-
1
-
-
0035799806
-
Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
-
COI: 1:STN:280:DC%2BD3M3kvFejsA%3D%3D, PID: 11333990
-
Tuomilehto J, Lindström J, Eriksson JG et al (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344:1343–1350
-
(2001)
N Engl J Med
, vol.344
, pp. 1343-1350
-
-
Tuomilehto, J.1
Lindström, J.2
Eriksson, J.G.3
-
2
-
-
0037034257
-
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
-
COI: 1:CAS:528:DC%2BD38XhtVWqurc%3D, PID: 11832527
-
Knowler WC, Barrett-Connor E et al (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393–403
-
(2002)
N Engl J Med
, vol.346
, pp. 393-403
-
-
Knowler, W.C.1
Barrett-Connor, E.2
-
3
-
-
43849111166
-
The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study
-
PID: 18502303
-
Li G, Zhang P, Wang J et al (2008) The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study. Lancet 371:1783–1789
-
(2008)
Lancet
, vol.371
, pp. 1783-1789
-
-
Li, G.1
Zhang, P.2
Wang, J.3
-
4
-
-
84862302415
-
Effect of regression from prediabetes to normal glucose regulation on long-term reduction in diabetes risk: results from the Diabetes Prevention Program Outcomes Study
-
COI: 1:CAS:528:DC%2BC38XosVejsr8%3D, PID: 22683134
-
Perreault L, Pan Q, Mather KJ et al (2012) Effect of regression from prediabetes to normal glucose regulation on long-term reduction in diabetes risk: results from the Diabetes Prevention Program Outcomes Study. Lancet 379:2243–2251
-
(2012)
Lancet
, vol.379
, pp. 2243-2251
-
-
Perreault, L.1
Pan, Q.2
Mather, K.J.3
-
5
-
-
33947153419
-
High visceral fat mass and high liver fat are associated with resistance to lifestyle intervention
-
Thamer C, Machann J, Stefan N et al (2007) High visceral fat mass and high liver fat are associated with resistance to lifestyle intervention. Obesity (Silver Spring) 15:531–538
-
(2007)
Obesity (Silver Spring)
, vol.15
, pp. 531-538
-
-
Thamer, C.1
Machann, J.2
Stefan, N.3
-
6
-
-
34249852535
-
Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention
-
COI: 1:CAS:528:DC%2BD2sXlt1Oktb8%3D, PID: 17327385
-
Stefan N, Thamer C, Staiger H et al (2007) Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention. J Clin Endocrinol Metab 92:1827–1833
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 1827-1833
-
-
Stefan, N.1
Thamer, C.2
Staiger, H.3
-
7
-
-
84946495886
-
A high-risk phenotype associates with reduced improvement in glycaemia during a lifestyle intervention in prediabetes
-
COI: 1:CAS:528:DC%2BC2MXhsFKktb%2FE, PID: 26404062
-
Stefan N, Staiger H, Wagner R et al (2015) A high-risk phenotype associates with reduced improvement in glycaemia during a lifestyle intervention in prediabetes. Diabetologia 58:2877–2884
-
(2015)
Diabetologia
, vol.58
, pp. 2877-2884
-
-
Stefan, N.1
Staiger, H.2
Wagner, R.3
-
8
-
-
0032742992
-
The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
-
COI: 1:CAS:528:DyaK1MXmtFGltbg%3D, PID: 10491414
-
Weyer C, Bogardus C, Mott DM, Pratley RE (1999) The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 104:787–794
-
(1999)
J Clin Invest
, vol.104
, pp. 787-794
-
-
Weyer, C.1
Bogardus, C.2
Mott, D.M.3
Pratley, R.E.4
-
9
-
-
84906940729
-
Definition of intervention points in prediabetes
-
PID: 24731662
-
Ferrannini E (2014) Definition of intervention points in prediabetes. Lancet Diabetes Endocrinol 2:667–675
-
(2014)
Lancet Diabetes Endocrinol
, vol.2
, pp. 667-675
-
-
Ferrannini, E.1
-
10
-
-
33845881411
-
Mechanisms linking obesity to insulin resistance and type 2 diabetes
-
COI: 1:CAS:528:DC%2BD28XhtlShtrzP, PID: 17167471
-
Kahn SE, Hull RL, Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444:840–846
-
(2006)
Nature
, vol.444
, pp. 840-846
-
-
Kahn, S.E.1
Hull, R.L.2
Utzschneider, K.M.3
-
11
-
-
0036318476
-
Accurate assessment of beta-cell function: the hyperbolic correction
-
COI: 1:CAS:528:DC%2BD38XhtVaqsbs%3D, PID: 11815482
-
Bergman RN, Ader M, Huecking K, Van Citters G (2002) Accurate assessment of beta-cell function: the hyperbolic correction. Diabetes 51(Suppl 1):S212–S220
-
(2002)
Diabetes
, vol.51
, pp. S212-S220
-
-
Bergman, R.N.1
Ader, M.2
Huecking, K.3
Van Citters, G.4
-
12
-
-
65549163338
-
Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men
-
PID: 19223598
-
Stancáková A, Javorský M, Kuulasmaa T, Haffner SM, Kuusisto J, Laakso M (2009) Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men. Diabetes 58:1212–1221
-
(2009)
Diabetes
, vol.58
, pp. 1212-1221
-
-
Stancáková, A.1
Javorský, M.2
Kuulasmaa, T.3
Haffner, S.M.4
Kuusisto, J.5
Laakso, M.6
-
13
-
-
0024348996
-
Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus
-
COI: 1:STN:280:DyaL1MzhsVWitg%3D%3D, PID: 2664520
-
Eriksson J, Franssila-Kallunki A, Ekstrand A et al (1989) Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N Engl J Med 321:337–343
-
(1989)
N Engl J Med
, vol.321
, pp. 337-343
-
-
Eriksson, J.1
Franssila-Kallunki, A.2
Ekstrand, A.3
-
14
-
-
55649105963
-
Clinical risk factors, DNA variants, and the development of type 2 diabetes
-
COI: 1:CAS:528:DC%2BD1cXhtl2gurnF, PID: 19020324
-
Lyssenko V, Jonsson A, Almgren P et al (2008) Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med 359:2220–2232
-
(2008)
N Engl J Med
, vol.359
, pp. 2220-2232
-
-
Lyssenko, V.1
Jonsson, A.2
Almgren, P.3
-
15
-
-
84943785470
-
Recent advances in understanding the genetic architecture of type 2 diabetes
-
COI: 1:CAS:528:DC%2BC2MXitVGjsrzJ, PID: 26160912
-
Mohlke KL, Boehnke M (2015) Recent advances in understanding the genetic architecture of type 2 diabetes. Hum Mol Genet 24:R85–R92
-
(2015)
Hum Mol Genet
, vol.24
, pp. R85-R92
-
-
Mohlke, K.L.1
Boehnke, M.2
-
16
-
-
84895868553
-
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
-
DIAbetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium
-
DIAbetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium et al (2014) Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet 46:234–244
-
(2014)
Nat Genet
, vol.46
, pp. 234-244
-
-
-
17
-
-
