Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion

Diabetes

Volumn 59, Issue 12, 2010, Pages 3247-3252

  Heni, Martin ^a   Ketterer, Caroline ^a   Thamer, Claus ^a   Herzberg Schäfer, Silke A ^a   Guthoff, Martina ^a   Stefan, Norbert ^a   Machicao, Fausto ^a   Staiger, Harald ^a   Fritsche, Andreas ^a   Häring, Hans Ulrich ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; GLUCOSE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; MEMBRANE PROTEIN; POTASSIUM CHANNEL KCNQ1; PROTEIN CDKAL1; PROTEIN HHEX; PROTEIN MTNR1B; PROTEIN SLC30A8; PROTEIN WFS1; SOMATOMEDIN BINDING PROTEIN 2; TRANSCRIPTION FACTOR 7 LIKE 2; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; BLOOD GLUCOSE MONITORING; GENE INTERACTION; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN RELEASE; INSULIN SENSITIVITY; LIFESTYLE MODIFICATION; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

BLOOD GLUCOSE; C-PEPTIDE; DIABETES MELLITUS, TYPE 2; GENE EXPRESSION REGULATION; GENETIC VARIATION; GENOTYPE; GLUCOSE TOLERANCE TEST; INCRETINS; INSULIN; INSULIN-SECRETING CELLS; MEMBRANE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK ASSESSMENT; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN;

EID: 78650063109     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db10-0674     Document Type: Article

References (25)

1. Staiger H, Machicao F, Fritsche A, Häring HU. Pathomechanisms of type 2 diabetes genes. Endocr Rev 2009;30:557-585
2. Wareham NJ, Franks PW, Harding AH. Establishing the role of gene-environment interactions in the etiology of type 2 diabetes. Endocrinol Metab Clin North Am 2002;31:553-566
3. Grarup N, Andersen G. Gene-environment interactions in the pathogenesis of type 2 diabetes and metabolism. Curr Opin Clin Nutr Metab Care 2007;10:420-426
4. Weyrich P, Stefan N, Häring HU, Laakso M, Fritsche A. Effect of genotype on success of lifestyle intervention in subjects at risk for type 2 diabetes. J Mol Med 2007;85:107-117
5. Tabák AG, Jokela M, Akbaraly TN, Brunner EJ, Kivimäki M, Witte DR. Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study. Lancet 2009;373:2215-2221
6. Poitout V, Robertson RP. Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr Rev 2008;29:351-366
7. Stumvoll M, Goldstein BJ, van Haeften TW. Type 2 diabetes: principles of pathogenesis and therapy. Lancet 2005;365:1333-1346
8. Kjems LL, Holst JJ, Vølund A, Madsbad S. The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects. Diabetes 2003;52:380-386
9. Drucker DJ. The biology of incretin hormones. Cell Metab 2006;3:153-165
10. McCarthy MI, Zeggini E. Genome-wide association studies in type 2 diabetes. Curr Diab Rep 2009;9:164-171
11. Schäfer S, Kantartzis K, Machann J, Venter C, Niess A, Schick F, Machicao F, Häring HU, Fritsche A, Stefan N. Lifestyle intervention in individuals with normal versus impaired glucose tolerance. Eur J Clin Invest 2007;37:535-543
12. Staiger H, Machicao F, Schafer SA, Kirchhoff K, Kantartzis K, Guthoff M, Silbernagel G, Stefan N, Haring HU, Fritsche A. Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function. PLoS One 2008;3:e3962
13. Schäfer SA, Müssig K, Staiger H, Machicao F, Stefan N, Gallwitz B, Häring HU, Fritsche A. A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion. Diabetologia 2009;52:1075-1082
14. Müssig K, Staiger H, Machicao F, Kirchhoff K, Guthoff M, Schäfer SA, Kantartzis K, Silbernagel G, Stefan N, Holst JJ, Gallwitz B, Häring HU, Fritsche A. Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion. Diabetes 2009;58:1715-1720
15. Schäfer SA, Tschritter O, Machicao F, Thamer C, Stefan N, Gallwitz B, Holst JJ, Dekker JM, 't Hart LM, Nijpels G, van Haeften TW, Häring HU, Fritsche A. Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms. Diabetologia 2007;50:2443-2450
16. Kirchhoff K, Machicao F, Haupt A, Schäfer SA, Tschritter O, Staiger H, Stefan N, Häring HU, Fritsche A. Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia 2008;51:597-601
17. Tschritter O, Stumvoll M, Machicao F, Holzwarth M, Weisser M, Maerker E, Teigeler A, Häring H, Fritsche A. The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.2) gene is associated with impaired glucagon suppression in response to hyperglycemia. Diabetes 2002;51:2854-2860
18. Staiger H, Machicao F, Stefan N, Tschritter O, Thamer C, Kantartzis K, Schafer SA, Kirchhoff K, Fritsche A, Haring HU. Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function. PLoS One 2007;2:e832
19. Tuomilehto J, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M, Finnish Diabetes Prevention Study Group. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001;344:1343-1350
20. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM, Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002;346:393-403
21. Haupt A, Thamer C, Heni M, Ketterer C, Machann J, Schick F, Machicao F, Stefan N, Claussen CD, Häring HU, Fritsche A, Staiger H. Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes. Diabetes 2010;59:747-750
22. Wang J, Kuusisto J, Vänttinen M, Kuulasmaa T, Lindström J, Tuomilehto J, Uusitupa M, Laakso M. Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion. Diabetologia 2007;50:1192-1200
23. Florez JC, Jablonski KA, Bayley N, Pollin TI, de Bakker PI, Shuldiner AR, Knowler WC, Nathan DM, Altshuler D, Diabetes Prevention Program Research Group. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 2006;355:241-250
24. Andreasen CH, Andersen G. Gene-environment interactions and obesity-further aspects of genomewide association studies. Nutrition 2009;25:998-1003
25. Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006;444:840-846