Dynamic Modelling of Pathways to Cellular Senescence Reveals Strategies for Targeted Interventions

PLoS Computational Biology

Volumn 10, Issue 8, 2014, Pages

  Dalle Pezze, Piero ^a   Nelson, Glyn ^a   Otten, Elsje G ^a   Korolchuk, Viktor I ^a   Kirkwood, Thomas B L ^a   von Zglinicki, Thomas ^a   Shanley, Daryl P ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CELL MEMBRANES; CELL SIGNALING; MITOCHONDRIA;

CELL-CYCLE ARREST; CELLULAR LEVELS; CELLULAR SENESCENCE; DNA DAMAGES; DYNAMICS MODELS; IN-VITRO; MITOCHONDRIAL DYSFUNCTION; NETWORKED SYSTEMS; OXIDATIVE STRESS RESPONSE; SYSTEMS BIOLOGY;

SENSITIVITY ANALYSIS;

ADENYLATE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR FKHRL1; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR;

ARTICLE; CELL AGING; CELL CYCLE ARREST; COMPUTER MODEL; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; IN VITRO STUDY; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MITOPHAGY; MOLECULAR DYNAMICS; OXIDATIVE STRESS; PREDICTION; SENESCENCE; SENSITIVITY ANALYSIS; SIGNAL NOISE RATIO; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; BIOLOGICAL MODEL; CELL LINE; COMPUTER SIMULATION; HUMAN; METABOLISM; PHYSIOLOGY;

CELL AGING; CELL LINE; COMPUTER SIMULATION; DNA DAMAGE; HUMANS; MITOCHONDRIA; MODELS, BIOLOGICAL; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS;

EID: 84926469999     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003728     Document Type: Article

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