84906219758
-
Peroxisome proliferator-activated receptor gamma (PPARG) modulates free fatty acid receptor 1 (FFAR1) dependent insulin secretion in humans
-
COI: 1:CAS:528:DC%2BC2cXht1agsL%2FO, PID: 25161890
-
Wagner R, Hieronimus A, Lamprinou A et al (2014) Peroxisome proliferator-activated receptor gamma (PPARG) modulates free fatty acid receptor 1 (FFAR1) dependent insulin secretion in humans. Mol Metab 3:676–680
-
(2014)
Mol Metab
, vol.3
, pp. 676-680
-
-
Wagner, R.1
Hieronimus, A.2
Lamprinou, A.3
-
18
-
-
84897108150
-
Untangling the interplay of genetic and metabolic influences on beta-cell function: examples of potential therapeutic implications involving TCF7L2 and FFAR1
-
COI: 1:CAS:528:DC%2BC2cXitlehur8%3D, PID: 24749055
-
Wagner R, Staiger H, Ullrich S, Stefan N, Fritsche A, Häring HU (2014) Untangling the interplay of genetic and metabolic influences on beta-cell function: examples of potential therapeutic implications involving TCF7L2 and FFAR1. Mol Metab 3:261–267
-
(2014)
Mol Metab
, vol.3
, pp. 261-267
-
-
Wagner, R.1
Staiger, H.2
Ullrich, S.3
Stefan, N.4
Fritsche, A.5
Häring, H.U.6
-
19
-
-
84883250341
-
Nor-1, a novel incretin-responsive regulator of insulin genes and insulin secretion
-
COI: 1:CAS:528:DC%2BC3sXhsFentbbM, PID: 24044104
-
Ordelheide AM, Gerst F, Rothfuss O et al (2013) Nor-1, a novel incretin-responsive regulator of insulin genes and insulin secretion. Mol Metab 2:243–255
-
(2013)
Mol Metab
, vol.2
, pp. 243-255
-
-
Ordelheide, A.M.1
Gerst, F.2
Rothfuss, O.3
-
20
-
-
35848942800
-
Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms
-
PID: 17661009
-
Schäfer SA, Tschritter O, Machicao F et al (2007) Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms. Diabetologia 50:2443–2450
-
(2007)
Diabetologia
, vol.50
, pp. 2443-2450
-
-
Schäfer, S.A.1
Tschritter, O.2
Machicao, F.3
-
21
-
-
67349190497
-
A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion
-
PID: 19330314
-
Schäfer SA, Müssig K, Staiger H et al (2009) A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion. Diabetologia 52:1075–1082
-
(2009)
Diabetologia
, vol.52
, pp. 1075-1082
-
-
Schäfer, S.A.1
Müssig, K.2
Staiger, H.3
-
22
-
-
67650251656
-
Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion
-
PID: 19366866
-
Müssig K, Staiger H, Machicao F et al (2009) Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion. Diabetes 58:1715–1720
-
(2009)
Diabetes
, vol.58
, pp. 1715-1720
-
-
Müssig, K.1
Staiger, H.2
Machicao, F.3
-
23
-
-
78650063109
-
Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
-
COI: 1:CAS:528:DC%2BC3MXlsVakug%3D%3D, PID: 20802253
-
Heni M, Ketterer C, Thamer C et al (2010) Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion. Diabetes 59:3247–3252
-
(2010)
Diabetes
, vol.59
, pp. 3247-3252
-
-
Heni, M.1
Ketterer, C.2
Thamer, C.3
-
24
-
-
0035032780
-
Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator—activated receptor-gamma2 gene
-
COI: 1:CAS:528:DC%2BD3MXkvFSgu7Y%3D, PID: 11334419
-
Stefan N, Fritsche A, Häring H, Stumvoll M (2001) Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator—activated receptor-gamma2 gene. Diabetes 50:1143–1148
-
(2001)
Diabetes
, vol.50
, pp. 1143-1148
-
-
Stefan, N.1
Fritsche, A.2
Häring, H.3
Stumvoll, M.4
-
25
-
-
84878230795
-
Reevaluation of fatty acid receptor 1 (FFAR1/GPR40) as drug target for the stimulation of insulin secretion in humans
-
COI: 1:CAS:528:DC%2BC3sXpt1Orsb8%3D, PID: 23378609
-
Wagner R, Kaiser G, Gerst F et al (2013) Reevaluation of fatty acid receptor 1 (FFAR1/GPR40) as drug target for the stimulation of insulin secretion in humans. Diabetes 62:2106–2111
-
(2013)
Diabetes
, vol.62
, pp. 2106-2111
-
-
Wagner, R.1
Kaiser, G.2
Gerst, F.3
-
26
-
-
84902440103
-
Clinical and non-targeted metabolomic profiling of homozygous carriers of transcription factor 7-like 2 variant rs7903146
-
COI: 1:CAS:528:DC%2BC2MXksVSqu7w%3D, PID: 24925104
-
Wagner R, Li J, Kenar E et al (2014) Clinical and non-targeted metabolomic profiling of homozygous carriers of transcription factor 7-like 2 variant rs7903146. Sci Rep 4:5296
-
(2014)
Sci Rep
, vol.4
, pp. 5296
-
-
Wagner, R.1
Li, J.2
Kenar, E.3
-
27
-
-
79953812139
-
Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B
-
COI: 1:CAS:528:DC%2BC3MXivFCgsbg%3D, PID: 21234743
-
Hribal ML, Presta I, Procopio T et al (2011) Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B. Diabetologia 54:795–802
-
(2011)
Diabetologia
, vol.54
, pp. 795-802
-
-
Hribal, M.L.1
Presta, I.2
Procopio, T.3
-
28
-
-
80051937658
-
Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin
-
COI: 1:CAS:528:DC%2BC3MXhtFyrs7vM, PID: 21887289
-
Wagner R, Dudziak K, Herzberg-Schäfer SA et al (2011) Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin. PLoS One 6, e23639
-
(2011)
PLoS One
, vol.6
-
-
Wagner, R.1
Dudziak, K.2
Herzberg-Schäfer, S.A.3
-
29
-
-
77449161166
-
Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps
-
PID: 19808892
-
‘t Hart LM, Simonis-Bik AM, Nijpels G et al (2010) Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps. Diabetes 59:287–292
-
(2010)
Diabetes
, vol.59
, pp. 287-292
-
-
‘t Hart, L.M.1
Simonis-Bik, A.M.2
Nijpels, G.3
-
30
-
-
66149119359
-
The inhibitory effect of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivity
-
COI: 1:CAS:528:DC%2BD1MXlvVCqurw%3D, PID: 19258404
-
Haupt A, Guthoff M, Schäfer SA et al (2009) The inhibitory effect of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivity. J Clin Endocrinol Metab 94:1775–1780
-
(2009)
J Clin Endocrinol Metab
, vol.94
, pp. 1775-1780
-
-
Haupt, A.1
Guthoff, M.2
Schäfer, S.A.3
-
31
-
-
59449091250
-
The risk allele load accelerates the age-dependent decline in beta cell function
-
COI: 1:STN:280:DC%2BD1M7hs12nsg%3D%3D, PID: 19172244
-
Haupt A, Staiger H, Schäfer SA et al (2009) The risk allele load accelerates the age-dependent decline in beta cell function. Diabetologia 52:457–462
-
(2009)
Diabetologia
, vol.52
, pp. 457-462
-
-
