메뉴 건너뛰기




Volumn 17, Issue 8, 2016, Pages 470-486

Crowdsourcing biomedical research: Leveraging communities as innovation engines

Author keywords

[No Author keywords available]

Indexed keywords

CROWDSOURCING; DATA ANALYSIS; MEDICAL RESEARCH; PRIORITY JOURNAL; REVIEW; TRANSLATIONAL RESEARCH; VALIDATION STUDY; ANIMAL; COOPERATION; HUMAN; INTERDISCIPLINARY COMMUNICATION; ORGANIZATION; ORGANIZATION AND MANAGEMENT;

EID: 84978541160     PISSN: 14710056     EISSN: 14710064     Source Type: Journal    
DOI: 10.1038/nrg.2016.69     Document Type: Review
Times cited : (136)

References (95)
  • 1
    • 84938709678 scopus 로고    scopus 로고
    • Big Data: Astronomical or genomical?
    • Stephens, Z. D. et al. Big Data: astronomical or genomical? PLoS Biol. 13, e1002195 (2015).
    • (2015) PLoS Biol , vol.13
    • Stephens, Z.D.1
  • 2
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • ENCODE Project Consortium
    • ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57-74 (2012).
    • (2012) Nature , vol.489 , pp. 57-74
  • 3
    • 84884994218 scopus 로고    scopus 로고
    • The Cancer Genome Atlas Pan-Cancer analysis project
    • The Cancer Genome Atlas Research Network et al
    • The Cancer Genome Atlas Research Network et al. The Cancer Genome Atlas Pan-Cancer analysis project. Nat. Genet. 45, 1113-1120 (2013).
    • (2013) Nat. Genet , vol.45 , pp. 1113-1120
  • 4
    • 77951115122 scopus 로고    scopus 로고
    • International network of cancer genome projects
    • International Cancer Genome Consortium et al
    • International Cancer Genome Consortium et al. International network of cancer genome projects. Nature 464, 993-998 (2010).
    • (2010) Nature , vol.464 , pp. 993-998
  • 5
    • 84920269464 scopus 로고    scopus 로고
    • Proteomics. Tissue-based map of the human proteome
    • Uhlén, M. et al. Proteomics. Tissue-based map of the human proteome. Science 347, 1260419 (2015).
    • (2015) Science , vol.347
    • Uhlén, M.1
  • 6
    • 84954466540 scopus 로고    scopus 로고
    • Big biomedical data as the key resource for discovery science
    • Toga, A. W. et al. Big biomedical data as the key resource for discovery science. J. Am. Med. Inform. Assoc. 22, 1126-1131 (2015).
    • (2015) J. Am. Med. Inform. Assoc , vol.22 , pp. 1126-1131
    • Toga, A.W.1
  • 7
    • 84905728456 scopus 로고    scopus 로고
    • Toward effective sharing of high-dimensional immunology data
    • Snijder, B., Kandasamy, R. K. & Superti-Furga, G. Toward effective sharing of high-dimensional immunology data. Nat. Biotechnol. 32, 755-759 (2014).
    • (2014) Nat. Biotechnol , vol.32 , pp. 755-759
    • Snijder, B.1    Kandasamy, R.K.2    Superti-Furga, G.3
  • 8
    • 84978514763 scopus 로고    scopus 로고
    • Unlocking and sharing data in astronomy
    • Henneken, E. Unlocking and sharing data in astronomy. Bul. Am. Soc. Info. Sci. Tech. 41, 40-43 (2015).
    • (2015) Bul. Am. Soc. Info. Sci. Tech , vol.41 , pp. 40-43
    • Henneken, E.1
  • 9
    • 84978514796 scopus 로고    scopus 로고
    • WMO
    • World Meteorological Organization. Climate data, management and exchange. WMO http://www.wmo.int/pages/themes/climate/climate-data-management-exchange.php (2009).
    • (2009) Climate Data, Management and Exchange
  • 12
    • 84876684810 scopus 로고    scopus 로고
    • Seeking the wisdom of crowds through challenge-based competitions in biomedical research
    • Costello, J. C. & Stolovitzky, G. Seeking the wisdom of crowds through challenge-based competitions in biomedical research. Clin. Pharmacol. Ther. 93, 396-398 (2013).
