Pathogenetic mechanisms in nephrotoxic acute renal failure

Seminars in Nephrology

Volumn 17, Issue 1, 1997, Pages 3-14

  Zager, Richard A ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; CALCIUM; DNA FRAGMENT; FREE RADICAL; HYDROGEN PEROXIDE; PHOSPHOLIPID;

ACUTE KIDNEY FAILURE; APOPTOSIS; CALCIUM HOMEOSTASIS; CELL ENERGY; CELL POLARITY; CYTOSKELETON; KIDNEY TUBULE DISORDER; NEPHROTOXICITY; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REVIEW; SODIUM CALCIUM EXCHANGE;

ANIMALS; APOPTOSIS; CALCIUM; HUMANS; KIDNEY; KIDNEY FAILURE, ACUTE; OXIDATIVE STRESS; PHARMACEUTICAL PREPARATIONS; PHOSPHOLIPIDS;

EID: 0031030991     PISSN: 02709295     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (97)

1. Humes HD: Aminoglycoside nephrotoxicity (Nephrology Forum). Kidney Int 33:900-911, 1988
2. Weinberg JM: The cellular basis of nephrotoxicity, in Schrier RW, Gottschalk CW (eds): Diseases of the Kidney. Boston, MA, Little Brown, 1993, pp 1031-1237
3. Zager RA, Foerder C, Bredl C: The influence of mannitol on myoglobinuric acute.renal faiilure. Functional, biochemical, and morphological assessments. J Am Soc Nephrol 2:848-855, 1991
4. Bennett WM, Hartnett MV, Gilbert D, et al: Effect of sodium intake on gentamicin nephrotoxicity. Proc Soc Exp BiolMed 151:736-738, 1976
5. Williams PD, Holtendorf GH: Inhibition of renal membrane binding and nephrotoxicity of aminoglycosides. Antimicrob Agents Chemother 31:570-574, 1987
6. Zager RA: Combined mannitol and deferoxamine therapy for myohemoglobinuiric renal injury and oxidant tubular stress. J Clin Invest 90:711-719, 1992
7. Moore RD, Smith CR, Lipsky JJ, et al: Risk factors for nephrotoxicity in patients treated with aminoglycosides. Ann Int Med 100:352-357, 1984
8. Moore RD, Smith CR, Lietman PS: Increased risk of renal dysfunction due to interaction of liver disease and aminoglycosides. Am J Med 80:1093-1097, 1986
9. Zager RA, Prior RB: Gentamicin and gram negative bacteremia: A synergism for the development of experimental nephrotoxic acute renal failure. J Clin Invest 78:196-204, 1986
10. Brezis M, Rosen S, Suva P, Epstein FH: Transport activity modifies thick ascending limb damage in the isolated perfused kidney. Kidney Int 25:65-72, 1984
11. Zager RA, Gmur DJ, Bredl CR et al: Degree and time sequence of hypothermie protection against experimental acute renal failure. Circ Res 65:1263-1269, 1989
12. Pfaller W, W Rittinger M: Quantitative morphology of the rat kidney. Int J Biochem 12:17-22, 1980
13. Simmons CF Jr, Bogusky RT, Humes HD: Inhibitory effects of gentamicin on renal cortical mitochondrial oxidative phosphorylation. J Pharmacol Exp Ther 214:709-713, 1980
14. Trifillis AL, Kahng MW, Trump BF: Metabolic studies of glycerol-induced acute renal failure in the rat. Exp Molec Pathol 35:1-13, 1981
15. Better OS, Stein JH: Early management of shock and prophylaxis of acute renal failure in traumatic rhabdomyolysis. N Engl J Med 324:1417-1422, 1990
16. Vetterlein R, Hoffmann F, Pedina J, et al: Disturbances in renal microcirculation induced by myoglobin and hemorrhagic hypotension in the anesthetized rat. Am J Physiol 268:F839-F846, 1995
17. Zager RA: Myoglobin depletes renal adenine nucleotide pools in the presence and absence of shock. Kidney Int 39:111-119, 1991
18. Sharma VS, Traylor TG, Gardiner R: Reaction of nitric oxide with heme proteins and model compounds of hemoglobin. Biochemistry 26:3837-3843, 1987
19. Wright CE, Rees DD, Moncada S: Protective and pathological roles of nitric oxide in endotoxin shock. Cardiovasc Res 26:48-57, 1992