Haupt, A.1
Staiger, H.2
Schäfer, S.A.3
-
32
-
-
49249094275
-
Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps
-
COI: 1:CAS:528:DC%2BD1cXpsVGitb4%3D, PID: 18618095
-
Groenewoud MJ, Dekker JM, Fritsche A et al (2008) Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps. Diabetologia 51:1659–1663
-
(2008)
Diabetologia
, vol.51
, pp. 1659-1663
-
-
Groenewoud, M.J.1
Dekker, J.M.2
Fritsche, A.3
-
33
-
-
41849117959
-
The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients—the EUGENE2 study
-
COI: 1:CAS:528:DC%2BD1cXkt1yjs78%3D, PID: 18324385
-
Boesgaard TW, Zilinskaite J, Vänttinen M et al (2008) The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients—the EUGENE2 study. Diabetologia 51:816–820
-
(2008)
Diabetologia
, vol.51
, pp. 816-820
-
-
Boesgaard, T.W.1
Zilinskaite, J.2
Vänttinen, M.3
-
34
-
-
40749087319
-
A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study
-
COI: 1:CAS:528:DC%2BD1cXhvVOktLc%3D, PID: 18039816
-
Staiger H, Stancáková A, Zilinskaite J et al (2008) A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study. Diabetes 57:514–517
-
(2008)
Diabetes
, vol.57
, pp. 514-517
-
-
Staiger, H.1
Stancáková, A.2
Zilinskaite, J.3
-
35
-
-
43249095915
-
Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance
-
PID: 18285412
-
Stancáková A, Pihlajamäki J, Kuusisto J et al (2008) Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance. J Clin Endocrinol Metab 93:1924–1930
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 1924-1930
-
-
Stancáková, A.1
Pihlajamäki, J.2
Kuusisto, J.3
-
36
-
-
58049198441
-
Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function
-
PID: 19088850
-
Staiger H, Machicao F, Schäfer SA et al (2008) Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function. PLoS One 3, e3962
-
(2008)
PLoS One
, vol.3
-
-
Staiger, H.1
Machicao, F.2
Schäfer, S.A.3
-
37
-
-
51549112931
-
Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes
-
PID: 18714373
-
Staiger H, Machicao F, Kantartzis K et al (2008) Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes. PLoS One 3, e3019
-
(2008)
PLoS One
, vol.3
-
-
Staiger, H.1
Machicao, F.2
Kantartzis, K.3
-
38
-
-
41149178492
-
Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion
-
COI: 1:CAS:528:DC%2BD1cXjsFGiu7o%3D, PID: 18264689
-
Kirchhoff K, Machicao F, Haupt A et al (2008) Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia 51:597–601
-
(2008)
Diabetologia
, vol.51
, pp. 597-601
-
-
Kirchhoff, K.1
Machicao, F.2
Haupt, A.3
-
39
-
-
38849129636
-
Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function
-
PID: 17786204
-
Staiger H, Machicao F, Stefan N et al (2007) Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function. PLoS One 2, e832
-
(2007)
PLoS One
, vol.2
-
-
Staiger, H.1
Machicao, F.2
Stefan, N.3
-
40
-
-
77950344135
-
Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes
-
COI: 1:CAS:528:DC%2BC3cXjslensr4%3D, PID: 20028944
-
Haupt A, Thamer C, Heni M et al (2010) Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes. Diabetes 59:747–750
-
(2010)
Diabetes
, vol.59
, pp. 747-750
-
-
Haupt, A.1
Thamer, C.2
Heni, M.3
-
41
-
-
84859073619
-
Dietary fiber intake modulates the association between variants in TCF7L2 and weight loss during a lifestyle intervention
-
PID: 22355027
-
Heni M, Herzberg-Schäfer S, Machicao F, Häring HU, Fritsche A (2012) Dietary fiber intake modulates the association between variants in TCF7L2 and weight loss during a lifestyle intervention. Diabetes Care 35, e24
-
(2012)
Diabetes Care
, vol.35
-
-
Heni, M.1
Herzberg-Schäfer, S.2
Machicao, F.3
Häring, H.U.4
Fritsche, A.5
-
42
-
-
40949141938
-
Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets
-
COI: 1:CAS:528:DC%2BD1cXjt1Chtbo%3D, PID: 18071026
-
Shu L, Sauter NS, Schulthess FT, Matveyenko AV, Oberholzer J, Maedler K (2008) Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets. Diabetes 57:645–653
-
(2008)
Diabetes
, vol.57
, pp. 645-653
-
-
Shu, L.1
Sauter, N.S.2
Schulthess, F.T.3
Matveyenko, A.V.4
Oberholzer, J.5
Maedler, K.6
-
43
-
-
67349102328
-
The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men
-
COI: 1:CAS:528:DC%2BD1MXms1yhs70%3D, PID: 19288077
-
Pilgaard K, Jensen CB, Schou JH et al (2009) The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men. Diabetologia 52:1298–1307
-
(2009)
Diabetologia
, vol.52
, pp. 1298-1307
-
-
Pilgaard, K.1
Jensen, C.B.2
Schou, J.H.3
-
44
-
-
77449099615
-
TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action
-
COI: 1:CAS:528:DC%2BC3cXhvVyru7Y%3D, PID: 19934000
-
Villareal DT, Robertson H, Bell GI et al (2010) TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. Diabetes 59:479–485
-
(2010)
Diabetes
, vol.59
, pp. 479-485
-
-
Villareal, D.T.1
Robertson, H.2
Bell, G.I.3
-
45
-
-
34547702501
-
Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes
-
COI: 1:CAS:528:DC%2BD2sXoslOnsrk%3D, PID: 17671651
-
Lyssenko V, Lupi R, Marchetti P et al (2007) Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 117:2155–2163
-
(2007)
J Clin Invest
, vol.117
, pp. 2155-2163
-
-
Lyssenko, V.1
Lupi, R.2
Marchetti, P.3
-
46
-
-
84905569407
-
Influence of TCF7L2 gene variants on the therapeutic response to the dipeptidylpeptidase-4 inhibitor linagliptin
-
COI: 1:CAS:528:DC%2BC2cXhtVShtbrL, PID: 24906949
-
Zimdahl H, Ittrich C, Graefe-Mody U et al (2014) Influence of TCF7L2 gene variants on the therapeutic response to the dipeptidylpeptidase-4 inhibitor linagliptin. Diabetologia 57:1869–1875
-
(2014)
Diabetologia
, vol.57
, pp. 1869-1875
-
-
Zimdahl, H.1
Ittrich, C.2
Graefe-Mody, U.3
-
47
-
-
33746075560
-
TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program
-
COI: 1:CAS:528:DC%2BD28XntVWktrw%3D, PID: 16855264
-
Florez JC, Jablonski KA, Bayley N et al (2006) TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 355:241–250
-
(2006)
N Engl J Med
, vol.355
, pp. 241-250
-
-
Florez, J.C.1
Jablonski, K.A.2
Bayley, N.3
-
48
-
-
53749085475
-
Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins
-
COI: 1:CAS:528:DC%2BD1cXht1GmurrP
-
Wegner L, Hussain MS, Pilgaard K et al (2008) Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins. Clin Endocrinol Metab 93:4013–4019
-
(2008)
Clin Endocrinol Metab
, vol.93
, pp. 4013-4019
-
-
Wegner, L.1
Hussain, M.S.2
Pilgaard, K.3
-
49
-
-
77951175614
-
The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest
-
COI: 1:CAS:528:DC%2BC3cXltFSmtr0%3D, PID: 20107109
-
Alibegovic AC, Sonne MP, Højbjerre L et al (2010) The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest. Diabetes 59:836–843
-
(2010)
Diabetes
, vol.59
, pp. 836-843
-
-
Alibegovic, A.C.1
Sonne, M.P.2
Højbjerre, L.3
-
50
-
-
84939125175
-
Glucose metabolism in high-risk subjects for type 2 diabetes carrying the rs7903146 TCF7L2 gene variant
-
PID: 26046964
-
Daniele G, Gaggini M, Comassi M et al (2015) Glucose metabolism in high-risk subjects for type 2 diabetes carrying the rs7903146 TCF7L2 gene variant. J Clin Endocrinol Metab 100:E1160–E1167
-
(2015)
J Clin Endocrinol Metab
, vol.100
, pp. E1160-E1167
-
-
Daniele, G.1
Gaggini, M.2
Comassi, M.3
-
51
-
-
84866072918
-
TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals
-
COI: 1:CAS:528:DC%2BC38XhtlWlsrjJ, PID: 22911383
-
Le Bacquer O, Kerr-Conte J, Gargani S et al (2012) TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals. Diabetologia 55:2677–2681
-
(2012)
Diabetologia
, vol.55
, pp. 2677-2681
-
-
Le Bacquer, O.1
Kerr-Conte, J.2
Gargani, S.3
-
52
-
-
77958546383
-
Follow-up whole-body assessment of adipose tissue compartments during a lifestyle intervention in a large cohort at increased risk for type 2 diabetes
-
PID: 20713612
-
Machann J, Thamer C, Stefan N et al (2010) Follow-up whole-body assessment of adipose tissue compartments during a lifestyle intervention in a large cohort at increased risk for type 2 diabetes. Radiology 257:353–363
-
(2010)
Radiology
, vol.257
, pp. 353-363
-
-
Machann, J.1
Thamer, C.2
Stefan, N.3
-
53
-
-
77957791292
-
Interscapular fat is strongly associated with insulin resistance
-
COI: 1:CAS:528:DC%2BC3cXhtlCktLjL, PID: 20660049
-
Thamer C, Machann J, Staiger H et al (2010) Interscapular fat is strongly associated with insulin resistance. J Clin Endocrinol Metab 95:4736–4742
-
(2010)
J Clin Endocrinol Metab
, vol.95
, pp. 4736-4742
-
-
Thamer, C.1
Machann, J.2
Staiger, H.3
-
54
-
-
53549086389
-
Perivascular fatty tissue at the brachial artery is linked to insulin resistance but not to local endothelial dysfunction
-
COI: 1:CAS:528:DC%2BD1cXht1amsrfM, PID: 18712517
-
Rittig K, Staib K, Machann J et al (2008) Perivascular fatty tissue at the brachial artery is linked to insulin resistance but not to local endothelial dysfunction. Diabetologia 51:2093–2099
-
(2008)
Diabetologia
, vol.51
, pp. 2093-2099
-
-
Rittig, K.1
Staib, K.2
Machann, J.3
-
55
-
-
49449092403
-
Identification and characterization of metabolically benign obesity in humans
-
PID: 18695074
-
Stefan N, Kantartzis K, Machann J et al (2008) Identification and characterization of metabolically benign obesity in humans. Arch Intern Med 168:1609–1616
-
(2008)
Arch Intern Med
, vol.168
, pp. 1609-1616
-
-
Stefan, N.1
Kantartzis, K.2
Machann, J.3
-
56
-
-
79953807628
-
Effects of a lifestyle intervention in metabolically benign and malign obesity
-
COI: 1:STN:280:DC%2BC3M3lt1aqsg%3D%3D, PID: 21174075
-
Kantartzis K, Machann J, Schick F et al (2011) Effects of a lifestyle intervention in metabolically benign and malign obesity. Diabetologia 54:864–868
-
(2011)
Diabetologia
, vol.54
, pp. 864-868
-
-
Kantartzis, K.1
Machann, J.2
Schick, F.3
-
57
-
-
84884500386
-
Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications
-
PID: 24622321
-
Stefan N, Häring HU, Hu FB, Schulze MB (2013) Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications. Lancet Diabetes Endocrinol 1:152–162
-
(2013)
Lancet Diabetes Endocrinol
, vol.1
, pp. 152-162
-
-
Stefan, N.1
Häring, H.U.2
Hu, F.B.3
Schulze, M.B.4
-
58
-
-
80052840577
-
The metabolically benign and malignant fatty liver
-
COI: 1:CAS:528:DC%2BC3MXhtValurvL, PID: 21788578
-
Stefan N, Häring HU (2011) The metabolically benign and malignant fatty liver. Diabetes 60:2011–2017
-
(2011)
Diabetes
, vol.60
, pp. 2011-2017
-
-
Stefan, N.1
Häring, H.U.2
-
59
-
-
56749096610
-
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
-
COI: 1:CAS:528:DC%2BD1cXhsVWgsrrP, PID: 18820647
-
Romeo S, Kozlitina J, Xing C et al (2008) Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 40:1461–1465
-
(2008)
Nat Genet
, vol.40
, pp. 1461-1465
-
-
Romeo, S.1
Kozlitina, J.2
Xing, C.3
-
60
-
-
70350550096
-
Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene
-
COI: 1:CAS:528:DC%2BD1MXhsVCht7%2FM, PID: 19651814
-
Kantartzis K, Peter A, Machicao F et al (2009) Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene. Diabetes 58:2616–2623
-
(2009)
Diabetes
, vol.58
, pp. 2616-2623
-
-
Kantartzis, K.1
Peter, A.2
Machicao, F.3
-
61
-
-
84926660045
-
PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans
-
COI: 1:CAS:528:DC%2BC2cXhtFShsbrL, PID: 24972532
-
Peter A, Kovarova M, Nadalin S et al (2014) PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans. Diabetologia 57:2103–2107
-
(2014)
Diabetologia
, vol.57
, pp. 2103-2107
-
-
Peter, A.1
Kovarova, M.2
Nadalin, S.3
-
62
-
-
84951083544
-
The genetic variant I148M in PNPLA3 is associated with increased hepatic retinyl-palmitate storage in humans
-
PID: 26439088
-
Kovarova M, Königsrainer I, Königsrainer A et al (2015) The genetic variant I148M in PNPLA3 is associated with increased hepatic retinyl-palmitate storage in humans. J Clin Endocrinol Metab 100:E1568–E1574
-
(2015)
J Clin Endocrinol Metab
, vol.100
, pp. E1568-E1574
-
-
Kovarova, M.1
Königsrainer, I.2
Königsrainer, A.3
-
63
-
-
84875549943
-
The role of hepatokines in metabolism
-
COI: 1:CAS:528:DC%2BC3sXjtVaktb4%3D, PID: 23337953
-
Stefan N, Häring HU (2013) The role of hepatokines in metabolism. Nat Rev Endocrinol 9:144–152