    • (2013) Clin. Pharmacol. Ther , vol.93 , pp. 396-398
    • Costello, J.C.1    Stolovitzky, G.2
  • 13
    • 84875329359 scopus 로고    scopus 로고
    • Using the crowd as an innovation partner
    • Boudreau, K. J. & Lakhani, K. R. Using the crowd as an innovation partner. Harv. Bus. Rev. 91, 60-69 (2013).
    • (2013) Harv. Bus. Rev , vol.91 , pp. 60-69
    • Boudreau, K.J.1    Lakhani, K.R.2
  • 14
    • 33847246935 scopus 로고    scopus 로고
    • The rise of crowdsourcing
    • Howe, J. The rise of crowdsourcing. Wired Magazine 14, 1-4 (2006). This article coined the term crowdsourcing and highlighted its potential.
    • (2006) Wired Magazine , vol.14 , pp. 1-4
    • Howe, J.1
  • 16
    • 84978514776 scopus 로고    scopus 로고
    • Heritage Provider Network Health Prize., (4 May 2011)
    • Heritage Provider Network Health Prize. Improve healthcare, win $3,000,000. WebCite http://www.webcitation.org/65IuEDAsc (4 May 2011).
    • Improve Healthcare, Win $3, 000, 000. WebCite
  • 17
    • 84856109055 scopus 로고    scopus 로고
    • Wikipedia, (updated 16 Jun 2016)
    • Wikipedia. List of crowdsourcing projects. Wikipedia https://en.wikipedia.org/wiki/List-of-crowdsourcing-projects (updated 16 Jun 2016).
    • List of Crowdsourcing Projects
  • 18
    • 84893020987 scopus 로고    scopus 로고
    • Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th Critical Assessment of Techniques for Protein Structure Prediction Experiment CASP10
    • Kryshtafovych, A. et al. Challenging the state of the art in protein structure prediction: highlights of experimental target structures for the 10th Critical Assessment of Techniques for Protein Structure Prediction Experiment CASP10. Proteins 82, 26-42 (2014).
    • (2014) Proteins , vol.82 , pp. 26-42
    • Kryshtafovych, A.1
  • 19
    • 0038359614 scopus 로고    scopus 로고
    • CAPRI: A Critical Assessment of PRedicted Interactions
    • Janin, J. et al. CAPRI: a Critical Assessment of PRedicted Interactions. Proteins 52, 2-9 (2003).
    • (2003) Proteins , vol.52 , pp. 2-9
    • Janin, J.1
  • 20
    • 84987617568 scopus 로고    scopus 로고
    • BioCreative-IV virtual issue
    • Arighi, C. N. et al. BioCreative-IV virtual issue. Database 2014, bau039 (2014).
    • (2014) Database , vol.2014
    • Arighi, C.N.1
  • 21
    • 84874666550 scopus 로고    scopus 로고
    • Critical assessment of automated flow cytometry data analysis techniques
    • Aghaeepour, N. et al. Critical assessment of automated flow cytometry data analysis techniques. Nat. Methods 10, 228-238 (2013).
    • (2013) Nat. Methods , vol.10 , pp. 228-238
    • Aghaeepour, N.1
  • 22
    • 84888861753 scopus 로고    scopus 로고
    • Systematic evaluation of spliced alignment programs for RNA-seq data
    • Engström, P. G. et al. Systematic evaluation of spliced alignment programs for RNA-seq data. Nat. Methods 10, 1185-1191 (2013).
    • (2013) Nat. Methods , vol.10 , pp. 1185-1191
    • Engström, P.G.1
  • 23
    • 84888871954 scopus 로고    scopus 로고
    • Assessment of transcript reconstruction methods for RNA-seq
    • Steijger, T. et al. Assessment of transcript reconstruction methods for RNA-seq. Nat. Methods 10, 1177-1184 (2013). References 22 and 23 describe RGASP as an early Benchmarking Challenge for RNA-seq data analysis.
    • (2013) Nat. Methods , vol.10 , pp. 1177-1184
    • Steijger, T.1
  • 24
    • 36249019789 scopus 로고    scopus 로고
    • Dialogue on reverse-engineering assessment and methods
    • Stolovitzky, G. A., Monroe, D. & Califano, A. Dialogue on reverse-engineering assessment and methods. Ann. NY Acad. Sci. 1115, 1-22 (2007).
    • (2007) Ann. NY Acad. Sci , vol.1115 , pp. 1-22
    • Stolovitzky, G.A.1    Monroe, D.2    Califano, A.3
  • 25
    • 84873594686 scopus 로고    scopus 로고
    • Evaluation of methods for modeling transcription factor sequence specificity
    • Weirauch, M. T. et al. Evaluation of methods for modeling transcription factor sequence specificity. Nat. Biotechnol. 31, 126-134 (2013).
