Thymoquinone and curcumin attenuate gentamicininduced renal oxidative stress, inflammation and apoptosis in rats

EXCLI Journal

Volumn 13, Issue , 2014, Pages 98-110

  Mahmoud, Ayman M ^a   Ahmed, Osama M ^a   Galaly, Sanaa R ^a  

^a BENI SUEF UNIVERSITY   (Egypt)

Author keywords

Apoptosis; Bcl 2; Curcumin; Gentamicin; Inflammation; Nephrotoxicity; Thymoquinone

Indexed keywords

CREATININE; CURCUMIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LIPID; PROTEIN BCL 2; SUPEROXIDE DISMUTASE; THYMOQUINONE; TUMOR NECROSIS FACTOR ALPHA; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; MALE; NEPHRITIS; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; RAT; RENAL PROTECTION;

EID: 84896830705     PISSN: None     EISSN: 16112156     Source Type: Journal    
DOI: None     Document Type: Article

References (64)

1. Abdel-Raheem IT, Abdel-Ghany AA, Mohamed GA. Protective effect of quercetin against gentamicin-induced nephrotoxicity in rats. Biol Pharm Bull 2009;32:61-7.
2. Akcay A, Nguyen Q, Edelstein CL. Mediators of inflammation in acute kidney injury. Mediators Inflamm 2009;2009:137072.
3. Al-Ghamdi MS. The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. J Ethnopharmacol 2001;76:45-8.
4. Araujo LP, Truzzi RR, Mendes GE, Luz MA, Burdmann EA, Oliani SM. Annexin A1 protein attenuates cyclosporine-induced renal hemodynamics changes and macrophage infiltration in rats. Inflamm Res 2012;61:189-96.
5. Attia A, Ragheb A, Sylwestrowicz T, Shoker A. Attenuation of high cholesterol-induced oxidative stress in rabbit liver by thymoquinone. Eur J Gastroenterol Hepatol 2010;22:826-34.
6. Baciewicz AM, Sokos DR, Cowan RI. Aminoglycoside-associated nephrotoxicity in the elderly. Ann Pharmacother 2003;37:182-6.
7. Badary OA. Thymoquinone attenuates ifosfamideinduced Fanconi syndrome in rats and enhances its anti-tumor activity in mice. J Ethnopharmacol 1999; 67:135-42.
8. Balakumar P, Chakkarwar VA, Kumar V, Jain A, Reddy J, Singh M. Experimental models for nephropathy. J Renin Angiotensin Aldosterone Syst 2008; 9:189-95.
9. Balakumar P, Rohilla A, Thangathirupathi A. Gentamicin-induced nephrotoxicity:Do we have a promising therapeutic approach to blunt it? Pharmacol Res 2010;62:179-86.
10. Barinaga M. Stroke-damaged neurons may commit cellular suicide. Science 1998;281(5381):1302-3.
11. Beutler E, Duron O, Kelly BM. Improved method for the determination of blood glutathione. J Lab Clin Mid 1963;61:882-8.
12. Bhattacharyya S, Mandal D, Saha B, Sen GS, Das T, Sa G. Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction. J Biol Chem 2007;282:15954-64.
13. Canadian Council on Animal Care. Guide to the care and use of experimental animals, Vol. 2. Ottawa, Ontario, Canada: CCAC, 1993.
14. Dutta S, Padhye S, Priyadarsini KI, Newton C. Antioxidant and antiproliferative activity of curcumin semicarbazone. Bioorg Med Chem Lett 2005;15: 2738-44.
15. El-Wakf AM, Elhabiby EM, El-kholy WM, Abd El-Ghany E. Use of tumeric and curcumin to alleviate adverse reproductive outcomes of water nitrate pollution in male rats. Nature Sci Sleep 2011;9:229-39.
16. Feinstein DL, Spagnolo A, Akar C, Weinberg G, Murphy P, Gavrilyuk V et al. Receptor-independent actions of PPAR thiazolidinedione agonists: is mitochondrial function the key? Biochem Pharmacol 2005;70:177-88.
17. Fredriksson L, Herpers B, Benedetti G, Matadin Q, Puigvert JC, de Bont H et al. Diclofenac inhibits tumor necrosis factor-alpha-induced nuclear factorkappaB activation causing synergistic hepatocyte apoptosis. Hepatology 2011;53:2027-41.
18. Geleilete TJ, Melo GC, Costa RS, Volpini RA, Soares TJ, Coimbra TM. Role of myofibroblasts, macrophages, transforming growth factor-beta, endothelin, angiotensin-II, and fibronectin in the progression of tubulointerstitial nephritis induced by gentamicin. J Nephrol 2002;15:633-42.
19. Hale AJ, Smith CA, Sutherland LC, Stoneman VE, Longthorne VL, Culhane AC et al. Apoptosis: molecular regulation of cell death. Eur J Biochem 1996; 236:1-26.
