-
1
-
-
84884995578
-
Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans
-
Comas I., Coscolla M., Luo T., Borrell S., Holt K.E., Kato-Maeda M., Parkhill J., Malla B., Berg S., Thwaites G., Yeboah-Manu D., Bothamley G., Mei J., Wei L., Bentley S., Harris S.R., Niemann S., Diel R., Aseffa A., Gao Q., Young D., Gagneux S. Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans. Nat. Genet. 2013, 45:1176-1182.
-
(2013)
Nat. Genet.
, vol.45
, pp. 1176-1182
-
-
Comas, I.1
Coscolla, M.2
Luo, T.3
Borrell, S.4
Holt, K.E.5
Kato-Maeda, M.6
Parkhill, J.7
Malla, B.8
Berg, S.9
Thwaites, G.10
Yeboah-Manu, D.11
Bothamley, G.12
Mei, J.13
Wei, L.14
Bentley, S.15
Harris, S.R.16
Niemann, S.17
Diel, R.18
Aseffa, A.19
Gao, Q.20
Young, D.21
Gagneux, S.22
more..
-
3
-
-
70149090840
-
The epidemiological fitness cost of drug resistance in Mycobacterium tuberculosis
-
Luciani F., Sisson S.A., Jiang H., Francis A.R., Tanaka M.M. The epidemiological fitness cost of drug resistance in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. 2009, 106:14711-14715.
-
(2009)
Proc. Natl. Acad. Sci.
, vol.106
, pp. 14711-14715
-
-
Luciani, F.1
Sisson, S.A.2
Jiang, H.3
Francis, A.R.4
Tanaka, M.M.5
-
4
-
-
84856711991
-
Totally drug-resistant tuberculosis in India
-
Udwadia Z.F., Amale R.A., Ajbani K.K., Rodrigues C. Totally drug-resistant tuberculosis in India. Clin. Infect. Dis. 2012, 54:579-581.
-
(2012)
Clin. Infect. Dis.
, vol.54
, pp. 579-581
-
-
Udwadia, Z.F.1
Amale, R.A.2
Ajbani, K.K.3
Rodrigues, C.4
-
5
-
-
84877267006
-
Advances in the development of new tuberculosis drugs and treatment regimens
-
Zumla A., Nahid P., Cole S.T. Advances in the development of new tuberculosis drugs and treatment regimens. Nat. Rev. Drug Discov. 2013, 12:388-404.
-
(2013)
Nat. Rev. Drug Discov.
, vol.12
, pp. 388-404
-
-
Zumla, A.1
Nahid, P.2
Cole, S.T.3
-
6
-
-
0031036065
-
Is death inevitable with multiresistant TB plus HIV infection
-
Drobniewski F. Is death inevitable with multiresistant TB plus HIV infection. Lancet 1997, 349:71-73.
-
(1997)
Lancet
, vol.349
, pp. 71-73
-
-
Drobniewski, F.1
-
7
-
-
33846081438
-
Tuberculosis and HIV co-infection: a practical therapeutic approach
-
Breen R.A.M. Tuberculosis and HIV co-infection: a practical therapeutic approach. Drugs 2006, 66:2299-2308.
-
(2006)
Drugs
, vol.66
, pp. 2299-2308
-
-
Breen, R.A.M.1
-
8
-
-
0027271988
-
Pharmacokinetic interaction between rifampin and zidovudine
-
Burger D.M. Pharmacokinetic interaction between rifampin and zidovudine. Antimicrob. Agents Chemother. 1993, 37:1426-1432.
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 1426-1432
-
-
Burger, D.M.1
-
9
-
-
0042163137
-
Pharmacokinetic interactions with rifampicin: clinical relevance
-
Niemi M. Pharmacokinetic interactions with rifampicin: clinical relevance. Clin. Pharmacokinet. 2003, 42:819-851.
-
(2003)
Clin. Pharmacokinet.
, vol.42
, pp. 819-851
-
-
Niemi, M.1
-
10
-
-
84906890048
-
ERS/WHO tuberculosis consilium assistance with extensively drug-resistant tuberculosis management in a child: case study of compassionate delamanid use
-
Esposito S., D'Ambrosio L., Tadolini M., Schaaf H.S., Caminero Luna J., Marais B., Centis R., Dara M., Matteelli A., Blasi F., Migliori G.B. ERS/WHO tuberculosis consilium assistance with extensively drug-resistant tuberculosis management in a child: case study of compassionate delamanid use. Eur. Respir. J. 2014, 44:811-815.
-
(2014)
Eur. Respir. J.
, vol.44
, pp. 811-815
-
-
Esposito, S.1
D'Ambrosio, L.2
Tadolini, M.3
Schaaf, H.S.4
Caminero Luna, J.5
Marais, B.6
Centis, R.7
Dara, M.8
Matteelli, A.9
Blasi, F.10
Migliori, G.B.11
-
11
-
-
84874258234
-
Emergence and spread of extensively and totally drug-resistant tuberculosis, South Africa
-
Marisa K., Robin Mark W., Cindy H., Nicolaas Claudius Gey van P., Elizabeth Maria S., Borna M., Frederick Adriaan S., Mamisa C.-N., Ebrahim H., Gerrit C., Paul David van H., Thomas Calldo V., André Phillip T. Emergence and spread of extensively and totally drug-resistant tuberculosis, South Africa. Emerg. Infect. Dis. J. 2013, 19:449.
-
(2013)
Emerg. Infect. Dis. J.
, vol.19
, pp. 449
-
-
Marisa, K.1
Robin Mark, W.2
Cindy, H.3
Nicolaas Claudius Gey van, P.4
Elizabeth Maria, S.5
Borna, M.6
Frederick Adriaan, S.7
Mamisa, C.-N.8
Ebrahim, H.9
Gerrit, C.10
Paul David van, H.11
Thomas Calldo, V.12
André Phillip, T.13
-
12
-
-
33750811319
-
XDR-TB: entering the post-antibiotic era?
-
Raviglione M. XDR-TB: entering the post-antibiotic era?. Int. J. Tuberc. Lung Dis. 2006, 10:1185-1187.
-
(2006)
Int. J. Tuberc. Lung Dis.
, vol.10
, pp. 1185-1187
-
-
Raviglione, M.1
-
13
-
-
84988530434
-
Clinical implications of the global multidrug-resistant tuberculosis epidemic
-
Kumar K., Abubakar I. Clinical implications of the global multidrug-resistant tuberculosis epidemic. Clin. Med. 2015, 15:s37-s42.
-
(2015)
Clin. Med.
, vol.15
, pp. s37-s42
-
-
Kumar, K.1
Abubakar, I.2
-
14
-
-
84861864703
-
Delamanid for multidrug-resistant pulmonary tuberculosis
-
Gler M.T., Skripconoka V., Sanchez-Garavito E., Xiao H., Cabrera-Rivero J.L., Vargas-Vasquez D.E., Gao M., Awad M., Park S.K., Shim T.S., Suh G.Y., Danilovits M., Ogata H., Kurve A., Chang J., Suzuki K., Tupasi T., Koh W.J., Seaworth B., Geiter L.J., Wells C.D. Delamanid for multidrug-resistant pulmonary tuberculosis. N. Engl. J. Med. 2012, 366:2151-2160.
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 2151-2160
-
-
Gler, M.T.1
Skripconoka, V.2
Sanchez-Garavito, E.3
Xiao, H.4
Cabrera-Rivero, J.L.5
Vargas-Vasquez, D.E.6
Gao, M.7
Awad, M.8
Park, S.K.9
Shim, T.S.10
Suh, G.Y.11
Danilovits, M.12
Ogata, H.13
Kurve, A.14
Chang, J.15
Suzuki, K.16
Tupasi, T.17
Koh, W.J.18
Seaworth, B.19
Geiter, L.J.20
Wells, C.D.21
more..
-
15
-
-
84872131305
-
Approval of novel TB drug celebrated-with restraint
-
Cohen J. Approval of novel TB drug celebrated-with restraint. Science 2013, 339:130.
-
(2013)
Science
, vol.339
, pp. 130
-
-
Cohen, J.1
-
16
-
-
84904039980
-
Delamanid: first global approval
-
Ryan N., Lo J. Delamanid: first global approval. Drugs 2014, 74:1041-1045.
-
(2014)
Drugs
, vol.74
, pp. 1041-1045
-
-
Ryan, N.1
Lo, J.2
-
17
-
-
84934829868
-
Molecular basis of drug resistance in Mycobacterium tuberculosis
-
Cohen K.A., Bishai W.R., Pym A.S. Molecular basis of drug resistance in Mycobacterium tuberculosis. Microbiol. Spectr. 2014, 2.
-
(2014)
Microbiol. Spectr.
, vol.2
-
-
Cohen, K.A.1
Bishai, W.R.2
Pym, A.S.3
-
18
-
-
84921509602
-
Drug resistance mechanisms in Mycobacterium tuberculosis
-
Palomino J., Martin A. Drug resistance mechanisms in Mycobacterium tuberculosis. Antibiotics 2014, 3:317.
-
(2014)
Antibiotics
, vol.3
, pp. 317
-
-
Palomino, J.1
Martin, A.2
-
19
-
-
84925261260
-
The complex evolution of antibiotic resistance in Mycobacterium tuberculosis
-
Fonseca J.D., Knight G.M., McHugh T.D. The complex evolution of antibiotic resistance in Mycobacterium tuberculosis. Int. J. Infect. Dis. 2015, 32:94-100.
-
(2015)
Int. J. Infect. Dis.
, vol.32
, pp. 94-100
-
-
Fonseca, J.D.1
Knight, G.M.2
McHugh, T.D.3
-
20
-
-
33745615117
-
The competitive cost of antibiotic resistance in Mycobacterium tuberculosis
-
Gagneux S., Long C.D., Small P.M., Van T., Schoolnik G.K., Bohannan B.J. The competitive cost of antibiotic resistance in Mycobacterium tuberculosis. Science 2006, 312:1944-1946.
-
(2006)
Science
, vol.312
, pp. 1944-1946
-
-
Gagneux, S.1
Long, C.D.2
Small, P.M.3
Van, T.4
Schoolnik, G.K.5
Bohannan, B.J.6
-
21
-
-
84895895475
-
Evolution and transmission of drug-resistant tuberculosis in a Russian population
-
Casali N., Nikolayevskyy V., Balabanova Y., Harris S.R., Ignatyeva O., Kontsevaya I., Corander J., Bryant J., Parkhill J., Nejentsev S., Horstmann R.D., Brown T., Drobniewski F. Evolution and transmission of drug-resistant tuberculosis in a Russian population. Nat. Genet. 2014, 46:279-286.