    • (2013) Nat. Biotechnol , vol.31 , pp. 126-134
    • Weirauch, M.T.1
  • 26
    • 84963940835 scopus 로고    scopus 로고
    • Crowdsourced analysis of clinical trial data to predict amyotrophic lateral sclerosis progression
    • Küffner, R. et al. Crowdsourced analysis of clinical trial data to predict amyotrophic lateral sclerosis progression. Nat. Biotechnol. 33, 51-57 (2015). A Challenge with direct clinical implications.
    • (2015) Nat. Biotechnol , vol.33 , pp. 51-57
    • Küffner, R.1
  • 27
    • 84876920284 scopus 로고    scopus 로고
    • Crowd computing: Using competitive dynamics to develop and refine highly predictive models
    • Bentzien, J., Muegge, I., Hamner, B. & Thompson, D. C. Crowd computing: using competitive dynamics to develop and refine highly predictive models. Drug Discov. Today 18, 472-478 (2013).
    • (2013) Drug Discov. Today , vol.18 , pp. 472-478
    • Bentzien, J.1    Muegge, I.2    Hamner, B.3    Thompson, D.C.4
  • 28
    • 84924338899 scopus 로고    scopus 로고
    • A community computational challenge to predict the activity of pairs of compounds
    • Bansal, M. et al. A community computational challenge to predict the activity of pairs of compounds. Nat. Biotechnol. 32, 1213-1222 (2014).
    • (2014) Nat. Biotechnol , vol.32 , pp. 1213-1222
    • Bansal, M.1
  • 29
    • 84906549588 scopus 로고    scopus 로고
    • A community effort to assess and improve drug sensitivity prediction algorithms
    • Costello, J. C. et al. A community effort to assess and improve drug sensitivity prediction algorithms. Nat. Biotechnol. 32, 1208-1212 (2014). A Challenge to benchmark methods for precision medicine.
    • (2014) Nat. Biotechnol , vol.32 , pp. 1208-1212
    • Costello, J.C.1
  • 30
    • 84897405787 scopus 로고    scopus 로고
    • Global optimization of somatic variant identification in cancer genomes with a global community challenge
    • Boutros, P. C. et al. Global optimization of somatic variant identification in cancer genomes with a global community challenge. Nat. Genet. 46, 318-319 (2014).
    • (2014) Nat. Genet , vol.46 , pp. 318-319
    • Boutros, P.C.1
  • 31
    • 84929119845 scopus 로고    scopus 로고
    • The project data sphere initiative: Accelerating cancer research by sharing data
    • Green, A. K. et al. The project data sphere initiative: accelerating cancer research by sharing data. Oncologist 20, 464-e20 (2015).
    • (2015) Oncologist , vol.20 , pp. 464-464e20
    • Green, A.K.1
  • 32
    • 84929076162 scopus 로고    scopus 로고
    • The Prostate Cancer DREAM Challenge: A community-wide effort to use open clinical trial data for the quantitative prediction of outcomes in metastatic prostate cancer
    • Abdallah, K., Hugh-Jones, C., Norman, T., Friend, S. & Stolovitzky, G. The Prostate Cancer DREAM Challenge: a community-wide effort to use open clinical trial data for the quantitative prediction of outcomes in metastatic prostate cancer. Oncologist 459-460 (2015).
    • (2015) Oncologist , pp. 459-460
    • Abdallah, K.1    Hugh-Jones, C.2    Norman, T.3    Friend, S.4    Stolovitzky, G.5
  • 33
    • 84921985362 scopus 로고    scopus 로고
    • The PRO-ACT database: Design, initial analyses, and predictive features
    • Atassi, N. et al. The PRO-ACT database: design, initial analyses, and predictive features. Neurology 83, 1719-1725 (2014).
    • (2014) Neurology , vol.83 , pp. 1719-1725
    • Atassi, N.1
  • 34
    • 84885012223 scopus 로고    scopus 로고
    • Enabling transparent and collaborative computational analysis of 12 tumor types within the Cancer Genome Atlas
    • Omberg, L. et al. Enabling transparent and collaborative computational analysis of 12 tumor types within The Cancer Genome Atlas. Nat. Genet. 45, 1121-1126 (2013).
