Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging

Cell Death and Differentiation

Volumn 20, Issue 2, 2013, Pages 259-269

  Kang, S ^a   Louboutin, J P ^a   Datta, P ^a   Landel, C P ^a   Martinez, D ^b   Zervos, A S ^c   Strayer, D S ^a   Fernandes Alnemri, T ^a   Alnemri, E S ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

aging; HtrA2; mitochondria; mitochondrial DNA; neurodegeneration; quality control

Indexed keywords

MITOCHONDRIAL DNA; SERINE PROTEINASE OMI;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CARDIOMEGALY; CENTRAL NERVOUS SYSTEM; DEATH; GENE DELETION; GENETIC LINKAGE; HAIR LOSS; MOUSE; NERVE DEGENERATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PREMATURE AGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN QUALITY; SPINE DISEASE; SPLENOMEGALY; SUBFERTILITY; WEIGHT REDUCTION;

AGING, PREMATURE; ANIMALS; AUTOPHAGY; CARDIOMYOPATHIES; CENTRAL NERVOUS SYSTEM; DNA, MITOCHONDRIAL; HUMANS; MICE; MICE, TRANSGENIC; MITOCHONDRIAL PROTEINS; PHENOTYPE; SERINE ENDOPEPTIDASES;

MAMMALIA; MUS;

EID: 84872355087     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2012.117     Document Type: Article

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