Effects of exercise training on glucose homeostasis: The HERITAGE family study

Diabetes Care

Volumn 28, Issue 1, 2005, Pages 108-114

  Boulé, Normand G ^a,j   Weisnagel, S John ^a,b   Lakka, Timo A ^c,d   Tremblay, Angelo ^a   Bergman, Richard N ^e   Rankinen, Tuomo ^c   Leon, Arthur S ^f   Skinner, James S ^g   Wilmore, Jack H ^h   Rao, D C ⁱ   Bouchard, Claude ^c,k,l  

^a UNIVERSITÉ LAVAL   (Canada)

^b LAVAL UNIVERSITY   (Canada)

^c PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^d UNIVERSITY OF EASTERN FINLAND   (Finland)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f UNIVERSITY OF MINNESOTA   (United States)

^g INDIANA UNIVERSITY   (United States)

^h TEXAS A AND M UNIVERSITY   (United States)

ⁱ WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j UNIVERSITY OF ALBERTA   (Canada)

^k NATIONAL INSTITUTES OF HEALTH   (United States)

^l BRISTOL MYERS SQUIBB   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

ADOLESCENT; ARTICLE; BICYCLE ERGOMETER; BODY MASS; ENDURANCE; EXERCISE; FEMALE; FITNESS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HUMAN; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESPONSE; INSULIN SENSITIVITY; INTRAVENOUS GLUCOSE TOLERANCE TEST; MALE; RACE DIFFERENCE; TRAINING;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; BLOOD GLUCOSE; EUROPEAN CONTINENTAL ANCESTRY GROUP; EXERCISE; EXERCISE TEST; FASTING; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; MALE; PHYSICAL FITNESS;

EID: 19944427874     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.28.1.108     Document Type: Article

References (37)