    • (2013) Nat. Genet , vol.45 , pp. 1121-1126
    • Omberg, L.1
  • 35
    • 80054088224 scopus 로고    scopus 로고
    • The self-assessment trap: Can we all be better than average?
    • Norel, R., Rice, J. J. & Stolovitzky, G. The self-assessment trap: can we all be better than average? Mol. Syst. Biol. 7, 537 (2011).
    • (2011) Mol. Syst. Biol , vol.7 , pp. 537
    • Norel, R.1    Rice, J.J.2    Stolovitzky, G.3
  • 36
    • 84978518295 scopus 로고    scopus 로고
    • DREAMTools: A Python package for scoring collaborative challenges [version2; Referees: 1 approved, 2 approved with reservations]
    • Cokelaer, T. et al. DREAMTools: a Python package for scoring collaborative challenges [version2; referees: 1 approved, 2 approved with reservations]. F1000Res. 4, 1030 (2015).
    • (2015) F1000Res , vol.4 , pp. 1030
    • Cokelaer, T.1
  • 37
    • 84878568206 scopus 로고    scopus 로고
    • Crowdsourcing genetic prediction of clinical utility in the Rheumatoid Arthritis Responder Challenge
    • Plenge, R. M. et al. Crowdsourcing genetic prediction of clinical utility in the Rheumatoid Arthritis Responder Challenge. Nat. Genet. 45, 468-469 (2013).
    • (2013) Nat. Genet , vol.45 , pp. 468-469
    • Plenge, R.M.1
  • 38
    • 84877765675 scopus 로고    scopus 로고
    • Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer
    • Margolin, A. A. et al. Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer. Sci. Transl. Med. 5, 181re1 (2013).
    • (2013) Sci. Transl. Med , vol.5
    • Margolin, A.A.1
  • 39
    • 84978621488 scopus 로고    scopus 로고
    • Inferring causal molecular networks: Empirical assessment through a community-based effort
    • Hill, S. M. et al. Inferring causal molecular networks: empirical assessment through a community-based effort. Nat. Methods 13, 310-318 (2016).
    • (2016) Nat. Methods , vol.13 , pp. 310-318
    • Hill, S.M.1
  • 40
    • 59649110273 scopus 로고    scopus 로고
    • Generating realistic in silico gene networks for performance assessment of reverse engineering methods
    • Marbach, D., Schaffter, T., Mattiussi, C. & Floreano, D. Generating realistic in silico gene networks for performance assessment of reverse engineering methods. J. Comput. Biol. 16, 229-239 (2009).
    • (2009) J. Comput. Biol , vol.16 , pp. 229-239
    • Marbach, D.1    Schaffter, T.2    Mattiussi, C.3    Floreano, D.4
  • 41
    • 77950910419 scopus 로고    scopus 로고
    • Revealing strengths and weaknesses of methods for gene network inference
    • Marbach, D. et al. Revealing strengths and weaknesses of methods for gene network inference. Proc. Natl Acad. Sci. USA 107, 6286-6291 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 6286-6291
    • Marbach, D.1
  • 42
    • 77949644952 scopus 로고    scopus 로고
    • Towards a rigorous assessment of systems biology models: The DREAM3 challenges
    • Prill, R. J. et al. Towards a rigorous assessment of systems biology models: the DREAM3 challenges. PLoS ONE 5, e9202 (2010).
    • (2010) PLoS ONE , vol.5
    • Prill, R.J.1
  • 43
    • 84870305264 scopus 로고    scopus 로고
    • Wisdom of crowds for robust gene network inference
    • Marbach, D. et al. Wisdom of crowds for robust gene network inference. Nat. Methods 9, 796-804 (2012). This paper introduces the wisdom-of-crowds concept in computational biology.
    • (2012) Nat. Methods , vol.9 , pp. 796-804
    • Marbach, D.1
  • 44
    • 63049128934 scopus 로고    scopus 로고
    • A yeast synthetic network for in vivo assessment of reverse-engineering and modeling approaches
    • Cantone, I. et al. A yeast synthetic network for in vivo assessment of reverse-engineering and modeling approaches. Cell 137, 172-181 (2009).
    • (2009) Cell , vol.137 , pp. 172-181
    • Cantone, I.1
  • 46
    • 2942694772 scopus 로고    scopus 로고
    • Artificial gene networks for objective comparison of analysis algorithms
    • Mendes, P., Sha, W. & Ye, K. Artificial gene networks for objective comparison of analysis algorithms. Bioinformatics 19 (Suppl 2), ii122-ii129 (2003).
