Protective effects of glycyrrhizic acid and 18β-glycyrrhetinic acid against cisplatin-induced nephrotoxicity in BALB/c mice

Journal of Agricultural and Food Chemistry

Volumn 63, Issue 4, 2015, Pages 1200-1209

  Wu, Chi Hao ^a   Chen, An Zhi ^b   Yen, Gow Chin ^b  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

18 glycyrrhetinic acid; anti inflammation; cisplatin; glycyrrhizic acid; nephrotoxicity

Indexed keywords

MAMMALS; UREA;

ANTI-INFLAMMATION; CIS-PLATIN; GLYCYRRHETINIC ACIDS; GLYCYRRHIZIC ACID; NEPHROTOXICITY;

PLATINUM COMPOUNDS;

GLYCYRRHIZA; MUS;

EID: 84922454872     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf505471a     Document Type: Article

References (39)

1. dos Santos, N. A.; Carvalho Rodrigues, M. A.; Martins, N. M.; dos Santos, A. C. Cisplatin-induced nephrotoxicity and targets of nephroprotection: An update Arch. Toxicol. 2012, 86, 1233-1250
2. Pabla, N.; Dong, Z. Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies Kidney Int. 2008, 73, 994-1007
3. Lin, Y. H.; Lin, S. F.; Hsiao, H. H.; Liu, Y. C.; Yang, W. C.; Hwang, D. Y.; Hung, C. C.; Hwang, S. J.; Guh, J. Y.; Chen, H. C. Recent update on cisplatin induced acute kidney injury J. Int. Med. Taiwan 2011, 22, 416-422
4. Arany, I.; Safirstein, R. L. Cisplatin nephrotoxicity Semin. Nephrol. 2003, 23, 460-464
5. Capizzi, R. L. Amifostine reduces the incidence of cumulative nephrotoxicity from cisplatin: Laboratory and clinical aspects Semin. Oncol. 1999, 26, 72-81
6. Asna, N.; Lewy, H.; Ashkenazi, I. E.; Deutsch, V.; Peretz, H.; Inbar, M.; Ron, I. G. Time dependent protection of amifostine from renal and hematopoietic cisplatin induced toxicity Life Sci. 2005, 76, 1825-1834
7. Kouvaris, J. R.; Kouloulias, V. E.; Vlahos, L. J. Amifostine: The first selective-target and broad-spectrum radioprotector Oncologist 2007, 12, 738-747
8. Blumenthal, M.; Goldberg, A.; Brinckmann, J. In Herbal Medicine: Expanded Commission E Monographs; Blumenthal, M., Ed.; American Botanical Council: Newton, MA, 2000; pp 233-236.
9. Akao, T.; Akao, T.; Hattori, M.; Kanaoka, M.; Yamamoto, K.; Namba, T.; Kobashi, K. Hydrolysis of glycyrrhizin to 18β-glycyrrhetyl monoglucuronide by lysosomal β- d -glucuronidase of animal livers Biochem. Pharmacol. 1991, 41, 1025-1029
10. Kao, T. C.; Wu, C. H.; Yen, G. C. Bioactivity and potential health benefits of licorice J. Agric. Food Chem. 2014, 62, 542-553
11. Kang, D. G.; Sohn, E. J.; Mun, Y. J.; Woo, W. H.; Lee, H. S. Glycyrrhizin ameliorates renal function defects in the early-phase of ischemia-induced acute renal failure Phytother. Res. 2003, 17, 947-951
12. 4-induced hepatocyte apoptosis in rats via a p53-mediated pathway World J. Gastroenterol. 2013, 19, 3781-3791
13. Ni, Y. F.; Kuai, J. K.; Lu, Z. F.; Yang, G. D.; Fu, H. Y.; Wang, J.; Tian, F.; Yan, X. L.; Zhao, Y. C.; Wang, Y. J.; Jiang, T. Glycyrrhizin treatment is associated with attenuation of lipopolysaccharide-induced acute lung injury by inhibiting cyclooxygenase-2 and inducible nitric oxide synthase expression J. Surg. Res. 2011, 165, e29-35
14. Arjumand, W.; Sultana, S. Glycyrrhizic acid: A phytochemical with a protective role against cisplatin-induced genotoxicity and nephrotoxicity Life Sci. 2011, 89, 422-429
15. Asl, M. N.; Hosseinzadeh, H. Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds Phytother. Res. 2008, 22, 709-724
16. Kalaiarasi, P.; Pugalendi, K. V. Antihyperglycemic effect of 18β-glycyrrhetinic acid, aglycone of glycyrrhizin, on streptozotocin-diabetic rats Eur. J. Pharmacol. 2009, 606, 269-273
17. Kao, T. C.; Shyu, M. H.; Yen, G. C. Neuroprotective effects of glycyrrhizic acid and 18β-glycyrrhetinic acid in PC12 cells via modulation of the PI3K/Akt pathway J. Agric. Food Chem. 2009, 57, 754-761
18. Wang, C. Y.; Kao, T. C.; Lo, W. H.; Yen, G. C. Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions J. Agric. Food Chem. 2011, 59, 7726-7733
19. Sanchez-Gonzalez, P. D.; Lopez-Hernandez, F. J.; Perez-Barriocanal, F.; Morales, A. I.; Lopez-Novoa, J. M. Quercetin reduces cisplatin nephrotoxicity in rats without compromising its anti-tumour activity Nephrol., Dial., Transplant. 2011, 26, 3484-3495