-
(2013)
Nat Rev Endocrinol
, vol.9
, pp. 144-152
-
-
Stefan, N.1
Häring, H.U.2
-
64
-
-
84878433548
-
Circulating fetuin-A and free fatty acids interact to predict insulin resistance in humans
-
COI: 1:CAS:528:DC%2BC3sXlt1aqtbo%3D, PID: 23558619
-
Stefan N, Häring HU (2013) Circulating fetuin-A and free fatty acids interact to predict insulin resistance in humans. Nat Med 19:394–395
-
(2013)
Nat Med
, vol.19
, pp. 394-395
-
-
Stefan, N.1
Häring, H.U.2
-
65
-
-
84918819322
-
Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease
-
PID: 25470709
-
Stefan N, Schick F, Häring HU (2014) Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. N Engl J Med 371:2236–2237
-
(2014)
N Engl J Med
, vol.371
, pp. 2236-2237
-
-
Stefan, N.1
Schick, F.2
Häring, H.U.3
-
66
-
-
56649094538
-
Plasma fetuin-A levels and the risk of type 2 diabetes
-
COI: 1:CAS:528:DC%2BD1MXhs1Knt74%3D, PID: 18633113
-
Stefan N, Fritsche A, Weikert C et al (2008) Plasma fetuin-A levels and the risk of type 2 diabetes. Diabetes 57:2762–2767
-
(2008)
Diabetes
, vol.57
, pp. 2762-2767
-
-
Stefan, N.1
Fritsche, A.2
Weikert, C.3
-
67
-
-
58149393662
-
Plasma fetuin-a levels and the risk of myocardial infarction and ischemic stroke
-
COI: 1:CAS:528:DC%2BD1cXhsVerurrM, PID: 19029462
-
Weikert C, Stefan N, Schulze MB et al (2008) Plasma fetuin-a levels and the risk of myocardial infarction and ischemic stroke. Circulation 118:2555–2562
-
(2008)
Circulation
, vol.118
, pp. 2555-2562
-
-
Weikert, C.1
Stefan, N.2
Schulze, M.B.3
-
68
-
-
77955069684
-
NF-kB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance
-
COI: 1:CAS:528:DC%2BC3cXovVCnsrc%3D, PID: 20482516
-
Dasgupta S, Bhattacharya S, Biswas A et al (2010) NF-kB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance. Biochem J 429:451–462
-
(2010)
Biochem J
, vol.429
, pp. 451-462
-
-
Dasgupta, S.1
Bhattacharya, S.2
Biswas, A.3
-
69
-
-
73249130996
-
High glucose induces transactivation of the alpha2-HS glycoprotein gene through the ERK1/2 signaling pathway
-
COI: 1:CAS:528:DC%2BD1MXht1antrjP, PID: 19672022
-
Takata H, Ikeda Y, Suehiro T et al (2009) High glucose induces transactivation of the alpha2-HS glycoprotein gene through the ERK1/2 signaling pathway. J Atheroscler Thromb 16:448–456
-
(2009)
J Atheroscler Thromb
, vol.16
, pp. 448-456
-
-
Takata, H.1
Ikeda, Y.2
Suehiro, T.3
-
70
-
-
84955475087
-
Exendin-4 inhibits the expression of SEPP1 and fetuin-A via improvement of palmitic acid-induced endoplasmic reticulum stress by AMPK
-
Lee J, Hong SW, Park SE et al (2015) Exendin-4 inhibits the expression of SEPP1 and fetuin-A via improvement of palmitic acid-induced endoplasmic reticulum stress by AMPK. Endocrinol Metab (Seoul) 2015:177–184
-
(2015)
Endocrinol Metab (Seoul)
, vol.2015
, pp. 177-184
-
-
Lee, J.1
Hong, S.W.2
Park, S.E.3
-
71
-
-
0027333427
-
Serum alpha 2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level
-
COI: 1:CAS:528:DyaK2cXhvVGqtbg%3D, PID: 7906861
-
Srinivas PR, Wagner AS, Reddy LV et al (1993) Serum alpha 2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level. Mol Endocrinol 7:1445–1455
-
(1993)
Mol Endocrinol
, vol.7
, pp. 1445-1455
-
-
Srinivas, P.R.1
Wagner, A.S.2
Reddy, L.V.3
-
72
-
-
84898597887
-
Fetuin-A influences vascular cell growth and production of proinflammatory and angiogenic proteins by human perivascular fat cells
-
COI: 1:CAS:528:DC%2BC2cXhs1KisLo%3D, PID: 24493202
-
Siegel-Axel DI, Ullrich S, Stefan N et al (2014) Fetuin-A influences vascular cell growth and production of proinflammatory and angiogenic proteins by human perivascular fat cells. Diabetologia 57:1057–1066
-
(2014)
Diabetologia
, vol.57
, pp. 1057-1066
-
-
Siegel-Axel, D.I.1
Ullrich, S.2
Stefan, N.3
-
73
-
-
84864657351
-
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
-
COI: 1:CAS:528:DC%2BC38XhtFWms73L, PID: 22842477
-
Pal D, Dasgupta S, Kundu R et al (2012) Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat Med 18:1279–1285
-
(2012)
Nat Med
, vol.18
, pp. 1279-1285
-
-
Pal, D.1
Dasgupta, S.2
Kundu, R.3
-
74
-
-
19744362790
-
Vasocrine” signalling from perivascular fat: a mechanism linking insulin resistance to vascular disease
-
PID: 15910955
-
Yudkin JS, Eringa E, Stehouwer CD (2005) “Vasocrine” signalling from perivascular fat: a mechanism linking insulin resistance to vascular disease. Lancet 365:1817–1820
-
(2005)
Lancet
, vol.365
, pp. 1817-1820
-
-
Yudkin, J.S.1
Eringa, E.2
Stehouwer, C.D.3
-
75
-
-
79955920129
-
Perivascular adipose tissue and its role in type 2 diabetes and cardiovascular disease
-
COI: 1:CAS:528:DC%2BC3MXlsFagsbs%3D, PID: 21461998
-
Meijer RI, Serne EH, Smulders YM, van Hinsbergh VW, Yudkin JS, Eringa EC (2011) Perivascular adipose tissue and its role in type 2 diabetes and cardiovascular disease. Curr Diab Rep 11:211–217
-
(2011)
Curr Diab Rep
, vol.11
, pp. 211-217
-
-
Meijer, R.I.1
Serne, E.H.2
Smulders, Y.M.3
van Hinsbergh, V.W.4
Yudkin, J.S.5
Eringa, E.C.6
-
76
-
-
84862564234
-
The secretion pattern of perivascular fat cells is different from that of subcutaneous and visceral fat cells
-
COI: 1:STN:280:DC%2BC38vislKisw%3D%3D, PID: 22327346
-
Rittig K, Dolderer JH, Balletshofer B et al (2012) The secretion pattern of perivascular fat cells is different from that of subcutaneous and visceral fat cells. Diabetologia 55:1514–1525
-
(2012)
Diabetologia
, vol.55
, pp. 1514-1525
-
-
Rittig, K.1
Dolderer, J.H.2
Balletshofer, B.3
-
77
-
-
84866358921
-
Exercise-induced albuminuria is associated with perivascular renal sinus fat in individuals at increased risk of type 2 diabetes
-
COI: 1:CAS:528:DC%2BC38Xotlelt7g%3D, PID: 22526613
-
Wagner R, Machann J, Lehmann R et al (2012) Exercise-induced albuminuria is associated with perivascular renal sinus fat in individuals at increased risk of type 2 diabetes. Diabetologia 55:2054–2058
-
(2012)
Diabetologia
, vol.55
, pp. 2054-2058
-
-
Wagner, R.1
Machann, J.2
Lehmann, R.3
-
78
-
