Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: A nuclear magnetic resonance study

Diabetes/Metabolism Research and Reviews

Volumn 26, Issue 3, 2010, Pages 200-205

  Heni, Martin ^a   Machann, Jürgen ^a   Staiger, Harald ^a   Schwenzer, Nina F ^a   Peter, Andreas ^a   Schick, Fritz ^a   Claussen, Claus D ^a   Stefan, Norbert ^a   Häring, Hans Ulrich ^a   Fritsche, Andreas ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Ectopic lipids; Hepatic lipids; Intrapancreatic fat; Visceral adipose tissue; cell function

Indexed keywords

C PEPTIDE; GLUCOSE; INSULIN;

ADULT; ARTICLE; BODY MASS; CELL FUNCTION; FEMALE; HUMAN; HUMAN EXPERIMENT; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; INTRAABDOMINAL FAT; INTRAHEPATIC FAT; MALE; MEASUREMENT; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PANCREAS ISLET CELL TUMOR; PANCREATIC FAT; PRIORITY JOURNAL; WAIST CIRCUMFERENCE;

EID: 77952396750     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.1073     Document Type: Article

References (19)

1. Barzilai N, She L, Liu BQ, et al. Surgical removal of visceral fat reverses hepatic insulin resistance. Diabetes 1999; 48(1): 94-98. (Pubitemid 29019357)
2. Gabriely I, Ma XH, Yang XM, et al. Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? Diabetes 2002; 51(10): 2951-2958.
3. Greco AV, Mingrone G, Giancaterini A, et al. Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion. Diabetes 2002; 51(1): 144-151. (Pubitemid 34517991)
4. Thamer C, Machann J, Bachmann O, et al. Intramyocellular lipids: anthropometric determinants and relationships with maximal aerobic capacity and insulin sensitivity. J Clin Endocrinol Metab 2003; 88(4): 1785-1791. (Pubitemid 36623405)
5. Seppala-Lindroos A, Vehkavaara S, Hakkinen AM, et al. Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 2002; 87(7): 3023-3028. (Pubitemid 34816338)
6. Kotronen A, Seppala-Lindroos A, Bergholm R, Yki-Jarvinen H. Tissue specificity of insulin resistance in humans: fat in the liver rather than muscle is associated with features of the metabolic syndrome. Diabetologia 2008; 51(1): 130-138. (Pubitemid 50003448)
7. Tushuizen ME, Bunck MC, Pouwels PJ, et al. Pancreatic fat content and beta-cell function in men with and without type 2 diabetes. Diabetes Care 2007; 30(11): 2916-2921.
8. Machann J, Thamer C, Schnoedt B, et al. Standardized assessment of whole body adipose tissue topography by MRI. J Magn Reson Imaging 2005; 21(4): 455-462. (Pubitemid 40446442)
9. Machann J, Thamer C, Schnoedt B, et al. Hepatic lipid accumulation in healthy subjects: a comparative study using spectral fat-selective MRI and volume-localized 1H-MR spectroscopy. Magn Reson Med 2006; 55(4): 913-917.
10. Schwenzer NF, Machann J, Martirosian P, et al. Quantification of pancreatic lipomatosis and liver steatosis by MRI - comparison of in/opposed-phase and spectral-spatial excitation techniques. Invest Radiol 2008; 43(5): 330-337. (Pubitemid 351572210)
11. Thamer C, Machann J, Haap M, et al. Intrahepatic lipids are predicted by visceral adipose tissue mass in healthy subjects. Diabetes Care 2004; 27(11): 2726-2729. (Pubitemid 39441477)
12. Stefan N, Machicao F, Staiger H, et al. Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. Diabetologia 2005; 48(11): 2282-2291. (Pubitemid 41618919)
13. Stumvoll M, Mitrakou A, Pimenta W, et al. Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care 2000; 23(3): 295-301. (Pubitemid 30131733)
14. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999; 22(9): 1462-1470. (Pubitemid 29418240)
15. Saisho Y, Butler AE, Meier JJ, et al. Pancreas volumes in humans from birth to age one hundred taking into account sex, obesity, and presence of type-2 diabetes. Clin Anat 2007; 20(8): 933-942. (Pubitemid 350074312)
16. Saisho Y, Butler AE, Butler PC. Pancreatic fat content and beta-cell function in men with and without type 2 diabetes: response to Tushuizen, et al. Diabetes Care 2008; 31(5): e38.
17. Utzschneider KM, Carr DB, Hull RL, et al. Impact of intraabdominal fat and age on insulin sensitivity and beta-cell function. Diabetes 2004; 53(11): 2867-2872.
18. Wagenknecht LE, Langefeld CD, Scherzinger AL, et al. Insulin sensitivity, insulin secretion, and abdominal fat: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study. Diabetes 2003; 52(10): 2490-2496.
19. Pinnick KE, Collins SC, Londos C, Gauguier D, Clark A, Fielding BA. Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. Obesity (Silver Spring) 2008; 16(3): 522-530. (Pubitemid 351328001)