20. Maree A, Peer G, Schwanz D, et al: Role of nitric oxide in glycerol-induced acute renal failure in rats. Nephrol Dialysis Transplant 9 (suppl): 78-81, 1994
21. Weinberg JM, Humes HD: Mechanisms of gentamicin-induced dysfunction of renal conical mitochondria. I. Effects on mitochondrial respiration. Arch Biochem Biophys 205:222-231, 1980
22. Kaloyanides GJ: Aminoglycoside nephrotoxicity, in Schrier RW, Gottschalk CW (eds): Diseases of the Kidney. Boston, MA, Little Brown, 1993, pp 1131-1164
23. Mela-Riker LM, Widener LL, Houghton DC, Bennett WM: Renal mitochondria! integrity during continuous gentamicin treatment. Biochem Pharmacol 35:979-984, 1986
24. Gunter TE, Pfeiffer DR: Mechanisms by which mitochondria transport calcium. Am J Physiol 258:C755-C786, 1990
25. Weinberg JM, Humes HD: Calcium transport and inner mitochondrial membrane damage in renal cortical mitochondria. Am J Physiol 248:F876-F889, 1985
26. Zager RA, Mahan J, Merola AJ: Effects of mannitol on the postischemic kidney. Biochemical, functional, and morphologic assessments. Lab Invest 53:433-442, 1985
27. Cronin RE, Newman JA: Protective effect of thyroxine but not parathyroidectomy on gentamicin nephrotoxicity. Am J Physiol 248:F332-F339, 1985
28. +, adenosine triphosphatase by gentamicin. J Pharmacol Exp Ther 231:248-253, 1984
29. Zager RA, Bredl CR, Schimpf BA: Direct amphotericin B-mediated tubular toxicity: Assessments of selected cytoprotective agents. Kidney Int: 41:1588-1594, 1992
30. 1). Relationships to phospholipid degradation and unesterified fatty acid accumulation. J Clin Invest 81:745-758, 1988
31. Halliwell B, Gutteridge JMC: Role of free radicals and catalytic metal ions in human disease: An overview. Methods Enzymol 186:1-85, 1990
32. Cross CE, Halliwell B, Borish ET, et al: Oxygen radicals and human disease. Ann Int Med 107:526-545, 1987
33. Halliwell B, Gutteridge MD: Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts. Arch Biochem Biophys 246:501-514, 1986
34. Freeman BA, Crapo JD: Biology of disease: Free radicals and tissue injury. Lab Invest 447:412-426, 1982
35. Shah SV: Evidence suggesting a role for hydroxyl radical in passive Heymann nephritis in rats. Am J Physiol 254:F337-F344, 1988
36. Palier MS, Hoidal JR, Ferris TF: Oxygen free radicals in ischemie acute renal failure in the rat. J Clin Invest 74:1156-1164, 1984
37. Walker PD, Shah S V: Evidence of the role of hydroxyl radical in gentamicin-induced acute renal failure in rats. J Clin Invest 81:334-341, 1988
38. Shah SV, Walker PD: Evidence suggesting a role for hydroxyl radical in glycerol-induced acute renal failure. Am J Physiol 255:F440-F445, 1988
39. Gutteridge JMC, Halliwell B: The measurement and mechanism of lipid peroxidation in biological systems. TIBS 15:129-135, 1990
40. McCord JM: Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 312:159-163, 1985
41. Nath KA, Salahudeen AK: Autoxidation of cysteine generates hydrogen peroxide: Cytotoxicity and attenuation by pyruvate. Am J Physiol 264:F306-F3I4, 1993
42. Klausner JM, Paterson IS, Goldman G, et al: Postischemie renal injury is mediated by neutrophils and leukotrienes. Am J Physiol 256:F794-F802, 1989
43. Linas SL, Shanley PF, Whittenburg D, et al: Neutrophils accenutate ischemic-reperfusion injury in isolated perfused rat kidneys. Am J Physiol 255:F728-F735, 1988
44. Rabb H, Mendiola CC, Dietz J, et al: Role of CD11a and CDllb in ischemic acute renal failure in rats. Am J Physiol 267:F1052-F1058, 1994
45. Kelly KJ, Williams WW Jr, Colvin RB, et al: Antibody to intercellular adhesion molecule 1 protects the kidney against ischemic injury. Proc Nat AcadSci USA 91:812-816, 1994
