메뉴 건너뛰기




Volumn 59, Issue 9, 2016, Pages 1806-1818

Novel phenotypes of prediabetes?

Author keywords

Brain insulin resistance; Insulin; Liver fat; Phenotype; Prediabetes; Review; Secretion; Sensitivity

Indexed keywords

FETUIN A; INCRETIN; INSULIN; TRANSCRIPTION FACTOR 7 LIKE 2;

EID: 84976292937     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-016-4015-3     Document Type: Review
Times cited : (39)

References (119)
  • 1
    • 0035799806 scopus 로고    scopus 로고
    • Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    • COI: 1:STN:280:DC%2BD3M3kvFejsA%3D%3D, PID: 11333990
    • Tuomilehto J, Lindström J, Eriksson JG et al (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344:1343–1350
    • (2001) N Engl J Med , vol.344 , pp. 1343-1350
    • Tuomilehto, J.1    Lindström, J.2    Eriksson, J.G.3
  • 2
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    • COI: 1:CAS:528:DC%2BD38XhtVWqurc%3D, PID: 11832527
    • Knowler WC, Barrett-Connor E et al (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393–403
    • (2002) N Engl J Med , vol.346 , pp. 393-403
    • Knowler, W.C.1    Barrett-Connor, E.2
  • 3
    • 43849111166 scopus 로고    scopus 로고
    • The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study
    • PID: 18502303
    • Li G, Zhang P, Wang J et al (2008) The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study. Lancet 371:1783–1789
    • (2008) Lancet , vol.371 , pp. 1783-1789
    • Li, G.1    Zhang, P.2    Wang, J.3
  • 4
    • 84862302415 scopus 로고    scopus 로고
    • Effect of regression from prediabetes to normal glucose regulation on long-term reduction in diabetes risk: results from the Diabetes Prevention Program Outcomes Study
    • COI: 1:CAS:528:DC%2BC38XosVejsr8%3D, PID: 22683134
    • Perreault L, Pan Q, Mather KJ et al (2012) Effect of regression from prediabetes to normal glucose regulation on long-term reduction in diabetes risk: results from the Diabetes Prevention Program Outcomes Study. Lancet 379:2243–2251
    • (2012) Lancet , vol.379 , pp. 2243-2251
    • Perreault, L.1    Pan, Q.2    Mather, K.J.3
  • 5
    • 33947153419 scopus 로고    scopus 로고
    • High visceral fat mass and high liver fat are associated with resistance to lifestyle intervention
    • Thamer C, Machann J, Stefan N et al (2007) High visceral fat mass and high liver fat are associated with resistance to lifestyle intervention. Obesity (Silver Spring) 15:531–538
    • (2007) Obesity (Silver Spring) , vol.15 , pp. 531-538
    • Thamer, C.1    Machann, J.2    Stefan, N.3
  • 6
    • 34249852535 scopus 로고    scopus 로고
    • Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention
    • COI: 1:CAS:528:DC%2BD2sXlt1Oktb8%3D, PID: 17327385
    • Stefan N, Thamer C, Staiger H et al (2007) Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention. J Clin Endocrinol Metab 92:1827–1833
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1827-1833
    • Stefan, N.1    Thamer, C.2    Staiger, H.3
  • 7
    • 84946495886 scopus 로고    scopus 로고
    • A high-risk phenotype associates with reduced improvement in glycaemia during a lifestyle intervention in prediabetes
    • COI: 1:CAS:528:DC%2BC2MXhsFKktb%2FE, PID: 26404062
    • Stefan N, Staiger H, Wagner R et al (2015) A high-risk phenotype associates with reduced improvement in glycaemia during a lifestyle intervention in prediabetes. Diabetologia 58:2877–2884
    • (2015) Diabetologia , vol.58 , pp. 2877-2884
    • Stefan, N.1    Staiger, H.2    Wagner, R.3
  • 8
    • 0032742992 scopus 로고    scopus 로고
    • The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
    • COI: 1:CAS:528:DyaK1MXmtFGltbg%3D, PID: 10491414
    • Weyer C, Bogardus C, Mott DM, Pratley RE (1999) The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 104:787–794
    • (1999) J Clin Invest , vol.104 , pp. 787-794
    • Weyer, C.1    Bogardus, C.2    Mott, D.M.3    Pratley, R.E.4
  • 9
    • 84906940729 scopus 로고    scopus 로고
    • Definition of intervention points in prediabetes
    • PID: 24731662
    • Ferrannini E (2014) Definition of intervention points in prediabetes. Lancet Diabetes Endocrinol 2:667–675
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 667-675
    • Ferrannini, E.1
  • 10
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • COI: 1:CAS:528:DC%2BD28XhtlShtrzP, PID: 17167471
    • Kahn SE, Hull RL, Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444:840–846
    • (2006) Nature , vol.444 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 11
    • 0036318476 scopus 로고    scopus 로고
    • Accurate assessment of beta-cell function: the hyperbolic correction
    • COI: 1:CAS:528:DC%2BD38XhtVaqsbs%3D, PID: 11815482
    • Bergman RN, Ader M, Huecking K, Van Citters G (2002) Accurate assessment of beta-cell function: the hyperbolic correction. Diabetes 51(Suppl 1):S212–S220
    • (2002) Diabetes , vol.51 , pp. S212-S220
    • Bergman, R.N.1    Ader, M.2    Huecking, K.3    Van Citters, G.4
  • 12
    • 65549163338 scopus 로고    scopus 로고
    • Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men
    • PID: 19223598
    • Stancáková A, Javorský M, Kuulasmaa T, Haffner SM, Kuusisto J, Laakso M (2009) Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men. Diabetes 58:1212–1221
    • (2009) Diabetes , vol.58 , pp. 1212-1221
    • Stancáková, A.1    Javorský, M.2    Kuulasmaa, T.3    Haffner, S.M.4    Kuusisto, J.5    Laakso, M.6
  • 13
    • 0024348996 scopus 로고
    • Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus
    • COI: 1:STN:280:DyaL1MzhsVWitg%3D%3D, PID: 2664520
    • Eriksson J, Franssila-Kallunki A, Ekstrand A et al (1989) Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N Engl J Med 321:337–343
    • (1989) N Engl J Med , vol.321 , pp. 337-343
    • Eriksson, J.1    Franssila-Kallunki, A.2    Ekstrand, A.3
  • 14
    • 55649105963 scopus 로고    scopus 로고
    • Clinical risk factors, DNA variants, and the development of type 2 diabetes
    • COI: 1:CAS:528:DC%2BD1cXhtl2gurnF, PID: 19020324
    • Lyssenko V, Jonsson A, Almgren P et al (2008) Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med 359:2220–2232
    • (2008) N Engl J Med , vol.359 , pp. 2220-2232
    • Lyssenko, V.1    Jonsson, A.2    Almgren, P.3
  • 15
    • 84943785470 scopus 로고    scopus 로고
    • Recent advances in understanding the genetic architecture of type 2 diabetes
    • COI: 1:CAS:528:DC%2BC2MXitVGjsrzJ, PID: 26160912
    • Mohlke KL, Boehnke M (2015) Recent advances in understanding the genetic architecture of type 2 diabetes. Hum Mol Genet 24:R85–R92
    • (2015) Hum Mol Genet , vol.24 , pp. R85-R92
    • Mohlke, K.L.1    Boehnke, M.2
  • 16
    • 84895868553 scopus 로고    scopus 로고
    • Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
    • DIAbetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium
    • DIAbetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium et al (2014) Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet 46:234–244
    • (2014) Nat Genet , vol.46 , pp. 234-244
  • 17
    • 84906219758 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma (PPARG) modulates free fatty acid receptor 1 (FFAR1) dependent insulin secretion in humans
    • COI: 1:CAS:528:DC%2BC2cXht1agsL%2FO, PID: 25161890
    • Wagner R, Hieronimus A, Lamprinou A et al (2014) Peroxisome proliferator-activated receptor gamma (PPARG) modulates free fatty acid receptor 1 (FFAR1) dependent insulin secretion in humans. Mol Metab 3:676–680
    • (2014) Mol Metab , vol.3 , pp. 676-680
    • Wagner, R.1    Hieronimus, A.2    Lamprinou, A.3
  • 18
    • 84897108150 scopus 로고    scopus 로고
    • Untangling the interplay of genetic and metabolic influences on beta-cell function: examples of potential therapeutic implications involving TCF7L2 and FFAR1
    • COI: 1:CAS:528:DC%2BC2cXitlehur8%3D, PID: 24749055
    • Wagner R, Staiger H, Ullrich S, Stefan N, Fritsche A, Häring HU (2014) Untangling the interplay of genetic and metabolic influences on beta-cell function: examples of potential therapeutic implications involving TCF7L2 and FFAR1. Mol Metab 3:261–267
    • (2014) Mol Metab , vol.3 , pp. 261-267
    • Wagner, R.1    Staiger, H.2    Ullrich, S.3    Stefan, N.4    Fritsche, A.5    Häring, H.U.6
  • 19
    • 84883250341 scopus 로고    scopus 로고
    • Nor-1, a novel incretin-responsive regulator of insulin genes and insulin secretion
    • COI: 1:CAS:528:DC%2BC3sXhsFentbbM, PID: 24044104
    • Ordelheide AM, Gerst F, Rothfuss O et al (2013) Nor-1, a novel incretin-responsive regulator of insulin genes and insulin secretion. Mol Metab 2:243–255
    • (2013) Mol Metab , vol.2 , pp. 243-255
    • Ordelheide, A.M.1    Gerst, F.2    Rothfuss, O.3
  • 20
    • 35848942800 scopus 로고    scopus 로고
    • Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms
    • PID: 17661009
    • Schäfer SA, Tschritter O, Machicao F et al (2007) Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms. Diabetologia 50:2443–2450
    • (2007) Diabetologia , vol.50 , pp. 2443-2450
    • Schäfer, S.A.1    Tschritter, O.2    Machicao, F.3
  • 21
    • 67349190497 scopus 로고    scopus 로고
    • A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion
    • PID: 19330314
    • Schäfer SA, Müssig K, Staiger H et al (2009) A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion. Diabetologia 52:1075–1082
    • (2009) Diabetologia , vol.52 , pp. 1075-1082
    • Schäfer, S.A.1    Müssig, K.2    Staiger, H.3
  • 22
    • 67650251656 scopus 로고    scopus 로고
    • Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion
    • PID: 19366866
    • Müssig K, Staiger H, Machicao F et al (2009) Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion. Diabetes 58:1715–1720
    • (2009) Diabetes , vol.58 , pp. 1715-1720
    • Müssig, K.1    Staiger, H.2    Machicao, F.3
  • 23
    • 78650063109 scopus 로고    scopus 로고
    • Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
    • COI: 1:CAS:528:DC%2BC3MXlsVakug%3D%3D, PID: 20802253
    • Heni M, Ketterer C, Thamer C et al (2010) Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion. Diabetes 59:3247–3252
    • (2010) Diabetes , vol.59 , pp. 3247-3252
    • Heni, M.1    Ketterer, C.2    Thamer, C.3
  • 24
    • 0035032780 scopus 로고    scopus 로고
    • Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator—activated receptor-gamma2 gene
    • COI: 1:CAS:528:DC%2BD3MXkvFSgu7Y%3D, PID: 11334419
    • Stefan N, Fritsche A, Häring H, Stumvoll M (2001) Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator—activated receptor-gamma2 gene. Diabetes 50:1143–1148
    • (2001) Diabetes , vol.50 , pp. 1143-1148
    • Stefan, N.1    Fritsche, A.2    Häring, H.3    Stumvoll, M.4
  • 25
    • 84878230795 scopus 로고    scopus 로고
    • Reevaluation of fatty acid receptor 1 (FFAR1/GPR40) as drug target for the stimulation of insulin secretion in humans
    • COI: 1:CAS:528:DC%2BC3sXpt1Orsb8%3D, PID: 23378609
    • Wagner R, Kaiser G, Gerst F et al (2013) Reevaluation of fatty acid receptor 1 (FFAR1/GPR40) as drug target for the stimulation of insulin secretion in humans. Diabetes 62:2106–2111
    • (2013) Diabetes , vol.62 , pp. 2106-2111
    • Wagner, R.1    Kaiser, G.2    Gerst, F.3
  • 26
    • 84902440103 scopus 로고    scopus 로고
    • Clinical and non-targeted metabolomic profiling of homozygous carriers of transcription factor 7-like 2 variant rs7903146
    • COI: 1:CAS:528:DC%2BC2MXksVSqu7w%3D, PID: 24925104
    • Wagner R, Li J, Kenar E et al (2014) Clinical and non-targeted metabolomic profiling of homozygous carriers of transcription factor 7-like 2 variant rs7903146. Sci Rep 4:5296
    • (2014) Sci Rep , vol.4 , pp. 5296
    • Wagner, R.1    Li, J.2    Kenar, E.3
  • 27
    • 79953812139 scopus 로고    scopus 로고
    • Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B
    • COI: 1:CAS:528:DC%2BC3MXivFCgsbg%3D, PID: 21234743
    • Hribal ML, Presta I, Procopio T et al (2011) Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B. Diabetologia 54:795–802
    • (2011) Diabetologia , vol.54 , pp. 795-802
    • Hribal, M.L.1    Presta, I.2    Procopio, T.3
  • 28
    • 80051937658 scopus 로고    scopus 로고
    • Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin
    • COI: 1:CAS:528:DC%2BC3MXhtFyrs7vM, PID: 21887289
    • Wagner R, Dudziak K, Herzberg-Schäfer SA et al (2011) Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin. PLoS One 6, e23639
    • (2011) PLoS One , vol.6
    • Wagner, R.1    Dudziak, K.2    Herzberg-Schäfer, S.A.3
  • 29
    • 77449161166 scopus 로고    scopus 로고
    • Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps
    • PID: 19808892
    • ‘t Hart LM, Simonis-Bik AM, Nijpels G et al (2010) Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps. Diabetes 59:287–292
    • (2010) Diabetes , vol.59 , pp. 287-292
    • ‘t Hart, L.M.1    Simonis-Bik, A.M.2    Nijpels, G.3
  • 30
    • 66149119359 scopus 로고    scopus 로고
    • The inhibitory effect of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivity
    • COI: 1:CAS:528:DC%2BD1MXlvVCqurw%3D, PID: 19258404
    • Haupt A, Guthoff M, Schäfer SA et al (2009) The inhibitory effect of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivity. J Clin Endocrinol Metab 94:1775–1780
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 1775-1780
    • Haupt, A.1    Guthoff, M.2    Schäfer, S.A.3
  • 31
    • 59449091250 scopus 로고    scopus 로고