20. Han SY, Chang EJ, Choi HJ, Kwak CS, Park SB, Kim HC et al. Apoptosis by cyclosporine in mesangial cells. Transplant Proc 2006;38:2244-6.
21. Harzallah HJ, Kouidhi B, Flamini G, Bakhrouf A, Mahjoub T. Chemical composition, antimicrobial potential against cariogenic bacteria and cytotoxic activity of Tunisian Nigella sativa essential oil and thymoquinone. Food Chem 2011;129:1469-74.
22. Hendriks JGE, van Horn JR, van der Mei HC, Busscher HJ. Backgrounds of antibiotic loaded bone cement and prosthesis-related infection. Biomaterials 2004;25:545-56.
23. Huang LH, Zhang GQ, Ye RG, Li YJ, Chen XH, Guan WM. The role of cell proliferation and apoptosis in renal tubulointerstitial fibrosis caused by unilateral ureteral obstruction. Chin J Nephrol 2000;16: 24-7.
24. Kadkhodaee M, Khastar H, Faghihi M, Ghaznavi R, Zahmatkesh M. Effects of co-supplementation of vitamins E and C on gentamicin-induced nephrotoxicity in rat. Exp Physiol 2005;90:571-6.
25. Kalayarasan S, Prabhu PN, Sriram N, Manikandan R, Arumugam M, Sudhandiran G. Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicininduced nephrotoxicity in Wistar rats. Eur J Pharmacol 2009;606:162-71.
26. Kanter M. Thymoquinone attenuates lung injury induced by chronic toluene exposure in rats. Toxicol Ind Health 2011;27:387-95.
27. Kanter M, Demir H, Karakaya C, Ozbek H. Gastroprotective activity of Nigella sativa L oil and its constituent, thymoquinone, against acute alcoholinduced gastric mucosal injury in rats. World J Gastroenterol 2005;11:6662-6.
28. Kaplan A. Urea. In: Kaplan LA, Pesce AJ: Clinical chemistry: theory, analysis and correlation (pp 1257-60; 437, 418). St. Louis, Miss.: Mosby, 1984.
29. Kar M, Mishra D. Catalase, peroxidase and polyphenoloxidase activities during rice leaf senescence. Plant Physiol 1976;57:315-9.
30. Karadeniz A, Yildirim A, Simsek N, Kalkan Y, Celebi F. Spirulina platensis protects against gentamicin-induced nephrotoxicity in rats. Phytother Res 2008;22:1506-10.
31. Kaul N, Siveski-Iliskovic N, Hill M., Slezak J, Singal PK. Free radicals and the heart. J Pharmacol Toxicol Methods 1993;30:55-67.
32. Korsmeyer SJ. Bcl-2 gene family and the regulation of programmed cell death. Cancer Res 1999;59: 1693-700.
33. Lakshmi BV, Neelima N, Kasthuri N, Umarani V, Sudhakar M. Protective effect of Bauhinia purpurea on gentamicin-induced nephrotoxicity in rats. Indian J Pharm Sci 2009;71:551-4.
34. Lopez-Novoa JM, Quiros Y, Vicente L, Morales AI, Lopez-Hernandez FJ. New insights into the mechanism of aminoglycoside nephrotoxicity:an integrative point of view. Kidney Int 2011;79:33-45.
35. Luster MI, Simeonova PP, Gallucci RM, Bruccoleri A, Blazka ME, Yucesoy B. Role of inflammation in chemical-induced hepatotoxicity. Toxicol Lett 2001; 120:317-21.
36. Marklund SL, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974;47:469-74.
37. Martinez-Salgado C, Lopez-Hernandez FJ, Lopez-Novoa JM. Glomerular nephrotoxicityof aminoglycosides. Toxicol Appl Pharmacol 2007;223:86-98.
38. Miglioli PA, Silini R, Carzeri O, Grabocka E, Allerberger F. Antibacterial activity of gentamicin and ciprofloxacin against gram-negative bacteria: interactions with pig and calf sera. Pharmacol Res 1999; 39:321-3.
39. Mysior M, Stefanczyk L. Doppler ultrasound criteria of physiological flow in asymmetrical vertebral arteries. Med Sci Monit 2007;13 (Suppl 1):73-7.
40. Nitha B, Janardhanan KK. Aqueous-ethanolic extract of morel mushroom mycelium Morchella esculenta, protects cisplatin and gentamicin induced nephrotoxicity in mice. Food Chem Toxicol 2008;46: 3193-9.
41. Pabla N, Dong Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int 2008;73:994-1007.
42. Padhye S, Banerjee A, Ahmad A, Mohammad R, Sarkar FH. From here to eternity-the secret of pharaohs: Therapeutic potential of black cumin seeds and beyond. Cancer Ther 2008;6:495-510.