    • (2003) Bioinformatics , vol.19 , pp. ii122-ii129
    • Mendes, P.1    Sha, W.2    Ye, K.3
  • 47
    • 79961200389 scopus 로고    scopus 로고
    • Gene Net Weaver in silico benchmark generation and performance profiling of network inference methods
    • Schaffter, T., Marbach, D. & Floreano, D. GeneNetWeaver: in silico benchmark generation and performance profiling of network inference methods. Bioinformatics 27, 2263-2270 (2011).
    • (2011) Bioinformatics , vol.27 , pp. 2263-2270
    • Schaffter, T.1    Marbach, D.2    Floreano, D.3
  • 48
    • 33646361583 scopus 로고    scopus 로고
    • GenePattern 2.0
    • Reich, M. et al. GenePattern 2.0. Nat. Genet. 38, 500-501 (2006).
    • (2006) Nat. Genet , vol.38 , pp. 500-501
    • Reich, M.1
  • 49
    • 84960145592 scopus 로고    scopus 로고
    • Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases
    • Marbach, D. et al. Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases. Nat. Methods 13, 366-370 (2016).
    • (2016) Nat. Methods , vol.13 , pp. 366-370
    • Marbach, D.1
  • 50
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • Hindorff, L. A. et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc. Natl Acad. Sci. USA 106, 9362-9367 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 9362-9367
    • Hindorff, L.A.1
  • 51
    • 84865822182 scopus 로고    scopus 로고
    • Systematic localization of common disease-associated variation in regulatory DNA
    • Maurano, M. T. et al. Systematic localization of common disease-associated variation in regulatory DNA. Science 337, 1190-1195 (2012).
    • (2012) Science , vol.337 , pp. 1190-1195
    • Maurano, M.T.1
  • 52
    • 67649982744 scopus 로고    scopus 로고
    • Diversity and complexity in DNA recognition by transcription factors
    • Badis, G. et al. Diversity and complexity in DNA recognition by transcription factors. Science 324, 1720-1723 (2009).
    • (2009) Science , vol.324 , pp. 1720-1723
    • Badis, G.1
  • 53
    • 0037109192 scopus 로고    scopus 로고
    • Additivity in protein-DNA interactions: How good an approximation is it?
    • Benos, P. V. Additivity in protein-DNA interactions: how good an approximation is it? Nucleic Acids Res. 30, 4442-4451 (2002).
    • (2002) Nucleic Acids Res , vol.30 , pp. 4442-4451
    • Benos, P.V.1
  • 54
    • 33846467150 scopus 로고    scopus 로고
    • A systems approach to measuring the binding energy landscapes of transcription factors
    • Maerkl, S. J. & Quake, S. R. A systems approach to measuring the binding energy landscapes of transcription factors. Science 315, 233-237 (2007).
    • (2007) Science , vol.315 , pp. 233-237
    • Maerkl, S.J.1    Quake, S.R.2
  • 55
    • 23844463779 scopus 로고    scopus 로고
    • Finding short DNA motifs using permuted Markov models
    • Zhao, X., Xiaoyue, Z., Haiyan, H. & Speed, T. P. Finding short DNA motifs using permuted Markov models. J. Comput. Biol. 12, 894-906 (2005).
    • (2005) J. Comput. Biol , vol.12 , pp. 894-906
    • Zhao, X.1    Xiaoyue, Z.2    Haiyan, H.3    Speed, T.P.4
  • 56
    • 50949097456 scopus 로고    scopus 로고
    • Feature based approach to modeling protein-DNA interactions
    • Sharon, E., Eilon, S., Shai, L. & Eran, S. A. Feature based approach to modeling protein-DNA interactions. PLoS Comput. Biol. 4, e1000154 (2008).
    • (2008) PLoS Comput. Biol , vol.4
    • Sharon, E.1    Eilon, S.2    Shai, L.3    Eran, S.A.4
  • 57
    • 77949524141 scopus 로고    scopus 로고
    • A biophysical model for analysis of transcription factor interaction and binding site arrangement from genome-wide binding data
    • He, X. et al. A biophysical model for analysis of transcription factor interaction and binding site arrangement from genome-wide binding data. PLoS ONE 4, e8155 (2009).
    • (2009) PLoS ONE , vol.4
    • He, X.1
  • 58
    • 33750882505 scopus 로고    scopus 로고
    • Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities
    • Berger, M. F. et al. Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities. Nat. Biotechnol. 24, 1429-1435 (2006).