    • The risk allele load accelerates the age-dependent decline in beta cell function
    • COI: 1:STN:280:DC%2BD1M7hs12nsg%3D%3D, PID: 19172244
    • Haupt A, Staiger H, Schäfer SA et al (2009) The risk allele load accelerates the age-dependent decline in beta cell function. Diabetologia 52:457–462
    • (2009) Diabetologia , vol.52 , pp. 457-462
    • Haupt, A.1    Staiger, H.2    Schäfer, S.A.3
  • 32
    • 49249094275 scopus 로고    scopus 로고
    • Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps
    • COI: 1:CAS:528:DC%2BD1cXpsVGitb4%3D, PID: 18618095
    • Groenewoud MJ, Dekker JM, Fritsche A et al (2008) Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps. Diabetologia 51:1659–1663
    • (2008) Diabetologia , vol.51 , pp. 1659-1663
    • Groenewoud, M.J.1    Dekker, J.M.2    Fritsche, A.3
  • 33
    • 41849117959 scopus 로고    scopus 로고
    • The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients—the EUGENE2 study
    • COI: 1:CAS:528:DC%2BD1cXkt1yjs78%3D, PID: 18324385
    • Boesgaard TW, Zilinskaite J, Vänttinen M et al (2008) The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients—the EUGENE2 study. Diabetologia 51:816–820
    • (2008) Diabetologia , vol.51 , pp. 816-820
    • Boesgaard, T.W.1    Zilinskaite, J.2    Vänttinen, M.3
  • 34
    • 40749087319 scopus 로고    scopus 로고
    • A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study
    • COI: 1:CAS:528:DC%2BD1cXhvVOktLc%3D, PID: 18039816
    • Staiger H, Stancáková A, Zilinskaite J et al (2008) A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study. Diabetes 57:514–517
    • (2008) Diabetes , vol.57 , pp. 514-517
    • Staiger, H.1    Stancáková, A.2    Zilinskaite, J.3
  • 35
    • 43249095915 scopus 로고    scopus 로고
    • Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance
    • PID: 18285412
    • Stancáková A, Pihlajamäki J, Kuusisto J et al (2008) Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance. J Clin Endocrinol Metab 93:1924–1930
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1924-1930
    • Stancáková, A.1    Pihlajamäki, J.2    Kuusisto, J.3
  • 36
    • 58049198441 scopus 로고    scopus 로고
    • Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function
    • PID: 19088850
    • Staiger H, Machicao F, Schäfer SA et al (2008) Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function. PLoS One 3, e3962
    • (2008) PLoS One , vol.3
    • Staiger, H.1    Machicao, F.2    Schäfer, S.A.3
  • 37
    • 51549112931 scopus 로고    scopus 로고
    • Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes
    • PID: 18714373
    • Staiger H, Machicao F, Kantartzis K et al (2008) Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes. PLoS One 3, e3019
    • (2008) PLoS One , vol.3
    • Staiger, H.1    Machicao, F.2    Kantartzis, K.3
  • 38
    • 41149178492 scopus 로고    scopus 로고
    • Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion
    • COI: 1:CAS:528:DC%2BD1cXjsFGiu7o%3D, PID: 18264689
    • Kirchhoff K, Machicao F, Haupt A et al (2008) Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia 51:597–601
    • (2008) Diabetologia , vol.51 , pp. 597-601
    • Kirchhoff, K.1    Machicao, F.2    Haupt, A.3
  • 39
    • 38849129636 scopus 로고    scopus 로고
    • Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function
    • PID: 17786204
    • Staiger H, Machicao F, Stefan N et al (2007) Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function. PLoS One 2, e832
    • (2007) PLoS One , vol.2
    • Staiger, H.1    Machicao, F.2    Stefan, N.3
  • 40
    • 77950344135 scopus 로고    scopus 로고
    • Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3cXjslensr4%3D, PID: 20028944
    • Haupt A, Thamer C, Heni M et al (2010) Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes. Diabetes 59:747–750
    • (2010) Diabetes , vol.59 , pp. 747-750
    • Haupt, A.1    Thamer, C.2    Heni, M.3
  • 41
    • 84859073619 scopus 로고    scopus 로고
    • Dietary fiber intake modulates the association between variants in TCF7L2 and weight loss during a lifestyle intervention
    • PID: 22355027
    • Heni M, Herzberg-Schäfer S, Machicao F, Häring HU, Fritsche A (2012) Dietary fiber intake modulates the association between variants in TCF7L2 and weight loss during a lifestyle intervention. Diabetes Care 35, e24
    • (2012) Diabetes Care , vol.35
    • Heni, M.1    Herzberg-Schäfer, S.2    Machicao, F.3    Häring, H.U.4    Fritsche, A.5
  • 42
    • 40949141938 scopus 로고    scopus 로고
    • Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets
    • COI: 1:CAS:528:DC%2BD1cXjt1Chtbo%3D, PID: 18071026
    • Shu L, Sauter NS, Schulthess FT, Matveyenko AV, Oberholzer J, Maedler K (2008) Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets. Diabetes 57:645–653
    • (2008) Diabetes , vol.57 , pp. 645-653
    • Shu, L.1    Sauter, N.S.2    Schulthess, F.T.3    Matveyenko, A.V.4    Oberholzer, J.5    Maedler, K.6
  • 43
    • 67349102328 scopus 로고    scopus 로고
    • The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men
    • COI: 1:CAS:528:DC%2BD1MXms1yhs70%3D, PID: 19288077
    • Pilgaard K, Jensen CB, Schou JH et al (2009) The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men. Diabetologia 52:1298–1307
    • (2009) Diabetologia , vol.52 , pp. 1298-1307
    • Pilgaard, K.1    Jensen, C.B.2    Schou, J.H.3
  • 44
    • 77449099615 scopus 로고    scopus 로고
    • TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action
    • COI: 1:CAS:528:DC%2BC3cXhvVyru7Y%3D, PID: 19934000
    • Villareal DT, Robertson H, Bell GI et al (2010) TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. Diabetes 59:479–485
    • (2010) Diabetes , vol.59 , pp. 479-485
    • Villareal, D.T.1    Robertson, H.2    Bell, G.I.3
  • 45
    • 34547702501 scopus 로고    scopus 로고
    • Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes
    • COI: 1:CAS:528:DC%2BD2sXoslOnsrk%3D, PID: 17671651
    • Lyssenko V, Lupi R, Marchetti P et al (2007) Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 117:2155–2163
    • (2007) J Clin Invest , vol.117 , pp. 2155-2163
    • Lyssenko, V.1    Lupi, R.2    Marchetti, P.3
  • 46
    • 84905569407 scopus 로고    scopus 로고
    • Influence of TCF7L2 gene variants on the therapeutic response to the dipeptidylpeptidase-4 inhibitor linagliptin
    • COI: 1:CAS:528:DC%2BC2cXhtVShtbrL, PID: 24906949
    • Zimdahl H, Ittrich C, Graefe-Mody U et al (2014) Influence of TCF7L2 gene variants on the therapeutic response to the dipeptidylpeptidase-4 inhibitor linagliptin. Diabetologia 57:1869–1875
    • (2014) Diabetologia , vol.57 , pp. 1869-1875
    • Zimdahl, H.1    Ittrich, C.2    Graefe-Mody, U.3
  • 47
    • 33746075560 scopus 로고    scopus 로고
    • TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program
    • COI: 1:CAS:528:DC%2BD28XntVWktrw%3D, PID: 16855264
    • Florez JC, Jablonski KA, Bayley N et al (2006) TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 355:241–250
    • (2006) N Engl J Med , vol.355 , pp. 241-250
    • Florez, J.C.1    Jablonski, K.A.2    Bayley, N.3
  • 48
    • 53749085475 scopus 로고    scopus 로고
    • Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins
    • COI: 1:CAS:528:DC%2BD1cXht1GmurrP
    • Wegner L, Hussain MS, Pilgaard K et al (2008) Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins. Clin Endocrinol Metab 93:4013–4019
    • (2008) Clin Endocrinol Metab , vol.93 , pp. 4013-4019
    • Wegner, L.1    Hussain, M.S.2    Pilgaard, K.3
  • 49
    • 77951175614 scopus 로고    scopus 로고
    • The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest
    • COI: 1:CAS:528:DC%2BC3cXltFSmtr0%3D, PID: 20107109
    • Alibegovic AC, Sonne MP, Højbjerre L et al (2010) The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest. Diabetes 59:836–843
    • (2010) Diabetes , vol.59 , pp. 836-843
    • Alibegovic, A.C.1    Sonne, M.P.2    Højbjerre, L.3
  • 50
    • 84939125175 scopus 로고    scopus 로고
    • Glucose metabolism in high-risk subjects for type 2 diabetes carrying the rs7903146 TCF7L2 gene variant
    • PID: 26046964
    • Daniele G, Gaggini M, Comassi M et al (2015) Glucose metabolism in high-risk subjects for type 2 diabetes carrying the rs7903146 TCF7L2 gene variant. J Clin Endocrinol Metab 100:E1160–E1167
    • (2015) J Clin Endocrinol Metab , vol.100 , pp. E1160-E1167
    • Daniele, G.1    Gaggini, M.2    Comassi, M.3
  • 51
    • 84866072918 scopus 로고    scopus 로고
    • TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals
    • COI: 1:CAS:528:DC%2BC38XhtlWlsrjJ, PID: 22911383
    • Le Bacquer O, Kerr-Conte J, Gargani S et al (2012) TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals. Diabetologia 55:2677–2681
    • (2012) Diabetologia , vol.55 , pp. 2677-2681
    • Le Bacquer, O.1    Kerr-Conte, J.2    Gargani, S.3
  • 52
    • 77958546383 scopus 로고    scopus 로고
    • Follow-up whole-body assessment of adipose tissue compartments during a lifestyle intervention in a large cohort at increased risk for type 2 diabetes
    • PID: 20713612
    • Machann J, Thamer C, Stefan N et al (2010) Follow-up whole-body assessment of adipose tissue compartments during a lifestyle intervention in a large cohort at increased risk for type 2 diabetes. Radiology 257:353–363
    • (2010) Radiology , vol.257 , pp. 353-363
    • Machann, J.1    Thamer, C.2    Stefan, N.3
  • 53
    • 77957791292 scopus 로고    scopus 로고
    • Interscapular fat is strongly associated with insulin resistance
    • COI: 1:CAS:528:DC%2BC3cXhtlCktLjL, PID: 20660049
    • Thamer C, Machann J, Staiger H et al (2010) Interscapular fat is strongly associated with insulin resistance. J Clin Endocrinol Metab 95:4736–4742
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 4736-4742
    • Thamer, C.1    Machann, J.2    Staiger, H.3
  • 54
    • 53549086389 scopus 로고    scopus 로고
    • Perivascular fatty tissue at the brachial artery is linked to insulin resistance but not to local endothelial dysfunction
    • COI: 1:CAS:528:DC%2BD1cXht1amsrfM, PID: 18712517
    • Rittig K, Staib K, Machann J et al (2008) Perivascular fatty tissue at the brachial artery is linked to insulin resistance but not to local endothelial dysfunction. Diabetologia 51:2093–2099
    • (2008) Diabetologia , vol.51 , pp. 2093-2099
    • Rittig, K.1    Staib, K.2    Machann, J.3
  • 55
    • 49449092403 scopus 로고    scopus 로고
    • Identification and characterization of metabolically benign obesity in humans
    • PID: 18695074
    • Stefan N, Kantartzis K, Machann J et al (2008) Identification and characterization of metabolically benign obesity in humans. Arch Intern Med 168:1609–1616
    • (2008) Arch Intern Med , vol.168 , pp. 1609-1616
    • Stefan, N.1    Kantartzis, K.2    Machann, J.3
  • 56
    • 79953807628 scopus 로고    scopus 로고
    • Effects of a lifestyle intervention in metabolically benign and malign obesity
    • COI: 1:STN:280:DC%2BC3M3lt1aqsg%3D%3D, PID: 21174075
    • Kantartzis K, Machann J, Schick F et al (2011) Effects of a lifestyle intervention in metabolically benign and malign obesity. Diabetologia 54:864–868
    • (2011) Diabetologia , vol.54 , pp. 864-868
    • Kantartzis, K.1    Machann, J.2    Schick, F.3
  • 57
    • 84884500386 scopus 로고    scopus 로고
    • Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications
    • PID: 24622321
    • Stefan N, Häring HU, Hu FB, Schulze MB (2013) Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications. Lancet Diabetes Endocrinol 1:152–162
    • (2013) Lancet Diabetes Endocrinol , vol.1 , pp. 152-162
    • Stefan, N.1    Häring, H.U.2    Hu, F.B.3    Schulze, M.B.4
  • 58
    • 80052840577 scopus 로고    scopus 로고
    • The metabolically benign and malignant fatty liver
    • COI: 1:CAS:528:DC%2BC3MXhtValurvL, PID: 21788578
    • Stefan N, Häring HU (2011) The metabolically benign and malignant fatty liver. Diabetes 60:2011–2017
    • (2011) Diabetes , vol.60 , pp. 2011-2017
    • Stefan, N.1    Häring, H.U.2
  • 59
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • COI: 1:CAS:528:DC%2BD1cXhsVWgsrrP, PID: 18820647
    • Romeo S, Kozlitina J, Xing C et al (2008) Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 40:1461–1465
    • (2008) Nat Genet , vol.40 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3
  • 60
    • 70350550096 scopus 로고    scopus 로고
    • Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene
    • COI: 1:CAS:528:DC%2BD1MXhsVCht7%2FM, PID: 19651814
    • Kantartzis K, Peter A, Machicao F et al (2009) Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene. Diabetes 58:2616–2623
    • (2009) Diabetes , vol.58 , pp. 2616-2623
    • Kantartzis, K.1    Peter, A.2    Machicao, F.3
  • 61
    • 84926660045 scopus 로고    scopus 로고
    • PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans
    • COI: 1:CAS:528:DC%2BC2cXhtFShsbrL, PID: 24972532
    • Peter A, Kovarova M, Nadalin S et al (2014) PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans. Diabetologia 57:2103–2107
    • (2014) Diabetologia , vol.57 , pp. 2103-2107
    • Peter, A.1    Kovarova, M.2    Nadalin, S.3
  • 62
    • 84951083544 scopus 로고    scopus 로고
    • The genetic variant I148M in PNPLA3 is associated with increased hepatic retinyl-palmitate storage in humans
    • PID: 26439088
    • Kovarova M, Königsrainer I, Königsrainer A et al (2015) The genetic variant I148M in PNPLA3 is associated with increased hepatic retinyl-palmitate storage in humans. J Clin Endocrinol Metab 100:E1568–E1574
