; SIDE EFFECT; STOMACH ULCER; THROMBOCYTE COUNT;

ANTIOXIDANTS; ARYLDIALKYLPHOSPHATASE; CARBOXYLIC ESTER HYDROLASES; HUMANS; METHOTREXATE; PSORIASIS;

EID: 84880917956     PISSN: 03403696     EISSN: 1432069X     Source Type: Journal    
DOI: 10.1007/s00403-013-1366-1     Document Type: Article

References (28)

1. Akbay TT, Sehirli O, Ercan F, Sener G (2010) Resveratrol protects against methotrexate-induced hepatic injury in rats. J Pharm Pharm Sci 13(2):303-310
2. Aslan M, Horoz M, Nazligul Y, Bolukbas C, Bolukbas FF, Selek S, Aksoy N, Erel O (2008) Serum paraoxonase and arylesterase activities for the evaluation of patients with chronic hepatitis. Int J Clin Pract 62(7):1050-1055
3. Attwa E, Swelam E (2011) Relationship between smoking-induced oxidative stress and the clinical severity of psoriasis. J Eur Acad Dermatol Venereol 25(7):782-787
4. Aviram M, Hardak E, Vaya J, Mahmood S, Milo S, Hoffman A, Billicke S, Draganov D, Rosenblat M (2000) Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions. Circulation 101:2510-2517
5. Aviram M, Rosenblat M, Billecke S, Erogul J, Sorenson R, Bisgaier CL, Newton RS, La Du B (1999) Human serum paraoxonase (PON1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants. Free Radic Biol Med 26:892-904
6. Babiak RM, Campello AP, Carnieri EG, Oliveira MB (1998) Methotrexate: pentose cycle and oxidative stress. Cell Biochem Funct 16:283-293
7. Baz K, Cimen MY, Kokturk A, Yazici AC, Eskandari G, Ikizoglu G, Api H, Atik U (2003) Oxidant/antioxidant status in patients with psoriasis. Yonsei Med J 44(6):987-990
8. Carretero G, Puig L, Dehesa L et al (2010) Guidelines on the use of methotrexate in psoriasis. Actas Dermosifiliogr 101(7):600-613
9. Devrim E, Cetin R, Kiliçoǧlu B, Ergüder BI, Avci A, Durak I (2005) Methotrexate causes oxidative stress in rat kidney tissues. Ren Fail 27(6):771-773
10. Draganov DI, La Du BN (2004) Pharmacogenetics of paraoxonases: a brief review. Arch Pharmacol 369:78-88
11. Emre S, Metin A, Demirseren DD, Kilic S, Isikoglu S, Erel O (2013) The relationship between oxidative stress, smoking and the clinical severity of psoriasis. J Eur Acad Dermatol Venereol 27(3):e370-e375
12. Ferretti G, Bacchetti T, Campanati A, Simonetti O, Liberati G, Offidani A (2012) Correlation between lipoprotein(a) and lipid peroxidation in psoriasis: role of the enzyme paraoxonase-1. Br J Dermatol 166(1):204-207
13. Fraga NA, de Oliveira Mde F, Follador I, Rocha Bde O, Rêgo VR (2012) Psoriasis and uveitis: a literature review. An Bras Dermatol 87(6):877-883
14. Gabr SA, Al-Ghadir AH (2012) Role of cellular oxidative stress and cytochrome c in the pathogenesis of psoriasis. Arch Dermatol Res 304(6):451-457
15. Igbal MP, Sultana F, Mehboobali N, Pervez S (2001) Folinic acid protects againts supression of growth by methotrexate in mice. Biopharm Drug Dispos 22(4):169-178
16. Jahovic N, Cevik H, Sehirli AO, Yegen BC, Sener G (2003) Melatonin prevents methotrexate-induced hepatorenal oxidative injury in rats. J Pineal Res 34:282-287
17. Kadam SP, Suryakar AN, Ankush RD, Kadam CY, Deshpande KH (2010) Role of oxidative stress in various stages of psoriasis. Indian J Clin Biochem 25(4):388-392
18. Kalb RE, Strober B, Weinstein G, Lebwohl M (2009) Methotrexate and psoriasis: 2009 National Psoriasis Foundation Consensus Conference. J Am Acad Dermatol 60(5):824-837
19. Kesik V, Uysal B, Kurt B, Kismet E, Koseoglu V (2009) Ozone ameliorates methotrexate-induced intestinal injury in rats. Cancer Biol Ther 8(17):1623-1628
20. Phillips DC, Woollard KJ, Griffiths HR (2003) The anti-inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species. Br J Pharmacol 138:501-511
21. Schulz JB, Lindenau J, Seyfried J, Dichgans J (2000) Glutathione, oxidative stress and neurodegeneration. Eur J Biochem 267:4904-4911
22. Tabassum H, Parvez S, Pasha ST, Banerjee BD, Raisuddin S (2010) Protective effect of lipoic acid against methotrexate-induced oxidative stress in liver mitochondria. Food Chem Toxicol 48:1973-1979
23. Tekin NS, Ilter N, Sancak B, Özden MG, Gürer MA (2006) Nitric oxide levels in patients with psoriasis treated with methotrexate. Mediators Inflamm 3:16043
24. Toker A, KadI M, YIldIrIm AK, Aksoy H, Akcay F (2009) Serum lipid profile paraoxonase and arylesterase activities in psoriasis. Cell Biochem Funct 27:176-180
25. Usta M, Turan E, Aral H, Inal BB, Gurel MS, Guvenen G (2011) Serum paraoxonase-1 activities and oxidative status in patients with plaque-type psoriasis with/without metabolic syndrome. J Clin Lab Anal 25(4):289-295
26. Uz E, Oktem F, Yilmaz HR, Uzar E, Ozgüner F (2005) The activities of purine-catabolizing enzymes and the level of nitric oxide in rat kidneys subjected to methotrexate: protective effect of caffeic acid phenethyl ester. Mol Cell Biochem 277:165-170
27. Wollina K, Stander K, Barta U (2001) Toxicity of methotrexate treatment in psoriasis and psoriatic arthritis - short- and long-term toxicity in 104 patients. Clin Rheumatol 20:406-410
28. Yuncu M, Eralp A, Celik A (2006) Effect of aged garlic extract against methotrexate-induced damage to the small intestine in rats. Phytother Res 20:504-510