-
84965163560
-
Obesity and renal disease: not all fat is created equal and not all obesity is harmful to the kidneys
-
PID: 24753460
-
Stefan N, Artunc F, Heyne N, Machann J, Schleicher ED, Häring HU (2016) Obesity and renal disease: not all fat is created equal and not all obesity is harmful to the kidneys. Nephrol Dial Transplant 31:726–730
-
(2016)
Nephrol Dial Transplant
, vol.31
, pp. 726-730
-
-
Stefan, N.1
Artunc, F.2
Heyne, N.3
Machann, J.4
Schleicher, E.D.5
Häring, H.U.6
-
79
-
-
77952396750
-
Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance study
-
COI: 1:CAS:528:DC%2BC3cXotFKlt7o%3D, PID: 20225188
-
Heni M, Machann J, Staiger H et al (2010) Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance study. Diabetes Metab Res Rev 26:200–205
-
(2010)
Diabetes Metab Res Rev
, vol.26
, pp. 200-205
-
-
Heni, M.1
Machann, J.2
Staiger, H.3
-
80
-
-
84898670730
-
Impact of the adipokine adiponectin and the hepatokine fetuin-A on the development of type 2 diabetes: prospective cohort- and cross-sectional phenotyping studies
-
PID: 24643166
-
Stefan N, Sun Q, Fritsche A et al (2014) Impact of the adipokine adiponectin and the hepatokine fetuin-A on the development of type 2 diabetes: prospective cohort- and cross-sectional phenotyping studies. PLoS One 9, e92238
-
(2014)
PLoS One
, vol.9
-
-
Stefan, N.1
Sun, Q.2
Fritsche, A.3
-
81
-
-
84870755708
-
High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet
-
COI: 1:CAS:528:DC%2BC38XhvVCgtLzL, PID: 23015656
-
Silbernagel G, Kovarova M, Cegan A et al (2012) High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet. J Clin Endocrinol Metab 97:E2288–E2292
-
(2012)
J Clin Endocrinol Metab
, vol.97
, pp. E2288-E2292
-
-
Silbernagel, G.1
Kovarova, M.2
Cegan, A.3
-
82
-
-
79955457155
-
Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction
-
COI: 1:CAS:528:DC%2BC3MXltlCqsbk%3D, PID: 21367948
-
Browning JD, Baker JA, Rogers T, Davis J, Satapati S, Burgess SC (2011) Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction. Am J Clin Nutr 93:1048–1052
-
(2011)
Am J Clin Nutr
, vol.93
, pp. 1048-1052
-
-
Browning, J.D.1
Baker, J.A.2
Rogers, T.3
Davis, J.4
Satapati, S.5
Burgess, S.C.6
-
83
-
-
34247643885
-
Serum alanine aminotransferase levels decrease further with carbohydrate than fat restriction in insulin-resistant adults
-
COI: 1:CAS:528:DC%2BD2sXmtFKnurs%3D, PID: 17351275
-
Ryan MC, Abbasi F, Lamendola C, Carter S, McLaughlin T (2007) Serum alanine aminotransferase levels decrease further with carbohydrate than fat restriction in insulin-resistant adults. Diabetes Care 30:1075–1080
-
(2007)
Diabetes Care
, vol.30
, pp. 1075-1080
-
-
Ryan, M.C.1
Abbasi, F.2
Lamendola, C.3
Carter, S.4
McLaughlin, T.5
-
84
-
-
84875020011
-
Beneficial effect of a weight-stable, low fat/ low-saturated fat/low-glycaemic index diet to reduce liver fat in older subjects
-
COI: 1:CAS:528:DC%2BC3sXjvVaktbs%3D, PID: 22849970
-
Utzschneider KM, Bayer-Carter JL, Arbuckle MD, Tidwell JM, Richards TL, Craft S (2013) Beneficial effect of a weight-stable, low fat/ low-saturated fat/low-glycaemic index diet to reduce liver fat in older subjects. Br J Nutr 109:1096–1104
-
(2013)
Br J Nutr
, vol.109
, pp. 1096-1104
-
-
Utzschneider, K.M.1
Bayer-Carter, J.L.2
Arbuckle, M.D.3
Tidwell, J.M.4
Richards, T.L.5
Craft, S.6
-
85
-
-
70349902776
-
Omega-3 fatty acid supplementation decreases liver fat content in polycystic ovary syndrome: a randomized controlled trial employing proton magnetic resonance spectroscopy
-
COI: 1:CAS:528:DC%2BD1MXht12ru7nM, PID: 19622617
-
Cussons AJ, Watts GF, Mori TA, Stuckey BG (2009) Omega-3 fatty acid supplementation decreases liver fat content in polycystic ovary syndrome: a randomized controlled trial employing proton magnetic resonance spectroscopy. J Clin Endocrinol Metab 94:3842–3848
-
(2009)
J Clin Endocrinol Metab
, vol.94
, pp. 3842-3848
-
-
Cussons, A.J.1
Watts, G.F.2
Mori, T.A.3
Stuckey, B.G.4
-
86
-
-
84927776586
-
Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: results from the Welcome study
-
COI: 1:CAS:528:DC%2BC2cXhs1Wlu7vJ, PID: 25043514
-
Scorletti E, Bhatia L, McCormick KG et al (2014) Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: results from the Welcome study. Hepatology 60:1211–1221
-
(2014)
Hepatology
, vol.60
, pp. 1211-1221
-
-
Scorletti, E.1
Bhatia, L.2
McCormick, K.G.3
-
87
-
-
27744492082
-
Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat
-
COI: 1:CAS:528:DC%2BD2MXht1Skt7vI, PID: 16205883
-
Stefan N, Machicao F, Staiger H et al (2005) Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. Diabetologia 48:2282–2291
-
(2005)
Diabetologia
, vol.48
, pp. 2282-2291
-
-
Stefan, N.1
Machicao, F.2
Staiger, H.3
-
88
-
-
42049105146
-
Variations in PPARD determine the change in body composition during lifestyle intervention: a whole-body magnetic resonance study
-
COI: 1:CAS:528:DC%2BD1cXks1agsLc%3D, PID: 18252792
-
Thamer C, Machann J, Stefan N et al (2008) Variations in PPARD determine the change in body composition during lifestyle intervention: a whole-body magnetic resonance study. J Clin Endocrinol Metab 93:1497–1500
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 1497-1500
-
-
Thamer, C.1
Machann, J.2
Stefan, N.3
-
89
-
-
84909979604
-
Integrative biology of exercise
-
COI: 1:CAS:528:DC%2BC2cXhvV2msrbF, PID: 25417152
-
Hawley JA, Hargreaves M, Joyner MJ, Zierath JR (2014) Integrative biology of exercise. Cell 159:738–749
-
(2014)
Cell
, vol.159
, pp. 738-749
-
-
Hawley, J.A.1
Hargreaves, M.2
Joyner, M.J.3
Zierath, J.R.4
-
90
-
-
84937434706
-
Changes in gene expression in responders and nonresponders to a low-intensity walking intervention
-
COI: 1:CAS:528:DC%2BC2MXhtFyms7%2FJ, PID: 25795414
-
Osler ME, Fritz T, Caidahl K et al (2015) Changes in gene expression in responders and nonresponders to a low-intensity walking intervention. Diabetes Care 38:1154–1160
-
(2015)
Diabetes Care
, vol.38
, pp. 1154-1160
-
-
Osler, M.E.1