    • (2015) J Clin Endocrinol Metab , vol.100 , pp. E1568-E1574
    • Kovarova, M.1    Königsrainer, I.2    Königsrainer, A.3
  • 63
    • 84875549943 scopus 로고    scopus 로고
    • The role of hepatokines in metabolism
    • COI: 1:CAS:528:DC%2BC3sXjtVaktb4%3D, PID: 23337953
    • Stefan N, Häring HU (2013) The role of hepatokines in metabolism. Nat Rev Endocrinol 9:144–152
    • (2013) Nat Rev Endocrinol , vol.9 , pp. 144-152
    • Stefan, N.1    Häring, H.U.2
  • 64
    • 84878433548 scopus 로고    scopus 로고
    • Circulating fetuin-A and free fatty acids interact to predict insulin resistance in humans
    • COI: 1:CAS:528:DC%2BC3sXlt1aqtbo%3D, PID: 23558619
    • Stefan N, Häring HU (2013) Circulating fetuin-A and free fatty acids interact to predict insulin resistance in humans. Nat Med 19:394–395
    • (2013) Nat Med , vol.19 , pp. 394-395
    • Stefan, N.1    Häring, H.U.2
  • 65
    • 84918819322 scopus 로고    scopus 로고
    • Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease
    • PID: 25470709
    • Stefan N, Schick F, Häring HU (2014) Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. N Engl J Med 371:2236–2237
    • (2014) N Engl J Med , vol.371 , pp. 2236-2237
    • Stefan, N.1    Schick, F.2    Häring, H.U.3
  • 66
    • 56649094538 scopus 로고    scopus 로고
    • Plasma fetuin-A levels and the risk of type 2 diabetes
    • COI: 1:CAS:528:DC%2BD1MXhs1Knt74%3D, PID: 18633113
    • Stefan N, Fritsche A, Weikert C et al (2008) Plasma fetuin-A levels and the risk of type 2 diabetes. Diabetes 57:2762–2767
    • (2008) Diabetes , vol.57 , pp. 2762-2767
    • Stefan, N.1    Fritsche, A.2    Weikert, C.3
  • 67
    • 58149393662 scopus 로고    scopus 로고
    • Plasma fetuin-a levels and the risk of myocardial infarction and ischemic stroke
    • COI: 1:CAS:528:DC%2BD1cXhsVerurrM, PID: 19029462
    • Weikert C, Stefan N, Schulze MB et al (2008) Plasma fetuin-a levels and the risk of myocardial infarction and ischemic stroke. Circulation 118:2555–2562
    • (2008) Circulation , vol.118 , pp. 2555-2562
    • Weikert, C.1    Stefan, N.2    Schulze, M.B.3
  • 68
    • 77955069684 scopus 로고    scopus 로고
    • NF-kB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance
    • COI: 1:CAS:528:DC%2BC3cXovVCnsrc%3D, PID: 20482516
    • Dasgupta S, Bhattacharya S, Biswas A et al (2010) NF-kB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance. Biochem J 429:451–462
    • (2010) Biochem J , vol.429 , pp. 451-462
    • Dasgupta, S.1    Bhattacharya, S.2    Biswas, A.3
  • 69
    • 73249130996 scopus 로고    scopus 로고
    • High glucose induces transactivation of the alpha2-HS glycoprotein gene through the ERK1/2 signaling pathway
    • COI: 1:CAS:528:DC%2BD1MXht1antrjP, PID: 19672022
    • Takata H, Ikeda Y, Suehiro T et al (2009) High glucose induces transactivation of the alpha2-HS glycoprotein gene through the ERK1/2 signaling pathway. J Atheroscler Thromb 16:448–456
    • (2009) J Atheroscler Thromb , vol.16 , pp. 448-456
    • Takata, H.1    Ikeda, Y.2    Suehiro, T.3
  • 70
    • 84955475087 scopus 로고    scopus 로고
    • Exendin-4 inhibits the expression of SEPP1 and fetuin-A via improvement of palmitic acid-induced endoplasmic reticulum stress by AMPK
    • Lee J, Hong SW, Park SE et al (2015) Exendin-4 inhibits the expression of SEPP1 and fetuin-A via improvement of palmitic acid-induced endoplasmic reticulum stress by AMPK. Endocrinol Metab (Seoul) 2015:177–184
    • (2015) Endocrinol Metab (Seoul) , vol.2015 , pp. 177-184
    • Lee, J.1    Hong, S.W.2    Park, S.E.3
  • 71
    • 0027333427 scopus 로고
    • Serum alpha 2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level
    • COI: 1:CAS:528:DyaK2cXhvVGqtbg%3D, PID: 7906861
    • Srinivas PR, Wagner AS, Reddy LV et al (1993) Serum alpha 2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level. Mol Endocrinol 7:1445–1455
    • (1993) Mol Endocrinol , vol.7 , pp. 1445-1455
    • Srinivas, P.R.1    Wagner, A.S.2    Reddy, L.V.3
  • 72
    • 84898597887 scopus 로고    scopus 로고
    • Fetuin-A influences vascular cell growth and production of proinflammatory and angiogenic proteins by human perivascular fat cells
    • COI: 1:CAS:528:DC%2BC2cXhs1KisLo%3D, PID: 24493202
    • Siegel-Axel DI, Ullrich S, Stefan N et al (2014) Fetuin-A influences vascular cell growth and production of proinflammatory and angiogenic proteins by human perivascular fat cells. Diabetologia 57:1057–1066
    • (2014) Diabetologia , vol.57 , pp. 1057-1066
    • Siegel-Axel, D.I.1    Ullrich, S.2    Stefan, N.3
  • 73
    • 84864657351 scopus 로고    scopus 로고
    • Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
    • COI: 1:CAS:528:DC%2BC38XhtFWms73L, PID: 22842477
    • Pal D, Dasgupta S, Kundu R et al (2012) Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat Med 18:1279–1285
    • (2012) Nat Med , vol.18 , pp. 1279-1285
    • Pal, D.1    Dasgupta, S.2    Kundu, R.3
  • 74
    • 19744362790 scopus 로고    scopus 로고
    • Vasocrine” signalling from perivascular fat: a mechanism linking insulin resistance to vascular disease
    • PID: 15910955
    • Yudkin JS, Eringa E, Stehouwer CD (2005) “Vasocrine” signalling from perivascular fat: a mechanism linking insulin resistance to vascular disease. Lancet 365:1817–1820
    • (2005) Lancet , vol.365 , pp. 1817-1820
    • Yudkin, J.S.1    Eringa, E.2    Stehouwer, C.D.3
  • 75
    • 79955920129 scopus 로고    scopus 로고
    • Perivascular adipose tissue and its role in type 2 diabetes and cardiovascular disease
    • COI: 1:CAS:528:DC%2BC3MXlsFagsbs%3D, PID: 21461998
    • Meijer RI, Serne EH, Smulders YM, van Hinsbergh VW, Yudkin JS, Eringa EC (2011) Perivascular adipose tissue and its role in type 2 diabetes and cardiovascular disease. Curr Diab Rep 11:211–217
    • (2011) Curr Diab Rep , vol.11 , pp. 211-217
    • Meijer, R.I.1    Serne, E.H.2    Smulders, Y.M.3    van Hinsbergh, V.W.4    Yudkin, J.S.5    Eringa, E.C.6
  • 76
    • 84862564234 scopus 로고    scopus 로고
    • The secretion pattern of perivascular fat cells is different from that of subcutaneous and visceral fat cells
    • COI: 1:STN:280:DC%2BC38vislKisw%3D%3D, PID: 22327346
    • Rittig K, Dolderer JH, Balletshofer B et al (2012) The secretion pattern of perivascular fat cells is different from that of subcutaneous and visceral fat cells. Diabetologia 55:1514–1525
    • (2012) Diabetologia , vol.55 , pp. 1514-1525
    • Rittig, K.1    Dolderer, J.H.2    Balletshofer, B.3
  • 77
    • 84866358921 scopus 로고    scopus 로고
    • Exercise-induced albuminuria is associated with perivascular renal sinus fat in individuals at increased risk of type 2 diabetes