20. Mitazaki, S.; Kato, N.; Suto, M.; Hiraiwa, K.; Abe, S. Interleukin-6 deficiency accelerates cisplatin-induced acute renal failure but not systemic injury Toxicology 2009, 265, 115-121
21. Shackelford, C.; Long, G.; Wolf, J.; Okerberg, C.; Herbert, R. Qualitative and quantitative analysis of nonneoplastic lesions in toxicology studies Toxicol. Pathol. 2002, 30, 93-96
22. Ohkawa, H.; Ohishi, N.; Yagi, K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal. Biochem. 1979, 95, 351-358
23. Ali, B. H.; Al Moundhri, M. S. Agents ameliorating or augmenting the nephrotoxicity of cisplatin and other platinum compounds: A review of some recent research Food Chem. Toxicol. 2006, 44, 1173-1183
24. Sahin, K.; Tuzcu, M.; Sahin, N.; Ali, S.; Kucuk, O. Nrf2/HO-1 signaling pathway may be the prime target for chemoprevention of cisplatin-induced nephrotoxicity by lycopene Food Chem. Toxicol. 2010, 48, 2670-2674
25. Husain, K.; Morris, C.; Whitworth, C.; Trammell, G. L.; Rybak, L. P.; Somani, S. M. Protection by ebselen against cisplatin-induced nephrotoxicity: Antioxidant system Mol. Cell. Biochem. 1998, 178, 127-133
26. Ajith, T. A.; Abhishek, G.; Roshny, D.; Sudheesh, N. P. Co-supplementation of single and multi doses of vitamins C and E ameliorates cisplatin-induced acute renal failure in mice Exp. Toxicol. Pathol. 2009, 61, 565-571
27. Kang, R.; Chen, R.; Zhang, Q.; Hou, W.; Wu, S.; Cao, L.; Huang, J.; Yu, Y.; Fan, X. G.; Yan, Z.; Sun, X.; Wang, H.; Wang, Q.; Tsung, A.; Billiar, T. R.; Zeh, H. J., III; Lotze, M. T.; Tang, D. HMGB1 in health and disease Mol. Aspects Med. 2014, 40, 1-116
28. Ozbek, E. Induction of oxidative stress in kidney Int. J. Nephrol. 2012, 2012, 465897
29. Behling, E. B.; Sendao, M. C.; Francescato, H. D.; Antunes, L. M.; Costa, R. S.; Bianchi Mde, L. Comparative study of multiple dosage of quercetin against cisplatin-induced nephrotoxicity and oxidative stress in rat kidneys Pharmacol. Rep. 2006, 58, 526-532
30. Sahu, B. D.; Kuncha, M.; Sindhura, G. J.; Sistla, R. Hesperidin attenuates cisplatin-induced acute renal injury by decreasing oxidative stress, inflammation and DNA damage Phytomedicine 2013, 20, 453-460
31. Kao, T. C.; Shyu, M. H.; Yen, G. C. Glycyrrhizic acid and 18beta-glycyrrhetinic acid inhibit inflammation via PI3K/Akt/GSK3β signaling and glucocorticoid receptor activation J. Agric. Food Chem. 2010, 58, 8623-8629
32. Malekinejad, H.; Farshid, A. A.; Mirzakhani, N. Liquorice plant extract reduces ochratoxin A-induced nephrotoxicity in rats Exp. Toxicol. Pathol. 2011, 63, 125-130
33. Sohn, E. J.; Kang, D. G.; Lee, H. S. Protective effects of glycyrrhizin on gentamicin-induced acute renal failure in rats Pharmacol. Toxicol. 2003, 93, 116-122
34. Huang, J.; Ni, J.; Liu, K.; Yu, Y.; Xie, M.; Kang, R.; Vernon, P.; Cao, L.; Tang, D. HMGB1 promotes drug resistance in osteosarcoma Cancer Res. 2012, 72, 230-238
35. Sitia, G.; Iannacone, M.; Muller, S.; Bianchi, M. E.; Guidotti, L. G. Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice J. Leukocyte Biol. 2007, 81, 100-107
36. Mollica, L.; De Marchis, F.; Spitaleri, A.; Dallacosta, C.; Pennacchini, D.; Zamai, M.; Agresti, A.; Trisciuoglio, L.; Musco, G.; Bianchi, M. E. Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activities Chem. Biol. 2007, 14, 431-441
37. Lin, G.; Nnane, I. P.; Cheng, T. Y. The effects of pretreatment with glycyrrhizin and glycyrrhetinic acid on the retrorsine-induced hepatotoxicity in rats Toxicon 1999, 37, 1259-1270
38. Jeong, H. G.; You, H. J.; Park, S. J.; Moon, A. R.; Chung, Y. C.; Kang, S. K.; Chun, H. K. Hepatoprotective effects of 18β-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: Inhibition of cytochrome P450 2E1 expression Pharmacol. Res. 2002, 46, 221-227
39. Ploeger, B.; Mensinga, T.; Sips, A.; Seinen, W.; Meulenbelt, J.; DeJongh, J. The pharmacokinetics of glycyrrhizic acid evaluated by physiologically based pharmacokinetic modeling Drug Metab. Rev. 2001, 33, 125-147