-
(2014)
Nat. Genet.
, vol.46
, pp. 279-286
-
-
Casali, N.1
Nikolayevskyy, V.2
Balabanova, Y.3
Harris, S.R.4
Ignatyeva, O.5
Kontsevaya, I.6
Corander, J.7
Bryant, J.8
Parkhill, J.9
Nejentsev, S.10
Horstmann, R.D.11
Brown, T.12
Drobniewski, F.13
-
22
-
-
84894068321
-
The path of anti-tuberculosis drugs: from blood to lesions to mycobacterial cells
-
Dartois V. The path of anti-tuberculosis drugs: from blood to lesions to mycobacterial cells. Nat. Rev. Microbiol. 2014, 12:159-167.
-
(2014)
Nat. Rev. Microbiol.
, vol.12
, pp. 159-167
-
-
Dartois, V.1
-
23
-
-
34248998479
-
Diarylquinolines target subunit c of mycobacterial ATP synthase
-
Koul A., Dendouga N., Vergauwen K., Molenberghs B., Vranckx L., Willebrords R., Ristic Z., Lill H., Dorange I., Guillemont J., Bald D., Andries K. Diarylquinolines target subunit c of mycobacterial ATP synthase. Nat. Chem. Biol. 2007, 3:323-324.
-
(2007)
Nat. Chem. Biol.
, vol.3
, pp. 323-324
-
-
Koul, A.1
Dendouga, N.2
Vergauwen, K.3
Molenberghs, B.4
Vranckx, L.5
Willebrords, R.6
Ristic, Z.7
Lill, H.8
Dorange, I.9
Guillemont, J.10
Bald, D.11
Andries, K.12
-
24
-
-
66649090346
-
The diarylquinoline TMC207 for multidrug-resistant tuberculosis
-
Diacon A.H., Pym A., Grobusch M., Patientia R., Rustomjee R., Page-Shipp L., Pistorius C., Krause R., Bogoshi M., Churchyard G., Venter A., Allen J., Palomino J.C., De Marez T., van Heeswijk R.P., Lounis N., Meyvisch P., Verbeeck J., Parys W., de Beule K., Andries K., Mc Neeley D.F. The diarylquinoline TMC207 for multidrug-resistant tuberculosis. N. Engl. J. Med. 2009, 360:2397-2405.
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 2397-2405
-
-
Diacon, A.H.1
Pym, A.2
Grobusch, M.3
Patientia, R.4
Rustomjee, R.5
Page-Shipp, L.6
Pistorius, C.7
Krause, R.8
Bogoshi, M.9
Churchyard, G.10
Venter, A.11
Allen, J.12
Palomino, J.C.13
De Marez, T.14
van Heeswijk, R.P.15
Lounis, N.16
Meyvisch, P.17
Verbeeck, J.18
Parys, W.19
de Beule, K.20
Andries, K.21
Mc Neeley, D.F.22
more..
-
25
-
-
19944429772
-
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
-
Andries K., Verhasselt P., Guillemont J., Göhlmann H.W.H., Neefs J.-M., Winkler H., Van Gestel J., Timmerman P., Zhu M., Lee E., Williams P., de Chaffoy D., Huitric E., Hoffner S., Cambau E., Truffot-Pernot C., Lounis N., Jarlier V. A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science 2005, 307:223-227.
-
(2005)
Science
, vol.307
, pp. 223-227
-
-
Andries, K.1
Verhasselt, P.2
Guillemont, J.3
Göhlmann, H.W.H.4
Neefs, J.-M.5
Winkler, H.6
Van Gestel, J.7
Timmerman, P.8
Zhu, M.9
Lee, E.10
Williams, P.11
de Chaffoy, D.12
Huitric, E.13
Hoffner, S.14
Cambau, E.15
Truffot-Pernot, C.16
Lounis, N.17
Jarlier, V.18
-
26
-
-
80055079575
-
Fumarate reductase activity maintains an energized membrane in anaerobic Mycobacterium tuberculosis
-
Watanabe S., Zimmermann M., Goodwin M.B., Sauer U., Barry C.E., Boshoff H.I. Fumarate reductase activity maintains an energized membrane in anaerobic Mycobacterium tuberculosis. PLoS Pathog. 2011, 7.
-
(2011)
PLoS Pathog.
, vol.7
-
-
Watanabe, S.1
Zimmermann, M.2
Goodwin, M.B.3
Sauer, U.4
Barry, C.E.5
Boshoff, H.I.6
-
27
-
-
54049095245
-
Impact of the interaction of R207910 with rifampin on the treatment of tuberculosis studied in the mouse model
-
Lounis N., Gevers T., Van Den Berg J., Andries K. Impact of the interaction of R207910 with rifampin on the treatment of tuberculosis studied in the mouse model. Antimicrob. Agents Chemother. 2008, 52:3568-3572.
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 3568-3572
-
-
Lounis, N.1
Gevers, T.2
Van Den Berg, J.3
Andries, K.4
-
28
-
-
85016596260
-
Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline
-
Preiss L., Langer J.D., Yildiz Ö., Eckhardt-Strelau L., Guillemont J.E.G., Koul A., Meier T. Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline. Sci. Adv. 2015, 1.
-
(2015)
Sci. Adv.
, vol.1
-
-
Preiss, L.1
Langer, J.D.2
Yildiz, Ö.3
Eckhardt-Strelau, L.4
Guillemont, J.E.G.5
Koul, A.6
Meier, T.7
-
29
-
-
84883824094
-
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis
-
Pethe K., Bifani P., Jang J., Kang S., Park S., Ahn S., Jiricek J., Jung J., Jeon H.K., Cechetto J., Christophe T., Lee H., Kempf M., Jackson M., Lenaerts A.J., Pham H., Jones V., Seo M.J., Kim Y.M., Seo M., Seo J.J., Park D., Ko Y., Choi I., Kim R., Kim S.Y., Lim S., Yim S.A., Nam J., Kang H., Kwon H., Oh C.T., Cho Y., Jang Y., Kim J., Chua A., Tan B.H., Nanjundappa M.B., Rao S.P., Barnes W.S., Wintjens R., Walker J.R., Alonso S., Lee S., Kim J., Oh S., Oh T., Nehrbass U., Han S.J., No Z., Lee J., Brodin P., Cho S.N., Nam K., Kim J. Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nat. Med. 2013, 19:1157-1160.
-
(2013)
Nat. Med.
, vol.19
, pp. 1157-1160
-
-
Pethe, K.1
Bifani, P.2
Jang, J.3
Kang, S.4
Park, S.5
Ahn, S.6
Jiricek, J.7
Jung, J.8
Jeon, H.K.9
Cechetto, J.10
Christophe, T.11
Lee, H.12
Kempf, M.13
Jackson, M.14
Lenaerts, A.J.15
Pham, H.16
Jones, V.17
Seo, M.J.18
Kim, Y.M.19
Seo, M.20
Seo, J.J.21
Park, D.22
Ko, Y.23
Choi, I.24
Kim, R.25
Kim, S.Y.26
Lim, S.27
Yim, S.A.28
Nam, J.29
Kang, H.30
Kwon, H.31
Oh, C.T.32
Cho, Y.33
Jang, Y.34
Kim, J.35
Chua, A.36
Tan, B.H.37
Nanjundappa, M.B.38
Rao, S.P.39
Barnes, W.S.40
Wintjens, R.41
Walker, J.R.42
Alonso, S.43
Lee, S.44
Kim, J.45
Oh, S.46
Oh, T.47
Nehrbass, U.48
Han, S.J.49
No, Z.50
Lee, J.51
Brodin, P.52
Cho, S.N.53
Nam, K.54
Kim, J.55
more..
-
30
-
-
84871764621
-
Identification of novel Imidazo[1,2-a]pyridine inhibitors targetingM. tuberculosis QcrB
-
Abrahams K.A., Cox J.A.G., Spivey V.L., Loman N.J., Pallen M.J., Constantinidou C., Fernández R., Alemparte C., Remuiñán M.J., Barros D., Ballell L., Besra G.S. Identification of novel Imidazo[1,2-a]pyridine inhibitors targetingM. tuberculosis QcrB. PLoS ONE 2012, 7.
-
(2012)
PLoS ONE
, vol.7
-
-
Abrahams, K.A.1
Cox, J.A.G.2
Spivey, V.L.3
Loman, N.J.4
Pallen, M.J.5
Constantinidou, C.6
Fernández, R.7
Alemparte, C.8
Remuiñán, M.J.9
Barros, D.10
Ballell, L.11
Besra, G.S.12
-
31
-
-
84969257176
-
Putting tuberculosis (TB) to rest: transformation of the Sleep Aid, Ambien, and "Anagrams" generated potent antituberculosis agents
-
Moraski G.C., Miller P.A., Bailey M.A., Ollinger J., Parish T., Boshoff H.I., Cho S., Anderson J.R., Mulugeta S., Franzblau S.G., Miller M.J. Putting tuberculosis (TB) to rest: transformation of the Sleep Aid, Ambien, and "Anagrams" generated potent antituberculosis agents. ACS Infect. Dis. 2015, 1:85-90.
-
(2015)
ACS Infect. Dis.
, vol.1
, pp. 85-90
-
-
Moraski, G.C.1
Miller, P.A.2
Bailey, M.A.3
Ollinger, J.4
Parish, T.5
Boshoff, H.I.6
Cho, S.7
Anderson, J.R.8
Mulugeta, S.9
Franzblau, S.G.10
Miller, M.J.11
-
32
-
-
0029589845
-
Synthesis of the arabinose donor.beta.-D-arabinofuranosyl-1-monophosphoryldecaprenol, development of a basic arabinosyl-transferase assay, and identification of ethambutol as an arabinosyl transferase inhibitor
-
Lee R.E., Mikusova K., Brennan P.J., Besra G.S. Synthesis of the arabinose donor.beta.-D-arabinofuranosyl-1-monophosphoryldecaprenol, development of a basic arabinosyl-transferase assay, and identification of ethambutol as an arabinosyl transferase inhibitor. J. Am. Chem. Soc. 1995, 117:11829-11832.