    • (2006) Nat. Biotechnol , vol.24 , pp. 1429-1435
    • Berger, M.F.1
  • 59
    • 79957562270 scopus 로고    scopus 로고
    • A linear model for transcription factor binding affinity prediction in protein binding microarrays
    • Annala, M., Laurila, K., Lähdesmäki, H. & Nykter, M. A linear model for transcription factor binding affinity prediction in protein binding microarrays. PLoS ONE 6, e20059 (2011).
    • (2011) PLoS ONE , vol.6
    • Annala, M.1    Laurila, K.2    Lähdesmäki, H.3    Nykter, M.4
  • 60
    • 84941076570 scopus 로고    scopus 로고
    • Prediction of human population responses to toxic compounds by a collaborative competition
    • Eduati, F. et al. Prediction of human population responses to toxic compounds by a collaborative competition. Nat. Biotechnol. 33, 933-940 (2015).
    • (2015) Nat. Biotechnol , vol.33 , pp. 933-940
    • Eduati, F.1
  • 61
    • 84966539175 scopus 로고    scopus 로고
    • Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease
    • Allen, G. I. et al. Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease. Alzheimers Dement. 12, 645-653 (2016).
    • (2016) Alzheimers Dement , vol.12 , pp. 645-653
    • Allen, G.I.1
  • 63
    • 84907588757 scopus 로고    scopus 로고
    • A probabilistic model to predict clinical phenotypic traits from genome sequencing
    • Chen, Y.-C. et al. A probabilistic model to predict clinical phenotypic traits from genome sequencing. PLoS Comput. Biol. 10, e1003825 (2014).
    • (2014) PLoS Comput. Biol , vol.10
    • Chen, Y.-C.1
  • 65
    • 84963544832 scopus 로고    scopus 로고
    • First design for data sharing
    • Wilbanks, J. & Friend, S. H. First, design for data sharing. Nat. Biotechnol. 34, 377-379 (2016).
    • (2016) Nat. Biotechnol , vol.34 , pp. 377-379
    • Wilbanks, J.1    Friend, S.H.2
  • 66
    • 84960090889 scopus 로고    scopus 로고
    • Crowdsourcing in biomedicine: Challenges and opportunities
    • Khare, R., Good, B. M., Leaman, R., Su, A. I. & Lu, Z. Crowdsourcing in biomedicine: challenges and opportunities. Brief. Bioinform. 17, 23-32 (2015).
    • (2015) Brief. Bioinform , vol.17 , pp. 23-32
    • Khare, R.1    Good, B.M.2    Leaman, R.3    Su, A.I.4    Lu, Z.5
  • 67
    • 84879603028 scopus 로고    scopus 로고
    • Data collection in a flat world: The strengths and weaknesses of Mechanical Turk samples
    • Goodman, J. K., Cryder, C. E. & Cheema, A. Data collection in a flat world: the strengths and weaknesses of Mechanical Turk samples. J. Behav. Decis. Mak. 26, 213-224 (2013).
    • (2013) J. Behav. Decis. Mak , vol.26 , pp. 213-224
    • Goodman, J.K.1    Cryder, C.E.2    Cheema, A.3
  • 68
    • 84885901309 scopus 로고    scopus 로고
    • On crowd-verification of biological networks
    • sbvIMPROVER project team. On crowd-verification of biological networks. Bioinform. Biol. Insights 7, 307-325 (2013).
    • (2013) Bioinform. Biol. Insights , vol.7 , pp. 307-325
  • 69
    • 84976868788 scopus 로고    scopus 로고
    • WikiPathways: Capturing the full diversity of pathway knowledge
    • Kutmon, M. et al. WikiPathways: capturing the full diversity of pathway knowledge. Nucleic Acids Res. 44, D488-D494 (2015).
    • (2015) Nucleic Acids Res , vol.44 , pp. D488-D494
    • Kutmon, M.1
  • 70
    • 84877315835 scopus 로고    scopus 로고
    • A community-driven global reconstruction of human metabolism
    • Thiele, I. et al. A community-driven global reconstruction of human metabolism. Nat. Biotechnol. 31, 419-425 (2013).
    • (2013) Nat. Biotechnol , vol.31 , pp. 419-425
    • Thiele, I.1
  • 71
    • 84863836914 scopus 로고    scopus 로고
    • Crowd sourcing a new paradigm for interactome driven drug target identification in Mycobacterium tuberculosis
    • Vashisht, R. et al. Crowd sourcing a new paradigm for interactome driven drug target identification in Mycobacterium tuberculosis. PLoS ONE 7, e39808 (2012).