43. Pannu N, Nadim M. An overview of drug induced acute kidney injury. Crit Care Med 2008;36 (Suppl 4):S216-23.
44. Pedraza-Chaverrí J, Barrera D, Maldonado PD, Chirino YI, Macías-Ruvalcaba NA, Medina-Campos ON et al. S-allylmercaptocysteine scavenges hydroxyl radical and singlet oxygen in vitro and attenuates gentamicin-induced oxidative and nitrosative stress and renal damage in vivo. BMC Clin Pharmacol 2004;4:5-18.
45. Pedrycz A, Czerny K. Immunohistochemical study of proteins linked to apoptosis in rat fetal kidney cells following pregnancy Adriamycin administration in mother. Acta Histochem 2008;110:519-23.
46. Piao RL, Liu YY, Tian D, Ma ZH, Zhang M, Zhao C et al. Adefovir dipivoxil modulates cytokine expression in Th1/Th2 cells in patients with chronic hepatitis B. Mol Med Rep 2012;5:184-9.
47. Polat A, Parlakpinar H, Tasdemir S, Colak C, Vardi N, Ucar M et al. Protective role of aminoguanidine on gentamicin-induced acute renal failure in rats. Acta Histochem 2006;108:365-71.
48. Preuss HG, Jarrell ST, Scheckenbach R, Lieberman S, Anderson RA. Comparative effect of chromium vanadium and Gymnema sylvestre on sugar-induced blood pressure elevation in SHR. J Am Coll Nutr 1998;17:116-23.
49. Quiros Y, Vicente-Vicente L, Morales AI, Lopez-Novoa JM, Lopez-Hernandez FJ. An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin. Toxicol Sci 2011;119:245-56.
50. Romero F, Perez M, Chavez M, Parra G, Durante P. Effect of uric acid on gentamicin-induced nephrotoxicity in rats-role of matrix metalloproteinases 2 and 9. Basic Clin Pharmacol Toxicol 2009;105:416-24.
51. Rooney S, Ryan MF. Modes of action of hederin and thymoquinone, active constituents of Nigella sativa, against HEp-2 cancer cells. Anticancer Res 2005;25: 4255-9.
52. Salem ML. Immunomodulatory and therapeutic properties of Nigella sativa L. seed. Int Immunopharmacol 2005;5:1749-70.
53. Sayed AA. Thymoquinine protects renal tubular cells against tubular injury. Cell Biochem Funct 2008;26:374-80.
54. Sener G, Sehirli AO, Altunbas HZ, Ersoy Y, Paskaloglu K, Arbak S et al. Melatonin protects against gentamicin-induced nephrotoxicity in rats. J Pineal Res 2002;32:231-6.
55. Shaw PJ, Hopfensperger MJ, Ganey PE, Roth RA. Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha. Toxicol Sci 2007; 100:259-66.
56. Silan C, Uzun O, Comunoǧlu NU, Gokçen S, Bedirhan S, Cengiz M. Gentamicin-induced nephrotoxicity in rats ameliorated and healing effects of resveratrol. Biol Pharm Bull 2007;30:79-83.
57. Soliman KM, Abdul-Hamid M, Othman AI. Effect of carnosine on gentamicin-induced nephrotoxicity. Med Sci Monit 2007;13:73-83.
58. Takahashi M, Saito H, Okuyama T, Miyashita T, Kosuga M, Sumisa F et al. Overexpression of Bcl-2 protects human hepatoma cells from Fas-antibodymediated apoptosis. J Hepatol 1999;31:315-22.
59. Tirkey N, Kaur G, Vij G, Chopra K. Curcumin a diferuloylmethane, attenuates cyclosporine induced renal dysfunction and oxidative stress in rat kidneys. J Biosci 2005;22:233-46.
60. Tsujimoto Y, Shimizu S, Eguchi Y, Kamiike W, Matsuda H. Bcl-2 and Bcl-XL block apoptosis as well as necrosis possible involvement of common mediators in apoptosic and necrotic signal transduction pathways. Leukemia 1997;11:380-2.
61. Ullah I, Ullah C, Naseer MI, Lee HY, Kim MO. Neuroprotection with metformin and thymoquinone against ethanol-induced apoptotic neurodegeneration in prenatal rat cortical neurons. BMC Neuroscience 2012;13:11.
62. Yaman I, Balikci E. Protective effects of nigella sativa against gentamicin-induced nephrotoxicity in rats. Exp Toxicol Pathol 2010;62:183-90.
63. th ed. 1995 Washington, DC: The American Association for Clinical Chemistry, AACC Press, 1995.
64. Zou W, Beggs KM, Sparkenbaugh EM, Jones AD, Younis HS, Roth RA et al. Sulindac metabolism and synergy with tumor necrosis factor-alpha in a druginflammation interaction model of idiosyncratic liver injury. J Pharmacol Exp Ther 2009;331:114-21.