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 11829-11832
-
-
Lee, R.E.1
Mikusova, K.2
Brennan, P.J.3
Besra, G.S.4
-
33
-
-
43549101762
-
Biosynthesis of D-arabinose in mycobacteria-a novel bacterial pathway with implications for antimycobacterial therapy
-
Wolucka B.A. Biosynthesis of D-arabinose in mycobacteria-a novel bacterial pathway with implications for antimycobacterial therapy. FEBS J. 2008, 275:2691-2711.
-
(2008)
FEBS J.
, vol.275
, pp. 2691-2711
-
-
Wolucka, B.A.1
-
34
-
-
84887406804
-
Why are membrane targets discovered by phenotypic screens and genome sequencing in Mycobacterium tuberculosis?
-
Goldman R.C. Why are membrane targets discovered by phenotypic screens and genome sequencing in Mycobacterium tuberculosis?. Tuberculosis (Edinb.) 2013, 93:569-588.
-
(2013)
Tuberculosis (Edinb.)
, vol.93
, pp. 569-588
-
-
Goldman, R.C.1
-
35
-
-
84885374789
-
The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis
-
Riccardi G., Pasca M., Chiarelli L., Manina G., Mattevi A., Binda C. The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis. Appl. Microbiol. Biotechnol. 2013, 97:8841-8848.
-
(2013)
Appl. Microbiol. Biotechnol.
, vol.97
, pp. 8841-8848
-
-
Riccardi, G.1
Pasca, M.2
Chiarelli, L.3
Manina, G.4
Mattevi, A.5
Binda, C.6
-
36
-
-
65649096556
-
Benzothiazinones kill Mycobacterium tuberculosis by blocking Arabinan synthesis
-
Makarov V., Manina G., Mikusova K., Möllmann U., Ryabova O., Saint-Joanis B., Dhar N., Pasca M.R., Buroni S., Lucarelli A.P., Milano A., De Rossi E., Belanova M., Bobovska A., Dianiskova P., Kordulakova J., Sala C., Fullam E., Schneider P., McKinney J.D., Brodin P., Christophe T., Waddell S., Butcher P., Albrethsen J., Rosenkrands I., Brosch R., Nandi V., Bharath S., Gaonkar S., Shandil R.K., Balasubramanian V., Balganesh T., Tyagi S., Grosset J., Riccardi G., Cole S.T. Benzothiazinones kill Mycobacterium tuberculosis by blocking Arabinan synthesis. Science 2009, 324:801-804.
-
(2009)
Science
, vol.324
, pp. 801-804
-
-
Makarov, V.1
Manina, G.2
Mikusova, K.3
Möllmann, U.4
Ryabova, O.5
Saint-Joanis, B.6
Dhar, N.7
Pasca, M.R.8
Buroni, S.9
Lucarelli, A.P.10
Milano, A.11
De Rossi, E.12
Belanova, M.13
Bobovska, A.14
Dianiskova, P.15
Kordulakova, J.16
Sala, C.17
Fullam, E.18
Schneider, P.19
McKinney, J.D.20
Brodin, P.21
Christophe, T.22
Waddell, S.23
Butcher, P.24
Albrethsen, J.25
Rosenkrands, I.26
Brosch, R.27
Nandi, V.28
Bharath, S.29
Gaonkar, S.30
Shandil, R.K.31
Balasubramanian, V.32
Balganesh, T.33
Tyagi, S.34
Grosset, J.35
Riccardi, G.36
Cole, S.T.37
more..
-
37
-
-
84896716778
-
Towards a new combination therapy for tuberculosis with next generation benzothiazinones
-
Makarov V., Lechartier B., Zhang M., Neres J., van der Sar A.M., Raadsen S.A., Hartkoorn R.C., Ryabova O.B., Vocat A., Decosterd L.A., Widmer N., Buclin T., Bitter W., Andries K., Pojer F., Dyson P.J., Cole S.T. Towards a new combination therapy for tuberculosis with next generation benzothiazinones. EMBO Mol. Med. 2014, 6:372-383.
-
(2014)
EMBO Mol. Med.
, vol.6
, pp. 372-383
-
-
Makarov, V.1
Lechartier, B.2
Zhang, M.3
Neres, J.4
van der Sar, A.M.5
Raadsen, S.A.6
Hartkoorn, R.C.7
Ryabova, O.B.8
Vocat, A.9
Decosterd, L.A.10
Widmer, N.11
Buclin, T.12
Bitter, W.13
Andries, K.14
Pojer, F.15
Dyson, P.J.16
Cole, S.T.17
-
38
-
-
77957310736
-
Benzothiazinones: prodrugs that covalently modify the decaprenylphosphoryl-β-d-ribose 2'-epimerase DprE1 of Mycobacterium tuberculosis
-
Trefzer C., Rengifo-Gonzalez M., Hinner M.J., Schneider P., Makarov V., Cole S.T., Johnsson K. Benzothiazinones: prodrugs that covalently modify the decaprenylphosphoryl-β-d-ribose 2'-epimerase DprE1 of Mycobacterium tuberculosis. J. Am. Chem. Soc. 2010, 132:13663-13665.
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 13663-13665
-
-
Trefzer, C.1
Rengifo-Gonzalez, M.2
Hinner, M.J.3
Schneider, P.4
Makarov, V.5
Cole, S.T.6
Johnsson, K.7
-
39
-
-
33845323336
-
OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice
-
Matsumoto M., Hashizume H., Tomishige T., Kawasaki M., Tsubouchi H., Sasaki H., Shimokawa Y., Komatsu M. OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice. PLoS Med. 2006, 3.
-
(2006)
PLoS Med.
, vol.3
-
-
Matsumoto, M.1
Hashizume, H.2
Tomishige, T.3
Kawasaki, M.4
Tsubouchi, H.5
Sasaki, H.6
Shimokawa, Y.7
Komatsu, M.8
-
40
-
-
84890543354
-
Azaindoles: noncovalent DprE1 inhibitors from scaffold morphing efforts, kill Mycobacterium tuberculosis and are efficacious in vivo
-
Shirude P.S., Shandil R., Sadler C., Naik M., Hosagrahara V., Hameed S., Shinde V., Bathula C., Humnabadkar V., Kumar N., Reddy J., Panduga V., Sharma S., Ambady A., Hegde N., Whiteaker J., McLaughlin R.E., Gardner H., Madhavapeddi P., Ramachandran V., Kaur P., Narayan A., Guptha S., Awasthy D., Narayan C., Mahadevaswamy J., Vishwas K.G., Ahuja V., Srivastava A., Prabhakar K.R., Bharath S., Kale R., Ramaiah M., Choudhury N.R., Sambandamurthy V.K., Solapure S., Iyer P.S., Narayanan S., Chatterji M. Azaindoles: noncovalent DprE1 inhibitors from scaffold morphing efforts, kill Mycobacterium tuberculosis and are efficacious in vivo. J. Med. Chem. 2013, 56:9701-9708.
-
(2013)
J. Med. Chem.
, vol.56
, pp. 9701-9708
-
-
Shirude, P.S.1
Shandil, R.2
Sadler, C.3
Naik, M.4
Hosagrahara, V.5
Hameed, S.6
Shinde, V.7
Bathula, C.8
Humnabadkar, V.9
Kumar, N.10
Reddy, J.11
Panduga, V.12
Sharma, S.13
Ambady, A.14
Hegde, N.15
Whiteaker, J.16
McLaughlin, R.E.17
Gardner, H.18
Madhavapeddi, P.19
Ramachandran, V.20
Kaur, P.21
Narayan, A.22
Guptha, S.23
Awasthy, D.24
Narayan, C.25
Mahadevaswamy, J.26
Vishwas, K.G.27
Ahuja, V.28
Srivastava, A.29
Prabhakar, K.R.30
Bharath, S.31
Kale, R.32
Ramaiah, M.33
Choudhury, N.R.34
Sambandamurthy, V.K.35
Solapure, S.36
Iyer, P.S.37
Narayanan, S.38
Chatterji, M.39
more..
-
41
-
-
84904364464
-
Lead optimization of 1,4-azaindoles as antimycobacterial agents
-
Shirude P.S., Shandil R.K., Manjunatha M.R., Sadler C., Panda M., Panduga V., Reddy J., Saralaya R., Nanduri R., Ambady A., Ravishankar S., Sambandamurthy V.K., Humnabadkar V., Jena L.K., Suresh R.S., Srivastava A., Prabhakar K.R., Whiteaker J., McLaughlin R.E., Sharma S., Cooper C.B., Mdluli K., Butler S., Iyer P.S., Narayanan S., Chatterji M. Lead optimization of 1,4-azaindoles as antimycobacterial agents. J. Med. Chem. 2014, 57:5728-5737.
-
(2014)
J. Med. Chem.
, vol.57
, pp. 5728-5737
-
-
Shirude, P.S.1
Shandil, R.K.2
Manjunatha, M.R.3
Sadler, C.4
Panda, M.5
Panduga, V.6
Reddy, J.7
Saralaya, R.8
Nanduri, R.9
Ambady, A.10
Ravishankar, S.11
Sambandamurthy, V.K.12
Humnabadkar, V.13
Jena, L.K.14
Suresh, R.S.15
Srivastava, A.16
Prabhakar, K.R.17
Whiteaker, J.18
McLaughlin, R.E.19
Sharma, S.20
Cooper, C.B.21
Mdluli, K.22
Butler, S.23
Iyer, P.S.24
Narayanan, S.25
Chatterji, M.26
more..
-
42
-
-
34250194065
-
Old and new drugs for the treatment of tuberculosis in children
-
Donald P.R., Schaaf H.S. Old and new drugs for the treatment of tuberculosis in children. Paediatr. Respir. Rev. 2007, 8:134-141.
-
(2007)
Paediatr. Respir. Rev.
, vol.8
, pp. 134-141
-
-
Donald, P.R.1
Schaaf, H.S.2
-
43
-
-
84879707160
-
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis
-
Wang F., Sambandan D., Halder R., Wang J., Batt S.M., Weinrick B., Ahmad I., Yang P., Zhang Y., Kim J., Hassani M., Huszar S., Trefzer C., Ma Z., Kaneko T., Mdluli K.E., Franzblau S., Chatterjee A.K., Johnsson K., Mikusova K., Besra G.S., Fütterer K., Robbins S.H., Barnes S.W., Walker J.R., Jacobs W.R., Schultz P.G. Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proc. Natl. Acad. Sci. 2013, 110:E2510-E2517.