1. Pan XR, Li GW, Hu YH, Wang JX, Yang WY, An ZX, Hu ZX, Lin J, Xiao JZ, Cao HB, Liu PA, Jiang XG, Jiang YY, Wang JP, Zheng H, Zhang H, Bennett PH, Howard BV: Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance: the Da Qing IGT and Diabetes Study. Diabetes Care 20:537-544, 1997
2. Helmrich SP, Ragland DR, Leung RW, Paffenbarger RS Jr: Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med 325:147-152, 1991
3. Manson JE, Rimm EB, Stampfer MJ, Colditz GA, Willett WC, Krolewski AS, Rosner B, Hennekens CH, Speizer FE: Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet 338:774-778, 1991
4. Manson JE, Nathan DM, Krolewski AS, Stampfer MJ, Willett WC, Hennekens CH: A prospective study of exercise and incidence of diabetes among US male physicians. JAMA 268:63-67, 1992
5. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393-403, 2002
6. Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M: Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344:1343-1350, 2001
7. Eriksson KF, Lindgarde F: Prevention of type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise: the 6-year Malmo feasibility study. Diabetologia 34:891-898, 1991
8. DeFronzo RA, Sherwin RS, Kraemer N: Effect of physical training on insulin action in obesity. Diabetes 36:1379-1385, 1987
9. Cox JH, Cortright RN, Dohm GL, Houmard JA: Effect of aging on response to exercise training in humans: skeletal muscle GLUT-4 and insulin sensitivity. J Appl Physiol 86:2019-2025, 1999
10. Perseghin G, Price TB, Petersen KF, Roden M, Cline GW, Gerow K, Rothman DL, Shulman GI: Increased glucose transport - phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N Engl J Med 335:1357-1362, 1996
11. Tonino RP: Effect of physical training on the insulin resistance Of aging. Am J Physiol 256:E352-E356, 1989
12. Hughes VA, Fiatarone MA, Fielding RA, Kahn BB, Ferrara CM, Shepherd P, Fisher EC, Wolfe RR, Elahi D, Evans WJ: Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance. Am J Physiol 264:E855-E862, 1993
13. Dela F, Larsen JJ, Mikines KJ, Ploug T, Peterson LN, Gablo H: Insulin-stimulated muscle glucose clearance in patients with NIDDM: effects of one-legged physical training. Diabetes 44:1010-1020, 1995
14. Burstein R, Polychronakos C, Toews CJ, MacDougall JD, Guyda HJ, Posner BI: Acute reversal of the enhanced insulin action in trained athletes: association with insulin receptor changes. Diabetes 34:756-760, 1985
15. Schneider SH, Amorosa LF, Khachadurian AK, Ruderman NB: Studies on the mechanism of improved glucose control during regular exercise in type 2 (non-insulin-dependent) diabetes. Diabetologia 26:355-360, 1984
16. Heath GW, Gavin JR 3rd, Hinderliter JM, Hagberg JM, Bloomfield SA, Holloszy JO: Effects of exercise and lack of exercise on glucose tolerance and insulin sensitivity. J Appl Physiol 55:512-517, 1983
17. Marsoobian V, Grosvenor M, Jacob M, Ipp E: Very-low-energy diets alter the counterregulatory response to falling plasma glucose concentrations. Am J Clin Nutr 61:373-378, 1995
18. Tremblay A, Doucet E, Imbeault P, Mauriege P, Despres JP, Richard D: Metabolic fitness in active reduced-obese individuals. Obes Res 7:556-563, 1999
19. Campfield LA, Smith FJ, Rosenbaum M, Hirsch J: Human eating: evidence for a physiological basis using a modified paradigm. Neurosci Biobehav Rev 20:133-137, 1996
20. Melanson KJ, Westerterp-Plantenga MS, Saris WH, Smith FJ, Campfield LA: Blood glucose patterns and appetite in time-blinded humans: carbohydrate versus fat. Am J Physiol 277:R337-R345, 1999
21. Boulé NG, Doucet E, Richard D, Tremblay A: Weight loss increases the risk of hypoglycemia in obese adults (Abstract). Int J Obes 25:P119, 2001
22. Bouchard C, Leon AS, Rao DC, Skinner JS, Wilmore JH, Gagnon J: The HERITAGE family study: aims, design, and measurement protocol. Med Sci Sports Exerc 27:721-729, 1995
23. Skinner JS, Wilmore KM, Krasnoff JB, Jaskolski A, Jaskolska A, Gagnon J, Province MA, Leon AS, Rao DC, Wilmore JH, Bouchard C: Adaptation to a standardized training program and changes in fitness in a large, heterogeneous population: the HERITAGE Family Study. Med Sci Sports Exerc 32:157-161, 2000
24. Walton C, Godsland IF, Proudler AJ, Felton C, Wynn V: Evaluation of four mathematical models of glucose and insulin dynamics with analysis of effects of age and obesity. Am J Physiol 262:E755-E762, 1992
25. An P, Hong Y, Weisnagel SJ, Rice T, Rankinen T, Leon AS, Skinner JS, Wilmore JH, Chagnon YC, Bergman RN, Bouchard C, Rao DC: Genomic scan of glucose and insulin metabolism phenotypes: the HERITAGE Family Study. Metabolism 52:246-253, 2003
26. Desbuquois B, Aurbach GD: Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays. J Clin Endocrinol Metab 37:732-738, 1971
27. Araujo-Vilar D, Garcia-Estevez DA, Cabezas-Cerrato J: Both a reduced acute insulin response to glucose and lower glucose effectiveness are responsible for the worsening of intravenous glucose tolerance in healthy subjects independently of the degree of obesity. Metabolism 47:313-320, 1998
28. Wilmore JH, Despres JP, Stanforth PR, Mandel S, Rice T, Gagnon J, Leon AS, Rao D, Skinner JS, Bouchard C: Alterations in body weight and composition consequent to 20 wk of endurance training: the HERITAGE Family Study. Am J Clin Nutr 70:346-352, 1999
29. Bouchard C, An P, Rice T, Skinner JS, Wilmore JH, Gagnon J, Perusse L, Leon AS, Rap DC: Familial aggregation of VO2max response to exercise training: results from the HERITAGE Family Study. J Appl Physiol 87:1003-1008, 1999
30. Holloszy JO, Schultz J, Kusnierkiewicz J, Hagberg JM, Ehsani AA: Effects of exercise on glucose tolerance and insulin resistance: brief review and some preliminary results. Acta Med Scand Suppl 711:55-65, 1986
31. Trovati M, Carta Q, Cavalot F, Vitali S, Banaudi C, Lucchina PG, Fiocchi F, Emanuelli G, Lenti G: Influence of physical training on blood glucose control, glucose tolerance, insulin secretion, and insulin action in non-insulin-dependent diabetic patients. Diabetes Care 7:416-420, 1984
32. Segal KR, Edano A, Abalos A, Albu J, Blando L, Tomas MB, Pi-Sunyer FX: Effect of exercise training on insulin sensitivity and glucose metabolism in lean, obese, and diabetic men. J Appl Physiol 71:2402-2411, 1991
33. Beard JC, Bergman RN, Ward WK, Porte D Jr: The insulin sensitivity index in non-diabetic man: correlation between clamp-derived and IVGTT-derived values. Diabetes 35:362-369, 1986
34. Pacini G, Tonolo G, Sambataro M, Maioli M, Ciccarese M, Brocco E, Avogaro A, Nosadini R: Insulin sensitivity and glucose effectiveness: minimal model analysis of regular and insulin-modified FSIGT. Am J Physiol 274:E592-E599, 1998
35. Lakka TA, Rankinen T, Weisnagel SJ, Chagnon YC, Rice T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C: A quantitative trait locus on 7q31 for the changes in plasma insulin in response to exercise training: the HERITAGE Family Study. Diabetes 52:1583-1587, 2003
36. Lakka TA, Rankinen T, Weisnagel SJ, Chagnon YC, Lakka HM, Ukkola O, Boule N, Rice T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bergman R, Bouchard C: Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE Family Study. Diabetes 53:1603-1608, 2004
37. Pratley RE, Weyer C: The role of impaired early insulin secretion in the pathogenesis of type II diabetes mellitus. Diabetologia 44:929-945, 2001