    • (2012) PLoS ONE , vol.7
    • Vashisht, R.1
  • 72
    • 84964697298 scopus 로고    scopus 로고
    • Using the wisdom of the crowds to find critical errors in biomedical ontologies: A study of SNOMED CT
    • Mortensen, J. M. et al. Using the wisdom of the crowds to find critical errors in biomedical ontologies: a study of SNOMED CT. J. Am. Med. Inform. Assoc. 22, 640-648 (2015).
    • (2015) J. Am. Med. Inform. Assoc , vol.22 , pp. 640-648
    • Mortensen, J.M.1
  • 73
    • 77955491294 scopus 로고    scopus 로고
    • Predicting protein structures with a multiplayer online game
    • Cooper, S. et al. Predicting protein structures with a multiplayer online game. Nature 466, 756-760 (2010).
    • (2010) Nature , vol.466 , pp. 756-760
    • Cooper, S.1
  • 75
    • 36749055649 scopus 로고    scopus 로고
    • Structure prediction for CASP7 targets using extensive all-atom refinement with Rosetta@home
    • Das, R. et al. Structure prediction for CASP7 targets using extensive all-atom refinement with Rosetta@home. Proteins 69 (Suppl. 8), 118-128 (2007).
    • (2007) Proteins , vol.69 , pp. 118-128
    • Das, R.1
  • 76
    • 84855206623 scopus 로고    scopus 로고
    • Games with a scientific purpose
    • Good, B. M. & Su, A. I. Games with a scientific purpose. Genome Biol. 12, 135 (2011).
    • (2011) Genome Biol , vol.12 , pp. 135
    • Good, B.M.1    Su, A.I.2
  • 77
    • 84923259662 scopus 로고    scopus 로고
    • Scientific rigor through videogames
    • Treuille, A. & Das, R. Scientific rigor through videogames. Trends Biochem. Sci. 39, 507-509 (2014).
    • (2014) Trends Biochem. Sci , vol.39 , pp. 507-509
    • Treuille, A.1    Das, R.2
  • 78
    • 84893831061 scopus 로고    scopus 로고
    • RNA design rules from a massive open laboratory
    • Lee, J. et al. RNA design rules from a massive open laboratory. Proc. Natl Acad. Sci. USA 111, 2122-2127 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 2122-2127
    • Lee, J.1
  • 79
    • 84964319443 scopus 로고    scopus 로고
    • Exploring the quantum speed limit with computer games
    • Sørensen, J. J. W. H. et al. Exploring the quantum speed limit with computer games. Nature 532, 210-213 (2016).
    • (2016) Nature , vol.532 , pp. 210-213
    • Sørensen, J.J.W.H.1
  • 80
    • 84901258583 scopus 로고    scopus 로고
    • Longitude Prize for the twenty-first century
    • Rees, M. A. Longitude Prize for the twenty-first century. Nature 509, 401 (2014).
    • (2014) Nature , vol.509 , pp. 401
    • Rees, M.A.1
  • 81
    • 84897823178 scopus 로고    scopus 로고
    • A doctor in the palm of your hand: How the Qualcomm Tricorder X-Prize could help to revolutionize medical diagnosis
    • Chandler, D. L. A doctor in the palm of your hand: how the Qualcomm Tricorder X-Prize could help to revolutionize medical diagnosis. IEEE Pulse 5, 50-54 (2014).
    • (2014) IEEE Pulse , vol.5 , pp. 50-54
    • Chandler, D.L.1
  • 82
    • 84887477282 scopus 로고    scopus 로고
    • Inferring gene expression from ribosomal promoter sequences, a crowdsourcing approach
    • Meyer, P. et al. Inferring gene expression from ribosomal promoter sequences, a crowdsourcing approach. Genome Res. 23, 1928-1937 (2013).
    • (2013) Genome Res , vol.23 , pp. 1928-1937
    • Meyer, P.1
  • 83
    • 84939199001 scopus 로고    scopus 로고
    • STATISTICS. The reusable holdout: Preserving validity in adaptive data analysis
    • Dwork, C. et al. STATISTICS. The reusable holdout: preserving validity in adaptive data analysis. Science 349, 636-638 (2015).