-
(2013)
Proc. Natl. Acad. Sci.
, vol.110
, pp. E2510-E2517
-
-
Wang, F.1
Sambandan, D.2
Halder, R.3
Wang, J.4
Batt, S.M.5
Weinrick, B.6
Ahmad, I.7
Yang, P.8
Zhang, Y.9
Kim, J.10
Hassani, M.11
Huszar, S.12
Trefzer, C.13
Ma, Z.14
Kaneko, T.15
Mdluli, K.E.16
Franzblau, S.17
Chatterjee, A.K.18
Johnsson, K.19
Mikusova, K.20
Besra, G.S.21
Fütterer, K.22
Robbins, S.H.23
Barnes, S.W.24
Walker, J.R.25
Jacobs, W.R.26
Schultz, P.G.27
more..
-
44
-
-
3042706671
-
Gene expression profile of Mycobacterium tuberculosis in a non-replicating state
-
Muttucumaru D.G.N., Roberts G., Hinds J., Stabler R.A., Parish T. Gene expression profile of Mycobacterium tuberculosis in a non-replicating state. Tuberculosis 2004, 84:239-246.
-
(2004)
Tuberculosis
, vol.84
, pp. 239-246
-
-
Muttucumaru, D.G.N.1
Roberts, G.2
Hinds, J.3
Stabler, R.A.4
Parish, T.5
-
45
-
-
19744376797
-
Contribution of the Mycobacterium tuberculosis MmpL protein family to virulence and drug resistance
-
Domenech P., Reed M.B., Barry C.E. Contribution of the Mycobacterium tuberculosis MmpL protein family to virulence and drug resistance. Infect. Immun. 2005, 73:3492-3501.
-
(2005)
Infect. Immun.
, vol.73
, pp. 3492-3501
-
-
Domenech, P.1
Reed, M.B.2
Barry, C.E.3
-
46
-
-
0038700567
-
Combinatorial lead optimization of [1,2]-diamines based on ethambutol as potential antituberculosis preclinical candidates
-
Lee R.E., Protopopova M., Crooks E., Slayden R.A., Terrot M., Barry C.E. Combinatorial lead optimization of [1,2]-diamines based on ethambutol as potential antituberculosis preclinical candidates. J. Comb. Chem. 2003, 5:172-187.
-
(2003)
J. Comb. Chem.
, vol.5
, pp. 172-187
-
-
Lee, R.E.1
Protopopova, M.2
Crooks, E.3
Slayden, R.A.4
Terrot, M.5
Barry, C.E.6
-
47
-
-
33846073563
-
New derivatives of BM212: A class of antimycobacterial compounds based on the pyrrole ring as a scaffold
-
Biava M., Porretta G.C., Manetti F. New derivatives of BM212: A class of antimycobacterial compounds based on the pyrrole ring as a scaffold. Mini-Rev. Med. Chem. 2007, 7:65-78.
-
(2007)
Mini-Rev. Med. Chem.
, vol.7
, pp. 65-78
-
-
Biava, M.1
Porretta, G.C.2
Manetti, F.3
-
48
-
-
84908288084
-
Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis
-
Li W., Upadhyay A., Fontes F.L., North E.J., Wang Y., Crans D.C., Grzegorzewicz A.E., Jones V., Franzblau S.G., Lee R.E., Crick D.C., Jackson M. Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 2014, 58:6413-6423.
-
(2014)
Antimicrob. Agents Chemother.
, vol.58
, pp. 6413-6423
-
-
Li, W.1
Upadhyay, A.2
Fontes, F.L.3
North, E.J.4
Wang, Y.5
Crans, D.C.6
Grzegorzewicz, A.E.7
Jones, V.8
Franzblau, S.G.9
Lee, R.E.10
Crick, D.C.11
Jackson, M.12
-
49
-
-
84874297088
-
Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection
-
Poce G., Bates R.H., Alfonso S., Cocozza M., Porretta G.C., Ballell L., Rullas J., Ortega F., De Logu A., Agus E., La Rosa V., Pasca M.R., De Rossi E., Wae B., Franzblau S.G., Manetti F., Botta M., Biava M. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection. PLoS One 2013, 8.
-
(2013)
PLoS One
, vol.8
-
-
Poce, G.1
Bates, R.H.2
Alfonso, S.3
Cocozza, M.4
Porretta, G.C.5
Ballell, L.6
Rullas, J.7
Ortega, F.8
De Logu, A.9
Agus, E.10
La Rosa, V.11
Pasca, M.R.12
De Rossi, E.13
Wae, B.14
Franzblau, S.G.15
Manetti, F.16
Botta, M.17
Biava, M.18
-
50
-
-
84898408111
-
Multitarget drug discovery for tuberculosis and other infectious diseases
-
Li K., Schurig-Briccio L.A., Feng X., Upadhyay A., Pujari V., Lechartier B., Fontes F.L., Yang H., Rao G., Zhu W., Gulati A., No J.H., Cintra G., Bogue S., Liu Y.-L., Molohon K., Orlean P., Mitchell D.A., Freitas-Junior L., Ren F., Sun H., Jiang T., Li Y., Guo R.-T., Cole S.T., Gennis R.B., Crick D.C., Oldfield E. Multitarget drug discovery for tuberculosis and other infectious diseases. J. Med. Chem. 2014, 57:3126-3139.
-
(2014)
J. Med. Chem.
, vol.57
, pp. 3126-3139
-
-
Li, K.1
Schurig-Briccio, L.A.2
Feng, X.3
Upadhyay, A.4
Pujari, V.5
Lechartier, B.6
Fontes, F.L.7
Yang, H.8
Rao, G.9
Zhu, W.10
Gulati, A.11
No, J.H.12
Cintra, G.13
Bogue, S.14
Liu, Y.-L.15
Molohon, K.16
Orlean, P.17
Mitchell, D.A.18
Freitas-Junior, L.19
Ren, F.20
Sun, H.21
Jiang, T.22
Li, Y.23
Guo, R.-T.24
Cole, S.T.25
Gennis, R.B.26
Crick, D.C.27
Oldfield, E.28
more..
-
51
-
-
84891722137
-
Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis
-
(214ra168)
-
Rao S.P., Lakshminarayana S.B., Kondreddi R.R., Herve M., Camacho L.R., Bifani P., Kalapala S.K., Jiricek J., Ma N.L., Tan B.H., Ng S.H., Nanjundappa M., Ravindran S., Seah P.G., Thayalan P., Lim S.H., Lee B.H., Goh A., Barnes W.S., Chen Z., Gagaring K., Chatterjee A.K., Pethe K., Kuhen K., Walker J., Feng G., Babu S., Zhang L., Blasco F., Beer D., Weaver M., Dartois V., Glynne R., Dick T., Smith P.W., Diagana T.T., Manjunatha U.H. Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis. Sci. Transl. Med. 2013, 5. (214ra168).
-
(2013)
Sci. Transl. Med.
, vol.5
-
-
Rao, S.P.1
Lakshminarayana, S.B.2
Kondreddi, R.R.3
Herve, M.4
Camacho, L.R.5
Bifani, P.6
Kalapala, S.K.7
Jiricek, J.8
Ma, N.L.9
Tan, B.H.10
Ng, S.H.11
Nanjundappa, M.12
Ravindran, S.13
Seah, P.G.14
Thayalan, P.15
Lim, S.H.16
Lee, B.H.17
Goh, A.18
Barnes, W.S.19
Chen, Z.20
Gagaring, K.21
Chatterjee, A.K.22
Pethe, K.23
Kuhen, K.24
Walker, J.25
Feng, G.26
Babu, S.27
Zhang, L.28
Blasco, F.29
Beer, D.30
Weaver, M.31
Dartois, V.32
Glynne, R.33
Dick, T.34
Smith, P.W.35
Diagana, T.T.36
Manjunatha, U.H.37
more..
-
52
-
-
84890954080
-
Indoleamides are active against drug-resistant Mycobacterium tuberculosis
-
Lun S., Guo H., Onajole O.K., Pieroni M., Gunosewoyo H., Chen G., Tipparaju S.K., Ammerman N.C., Kozikowski A.P., Bishai W.R. Indoleamides are active against drug-resistant Mycobacterium tuberculosis. Nat. Commun. 2013, 4.
-
(2013)
Nat. Commun.
, vol.4
-
-
Lun, S.1
Guo, H.2
Onajole, O.K.3
Pieroni, M.4
Gunosewoyo, H.5
Chen, G.6
Tipparaju, S.K.7
Ammerman, N.C.8
Kozikowski, A.P.9
Bishai, W.R.10
-
53
-
-
35748965549
-
Antibacterial targets in fatty acid biosynthesis
-
Wright H.T., Reynolds K.A. Antibacterial targets in fatty acid biosynthesis. Curr. Opin. Microbiol. 2007, 10:447-453.
-
(2007)
Curr. Opin. Microbiol.
, vol.10
, pp. 447-453
-
-
Wright, H.T.1
Reynolds, K.A.2
-
54
-
-
33745817391
-
Inhibiting bacterial fatty acid synthesis
-
Zhang Y.-M., White S.W., Rock C.O. Inhibiting bacterial fatty acid synthesis. J. Biol. Chem. 2006, 281:17541-17544.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 17541-17544
-
-
Zhang, Y.-M.1
White, S.W.2
Rock, C.O.3
-
55
-
-
84899111509
-
A structural and energetic model for the slow-onset inhibition of the Mycobacterium tuberculosis Enoyl-ACP reductase InhA
-
Li H.-J., Lai C.-T., Pan P., Yu W., Liu N., Bommineni G.R., Garcia-Diaz M., Simmerling C., Tonge P.J. A structural and energetic model for the slow-onset inhibition of the Mycobacterium tuberculosis Enoyl-ACP reductase InhA. ACS Chem. Biol. 2014, 9:986-993.
-
(2014)
ACS Chem. Biol.
, vol.9
, pp. 986-993
-
-
Li, H.-J.1
Lai, C.-T.2
Pan, P.3
Yu, W.4
Liu, N.5
Bommineni, G.R.6
Garcia-Diaz, M.7
Simmerling, C.8
Tonge, P.J.9
-
56
-
-
0345133299
-
The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance
-
Rawat R., Whitty A., Tonge P.J. The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance. Proc. Natl. Acad. Sci. 2003, 100:13881-13886.
-
(2003)
Proc. Natl. Acad. Sci.