46. Zager RA, Burkhart KM, Conrad DS, et ai: Iron, heme oxygenase, and glutathione: Effects on myohemoglobinuric proximal tubular injury. Kidney Int 48:1624-1634, 1995
47. 2 generation by rat kidney in glycerol-induced acute renal failure. Am J Physiol 257:F440-F445, 1989
48. Palier MS: Hemoglobin- and myoglobin-induced acute renal failure in rats: Role of iron in nephrotoxicity. Am J Physiol 255:F539-F544, 1988
49. Zager RA: Mitochondrial free radical production induces lipid peroxidation during myohemoglobinuria. Kidney Int 49:741-751, 1996
50. Walker PD, Shah SV: Gentamicin enhanced production of hydrogen peroxide by renal cortical mitochondria. Am J Physiol 253:C495-C499, 1987
51. Abul-Ezz SR, Walker PD, Shah SV: Role of glutathione in an animal model of myoglobinuric acute renal failure. Proc Natl Acad Sci USA 88:9833-9837, 1991
52. Carafoli E: Intracellular calcium homeostasis. Annu Rev Biochem 56:395-433, 1987
53. Orrenius S, Nicotera P: On the role of calcium in chemical toxicity. Arch Toxicol Suppl 11:11-19, 1987
54. Schrier RW, Arnold PE, Van Putten VJ, Burke TJ: Cellular calcium in ischemic acute renal failure: Role of calcium channel blockers. Kidney Int 32:313-321, 1987
55. Takano T, Soltoff SP, Murdaugh S, Mandel U: Intracellular respiratory dysfunction and cell injury in short-term anoxia of rabbit renal proximal tubules. J Clin Invest 76:2377-2384, 1985
56. 2+ of cultured rabbit renal tubular cells. Biochim Biophys Acta 931:130-142, 1987
57. Weinberg JM, Davis JA, Roeser NF, Venkatachalam MA: Role of increased cytosolic free calcium in the pathogenesis of rabbit proximal tubule cell injury and protection from glycine. J Clin Invest 87:581-590, 1991
58. Schrier RW, Burke TJ: Role of calcium channel blockers in preventing acute and chronic renal injury. J Cardiovasc Pharmacol 18:S38-S43, 1991
59. Iwata M, Herrington J, Zager RA: Protein synthesis inhibition induces cytoresistance in cultured human proximal tubular (HK-2) cells. Am J Physiol 37:F1154-F1163, 1995
60. 2+ ionophore-induced attack. Lab Invest 72:592-600, 1995
61. 2-induced cytoprotection of proximal tubules: potential determinants and specificity for ATP depletion mediation injury. J Am Soc Nephrol 7:74-72, 1996
62. Bonventre JV: Mechanisms of ischemic acute renal failure (Nephrology Forum). Kidney Int 43:1160-1178, 1993
63. Wilson PD, Hartz PA: Mechanisms of cyclosporin A toxicity in defined cultures of renal tubule epithelia: A role for cysteine proteases. Cell Biol Int Reports 15:1243-1258, 1991
64. Green D, Fry M, Blondin G: Phospholipids as the molecular instruments of ion and solute transport in biological membranes. Proc Natl AcadSci USA 77:257-261, 1980
65. Lipsky JJ, Lietman PS: Neomycin inhibition of adenosine triphosphatase: Evidence for a neomycin-phospholipid interaction. Antimicrob Agents Chermother 18:532-535, 1982
66. Weinberg JM: The cell biology of ischemic renal injury (Nephrology Forum). Kidney Int 39:476-500, 1991
67. Portilla D, Creer MH: Plasmalogen phospholipid hydrolysis during hypoxic injury of rabbit proximal tubules. Kidney Int 47:1087-1094, 1995
68. Matthys E, Patel Y, Kresiberg, et al: Lipid alterations induced by renal ischemia: Pathogenic factor in membrane damage. Kidney Int 26:153-161, 1984
69. 2+ uptake, fatty acid, and LDH release during proximal tubule hypoxia: Effects of mepacrine and dibucaine. Am J Physiol 266:F196-F201, 1994
70. 2 can protect renal tubules from oxygen deprivation injury. Proc Natl AcadSci USA 90:8297-8301, 1993
71. Troyer DA, Kreisberg JI, Venaktachalam MA: Lipid alterations in LLC-PK, cells exposed to mercuric chloride. Kidney Int 29:530-538, 1986