Fritz, T.2
Caidahl, K.3
-
91
-
-
68849104744
-
High cardiorespiratory fitness is an independent predictor of the reduction in liver fat during a lifestyle intervention in non-alcoholic fatty liver disease
-
COI: 1:STN:280:DC%2BD1Mrks1yqtw%3D%3D, PID: 19074179
-
Kantartzis K, Thamer C, Peter A et al (2009) High cardiorespiratory fitness is an independent predictor of the reduction in liver fat during a lifestyle intervention in non-alcoholic fatty liver disease. Gut 58:1281–1288
-
(2009)
Gut
, vol.58
, pp. 1281-1288
-
-
Kantartzis, K.1
Thamer, C.2
Peter, A.3
-
92
-
-
84959533315
-
Exercise and diabetes: relevance and causes for response variability
-
PID: 26643313
-
Böhm A, Weigert C, Staiger H, Häring HU (2016) Exercise and diabetes: relevance and causes for response variability. Endocrine 51:390–401
-
(2016)
Endocrine
, vol.51
, pp. 390-401
-
-
Böhm, A.1
Weigert, C.2
Staiger, H.3
Häring, H.U.4
-
93
-
-
84939573210
-
A transcriptional signature of ‘exercise resistance’ in skeletal muscle of individuals with type 2 diabetes mellitus
-
COI: 1:CAS:528:DC%2BC2MXhtFCkt7nM, PID: 26163877
-
Stephens NA, Xie H, Johannsen NM, Church TS, Smith SR, Sparks LM (2015) A transcriptional signature of ‘exercise resistance’ in skeletal muscle of individuals with type 2 diabetes mellitus. Metabolism 64:999–1004
-
(2015)
Metabolism
, vol.64
, pp. 999-1004
-
-
Stephens, N.A.1
Xie, H.2
Johannsen, N.M.3
Church, T.S.4
Smith, S.R.5
Sparks, L.M.6
-
94
-
-
19944427874
-
Effects of exercise training on glucose homeostasis: the HERITAGE Family Study
-
PID: 15616242
-
Boulé NG, Weisnagel SJ, Lakka TA et al (2005) Effects of exercise training on glucose homeostasis: the HERITAGE Family Study. Diabetes Care 28:108–114
-
(2005)
Diabetes Care
, vol.28
, pp. 108-114
-
-
Boulé, N.G.1
Weisnagel, S.J.2
Lakka, T.A.3
-
95
-
-
84872375286
-
Interleukin-6 promotes myogenic differentiation of mouse skeletal muscle cells: role of the STAT3 pathway
-
COI: 1:CAS:528:DC%2BC3sXit1ynsbo%3D, PID: 23114963
-
Hoene M, Runge H, Häring HU, Schleicher ED, Weigert C (2013) Interleukin-6 promotes myogenic differentiation of mouse skeletal muscle cells: role of the STAT3 pathway. Am J Physiol Cell Physiol 304:C128–C136
-
(2013)
Am J Physiol Cell Physiol
, vol.304
, pp. C128-C136
-
-
Hoene, M.1
Runge, H.2
Häring, H.U.3
Schleicher, E.D.4
Weigert, C.5
-
96
-
-
84885585271
-
Cytokine response of primary human myotubes in an in vitro exercise model
-
COI: 1:CAS:528:DC%2BC3sXhslejtbzP, PID: 23926130
-
Scheler M, Irmler M, Lehr S et al (2013) Cytokine response of primary human myotubes in an in vitro exercise model. Am J Physiol Cell Physiol 305:C877–C886
-
(2013)
Am J Physiol Cell Physiol
, vol.305
, pp. C877-C886
-
-
Scheler, M.1
Irmler, M.2
Lehr, S.3
-
97
-
-
84937525633
-
Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery
-
COI: 1:CAS:528:DC%2BC2MXhtVegtr3K, PID: 26067360
-
Hansen JS, Zhao X, Irmler M et al (2015) Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery. Diabetologia 58:1845–1854
-
(2015)
Diabetologia
, vol.58
, pp. 1845-1854
-
-
Hansen, J.S.1
Zhao, X.2
Irmler, M.3
-
98
-
-
84893496615
-
The secretome of the working human skeletal muscle—a promising opportunity to combat the metabolic disaster?
-
COI: 1:CAS:528:DC%2BC2cXhsl2gu7k%3D, PID: 24376246
-
Weigert C, Lehmann R, Hartwig S, Lehr S (2014) The secretome of the working human skeletal muscle—a promising opportunity to combat the metabolic disaster? Proteomics Clin Appl 8:5–18
-
(2014)
Proteomics Clin Appl
, vol.8
, pp. 5-18
-
-
Weigert, C.1
Lehmann, R.2
Hartwig, S.3
Lehr, S.4
-
99
-
-
0019458387
-
Insulin and insulin receptors in rodent brain
-
COI: 1:CAS:528:DyaL3MXktVeqtrc%3D, PID: 7014325
-
Havrankova J, Brownstein M, Roth J (1981) Insulin and insulin receptors in rodent brain. Diabetologia 20(Suppl):268–273
-
(1981)
Diabetologia
, vol.20
, pp. 268-273
-
-
Havrankova, J.1
Brownstein, M.2
Roth, J.3
-
100
-
-
0018090354
-
Insulin receptors are widely distributed in the central nervous system of the rat
-
COI: 1:CAS:528:DyaE1cXkvVCqt7g%3D, PID: 205798
-
Havrankova J, Roth J, Brownstein M (1978) Insulin receptors are widely distributed in the central nervous system of the rat. Nature 272:827–829
-
(1978)
Nature
, vol.272
, pp. 827-829
-
-
Havrankova, J.1
Roth, J.2
Brownstein, M.3
-
101
-
-
0034703229
-
Role of brain insulin receptor in control of body weight and reproduction
-
PID: 11000114
-
Brüning JC, Gautam D, Burks DJ et al (2000) Role of brain insulin receptor in control of body weight and reproduction. Science 289:2122–2125
-
(2000)
Science
, vol.289
, pp. 2122-2125
-
-
Brüning, J.C.1
Gautam, D.2
Burks, D.J.3
-
102
-
-
4043106461
-
Transgenic rescue of insulin receptor-deficient mice
-
COI: 1:CAS:528:DC%2BD2cXlvFWmsLc%3D, PID: 15254588
-
Okamoto H, Nakae J, Kitamura T, Park BC, Dragatsis I, Accili D (2004) Transgenic rescue of insulin receptor-deficient mice. J Clin Invest 114:214–223
-
(2004)
J Clin Invest
, vol.114
, pp. 214-223
-
-
Okamoto, H.1
Nakae, J.2
Kitamura, T.3
Park, B.C.4
Dragatsis, I.5
Accili, D.6
-
103
-
-
9644260563
-
Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes
-
COI: 1:CAS:528:DC%2BD2cXot12gtr0%3D, PID: 15467829
-
Lin X, Taguchi A, Park S et al (2004) Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest 114:908–916
-
(2004)
J Clin Invest
, vol.114
, pp. 908-916
-
-
Lin, X.1
Taguchi, A.2
Park, S.3
-
104
-
-
33747058235
-
The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: a magnetoencephalographic study
-
COI: 1:CAS:528:DC%2BD28Xotlyis7o%3D, PID: 16877540
-
Tschritter O, Preissl H, Hennige AM et al (2006) The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: a magnetoencephalographic study. Proc Natl Acad Sci U S A 103:12103–12108
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 12103-12108
-
-
Tschritter, O.1
Preissl, H.2
Hennige, A.M.3
-
105
-
-
84947614766
-
Impaired insulin action in the human brain: causes and metabolic consequences
-