, vol.100
, pp. 13881-13886
-
-
Rawat, R.1
Whitty, A.2
Tonge, P.J.3
-
57
-
-
84938594669
-
Rational modulation of the induced-fit conformational change for slow-onset inhibition in Mycobacterium tuberculosis InhA
-
Lai C.-T., Li H.-J., Yu W., Shah S., Bommineni G.R., Perrone V., Garcia-Diaz M., Tonge P.J., Simmerling C. Rational modulation of the induced-fit conformational change for slow-onset inhibition in Mycobacterium tuberculosis InhA. Biochemistry 2015, 54:4683-4691.
-
(2015)
Biochemistry
, vol.54
, pp. 4683-4691
-
-
Lai, C.-T.1
Li, H.-J.2
Yu, W.3
Shah, S.4
Bommineni, G.R.5
Perrone, V.6
Garcia-Diaz, M.7
Tonge, P.J.8
Simmerling, C.9
-
58
-
-
77955329488
-
Drug-target residence time: critical information for lead optimization
-
Lu H., Tonge P.J. Drug-target residence time: critical information for lead optimization. Curr. Opin. Chem. Biol. 2010, 14:467-474.
-
(2010)
Curr. Opin. Chem. Biol.
, vol.14
, pp. 467-474
-
-
Lu, H.1
Tonge, P.J.2
-
59
-
-
44049103958
-
Residence time of receptor-ligand complexes and its effect on biological function
-
Tummino P.J., Copeland R.A. Residence time of receptor-ligand complexes and its effect on biological function. Biochemistry 2008, 47:5481-5492.
-
(2008)
Biochemistry
, vol.47
, pp. 5481-5492
-
-
Tummino, P.J.1
Copeland, R.A.2
-
60
-
-
33748325882
-
Drug-target residence time and its implications for lead optimization
-
Copeland R.A., Pompliano D.L., Meek T.D. Drug-target residence time and its implications for lead optimization. Nat. Rev. Drug Discov. 2006, 5:730-739.
-
(2006)
Nat. Rev. Drug Discov.
, vol.5
, pp. 730-739
-
-
Copeland, R.A.1
Pompliano, D.L.2
Meek, T.D.3
-
61
-
-
65249139978
-
Slow-onset inhibition of the fabi enoyl reductase from Francisella tularensis: residence time and in vivo activity
-
Lu H., England K., am Ende C., Truglio J.J., Luckner S., Reddy B.G., Marlenee N.L., Knudson S.E., Knudson D.L., Bowen R.A., Kisker C., Slayden R.A., Tonge P.J. Slow-onset inhibition of the fabi enoyl reductase from Francisella tularensis: residence time and in vivo activity. ACS Chem. Biol. 2009, 4:221-231.
-
(2009)
ACS Chem. Biol.
, vol.4
, pp. 221-231
-
-
Lu, H.1
England, K.2
am Ende, C.3
Truglio, J.J.4
Luckner, S.5
Reddy, B.G.6
Marlenee, N.L.7
Knudson, S.E.8
Knudson, D.L.9
Bowen, R.A.10
Kisker, C.11
Slayden, R.A.12
Tonge, P.J.13
-
62
-
-
84868026542
-
Mode of action, in vitro activity, and in vivo efficacy of AFN-1252, a selective antistaphylococcal FabI inhibitor
-
Kaplan N., Albert M., Awrey D., Bardouniotis E., Berman J., Clarke T., Dorsey M., Hafkin B., Ramnauth J., Romanov V., Schmid M.B., Thalakada R., Yethon J., Pauls H.W. Mode of action, in vitro activity, and in vivo efficacy of AFN-1252, a selective antistaphylococcal FabI inhibitor. Antimicrob. Agents Chemother. 2012, 56:5865-5874.
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 5865-5874
-
-
Kaplan, N.1
Albert, M.2
Awrey, D.3
Bardouniotis, E.4
Berman, J.5
Clarke, T.6
Dorsey, M.7
Hafkin, B.8
Ramnauth, J.9
Romanov, V.10
Schmid, M.B.11
Thalakada, R.12
Yethon, J.13
Pauls, H.W.14
-
63
-
-
80052846256
-
The MUT056399 inhibitor of FabI is a new antistaphylococcal compound
-
Escaich S., Prouvensier L., Saccomani M., Durant L., Oxoby M., Gerusz V., Moreau F., Vongsouthi V., Maher K., Morrissey I., Soulama-Mouze C. The MUT056399 inhibitor of FabI is a new antistaphylococcal compound. Antimicrob. Agents Chemother. 2011, 55:4692-4697.
-
(2011)
Antimicrob. Agents Chemother.
, vol.55
, pp. 4692-4697
-
-
Escaich, S.1
Prouvensier, L.2
Saccomani, M.3
Durant, L.4
Oxoby, M.5
Gerusz, V.6
Moreau, F.7
Vongsouthi, V.8
Maher, K.9
Morrissey, I.10
Soulama-Mouze, C.11
-
64
-
-
84921454584
-
Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis
-
Šink R., Sosič I., Živec M., Fernandez-Menendez R., Turk S., Pajk S., Alvarez-Gomez D., Lopez-Roman E.M., Gonzales-Cortez C., Rullas-Triconado J., Angulo-Barturen I., Barros D., Ballell-Pages L., Young R.J., Encinas L., Gobec S. Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis. J. Med. Chem. 2015, 58:613-624.
-
(2015)
J. Med. Chem.
, vol.58
, pp. 613-624
-
-
Šink, R.1
Sosič, I.2
Živec, M.3
Fernandez-Menendez, R.4
Turk, S.5
Pajk, S.6
Alvarez-Gomez, D.7
Lopez-Roman, E.M.8
Gonzales-Cortez, C.9
Rullas-Triconado, J.10
Angulo-Barturen, I.11
Barros, D.12
Ballell-Pages, L.13
Young, R.J.14
Encinas, L.15
Gobec, S.16
-
65
-
-
84887896126
-
Methyl-thiazoles: a novel mode of inhibition with the potential to develop novel inhibitors targeting InhA in Mycobacterium tuberculosis
-
Shirude P.S., Madhavapeddi P., Naik M., Murugan K., Shinde V., Nandishaiah R., Bhat J., Kumar A., Hameed S., Holdgate G., Davies G., McMiken H., Hegde N., Ambady A., Venkatraman J., Panda M., Bandodkar B., Sambandamurthy V.K., Read J.A. Methyl-thiazoles: a novel mode of inhibition with the potential to develop novel inhibitors targeting InhA in Mycobacterium tuberculosis. J. Med. Chem. 2013, 56:8533-8542.
-
(2013)
J. Med. Chem.
, vol.56
, pp. 8533-8542
-
-
Shirude, P.S.1
Madhavapeddi, P.2
Naik, M.3
Murugan, K.4
Shinde, V.5
Nandishaiah, R.6
Bhat, J.7
Kumar, A.8
Hameed, S.9
Holdgate, G.10
Davies, G.11
McMiken, H.12
Hegde, N.13
Ambady, A.14
Venkatraman, J.15
Panda, M.16
Bandodkar, B.17
Sambandamurthy, V.K.18
Read, J.A.19
-
66
-
-
84920711914
-
Direct inhibitors of InhA are active against Mycobacterium tuberculosis
-
(269ra263)
-
Manjunatha U.H., Rao S.P.S., Kondreddi R.R., Noble C.G., Camacho L.R., Tan B.H., Ng S.H., Ng P.S., Ma N.L., Lakshminarayana S.B., Herve M., Barnes S.W., Yu W., Kuhen K., Blasco F., Beer D., Walker J.R., Tonge P.J., Glynne R., Smith P.W., Diagana T.T. Direct inhibitors of InhA are active against Mycobacterium tuberculosis. Sci. Transl. Med. 2015, 7. (269ra263).
-
(2015)
Sci. Transl. Med.
, vol.7
-
-
Manjunatha, U.H.1
Rao, S.P.S.2
Kondreddi, R.R.3
Noble, C.G.4
Camacho, L.R.5
Tan, B.H.6
Ng, S.H.7
Ng, P.S.8
Ma, N.L.9
Lakshminarayana, S.B.10
Herve, M.11
Barnes, S.W.12
Yu, W.13
Kuhen, K.14
Blasco, F.15
Beer, D.16
Walker, J.R.17
Tonge, P.J.18
Glynne, R.19
Smith, P.W.20
Diagana, T.T.21
more..
-
67
-
-
84908351878
-
Oldie but goodie: repurposing penicillin for tuberculosis
-
Keener A.B. Oldie but goodie: repurposing penicillin for tuberculosis. Nat. Med. 2014, 20:976-978.
-
(2014)
Nat. Med.
, vol.20
, pp. 976-978
-
-
Keener, A.B.1
-
68
-
-
0025829552
-
AMoxicillin-clavulanic acid for treating drug-resistant Mycobacterium tuberculosis
-
Nadler J.P., Berger J., Nord J.A., Cofsky R., Saxena M. AMoxicillin-clavulanic acid for treating drug-resistant Mycobacterium tuberculosis. Chest 1991, 99:1025-1026.
-
(1991)
Chest
, vol.99
, pp. 1025-1026
-
-
Nadler, J.P.1
Berger, J.2
Nord, J.A.3
Cofsky, R.4
Saxena, M.5
-
69
-
-
84868004842
-
World Health Organization group 5 drugs for the treatment of drug-resistant tuberculosis: unclear efficacy or untapped potential?
-
Dooley K.E., Obuku E.A., Durakovic N., Belitsky V., Mitnick C., Nuermberger E.L. World Health Organization group 5 drugs for the treatment of drug-resistant tuberculosis: unclear efficacy or untapped potential?. J. Infect. Dis. 2013, 207:1352-1358.
-
(2013)
J. Infect. Dis.
, vol.207
, pp. 1352-1358
-
-
Dooley, K.E.1
Obuku, E.A.2
Durakovic, N.3
Belitsky, V.4
Mitnick, C.5
Nuermberger, E.L.6
-
70
-
-
84864386270
-
Inactivation of Mycobacterium tuberculosis l,d-Transpeptidase LdtMt1 by carbapenems and cephalosporins
-
Dubée V., Triboulet S., Mainardi J.-L., Ethève-Quelquejeu M., Gutmann L., Marie A., Dubost L., Hugonnet J.-E., Arthur M. Inactivation of Mycobacterium tuberculosis l,d-Transpeptidase LdtMt1 by carbapenems and cephalosporins. Antimicrob. Agents Chemother. 2012, 56:4189-4195.