    • COI: 1:CAS:528:DC%2BC38Xotlelt7g%3D, PID: 22526613
    • Wagner R, Machann J, Lehmann R et al (2012) Exercise-induced albuminuria is associated with perivascular renal sinus fat in individuals at increased risk of type 2 diabetes. Diabetologia 55:2054–2058
    • (2012) Diabetologia , vol.55 , pp. 2054-2058
    • Wagner, R.1    Machann, J.2    Lehmann, R.3
  • 78
    • 84965163560 scopus 로고    scopus 로고
    • Obesity and renal disease: not all fat is created equal and not all obesity is harmful to the kidneys
    • PID: 24753460
    • Stefan N, Artunc F, Heyne N, Machann J, Schleicher ED, Häring HU (2016) Obesity and renal disease: not all fat is created equal and not all obesity is harmful to the kidneys. Nephrol Dial Transplant 31:726–730
    • (2016) Nephrol Dial Transplant , vol.31 , pp. 726-730
    • Stefan, N.1    Artunc, F.2    Heyne, N.3    Machann, J.4    Schleicher, E.D.5    Häring, H.U.6
  • 79
    • 77952396750 scopus 로고    scopus 로고
    • Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance study
    • COI: 1:CAS:528:DC%2BC3cXotFKlt7o%3D, PID: 20225188
    • Heni M, Machann J, Staiger H et al (2010) Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance study. Diabetes Metab Res Rev 26:200–205
    • (2010) Diabetes Metab Res Rev , vol.26 , pp. 200-205
    • Heni, M.1    Machann, J.2    Staiger, H.3
  • 80
    • 84898670730 scopus 로고    scopus 로고
    • Impact of the adipokine adiponectin and the hepatokine fetuin-A on the development of type 2 diabetes: prospective cohort- and cross-sectional phenotyping studies
    • PID: 24643166
    • Stefan N, Sun Q, Fritsche A et al (2014) Impact of the adipokine adiponectin and the hepatokine fetuin-A on the development of type 2 diabetes: prospective cohort- and cross-sectional phenotyping studies. PLoS One 9, e92238
    • (2014) PLoS One , vol.9
    • Stefan, N.1    Sun, Q.2    Fritsche, A.3
  • 81
    • 84870755708 scopus 로고    scopus 로고
    • High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet
    • COI: 1:CAS:528:DC%2BC38XhvVCgtLzL, PID: 23015656
    • Silbernagel G, Kovarova M, Cegan A et al (2012) High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet. J Clin Endocrinol Metab 97:E2288–E2292
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. E2288-E2292
    • Silbernagel, G.1    Kovarova, M.2    Cegan, A.3
  • 82
    • 79955457155 scopus 로고    scopus 로고
    • Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction
    • COI: 1:CAS:528:DC%2BC3MXltlCqsbk%3D, PID: 21367948
    • Browning JD, Baker JA, Rogers T, Davis J, Satapati S, Burgess SC (2011) Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction. Am J Clin Nutr 93:1048–1052
    • (2011) Am J Clin Nutr , vol.93 , pp. 1048-1052
    • Browning, J.D.1    Baker, J.A.2    Rogers, T.3    Davis, J.4    Satapati, S.5    Burgess, S.C.6
  • 83
    • 34247643885 scopus 로고    scopus 로고
    • Serum alanine aminotransferase levels decrease further with carbohydrate than fat restriction in insulin-resistant adults
    • COI: 1:CAS:528:DC%2BD2sXmtFKnurs%3D, PID: 17351275
    • Ryan MC, Abbasi F, Lamendola C, Carter S, McLaughlin T (2007) Serum alanine aminotransferase levels decrease further with carbohydrate than fat restriction in insulin-resistant adults. Diabetes Care 30:1075–1080
    • (2007) Diabetes Care , vol.30 , pp. 1075-1080
    • Ryan, M.C.1    Abbasi, F.2    Lamendola, C.3    Carter, S.4    McLaughlin, T.5
  • 84
    • 84875020011 scopus 로고    scopus 로고
    • Beneficial effect of a weight-stable, low fat/ low-saturated fat/low-glycaemic index diet to reduce liver fat in older subjects
    • COI: 1:CAS:528:DC%2BC3sXjvVaktbs%3D, PID: 22849970
    • Utzschneider KM, Bayer-Carter JL, Arbuckle MD, Tidwell JM, Richards TL, Craft S (2013) Beneficial effect of a weight-stable, low fat/ low-saturated fat/low-glycaemic index diet to reduce liver fat in older subjects. Br J Nutr 109:1096–1104
    • (2013) Br J Nutr , vol.109 , pp. 1096-1104
    • Utzschneider, K.M.1    Bayer-Carter, J.L.2    Arbuckle, M.D.3    Tidwell, J.M.4    Richards, T.L.5    Craft, S.6
  • 85
    • 70349902776 scopus 로고    scopus 로고
    • Omega-3 fatty acid supplementation decreases liver fat content in polycystic ovary syndrome: a randomized controlled trial employing proton magnetic resonance spectroscopy
    • COI: 1:CAS:528:DC%2BD1MXht12ru7nM, PID: 19622617
    • Cussons AJ, Watts GF, Mori TA, Stuckey BG (2009) Omega-3 fatty acid supplementation decreases liver fat content in polycystic ovary syndrome: a randomized controlled trial employing proton magnetic resonance spectroscopy. J Clin Endocrinol Metab 94:3842–3848
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 3842-3848
    • Cussons, A.J.1    Watts, G.F.2    Mori, T.A.3    Stuckey, B.G.4
  • 86
    • 84927776586 scopus 로고    scopus 로고
    • Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: results from the Welcome study
    • COI: 1:CAS:528:DC%2BC2cXhs1Wlu7vJ, PID: 25043514
    • Scorletti E, Bhatia L, McCormick KG et al (2014) Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: results from the Welcome study. Hepatology 60:1211–1221
    • (2014) Hepatology , vol.60 , pp. 1211-1221
    • Scorletti, E.1    Bhatia, L.2    McCormick, K.G.3
  • 87
    • 27744492082 scopus 로고    scopus 로고
    • Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat
    • COI: 1:CAS:528:DC%2BD2MXht1Skt7vI, PID: 16205883
    • Stefan N, Machicao F, Staiger H et al (2005) Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. Diabetologia 48:2282–2291
    • (2005) Diabetologia , vol.48 , pp. 2282-2291
    • Stefan, N.1    Machicao, F.2    Staiger, H.3
  • 88
    • 42049105146 scopus 로고    scopus 로고
    • Variations in PPARD determine the change in body composition during lifestyle intervention: a whole-body magnetic resonance study
    • COI: 1:CAS:528:DC%2BD1cXks1agsLc%3D, PID: 18252792
    • Thamer C, Machann J, Stefan N et al (2008) Variations in PPARD determine the change in body composition during lifestyle intervention: a whole-body magnetic resonance study. J Clin Endocrinol Metab 93:1497–1500
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1497-1500
    • Thamer, C.1    Machann, J.2    Stefan, N.3
  • 89
    • 84909979604 scopus 로고    scopus 로고
    • Integrative biology of exercise
    • COI: 1:CAS:528:DC%2BC2cXhvV2msrbF, PID: 25417152
    • Hawley JA, Hargreaves M, Joyner MJ, Zierath JR (2014) Integrative biology of exercise. Cell 159:738–749
    • (2014) Cell , vol.159 , pp. 738-749
    • Hawley, J.A.1    Hargreaves, M.2    Joyner, M.J.3    Zierath, J.R.4
  • 90
    • 84937434706 scopus 로고    scopus 로고