COI: 1:CAS:528:DC%2BC2MXhs1Cqur%2FM, PID: 26460339
-
Heni M, Kullmann S, Preissl H, Fritsche A, Häring HU (2015) Impaired insulin action in the human brain: causes and metabolic consequences. Nat Rev Endocrinol 11:701–711
-
(2015)
Nat Rev Endocrinol
, vol.11
, pp. 701-711
-
-
Heni, M.1
Kullmann, S.2
Preissl, H.3
Fritsche, A.4
Häring, H.U.5
-
106
-
-
84938302676
-
Selective insulin resistance in homeostatic and cognitive control brain areas in overweight and obese adults
-
COI: 1:CAS:528:DC%2BC2MXhtFymsrfO, PID: 25795413
-
Kullmann S, Heni M, Veit R et al (2015) Selective insulin resistance in homeostatic and cognitive control brain areas in overweight and obese adults. Diabetes Care 38:1044–1050
-
(2015)
Diabetes Care
, vol.38
, pp. 1044-1050
-
-
Kullmann, S.1
Heni, M.2
Veit, R.3
-
107
-
-
84911916822
-
Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men
-
COI: 1:CAS:528:DC%2BC2cXitVCgsbfP, PID: 25028522
-
Heni M, Wagner R, Kullmann S et al (2014) Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men. Diabetes 63:4083–4088
-
(2014)
Diabetes
, vol.63
, pp. 4083-4088
-
-
Heni, M.1
Wagner, R.2
Kullmann, S.3
-
108
-
-
76149103529
-
Insulin modulates food-related activity in the central nervous system
-
COI: 1:CAS:528:DC%2BC3cXitVaisLo%3D, PID: 19996309
-
Guthoff M, Grichisch Y, Canova C et al (2010) Insulin modulates food-related activity in the central nervous system. J Clin Endocrinol Metab 95:748–755
-
(2010)
J Clin Endocrinol Metab
, vol.95
, pp. 748-755
-
-
Guthoff, M.1
Grichisch, Y.2
Canova, C.3
-
109
-
-
84855915021
-
Differential effects of intranasal insulin and caffeine on cerebral blood flow
-
PID: 21391271
-
Grichisch Y, Çavuşoğlu M, Preissl H et al (2012) Differential effects of intranasal insulin and caffeine on cerebral blood flow. Hum Brain Mapp 33:280–287
-
(2012)
Hum Brain Mapp
, vol.33
, pp. 280-287
-
-
Grichisch, Y.1
Çavuşoğlu, M.2
Preissl, H.3
-
110
-
-
84865434170
-
Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and reward-related human brain regions
-
COI: 1:CAS:528:DC%2BC38Xms1yqt7o%3D, PID: 22434537
-
Heni M, Kullmann S, Ketterer C et al (2012) Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and reward-related human brain regions. Diabetologia 55:1773–1782
-
(2012)
Diabetologia
, vol.55
, pp. 1773-1782
-
-
Heni, M.1
Kullmann, S.2
Ketterer, C.3
-
111
-
-
84876283390
-
Intranasal insulin modulates intrinsic reward and prefrontal circuitry of the human brain in lean women
-
COI: 1:CAS:528:DC%2BC3sXlt1Glsr8%3D, PID: 22922661
-
Kullmann S, Frank S, Heni M et al (2013) Intranasal insulin modulates intrinsic reward and prefrontal circuitry of the human brain in lean women. Neuroendocrinology 97:176–182
-
(2013)
Neuroendocrinology
, vol.97
, pp. 176-182
-
-
Kullmann, S.1
Frank, S.2
Heni, M.3
-
112
-
-
84856719077
-
High cerebral insulin sensitivity is associated with loss of body fat during lifestyle intervention
-
COI: 1:CAS:528:DC%2BC3MXhsFOqu77E, PID: 21927893
-
Tschritter O, Preissl H, Hennige AM et al (2012) High cerebral insulin sensitivity is associated with loss of body fat during lifestyle intervention. Diabetologia 55:175–178
-
(2012)
Diabetologia
, vol.55
, pp. 175-178
-
-
Tschritter, O.1
Preissl, H.2
Hennige, A.M.3
-
113
-
-
84964352862
-
Insulin regulates hepatic triglyceride secretion and lipid content via signaling in the brain
-
Scherer T, Lindtner C, O’Hare J et al (2016) Insulin regulates hepatic triglyceride secretion and lipid content via signaling in the brain. Diabetes. doi:10.2337/db15-1552
-
(2016)
Diabetes
-
-
Scherer, T.1
Lindtner, C.2
O’Hare, J.3
-
114
-
-
84903173931
-
Insulin action in brain regulates systemic metabolism and brain function
-
PID: 24931034
-
Kleinridders A, Ferris HA, Cai W, Kahn CR (2014) Insulin action in brain regulates systemic metabolism and brain function. Diabetes 63:2232–2243
-
(2014)
Diabetes
, vol.63
, pp. 2232-2243
-
-
Kleinridders, A.1
Ferris, H.A.2
Cai, W.3
Kahn, C.R.4
-
115
-
-
17844379717
-
Hypothalamic K(ATP) channels control hepatic glucose production
-
COI: 1:CAS:528:DC%2BD2MXjsVequrk%3D, PID: 15846348
-
Pocai A, Lam TK, Gutierrez-Juarez R et al (2005) Hypothalamic K(ATP) channels control hepatic glucose production. Nature 434:1026–1031
-
(2005)
Nature
, vol.434
, pp. 1026-1031
-
-
Pocai, A.1
Lam, T.K.2
Gutierrez-Juarez, R.3
-
116
-
-
0036267472
-
Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
-
COI: 1:CAS:528:DC%2BD38XjvVynsro%3D, PID: 12021765
-
Obici S, Feng Z, Karkanias G, Baskin DG, Rossetti L (2002) Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci 5:566–572
-
(2002)
Nat Neurosci
, vol.5
, pp. 566-572
-
-
Obici, S.1
Feng, Z.2
Karkanias, G.3
Baskin, D.G.4
Rossetti, L.5
-
117
-
-
84931289812
-
Effects of intranasal insulin on hepatic fat accumulation and energy metabolism in humans
-
COI: 1:CAS:528:DC%2BC2MXhtVSjsrjP, PID: 25576060
-
Gancheva S, Koliaki C, Bierwagen A et al (2015) Effects of intranasal insulin on hepatic fat accumulation and energy metabolism in humans. Diabetes 64:1966–1975
-
(2015)
Diabetes
, vol.64
, pp. 1966-1975
-
-
Gancheva, S.1
Koliaki, C.2
Bierwagen, A.3
-
118
-
-
84901196954
-
Maternal insulin sensitivity is associated with oral glucose-induced changes in fetal brain activity
-
COI: 1:CAS:528:DC%2BC2cXltFygsrg%3D, PID: 24671273
-
Linder K, Schleger F, Ketterer C et al (2014) Maternal insulin sensitivity is associated with oral glucose-induced changes in fetal brain activity. Diabetologia 57:1192–1198
-
(2014)
Diabetologia
, vol.57
, pp. 1192-1198
-
-
Linder, K.1
Schleger, F.2
Ketterer, C.3
-
119
-
-
84958658384
-
Gestational diabetes impairs human fetal postprandial brain activity
-
COI: 1:CAS:528:DC%2BC28XjtlSnsL4%3D, PID: 26465393
-
Linder K, Schleger F, Kiefer-Schmidt I et al (2015) Gestational diabetes impairs human fetal postprandial brain activity. J Clin Endocrinol Metab 100:4029–4036
-
(2015)
J Clin Endocrinol Metab
, vol.100
, pp. 4029-4036
-
-
Linder, K.1
Schleger, F.2
Kiefer-Schmidt, I.3
|