72. Kozek JC, Mazze Rl, Cousins MJ: Nephrotoxicity of gentamicin. Lab Invest 30:48-57, 1974
73. Guiiliano RA, Paulus GJ, Verpooten GA, et al: Recovery of cortical phospholipidosis and necrosis after acute gentamicin loading in rats. Kidney Int 26:838-847, 1984
74. Josepovitz C, Pastoriza-Munoz E, Timmerman D, et al: Effect of netilmicin on the phospholipid composition of subcellular fractions of rat renal cortex. J Pharmacol Exp Ther 235:810-819, 1985
75. Carlier MB, Laurent G, Glases PJ, et al: Inhibition of lysosomal phospholipases by aminoglycoside antibiotics. Antimicrob Agents Chemother 23:440-449, 1983
76. Ramsammy LS, Kaloyanides GJ: The effect of gentamicin on the biophysical properties of phosphatidic acid liposomes is influenced by the O-C=O group of the lipid. Biochemistry 27:8249-8254, 1988
77. Ramsammy LS, Josepovitz C, Kaloyanides GJ: Gentamicin inhibits agonist stimulation of the phosphatidylinositiol cascade in primary cultures of rabbit proximal tubular cells and in rat renal cortex. J Pharmacol Exp Ther 247:989-996, 1988
78. Fish EM, Moutons BA: Alterations in epithelial polarity and the pathogenesis of disease states. N Engl J Med 330:1580-1588, 1994
79. Molitoris BA: Ischemia-induced loss of epithelial polarity: Potential role of the actin cytoskeleton. Am J Physiol 260:F769-F778, 1991
80. Goligorsky MS, Lieberthal W, Racusen L, Simon EE: Integrin receptors in renal tubular epithelium: New insights into pathophysiology of acute renal failure. Am J Physiol 264:F1-F8, 1993
81. Goligorsky MS, DiBona GF: Pathogenetic role of ArgGly-Asp recognizing integrins in acute renal failure. Proc Natl AcadSci USA 90:5700-5704, 1993
82. Lindquist S: The heat shock response. Annu Rev Biochem 55:1151-1191, 1986
83. Sorger PK: Heat shock factor and the heat shock response. Cell 65:363-366, 1991
84. Agard DA: To fold or not to fold. Science 260:1903-1904, 1994
85. Honda N, Yonemura K: Acquired resistance to acute renal failure. Kidney Int 31:1233-1238, 1987
86. 2 deprivation injury. Kidney Im 45:1760-1768, 1994
87. Zager RA: Heme protein-induced cytoresistance: Expression at the plasma membrane level. Kidney Int 47:1336-1345, 1995
88. Goering PL, Fisher BR, Chaudhary PP, Dick CA: Relationship between stress protein induction in rat kidney by mercuric chloride and nephrotoxicity. Toxicol Appl Pharmacol 113:184-191, 1992
89. Bennett WM, Mela-Rika LM, Houghton DC, et al: Microsomal protein synthesis inhibition: An early manifestation of gentamicin nephrotoxicity. Am J Physiol 255:F265-F269, 1988
90. Tay LK, Bregman CL, Masters BA, Williams PD: Effects of cis-diamminedichloroplatinum (II) on rabbit kidney in vivo and on rabbit renal proximal tubules in culture. Cancer Res 48:2538-2543, 1988
91. Savill J: Apoptosis and the kidney. J Am Soc Nephrol 5:12-21, 1994
92. Ueda N, Shah SV: Apoptosis. J Lab Clin Med 124:169-177, 1994
93. Schumer M, Colombel MC, Sawczuk IS, et al: Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia. Am J Pathol 140:831-838, 1992
94. Ueda N, Shah SV: Endonuclease-induced DNA damage and cell death in oxidant injury to renal tubular cells. J Clin Invest 90:2593-2597, 1992
95. Beeri R, Brezis M, Ben-Sasson SA, et al: Rapid DNA fragmentation from hypoxia along the thick ascending limb of rat kidneys. Kidney Int 47:1806-1810, 1995
96. Zager RA, Fuerstenberg SM, Baehr PH, et al: An evaluation of antioxidant effects on recovery from postischemic acute renal failure. J Am Soc Nephrol 4:1588-1597, 1994
97. Iwata Myerson B, Torok-Storb B, et al: An evaluation of renal tubular DNA laddering in response to oxygen deprivation and oxidant injury. J Am Soc Nephrol 5:1307-1313, 1994