Diversity and complexity in DNA recognition by transcription factors

Science

Volumn 324, Issue 5935, 2009, Pages 1720-1723

  Badis, Gwenael ^a   Berger, Michael F ^b,c   Philippakis, Anthony A ^b,c,d   Talukder, Shaheynoor ^a,e   Gehrke, Andrew R ^b   Jaeger, Savina A ^b   Chan, Esther T ^e   Metzler, Genita ^f   Vedenko, Anastasia ^g   Chen, Xiaoyu ^a   Kuznetsov, Hanna ^f   Wang, Chi Fong ^f   Coburn, David ^a   Newburger, Daniel E ^b   Morris, Quaid ^a,e   Hughes, Timothy R ^a,e   Bulyk, Martha L ^b,c,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD UNIVERSITY   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF TORONTO   (Canada)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^g WELLESLEY COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA BINDING PROTEIN; TRANSCRIPTION FACTOR; HYBRID PROTEIN;

COMPLEXITY; CYTOLOGY; DNA; EVOLUTION; PROTEIN; SPECIES DIVERSITY;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; DNA DETERMINATION; DNA MICROARRAY; DNA SEQUENCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN DNA INTERACTION; PROTEIN MOTIF; PROTEIN STRUCTURE; ANIMAL; CHEMISTRY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; HUMAN; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN MICROARRAY; PROTEIN TERTIARY STRUCTURE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; DNA; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; HUMANS; MICE; PROTEIN ARRAY ANALYSIS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; TRANSCRIPTION FACTORS;

EID: 67649982744     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1162327     Document Type: Article

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35. This project was supported by funding from the Canadian Institutes of Health Research (MOP-77721 and postdoctoral fellowship to G.B.); Genome Canada through the Ontario Genomics Institute, the Ontario Research Fund, and the Canadian Institute for Advanced Research (to T.R.H.); NSF (to M.F.B.); the Canadian Foundation for Innovation and Ontario Research Fund (to Q.M.); and grant R01 HG003985 from NIH/National Human Genome Research Institute (to M.L.B.). We thank L Peña-Castillo, A. Cheung, M. Chan, S. Bhinder, F. Bréard, P. Qureshi, S. Mnaimneh, M. Kekis, F. Khalid, J. Holroyd, D. Terterov, and K. Robasky for technical assistance and S. Gisselbrecht, K. Struhl, and S. Sunyaev for critical reading of the manuscript. PBM data are available at http://the-brain.bwh.harvard.edu/pbms/ webworks/ and also via the publicly available UniPROBE database (31).