메뉴 건너뛰기




Volumn 4, Issue , 2014, Pages

Clinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; FATTY ACID; GLUCOSE BLOOD LEVEL; INSULIN; TCF7L2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR 7 LIKE 2;

EID: 84902440103     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep05296     Document Type: Article
Times cited : (11)

References (32)
  • 2
    • 84866128825 scopus 로고    scopus 로고
    • Impact of transcription factor 7-like 2 (TCF7L2) on pancreatic islet function and morphology in mice and men
    • Renstrom, E. Impact of transcription factor 7-like 2 (TCF7L2) on pancreatic islet function and morphology in mice and men. Diabetologia 55, 2559-2561 (2012
    • (2012) Diabetologia , vol.55 , pp. 2559-2561
    • Renstrom, E.1
  • 4
    • 79953776123 scopus 로고    scopus 로고
    • Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test
    • Gjesing, A. P. et al. Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test. Diabetologia 54, 103-110 (2011
    • (2011) Diabetologia , vol.54 , pp. 103-110
    • Gjesing, A.P.1
  • 5
    • 40949141938 scopus 로고    scopus 로고
    • Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets
    • Shu, L. et al. Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets. Diabetes 57, 645-653 (2008
    • (2008) Diabetes , vol.57 , pp. 645-653
    • Shu, L.1
  • 6
    • 84873345249 scopus 로고    scopus 로고
    • TCF7L2 and diabetes: A tale of two tissues, and of two species
    • McCarthy, M. I., Rorsman, P. & Gloyn, A. L. TCF7L2 and Diabetes: A Tale of Two Tissues, and of Two Species. Cell Metab 17, 157-159 (2013
    • (2013) Cell Metab , vol.17 , pp. 157-159
    • Mc Carthy, M.I.1    Rorsman, P.2    Gloyn, A.L.3
  • 7
    • 84866072918 scopus 로고    scopus 로고
    • TCF7L2 rs7903146 impairs islet function andmorphology in non-diabetic individuals
    • Le Bacquer, O. et al. TCF7L2 rs7903146 impairs islet function andmorphology in non-diabetic individuals. Diabetologia 55, 2677-2681 (2012
    • (2012) Diabetologia , vol.55 , pp. 2677-2681
    • Le Bacquer, O.1
  • 8
    • 84866107559 scopus 로고    scopus 로고
    • Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice
    • da Silva Xavier, G. et al. Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice. Diabetologia 55, 2667-2676 (2012
    • (2012) Diabetologia , vol.55 , pp. 2667-2676
    • Da Silva Xavier, G.1
  • 9
    • 84871596296 scopus 로고    scopus 로고
    • Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand
    • Boj, S. F. et al. Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell 151, 1595-1607 (2012
    • (2012) Cell , vol.151 , pp. 1595-1607
    • Boj, S.F.1
  • 11
    • 84871261217 scopus 로고    scopus 로고
    • The Wnt signaling pathway effector TCF7L2 controls gut and brain proglucagon gene expression and glucose homeostasis
    • Shao, W. et al. The Wnt signaling pathway effector TCF7L2 controls gut and brain proglucagon gene expression and glucose homeostasis. Diabetes 62, 789-800 (2013
    • (2013) Diabetes , vol.62 , pp. 789-800
    • Shao, W.1
  • 12
    • 84868014745 scopus 로고    scopus 로고
    • Understanding the elusive mechanism of action of TCF7L2 in metabolism
    • Grant, S. F. Understanding the elusive mechanism of action of TCF7L2 in metabolism. Diabetes 61, 2657-2658 (2012
    • (2012) Diabetes , vol.61 , pp. 2657-2658
    • Grant, S.F.1
  • 14
    • 70350560562 scopus 로고    scopus 로고
    • Metabolomics applied to diabetes research: Moving from information to knowledge
    • Bain, J. R. et al. Metabolomics applied to diabetes research: moving from information to knowledge. Diabetes 58, 2429-2443 (2009
    • (2009) Diabetes , vol.58 , pp. 2429-2443
    • Bain, J.R.1
  • 15
    • 84892686032 scopus 로고    scopus 로고
    • Serum levels of acylcarnitines are altered in prediabetic conditions
    • Mai, M. et al. Serum levels of acylcarnitines are altered in prediabetic conditions. PLoS. ONE. 8, e82459 (2013
    • (2013) PLoS. ONE , vol.8
    • Mai, M.1
  • 16
    • 84886256198 scopus 로고    scopus 로고
    • Plasma metabolomics reveal alterations of sphingo-and glycerophospholipid levels in non-diabetic carriers of the transcription factor 7-like 2 polymorphism rs7903146
    • Then, C. et al. Plasma metabolomics reveal alterations of sphingo-and glycerophospholipid levels in non-diabetic carriers of the Transcription Factor 7-Like 2 polymorphism rs7903146. PLoS. ONE. 8, e78430 (2013
    • (2013) PLoS. ONE , vol.8
    • Then, C.1
  • 17
    • 84873026980 scopus 로고    scopus 로고