    • Changes in gene expression in responders and nonresponders to a low-intensity walking intervention
    • COI: 1:CAS:528:DC%2BC2MXhtFyms7%2FJ, PID: 25795414
    • Osler ME, Fritz T, Caidahl K et al (2015) Changes in gene expression in responders and nonresponders to a low-intensity walking intervention. Diabetes Care 38:1154–1160
    • (2015) Diabetes Care , vol.38 , pp. 1154-1160
    • Osler, M.E.1    Fritz, T.2    Caidahl, K.3
  • 91
    • 68849104744 scopus 로고    scopus 로고
    • High cardiorespiratory fitness is an independent predictor of the reduction in liver fat during a lifestyle intervention in non-alcoholic fatty liver disease
    • COI: 1:STN:280:DC%2BD1Mrks1yqtw%3D%3D, PID: 19074179
    • Kantartzis K, Thamer C, Peter A et al (2009) High cardiorespiratory fitness is an independent predictor of the reduction in liver fat during a lifestyle intervention in non-alcoholic fatty liver disease. Gut 58:1281–1288
    • (2009) Gut , vol.58 , pp. 1281-1288
    • Kantartzis, K.1    Thamer, C.2    Peter, A.3
  • 92
    • 84959533315 scopus 로고    scopus 로고
    • Exercise and diabetes: relevance and causes for response variability
    • PID: 26643313
    • Böhm A, Weigert C, Staiger H, Häring HU (2016) Exercise and diabetes: relevance and causes for response variability. Endocrine 51:390–401
    • (2016) Endocrine , vol.51 , pp. 390-401
    • Böhm, A.1    Weigert, C.2    Staiger, H.3    Häring, H.U.4
  • 93
    • 84939573210 scopus 로고    scopus 로고
    • A transcriptional signature of ‘exercise resistance’ in skeletal muscle of individuals with type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BC2MXhtFCkt7nM, PID: 26163877
    • Stephens NA, Xie H, Johannsen NM, Church TS, Smith SR, Sparks LM (2015) A transcriptional signature of ‘exercise resistance’ in skeletal muscle of individuals with type 2 diabetes mellitus. Metabolism 64:999–1004
    • (2015) Metabolism , vol.64 , pp. 999-1004
    • Stephens, N.A.1    Xie, H.2    Johannsen, N.M.3    Church, T.S.4    Smith, S.R.5    Sparks, L.M.6
  • 94
    • 19944427874 scopus 로고    scopus 로고
    • Effects of exercise training on glucose homeostasis: the HERITAGE Family Study
    • PID: 15616242
    • Boulé NG, Weisnagel SJ, Lakka TA et al (2005) Effects of exercise training on glucose homeostasis: the HERITAGE Family Study. Diabetes Care 28:108–114
    • (2005) Diabetes Care , vol.28 , pp. 108-114
    • Boulé, N.G.1    Weisnagel, S.J.2    Lakka, T.A.3
  • 95
    • 84872375286 scopus 로고    scopus 로고
    • Interleukin-6 promotes myogenic differentiation of mouse skeletal muscle cells: role of the STAT3 pathway
    • COI: 1:CAS:528:DC%2BC3sXit1ynsbo%3D, PID: 23114963
    • Hoene M, Runge H, Häring HU, Schleicher ED, Weigert C (2013) Interleukin-6 promotes myogenic differentiation of mouse skeletal muscle cells: role of the STAT3 pathway. Am J Physiol Cell Physiol 304:C128–C136
    • (2013) Am J Physiol Cell Physiol , vol.304 , pp. C128-C136
    • Hoene, M.1    Runge, H.2    Häring, H.U.3    Schleicher, E.D.4    Weigert, C.5
  • 96
    • 84885585271 scopus 로고    scopus 로고
    • Cytokine response of primary human myotubes in an in vitro exercise model
    • COI: 1:CAS:528:DC%2BC3sXhslejtbzP, PID: 23926130
    • Scheler M, Irmler M, Lehr S et al (2013) Cytokine response of primary human myotubes in an in vitro exercise model. Am J Physiol Cell Physiol 305:C877–C886
    • (2013) Am J Physiol Cell Physiol , vol.305 , pp. C877-C886
    • Scheler, M.1    Irmler, M.2    Lehr, S.3
  • 97
    • 84937525633 scopus 로고    scopus 로고
    • Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery
    • COI: 1:CAS:528:DC%2BC2MXhtVegtr3K, PID: 26067360
    • Hansen JS, Zhao X, Irmler M et al (2015) Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery. Diabetologia 58:1845–1854
    • (2015) Diabetologia , vol.58 , pp. 1845-1854
    • Hansen, J.S.1    Zhao, X.2    Irmler, M.3
  • 98
    • 84893496615 scopus 로고    scopus 로고
    • The secretome of the working human skeletal muscle—a promising opportunity to combat the metabolic disaster?
    • COI: 1:CAS:528:DC%2BC2cXhsl2gu7k%3D, PID: 24376246
    • Weigert C, Lehmann R, Hartwig S, Lehr S (2014) The secretome of the working human skeletal muscle—a promising opportunity to combat the metabolic disaster? Proteomics Clin Appl 8:5–18
    • (2014) Proteomics Clin Appl , vol.8 , pp. 5-18
    • Weigert, C.1    Lehmann, R.2    Hartwig, S.3    Lehr, S.4
  • 99
    • 0019458387 scopus 로고
    • Insulin and insulin receptors in rodent brain
    • COI: 1:CAS:528:DyaL3MXktVeqtrc%3D, PID: 7014325
    • Havrankova J, Brownstein M, Roth J (1981) Insulin and insulin receptors in rodent brain. Diabetologia 20(Suppl):268–273
    • (1981) Diabetologia , vol.20 , pp. 268-273
    • Havrankova, J.1    Brownstein, M.2    Roth, J.3
  • 100
    • 0018090354 scopus 로고
    • Insulin receptors are widely distributed in the central nervous system of the rat
    • COI: 1:CAS:528:DyaE1cXkvVCqt7g%3D, PID: 205798
    • Havrankova J, Roth J, Brownstein M (1978) Insulin receptors are widely distributed in the central nervous system of the rat. Nature 272:827–829
    • (1978) Nature , vol.272 , pp. 827-829
    • Havrankova, J.1    Roth, J.2    Brownstein, M.3
  • 101
    • 0034703229 scopus 로고    scopus 로고
    • Role of brain insulin receptor in control of body weight and reproduction
    • PID: 11000114
    • Brüning JC, Gautam D, Burks DJ et al (2000) Role of brain insulin receptor in control of body weight and reproduction. Science 289:2122–2125
    • (2000) Science , vol.289 , pp. 2122-2125
    • Brüning, J.C.1    Gautam, D.2    Burks, D.J.3
  • 103
    • 9644260563 scopus 로고    scopus 로고
    • Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes
    • COI: 1:CAS:528:DC%2BD2cXot12gtr0%3D, PID: 15467829
    • Lin X, Taguchi A, Park S et al (2004) Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest 114:908–916
    • (2004) J Clin Invest , vol.114 , pp. 908-916
    • Lin, X.1    Taguchi, A.2    Park, S.3
  • 104
    • 33747058235 scopus 로고    scopus 로고
    • The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: a magnetoencephalographic study
    • COI: 1:CAS:528:DC%2BD28Xotlyis7o%3D, PID: 16877540
    • Tschritter O, Preissl H, Hennige AM et al (2006) The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: a magnetoencephalographic study. Proc Natl Acad Sci U S A 103:12103–12108
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 12103-12108
    • Tschritter, O.1    Preissl, H.2    Hennige, A.M.3
  • 105
    • 84947614766 scopus 로고    scopus 로고
    • Impaired insulin action in the human brain: causes and metabolic consequences
    • COI: 1:CAS:528:DC%2BC2MXhs1Cqur%2FM, PID: 26460339