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 4189-4195
-
-
Dubée, V.1
Triboulet, S.2
Mainardi, J.-L.3
Ethève-Quelquejeu, M.4
Gutmann, L.5
Marie, A.6
Dubost, L.7
Hugonnet, J.-E.8
Arthur, M.9
-
71
-
-
84921752521
-
Mechanisms of [beta]-lactam killing and resistance in the context of Mycobacterium tuberculosis
-
Wivagg C.N., Bhattacharyya R.P., Hung D.T. Mechanisms of [beta]-lactam killing and resistance in the context of Mycobacterium tuberculosis. J. Antibiot. 2014, 67:645-654.
-
(2014)
J. Antibiot.
, vol.67
, pp. 645-654
-
-
Wivagg, C.N.1
Bhattacharyya, R.P.2
Hung, D.T.3
-
72
-
-
84870747517
-
Efficacy and safety of meropenem-clavulanate added to linezolid-containing regimens in the treatment of MDR-/XDR-TB
-
De Lorenzo S., Alffenaar J.W., Sotgiu G., Centis R., D'Ambrosio L., Tiberi S., Bolhuis M.S., van Altena R., Viggiani P., Piana A., Spanevello A., Migliori G.B. Efficacy and safety of meropenem-clavulanate added to linezolid-containing regimens in the treatment of MDR-/XDR-TB. Eur. Respir. J. 2013, 41:1386-1392.
-
(2013)
Eur. Respir. J.
, vol.41
, pp. 1386-1392
-
-
De Lorenzo, S.1
Alffenaar, J.W.2
Sotgiu, G.3
Centis, R.4
D'Ambrosio, L.5
Tiberi, S.6
Bolhuis, M.S.7
van Altena, R.8
Viggiani, P.9
Piana, A.10
Spanevello, A.11
Migliori, G.B.12
-
73
-
-
21444441075
-
Imipenem for treatment of tuberculosis in mice and humans
-
Chambers H.F., Turner J., Schecter G.F., Kawamura M., Hopewell P.C. Imipenem for treatment of tuberculosis in mice and humans. Antimicrob. Agents Chemother. 2005, 49:2816-2821.
-
(2005)
Antimicrob. Agents Chemother.
, vol.49
, pp. 2816-2821
-
-
Chambers, H.F.1
Turner, J.2
Schecter, G.F.3
Kawamura, M.4
Hopewell, P.C.5
-
74
-
-
61349183785
-
Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis
-
Hugonnet J.-E., Tremblay L.W., Boshoff H.I., Barry C.E., Blanchard J.S. Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis. Science 2009, 323:1215-1218.
-
(2009)
Science
, vol.323
, pp. 1215-1218
-
-
Hugonnet, J.-E.1
Tremblay, L.W.2
Boshoff, H.I.3
Barry, C.E.4
Blanchard, J.S.5
-
75
-
-
84858638496
-
Clinical use of the meropenem-clavulanate combination for extensively drug-resistant tuberculosis
-
Payen M.C., De Wit S., Martin C., Sergysels R., Muylle I., Van Laethem Y., Clumeck N. Clinical use of the meropenem-clavulanate combination for extensively drug-resistant tuberculosis. Int. J. Tuberc. Lung Dis. 2012, 16:558-560.
-
(2012)
Int. J. Tuberc. Lung Dis.
, vol.16
, pp. 558-560
-
-
Payen, M.C.1
De Wit, S.2
Martin, C.3
Sergysels, R.4
Muylle, I.5
Van Laethem, Y.6
Clumeck, N.7
-
76
-
-
84961616364
-
Advances in drug discovery and development for pediatric tuberculosis
-
Hoagland D., Zhao Y., Lee R. Advances in drug discovery and development for pediatric tuberculosis. Mini-Rev. Med. Chem. 2016, 16:481-497.
-
(2016)
Mini-Rev. Med. Chem.
, vol.16
, pp. 481-497
-
-
Hoagland, D.1
Zhao, Y.2
Lee, R.3
-
77
-
-
0037340484
-
Faropenem, a new oral penem: antibacterial activity against selected anaerobic and fastidious periodontal isolates
-
Milazzo I., Blandino G., Caccamo F., Musumeci R., Nicoletti G., Speciale A. Faropenem, a new oral penem: antibacterial activity against selected anaerobic and fastidious periodontal isolates. J. Antimicrob. Chemother. 2003, 51:721-725.
-
(2003)
J. Antimicrob. Chemother.
, vol.51
, pp. 721-725
-
-
Milazzo, I.1
Blandino, G.2
Caccamo, F.3
Musumeci, R.4
Nicoletti, G.5
Speciale, A.6
-
78
-
-
34247855081
-
Faropenem: review of a new oral penem
-
Schurek K.N., Wiebe R., Karlowsky J.A., Rubinstein E., Hoban D.J., Zhanel G.G. Faropenem: review of a new oral penem. Expert Rev. Anti-Infect. Ther. 2007, 5:185-198.
-
(2007)
Expert Rev. Anti-Infect. Ther.
, vol.5
, pp. 185-198
-
-
Schurek, K.N.1
Wiebe, R.2
Karlowsky, J.A.3
Rubinstein, E.4
Hoban, D.J.5
Zhanel, G.G.6
-
79
-
-
84921908372
-
Rapid cytolysis of Mycobacterium tuberculosis by Faropenem, an orally bioavailable β-lactam antibiotic
-
Dhar N., Dubée V., Ballell L., Cuinet G., Hugonnet J.-E., Signorino-Gelo F., Barros D., Arthur M., McKinney J.D. Rapid cytolysis of Mycobacterium tuberculosis by Faropenem, an orally bioavailable β-lactam antibiotic. Antimicrob. Agents Chemother. 2015, 59:1308-1319.
-
(2015)
Antimicrob. Agents Chemother.
, vol.59
, pp. 1308-1319
-
-
Dhar, N.1
Dubée, V.2
Ballell, L.3
Cuinet, G.4
Hugonnet, J.-E.5
Signorino-Gelo, F.6
Barros, D.7
Arthur, M.8
McKinney, J.D.9
-
80
-
-
84867614599
-
Linezolid for treatment of chronic extensively drug-resistant tuberculosis
-
Lee M., Lee J., Carroll M.W., Choi H., Min S., Song T., Via L.E., Goldfeder L.C., Kang E., Jin B., Park H., Kwak H., Kim H., Jeon H.S., Jeong I., Joh J.S., Chen R.Y., Olivier K.N., Shaw P.A., Follmann D., Song S.D., Lee J.K., Lee D., Kim C.T., Dartois V., Park S.K., Cho S.N., Barry C.E. Linezolid for treatment of chronic extensively drug-resistant tuberculosis. N. Engl. J. Med. 2012, 367:1508-1518.
-
(2012)
N. Engl. J. Med.
, vol.367
, pp. 1508-1518
-
-
Lee, M.1
Lee, J.2
Carroll, M.W.3
Choi, H.4
Min, S.5
Song, T.6
Via, L.E.7
Goldfeder, L.C.8
Kang, E.9
Jin, B.10
Park, H.11
Kwak, H.12
Kim, H.13
Jeon, H.S.14
Jeong, I.15
Joh, J.S.16
Chen, R.Y.17
Olivier, K.N.18
Shaw, P.A.19
Follmann, D.20
Song, S.D.21
Lee, J.K.22
Lee, D.23
Kim, C.T.24
Dartois, V.25
Park, S.K.26
Cho, S.N.27
Barry, C.E.28
more..
-
81
-
-
0025992490
-
Oxazolidinones, a new class of synthetic antituberculosis agent. In vitro and in vivo activities of DuP-721 against Mycobacterium tuberculosis
-
Ashtekar D.R., Costa-Periera R., Shrinivasan T., Iyyer R., Vishvanathan N., Rittel W. Oxazolidinones, a new class of synthetic antituberculosis agent. In vitro and in vivo activities of DuP-721 against Mycobacterium tuberculosis. Diagn. Microbiol. Infect. Dis. 1991, 14:465-471.
-
(1991)
Diagn. Microbiol. Infect. Dis.
, vol.14
, pp. 465-471
-
-
Ashtekar, D.R.1
Costa-Periera, R.2
Shrinivasan, T.3
Iyyer, R.4
Vishvanathan, N.5
Rittel, W.6
-
82
-
-
84870223120
-
Linezolid-containing regimens for the treatment of drug-resistant tuberculosis in South African children
-
Rose P.C., Hallbauer U.M., Seddon J.A., Hesseling A.C., Schaaf H.S. Linezolid-containing regimens for the treatment of drug-resistant tuberculosis in South African children. Int. J. Tuberc. Lung Dis. 2012, 16:1588-1593.
-
(2012)
Int. J. Tuberc. Lung Dis.
, vol.16
, pp. 1588-1593
-
-
Rose, P.C.1
Hallbauer, U.M.2
Seddon, J.A.3
Hesseling, A.C.4
Schaaf, H.S.5
-
83
-
-
77952564621
-
Linezolid use for treatment of multidrug-resistant and extensively drug-resistant tuberculosis, New York City, 2000-06
-
Anger H.A., Dworkin F., Sharma S., Munsiff S.S., Nilsen D.M., Ahuja S.D. Linezolid use for treatment of multidrug-resistant and extensively drug-resistant tuberculosis, New York City, 2000-06. J. Antimicrob. Chemother. 2010, 65:775-783.
-
(2010)
J. Antimicrob. Chemother.
, vol.65
, pp. 775-783
-
-
Anger, H.A.1
Dworkin, F.2
Sharma, S.3
Munsiff, S.S.4
Nilsen, D.M.5
Ahuja, S.D.6
-
84
-
-
84893907642
-
Linezolid for the treatment of drug-resistant tuberculosis in children: a review and recommendations
-
Garcia-Prats A.J., Rose P.C., Hesseling A.C., Schaaf H.S. Linezolid for the treatment of drug-resistant tuberculosis in children: a review and recommendations. Tuberculosis (Edinb.) 2014, 94:93-104.
-
(2014)
Tuberculosis (Edinb.)