    • (2015) Science , vol.349 , pp. 636-638
    • Dwork, C.1
  • 85
    • 84961577158 scopus 로고    scopus 로고
    • Community-driven development for computational biology at Sprints, Hackathons and Codefests
    • Möller, S. et al. Community-driven development for computational biology at Sprints, Hackathons and Codefests. BMC Bioinformatics 15, S7 (2014).
    • (2014) BMC Bioinformatics , vol.15
    • Möller, S.1
  • 86
    • 84926291678 scopus 로고    scopus 로고
    • Mitigating risk in academic preclinical drug discovery
    • Dahlin, J. L., Inglese, J. & Walters, M. A. Mitigating risk in academic preclinical drug discovery. Nat. Rev. Drug Discov. 14, 279-294 (2015).
    • (2015) Nat. Rev. Drug Discov , vol.14 , pp. 279-294
    • Dahlin, J.L.1    Inglese, J.2    Walters, M.A.3
  • 87
    • 80052730617 scopus 로고    scopus 로고
    • Verification of systems biology research in the age of collaborative competition
    • Meyer, P. et al. Verification of systems biology research in the age of collaborative competition. Nat. Biotechnol. 29, 811-815 (2011).
    • (2011) Nat. Biotechnol , vol.29 , pp. 811-815
    • Meyer, P.1
  • 88
    • 84877737214 scopus 로고    scopus 로고
    • Development of a prognostic model for breast cancer survival in an open challenge environment
    • Cheng, W.-Y., Ou Yang, T.-H. & Anastassiou, D. Development of a prognostic model for breast cancer survival in an open challenge environment. Sci. Transl. Med. 5, 181ra50 (2013).
    • (2013) Sci. Transl. Med , vol.5
    • Cheng, W.-Y.1    Ou Yang, T.-H.2    Anastassiou, D.3
  • 89
    • 85003049798 scopus 로고    scopus 로고
    • Toward better benchmarking: Challenge-based methods assessment in cancer genomics
    • Boutros, P. C., Margolin, A. A., Stuart, J. M., Califano, A. & Stolovitzky, G. Toward better benchmarking: challenge-based methods assessment in cancer genomics. Genome Biol. 15, 462 (2014).
    • (2014) Genome Biol , vol.15 , pp. 462
    • Boutros, P.C.1    Margolin, A.A.2    Stuart, J.M.3    Califano, A.4    Stolovitzky, G.5
  • 90
    • 84893710009 scopus 로고    scopus 로고
    • Network topology and parameter estimation: From experimental design methods to gene regulatory network kinetics using a community based approach
    • Meyer, P. et al. Network topology and parameter estimation: from experimental design methods to gene regulatory network kinetics using a community based approach. BMC Syst. Biol. 8, 13 (2014).
    • (2014) BMC Syst. Biol , vol.8 , pp. 13
    • Meyer, P.1
  • 91
    • 76749102991 scopus 로고    scopus 로고
    • The Japanese toxicogenomics project: Application of toxicogenomics
    • Uehara, T. et al. The Japanese toxicogenomics project: application of toxicogenomics. Mol. Nutr. Food Res. 54, 218-227 (2010).
    • (2010) Mol. Nutr. Food Res , vol.54 , pp. 218-227
    • Uehara, T.1
  • 92
    • 83055181941 scopus 로고    scopus 로고
    • Assemblathon 1: A competitive assessment of de novo short read assembly methods
    • Earl, D. et al. Assemblathon 1: a competitive assessment of de novo short read assembly methods. Genome Res. 21, 2224-2241 (2011).
    • (2011) Genome Res , vol.21 , pp. 2224-2241
    • Earl, D.1
  • 93
    • 84991528460 scopus 로고    scopus 로고
    • Assemblathon 2: Evaluating de novo methods of genome assembly in three vertebrate species
    • Bradnam, K. R. et al. Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species. Gigascience 2, 10 (2013).
    • (2013) Gigascience , vol.2 , pp. 10
    • Bradnam, K.R.1
  • 94
    • 84913533708 scopus 로고    scopus 로고
    • Alignathon: A competitive assessment of whole-genome alignment methods
    • Earl, D. et al. Alignathon: a competitive assessment of whole-genome alignment methods. Genome Res. 24, 2077-2089 (2014).
    • (2014) Genome Res , vol.24 , pp. 2077-2089
    • Earl, D.1
  • 95
    • 84937191337 scopus 로고    scopus 로고
    • Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection
    • Ewing, A. D. et al. Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection. Nat. Methods 12, 623-630 (2015).
    • (2015) Nat. Methods , vol.12 , pp. 623-630
    • Ewing, A.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.