    • Heni M, Kullmann S, Preissl H, Fritsche A, Häring HU (2015) Impaired insulin action in the human brain: causes and metabolic consequences. Nat Rev Endocrinol 11:701–711
    • (2015) Nat Rev Endocrinol , vol.11 , pp. 701-711
    • Heni, M.1    Kullmann, S.2    Preissl, H.3    Fritsche, A.4    Häring, H.U.5
  • 106
    • 84938302676 scopus 로고    scopus 로고
    • Selective insulin resistance in homeostatic and cognitive control brain areas in overweight and obese adults
    • COI: 1:CAS:528:DC%2BC2MXhtFymsrfO, PID: 25795413
    • Kullmann S, Heni M, Veit R et al (2015) Selective insulin resistance in homeostatic and cognitive control brain areas in overweight and obese adults. Diabetes Care 38:1044–1050
    • (2015) Diabetes Care , vol.38 , pp. 1044-1050
    • Kullmann, S.1    Heni, M.2    Veit, R.3
  • 107
    • 84911916822 scopus 로고    scopus 로고
    • Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men
    • COI: 1:CAS:528:DC%2BC2cXitVCgsbfP, PID: 25028522
    • Heni M, Wagner R, Kullmann S et al (2014) Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men. Diabetes 63:4083–4088
    • (2014) Diabetes , vol.63 , pp. 4083-4088
    • Heni, M.1    Wagner, R.2    Kullmann, S.3
  • 108
    • 76149103529 scopus 로고    scopus 로고
    • Insulin modulates food-related activity in the central nervous system
    • COI: 1:CAS:528:DC%2BC3cXitVaisLo%3D, PID: 19996309
    • Guthoff M, Grichisch Y, Canova C et al (2010) Insulin modulates food-related activity in the central nervous system. J Clin Endocrinol Metab 95:748–755
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 748-755
    • Guthoff, M.1    Grichisch, Y.2    Canova, C.3
  • 109
    • 84855915021 scopus 로고    scopus 로고
    • Differential effects of intranasal insulin and caffeine on cerebral blood flow
    • PID: 21391271
    • Grichisch Y, Çavuşoğlu M, Preissl H et al (2012) Differential effects of intranasal insulin and caffeine on cerebral blood flow. Hum Brain Mapp 33:280–287
    • (2012) Hum Brain Mapp , vol.33 , pp. 280-287
    • Grichisch, Y.1    Çavuşoğlu, M.2    Preissl, H.3
  • 110
    • 84865434170 scopus 로고    scopus 로고
    • Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and reward-related human brain regions
    • COI: 1:CAS:528:DC%2BC38Xms1yqt7o%3D, PID: 22434537
    • Heni M, Kullmann S, Ketterer C et al (2012) Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and reward-related human brain regions. Diabetologia 55:1773–1782
    • (2012) Diabetologia , vol.55 , pp. 1773-1782
    • Heni, M.1    Kullmann, S.2    Ketterer, C.3
  • 111
    • 84876283390 scopus 로고    scopus 로고
    • Intranasal insulin modulates intrinsic reward and prefrontal circuitry of the human brain in lean women
    • COI: 1:CAS:528:DC%2BC3sXlt1Glsr8%3D, PID: 22922661
    • Kullmann S, Frank S, Heni M et al (2013) Intranasal insulin modulates intrinsic reward and prefrontal circuitry of the human brain in lean women. Neuroendocrinology 97:176–182
    • (2013) Neuroendocrinology , vol.97 , pp. 176-182
    • Kullmann, S.1    Frank, S.2    Heni, M.3
  • 112
    • 84856719077 scopus 로고    scopus 로고
    • High cerebral insulin sensitivity is associated with loss of body fat during lifestyle intervention
    • COI: 1:CAS:528:DC%2BC3MXhsFOqu77E, PID: 21927893
    • Tschritter O, Preissl H, Hennige AM et al (2012) High cerebral insulin sensitivity is associated with loss of body fat during lifestyle intervention. Diabetologia 55:175–178
    • (2012) Diabetologia , vol.55 , pp. 175-178
    • Tschritter, O.1    Preissl, H.2    Hennige, A.M.3
  • 113
    • 84964352862 scopus 로고    scopus 로고
    • Insulin regulates hepatic triglyceride secretion and lipid content via signaling in the brain
    • Scherer T, Lindtner C, O’Hare J et al (2016) Insulin regulates hepatic triglyceride secretion and lipid content via signaling in the brain. Diabetes. doi:10.2337/db15-1552
    • (2016) Diabetes
    • Scherer, T.1    Lindtner, C.2    O’Hare, J.3
  • 114
    • 84903173931 scopus 로고    scopus 로고
    • Insulin action in brain regulates systemic metabolism and brain function
    • PID: 24931034
    • Kleinridders A, Ferris HA, Cai W, Kahn CR (2014) Insulin action in brain regulates systemic metabolism and brain function. Diabetes 63:2232–2243
    • (2014) Diabetes , vol.63 , pp. 2232-2243
    • Kleinridders, A.1    Ferris, H.A.2    Cai, W.3    Kahn, C.R.4
  • 115
    • 17844379717 scopus 로고    scopus 로고
    • Hypothalamic K(ATP) channels control hepatic glucose production
    • COI: 1:CAS:528:DC%2BD2MXjsVequrk%3D, PID: 15846348
    • Pocai A, Lam TK, Gutierrez-Juarez R et al (2005) Hypothalamic K(ATP) channels control hepatic glucose production. Nature 434:1026–1031
    • (2005) Nature , vol.434 , pp. 1026-1031
    • Pocai, A.1    Lam, T.K.2    Gutierrez-Juarez, R.3
  • 116
    • 0036267472 scopus 로고    scopus 로고
    • Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
    • COI: 1:CAS:528:DC%2BD38XjvVynsro%3D, PID: 12021765
    • Obici S, Feng Z, Karkanias G, Baskin DG, Rossetti L (2002) Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci 5:566–572
    • (2002) Nat Neurosci , vol.5 , pp. 566-572
    • Obici, S.1    Feng, Z.2    Karkanias, G.3    Baskin, D.G.4    Rossetti, L.5
  • 117
    • 84931289812 scopus 로고    scopus 로고
    • Effects of intranasal insulin on hepatic fat accumulation and energy metabolism in humans
    • COI: 1:CAS:528:DC%2BC2MXhtVSjsrjP, PID: 25576060
    • Gancheva S, Koliaki C, Bierwagen A et al (2015) Effects of intranasal insulin on hepatic fat accumulation and energy metabolism in humans. Diabetes 64:1966–1975
    • (2015) Diabetes , vol.64 , pp. 1966-1975
    • Gancheva, S.1    Koliaki, C.2    Bierwagen, A.3
  • 118
    • 84901196954 scopus 로고    scopus 로고
    • Maternal insulin sensitivity is associated with oral glucose-induced changes in fetal brain activity
    • COI: 1:CAS:528:DC%2BC2cXltFygsrg%3D, PID: 24671273
    • Linder K, Schleger F, Ketterer C et al (2014) Maternal insulin sensitivity is associated with oral glucose-induced changes in fetal brain activity. Diabetologia 57:1192–1198
    • (2014) Diabetologia , vol.57 , pp. 1192-1198
    • Linder, K.1    Schleger, F.2    Ketterer, C.3
  • 119
    • 84958658384 scopus 로고    scopus 로고
    • Gestational diabetes impairs human fetal postprandial brain activity
    • COI: 1:CAS:528:DC%2BC28XjtlSnsL4%3D, PID: 26465393
    • Linder K, Schleger F, Kiefer-Schmidt I et al (2015) Gestational diabetes impairs human fetal postprandial brain activity. J Clin Endocrinol Metab 100:4029–4036
    • (2015) J Clin Endocrinol Metab , vol.100 , pp. 4029-4036
    • Linder, K.1    Schleger, F.2    Kiefer-Schmidt, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.