, vol.94
, pp. 93-104
-
-
Garcia-Prats, A.J.1
Rose, P.C.2
Hesseling, A.C.3
Schaaf, H.S.4
-
85
-
-
84891550770
-
Bactericidal activity and mechanism of action of AZD5847, a novel oxazolidinone for treatment of tuberculosis
-
Balasubramanian V., Solapure S., Iyer H., Ghosh A., Sharma S., Kaur P., Deepthi R., Subbulakshmi V., Ramya V., Ramachandran V., Balganesh M., Wright L., Melnick D., Butler S.L., Sambandamurthy V.K. Bactericidal activity and mechanism of action of AZD5847, a novel oxazolidinone for treatment of tuberculosis. Antimicrob. Agents Chemother. 2014, 58:495-502.
-
(2014)
Antimicrob. Agents Chemother.
, vol.58
, pp. 495-502
-
-
Balasubramanian, V.1
Solapure, S.2
Iyer, H.3
Ghosh, A.4
Sharma, S.5
Kaur, P.6
Deepthi, R.7
Subbulakshmi, V.8
Ramya, V.9
Ramachandran, V.10
Balganesh, M.11
Wright, L.12
Melnick, D.13
Butler, S.L.14
Sambandamurthy, V.K.15
-
86
-
-
84941629631
-
In vitro and in vivo evaluation of synergism between anti-tubercular spectinamides and non-classical tuberculosis antibiotics
-
Bruhn D.F., Scherman M.S., Liu J., Scherbakov D., Meibohm B., Böttger E.C., Lenaerts A.J., Lee R.E. In vitro and in vivo evaluation of synergism between anti-tubercular spectinamides and non-classical tuberculosis antibiotics. Sci. Rep. 2015, 5:13985.
-
(2015)
Sci. Rep.
, vol.5
, pp. 13985
-
-
Bruhn, D.F.1
Scherman, M.S.2
Liu, J.3
Scherbakov, D.4
Meibohm, B.5
Böttger, E.C.6
Lenaerts, A.J.7
Lee, R.E.8
-
87
-
-
34250799619
-
An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site
-
Rock F.L., Mao W., Yaremchuk A., Tukalo M., Crépin T., Zhou H., Zhang Y.-K., Hernandez V., Akama T., Baker S.J., Plattner J.J., Shapiro L., Martinis S.A., Benkovic S.J., Cusack S., Alley M.R.K. An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Science 2007, 316:1759-1761.
-
(2007)
Science
, vol.316
, pp. 1759-1761
-
-
Rock, F.L.1
Mao, W.2
Yaremchuk, A.3
Tukalo, M.4
Crépin, T.5
Zhou, H.6
Zhang, Y.-K.7
Hernandez, V.8
Akama, T.9
Baker, S.J.10
Plattner, J.J.11
Shapiro, L.12
Martinis, S.A.13
Benkovic, S.J.14
Cusack, S.15
Alley, M.R.K.16
-
88
-
-
84883167965
-
Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase
-
Hu Q.-H., Liu R.-J., Fang Z.-P., Zhang J., Ding Y.-Y., Tan M., Wang M., Pan W., Zhou H.-C., Wang E.-D. Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase. Sci. Rep. 2013, 3.
-
(2013)
Sci. Rep.
, vol.3
-
-
Hu, Q.-H.1
Liu, R.-J.2
Fang, Z.-P.3
Zhang, J.4
Ding, Y.-Y.5
Tan, M.6
Wang, M.7
Pan, W.8
Zhou, H.-C.9
Wang, E.-D.10
-
89
-
-
84874038233
-
Discovery of a novel class of boron-based antibacterials with activity against Gram-negative bacteria
-
Hernandez V., Crépin T., Palencia A., Cusack S., Akama T., Baker S.J., Bu W., Feng L., Freund Y.R., Liu L., Meewan M., Mohan M., Mao W., Rock F.L., Sexton H., Sheoran A., Zhang Y., Zhang Y.-K., Zhou Y., Nieman J.A., Anugula M.R., Keramane E.M., Savariraj K., Reddy D.S., Sharma R., Subedi R., Singh R., O'Leary A., Simon N.L., De Marsh P.L., Mushtaq S., Warner M., Livermore D.M., Alley M.R.K., Plattner J.J. Discovery of a novel class of boron-based antibacterials with activity against Gram-negative bacteria. Antimicrob. Agents Chemother. 2013, 57:1394-1403.
-
(2013)
Antimicrob. Agents Chemother.
, vol.57
, pp. 1394-1403
-
-
Hernandez, V.1
Crépin, T.2
Palencia, A.3
Cusack, S.4
Akama, T.5
Baker, S.J.6
Bu, W.7
Feng, L.8
Freund, Y.R.9
Liu, L.10
Meewan, M.11
Mohan, M.12
Mao, W.13
Rock, F.L.14
Sexton, H.15
Sheoran, A.16
Zhang, Y.17
Zhang, Y.-K.18
Zhou, Y.19
Nieman, J.A.20
Anugula, M.R.21
Keramane, E.M.22
Savariraj, K.23
Reddy, D.S.24
Sharma, R.25
Subedi, R.26
Singh, R.27
O'Leary, A.28
Simon, N.L.29
De Marsh, P.L.30
Mushtaq, S.31
Warner, M.32
Livermore, D.M.33
Alley, M.R.K.34
Plattner, J.J.35
more..
-
91
-
-
35348857512
-
A steric block in translation caused by the antibiotic spectinomycin
-
Borovinskaya M.A., Shoji S., Holton J.M., Fredrick K., Cate J.H.D. A steric block in translation caused by the antibiotic spectinomycin. ACS Chem. Biol. 2007, 2:545-552.
-
(2007)
ACS Chem. Biol.
, vol.2
, pp. 545-552
-
-
Borovinskaya, M.A.1
Shoji, S.2
Holton, J.M.3
Fredrick, K.4
Cate, J.H.D.5
-
92
-
-
34250157042
-
Mutations in 16S rRNA and ribosomal protein S5 associated with high-level spectinomycin resistance in Pasteurella multocida
-
Kehrenberg C., Schwarz S. Mutations in 16S rRNA and ribosomal protein S5 associated with high-level spectinomycin resistance in Pasteurella multocida. Antimicrob. Agents Chemother. 2007, 51:2244-2246.
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, pp. 2244-2246
-
-
Kehrenberg, C.1
Schwarz, S.2
-
93
-
-
84893661669
-
Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux
-
Lee R.E., Hurdle J.G., Liu J., Bruhn D.F., Matt T., Scherman M.S., Vaddady P.K., Zheng Z., Qi J., Akbergenov R., Das S., Madhura D.B., Rathi C., Trivedi A., Villellas C., Lee R.B., Rakesh, Waidyarachchi S.L., Sun D., McNeil M.R., Ainsa J.A., Boshoff H.I., Gonzalez-Juarrero M., Meibohm B., Bottger E.C., Lenaerts A.J. Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux. Nat. Med. 2014, 20:152-158.
-
(2014)
Nat. Med.
, vol.20
, pp. 152-158
-
-
Lee, R.E.1
Hurdle, J.G.2
Liu, J.3
Bruhn, D.F.4
Matt, T.5
Scherman, M.S.6
Vaddady, P.K.7
Zheng, Z.8
Qi, J.9
Akbergenov, R.10
Das, S.11
Madhura, D.B.12
Rathi, C.13
Trivedi, A.14
Villellas, C.15
Lee, R.B.16
Rakesh17
Waidyarachchi, S.L.18
Sun, D.19
McNeil, M.R.20
Ainsa, J.A.21
Boshoff, H.I.22
Gonzalez-Juarrero, M.23
Meibohm, B.24
Bottger, E.C.25
Lenaerts, A.J.26
more..
-
94
-
-
76549188916
-
Experimental antituberculous action of a new antibiotic: RP 11,072
-
Noufflard-Guy-Loe H., Berteaux S. Experimental antituberculous action of a new antibiotic: RP 11,072. Rev. Tuberc. Pneumol. 1965, 29:301-326.
-
(1965)
Rev. Tuberc. Pneumol.
, vol.29
, pp. 301-326
-
-
Noufflard-Guy-Loe, H.1
Berteaux, S.2
-
95
-
-
0015073884
-
Structure of griselimycin, polypeptide antibiotic extracted from streptomyces cultures. II. Structure of griselimycin
-
Terlain B., Thomas J.P. Structure of griselimycin, polypeptide antibiotic extracted from streptomyces cultures. II. Structure of griselimycin. Bull. Soc. Chim. Fr. 1971, 6:2357-2362.
-
(1971)
Bull. Soc. Chim. Fr.
, vol.6
, pp. 2357-2362
-
-
Terlain, B.1
Thomas, J.P.2
-
96
-
-
84930647575
-
Targeting DnaN for tuberculosis therapy using novel griselimycins
-
Kling A., Lukat P., Almeida D.V., Bauer A., Fontaine E., Sordello S., Zaburannyi N., Herrmann J., Wenzel S.C., König C., Ammerman N.C., Barrio M.B., Borchers K., Bordon-Pallier F., Brönstrup M., Courtemanche G., Gerlitz M., Geslin M., Hammann P., Heinz D.W., Hoffmann H., Klieber S., Kohlmann M., Kurz M., Lair C., Matter H., Nuermberger E., Tyagi S., Fraisse L., Grosset J.H., Lagrange S., Müller R. Targeting DnaN for tuberculosis therapy using novel griselimycins. Science 2015, 348:1106-1112.
-
(2015)
Science
, vol.348
, pp. 1106-1112
-
-
Kling, A.1
Lukat, P.2
Almeida, D.V.3
Bauer, A.4
Fontaine, E.5
Sordello, S.6
Zaburannyi, N.7
Herrmann, J.8
Wenzel, S.C.9
König, C.10
Ammerman, N.C.11
Barrio, M.B.12
Borchers, K.13
Bordon-Pallier, F.14
Brönstrup, M.15
Courtemanche, G.16
Gerlitz, M.17
Geslin, M.18
Hammann, P.19
Heinz, D.W.20
Hoffmann, H.21
Klieber, S.22
Kohlmann, M.23
Kurz, M.24
Lair, C.25
Matter, H.26
Nuermberger, E.27
Tyagi, S.28
Fraisse, L.29
Grosset, J.H.30
Lagrange, S.31
Müller, R.32
more..
-
97
-
-
38649100344
-
In vitro antimycobacterial activities of Capuramycin Analogues
-
Reddy V.M., Einck L., Nacy C.A. In vitro antimycobacterial activities of Capuramycin Analogues. Antimicrob. Agents Chemother. 2008, 52:719-721.