    • Metabolite profiling reveals normal metabolic control in carriers of mutations in the glucokinase gene (MODY2
    • Spegel, P. et al.Metabolite profiling reveals normal metabolic control in carriers of mutations in the glucokinase gene (MODY2). Diabetes 62, 653-661 (2013
    • (2013) Diabetes , vol.62 , pp. 653-661
    • Spegel, P.1
  • 18
    • 84864487679 scopus 로고    scopus 로고
    • Metabolic profiling in maturity-onset diabetes of the young (mody) and young onset type 2 diabetes fails to detect robust urinary biomarkers
    • Gloyn, A. L. et al. Metabolic profiling in Maturity-onset diabetes of the young (MODY) and young onset type 2 diabetes fails to detect robust urinary biomarkers. PLoS. ONE. 7, e40962 (2012
    • (2012) PLoS. ONE , vol.7
    • Gloyn, A.L.1
  • 19
    • 84874415566 scopus 로고    scopus 로고
    • TCF7L2 and glucose metabolism: Time to look beyond the pancreas
    • Nobrega, M. A. TCF7L2 and glucose metabolism: time to look beyond the pancreas. Diabetes 62, 706-708 (2013
    • (2013) Diabetes , vol.62 , pp. 706-708
    • Nobrega, M.A.1
  • 20
    • 64649105053 scopus 로고    scopus 로고
    • TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells
    • da Silva Xavier,G. et al. TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells. Diabetes 58, 894-905 (2009
    • (2009) Diabetes , vol.58 , pp. 894-905
    • Da Silva Xavier, G.1
  • 21
    • 80052527283 scopus 로고    scopus 로고
    • Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism
    • Savic, D. et al.Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism. Genome Res. 21, 1417-1425 (2011
    • (2011) Genome Res , vol.21 , pp. 1417-1425
    • Savic, D.1
  • 24
    • 79960202841 scopus 로고    scopus 로고
    • Type 2 diabetes across generations: From pathophysiology to prevention and management
    • Nolan, C. J., Damm, P. & Prentki, M. Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet 378, 169-181 (2011
    • (2011) Lancet , vol.378 , pp. 169-181
    • Nolan, C.J.1    Damm, P.2    Prentki, M.3
  • 25
    • 84863100135 scopus 로고    scopus 로고
    • Allele summation of diabetes risk genes predicts impaired glucose tolerance in female and obese individuals
    • Linder, K. et al. Allele summation of diabetes risk genes predicts impaired glucose tolerance in female and obese individuals. PLoS. ONE. 7, e38224 (2012
    • (2012) PLoS. ONE , vol.7
    • Linder, K.1
  • 26
    • 78650063109 scopus 로고    scopus 로고
    • Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
    • Heni, M. et al. Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion. Diabetes 59, 3247-3252 (2010
    • (2010) Diabetes , vol.59 , pp. 3247-3252
    • Heni, M.1
  • 28
    • 84897108150 scopus 로고    scopus 로고
    • Untangling the interplay of genetic and metabolic influences on beta-cell function: Examples of potential therapeutic implications involving TCF7L2 and FFAR1
    • Wagner, R. et al. Untangling the interplay of genetic and metabolic influences on beta-cell function: Examples of potential therapeutic implications involving TCF7L2 and FFAR1. Mol. Metab 3, 261-267 (2014
    • (2014) Mol. Metab , vol.3 , pp. 261-267
    • Wagner, R.1
  • 29
    • 0032821965 scopus 로고    scopus 로고
    • Insulin sensitivity indices obtained from oral glucose tolerance testing: Comparison with the euglycemic insulin clamp
    • DOI 10.2337/diacare.22.9.1462
    • Matsuda, M. & DeFronzo, R. A. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22, 1462-1470 (1999 (Pubitemid 29418240)
    • (1999) Diabetes Care , vol.22 , Issue.9 , pp. 1462-1470
    • Matsuda, M.1    DeFronzo, R.A.2
  • 30
    • 84882632229 scopus 로고    scopus 로고
    • Metabolic characterization of hepatocellular carcinoma using nontargeted tissue metabolomics
    • Huang, Q. et al. Metabolic characterization of hepatocellular carcinoma using nontargeted tissue metabolomics. Cancer Res. 73, 4992-5002 (2013
    • (2013) Cancer Res , vol.73 , pp. 4992-5002
    • Huang, Q.1
  • 31
    • 34548146614 scopus 로고    scopus 로고
    • Within-day reproducibility of an HPLC-MS-based method for metabonomic analysis: Application to human urine
    • DOI 10.1021/pr070183p
    • Gika, H. G., Theodoridis, G. A., Wingate, J. E. & Wilson, I. D. Within-day reproducibility of an HPLC-MS-based method for metabonomic analysis: application to human urine. J. Proteome. Res. 6, 3291-3303 (2007 (Pubitemid 47310213)
    • (2007) Journal of Proteome Research , vol.6 , Issue.8 , pp. 3291-3303
    • Gika, H.G.1    Theodoridis, G.A.2    Wingate, J.E.3    Wilson, I.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.