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 719-721
-
-
Reddy, V.M.1
Einck, L.2
Nacy, C.A.3
-
98
-
-
67649950670
-
Activity of SQ641, a capuramycin analog, in a murine model of tuberculosis
-
Nikonenko B.V., Reddy V.M., Protopopova M., Bogatcheva E., Einck L., Nacy C.A. Activity of SQ641, a capuramycin analog, in a murine model of tuberculosis. Antimicrob. Agents Chemother. 2009, 53:3138-3139.
-
(2009)
Antimicrob. Agents Chemother.
, vol.53
, pp. 3138-3139
-
-
Nikonenko, B.V.1
Reddy, V.M.2
Protopopova, M.3
Bogatcheva, E.4
Einck, L.5
Nacy, C.A.6
-
99
-
-
84891526259
-
Therapeutic efficacy of SQ641-NE against Mycobacterium tuberculosis
-
Nikonenko B., Reddy V.M., Bogatcheva E., Protopopova M., Einck L., Nacy C.A. Therapeutic efficacy of SQ641-NE against Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 2014, 58:587-589.
-
(2014)
Antimicrob. Agents Chemother.
, vol.58
, pp. 587-589
-
-
Nikonenko, B.1
Reddy, V.M.2
Bogatcheva, E.3
Protopopova, M.4
Einck, L.5
Nacy, C.A.6
-
100
-
-
84881534406
-
Biopharmaceutical in vitro characterization of CPZEN-45, a drug candidate for inhalation therapy of tuberculosis
-
Salomon J.J., Galeron P., Schulte N., Morow P.R., Severynse-Stevens D., Huwer H., Daum N., Lehr C.-M., Hickey A.J., Ehrhardt C. Biopharmaceutical in vitro characterization of CPZEN-45, a drug candidate for inhalation therapy of tuberculosis. Ther. Deliv. 2013, 4:915-923.
-
(2013)
Ther. Deliv.
, vol.4
, pp. 915-923
-
-
Salomon, J.J.1
Galeron, P.2
Schulte, N.3
Morow, P.R.4
Severynse-Stevens, D.5
Huwer, H.6
Daum, N.7
Lehr, C.-M.8
Hickey, A.J.9
Ehrhardt, C.10
-
101
-
-
84867067622
-
Towards a new tuberculosis drug: pyridomycin - nature's isoniazid
-
Hartkoorn R.C., Sala C., Neres J., Pojer F., Magnet S., Mukherjee R., Uplekar S., Boy-Röttger S., Altmann K.-H., Cole S.T. Towards a new tuberculosis drug: pyridomycin - nature's isoniazid. EMBO Mol. Med. 2012, 4:1032-1042.
-
(2012)
EMBO Mol. Med.
, vol.4
, pp. 1032-1042
-
-
Hartkoorn, R.C.1
Sala, C.2
Neres, J.3
Pojer, F.4
Magnet, S.5
Mukherjee, R.6
Uplekar, S.7
Boy-Röttger, S.8
Altmann, K.-H.9
Cole, S.T.10
-
102
-
-
84897108482
-
Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA
-
Hartkoorn R.C., Pojer F., Read J.A., Gingell H., Neres J., Horlacher O.P., Altmann K.-H., Cole S.T. Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA. Nat. Chem. Biol. 2014, 10:96-98.
-
(2014)
Nat. Chem. Biol.
, vol.10
, pp. 96-98
-
-
Hartkoorn, R.C.1
Pojer, F.2
Read, J.A.3
Gingell, H.4
Neres, J.5
Horlacher, O.P.6
Altmann, K.-H.7
Cole, S.T.8
-
103
-
-
84896455574
-
New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects
-
Zumla A.I., Gillespie S.H., Hoelscher M., Philips P.P.J., Cole S.T., Abubakar I., McHugh T.D., Schito M., Maeurer M., Nunn A.J. New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects. Lancet Infect. Dis. 2014, 14:327-340.
-
(2014)
Lancet Infect. Dis.
, vol.14
, pp. 327-340
-
-
Zumla, A.I.1
Gillespie, S.H.2
Hoelscher, M.3
Philips, P.P.J.4
Cole, S.T.5
Abubakar, I.6
McHugh, T.D.7
Schito, M.8
Maeurer, M.9
Nunn, A.J.10
-
104
-
-
84919816717
-
Trends in discovery of new drugs for tuberculosis therapy
-
Riccardi G., Pasca M.R. Trends in discovery of new drugs for tuberculosis therapy. J. Antibiot. 2014, 67:655-659.
-
(2014)
J. Antibiot.
, vol.67
, pp. 655-659
-
-
Riccardi, G.1
Pasca, M.R.2
-
105
-
-
84965189952
-
The tuberculosis drug discovery and development pipeline and emerging drug targets
-
Mdluli K., Kaneko T., Upton A. The tuberculosis drug discovery and development pipeline and emerging drug targets. Cold Spring Harb. Perspect. Med. 2015, 5.
-
(2015)
Cold Spring Harb. Perspect. Med.
, vol.5
-
-
Mdluli, K.1
Kaneko, T.2
Upton, A.3
-
106
-
-
84884505005
-
Identification of new drug targets and resistance mechanisms inMycobacterium tuberculosis
-
Ioerger T.R., O'Malley T., Liao R., Guinn K.M., Hickey M.J., Mohaideen N., Murphy K.C., Boshoff H.I.M., Mizrahi V., Rubin E.J., Sassetti C.M., Barry C.E., Sherman D.R., Parish T., Sacchettini J.C. Identification of new drug targets and resistance mechanisms inMycobacterium tuberculosis. PLoS ONE 2013, 8.
-
(2013)
PLoS ONE
, vol.8
-
-
Ioerger, T.R.1
O'Malley, T.2
Liao, R.3
Guinn, K.M.4
Hickey, M.J.5
Mohaideen, N.6
Murphy, K.C.7
Boshoff, H.I.M.8
Mizrahi, V.9
Rubin, E.J.10
Sassetti, C.M.11
Barry, C.E.12
Sherman, D.R.13
Parish, T.14
Sacchettini, J.C.15
-
107
-
-
84877863368
-
The Mtb Proteome Library: a resource of assays to quantify the complete proteome of Mycobacterium tuberculosis
-
Schubert O.T., Mouritsen J., Ludwig C., Röst H.L., Rosenberger G., Arthur P.K., Claassen M., Campbell D.S., Sun Z., Farrah T., Gengenbacher M., Maiolica A., Kaufmann S.H.E., Moritz R.L., Aebersold R. The Mtb Proteome Library: a resource of assays to quantify the complete proteome of Mycobacterium tuberculosis. Cell Host Microbe 2013, 13:602-612.
-
(2013)
Cell Host Microbe
, vol.13
, pp. 602-612
-
-
Schubert, O.T.1
Mouritsen, J.2
Ludwig, C.3
Röst, H.L.4
Rosenberger, G.5
Arthur, P.K.6
Claassen, M.7
Campbell, D.S.8
Sun, Z.9
Farrah, T.10
Gengenbacher, M.11
Maiolica, A.12
Kaufmann, S.H.E.13
Moritz, R.L.14
Aebersold, R.15
-
108
-
-
85042791367
-
Evolution of extensively drug-resistant tuberculosis over four decades revealed by whole genome sequencing of Mycobacterium tuberculosis from KwaZulu-Natal, South Africa
-
Cohen K.A., Abeel T., McGuire A.M., Desjardins C.A., Munsamy V., Shea T.P., Walker B.J., Bantubani N., Almeida D.V., Alvarado L., Chapman S., Mvelase N.R., Duffy E.Y., Fitzgerald M.G., Govender P., Gujja S., Hamilton S., Howarth C., Larimer J.D., Maharaj K., Pearson M.D., Priest M.E., Zeng Q., Padayatchi N., Grosset J., Young S.K., Wortman J., Mlisana K.P., O'Donnell M.R., Birren B.W., Bishai W.R., Pym A.S., Earl A.M. Evolution of extensively drug-resistant tuberculosis over four decades revealed by whole genome sequencing of Mycobacterium tuberculosis from KwaZulu-Natal, South Africa. Int. J. Mycobacteriol. 2015, 4(Suppl. 1):24-25.
-
(2015)
Int. J. Mycobacteriol.
, vol.4
, pp. 24-25
-
-
Cohen, K.A.1
Abeel, T.2
McGuire, A.M.3
Desjardins, C.A.4
Munsamy, V.5
Shea, T.P.6
Walker, B.J.7
Bantubani, N.8
Almeida, D.V.9
Alvarado, L.10
Chapman, S.11
Mvelase, N.R.12
Duffy, E.Y.13
Fitzgerald, M.G.14
Govender, P.15
Gujja, S.16
Hamilton, S.17
Howarth, C.18
Larimer, J.D.19
Maharaj, K.20
Pearson, M.D.21
Priest, M.E.22
Zeng, Q.23
Padayatchi, N.24
Grosset, J.25
Young, S.K.26
Wortman, J.27
Mlisana, K.P.28
O'Donnell, M.R.29
Birren, B.W.30
Bishai, W.R.31
Pym, A.S.32
Earl, A.M.33
more..
-
109
-
-
84938349050
-
Genome analysis of the first extensively drug-resistant (XDR) Mycobacterium tuberculosis in Malaysia provides insights into the genetic basis of its biology and drug resistance
-
Kuan C.S., Chan C.L., Yew S.M., Toh Y.F., Khoo J.-S., Chong J., Lee K.W., Tan Y.-C., Yee W.-Y., Ngeow Y.F., Ng K.P. Genome analysis of the first extensively drug-resistant (XDR) Mycobacterium tuberculosis in Malaysia provides insights into the genetic basis of its biology and drug resistance. PLoS One 2015, 10.
-
(2015)
PLoS One
, vol.10
-
-
Kuan, C.S.1
Chan, C.L.2
Yew, S.M.3
Toh, Y.F.4
Khoo, J.-S.5
Chong, J.6
Lee, K.W.7
Tan, Y.-C.8
Yee, W.-Y.9
Ngeow, Y.F.10
Ng, K.P.11
-
110
-
-
84925270106
-
Construction of conditional knockdown mutants in mycobacteria
-
Springer, New York, T. Parish, D.M. Roberts (Eds.)
-
Schnappinger D., O'Brien K., Ehrt S. Construction of conditional knockdown mutants in mycobacteria. Mycobacteria Protocols 2015, 151-175. Springer, New York. T. Parish, D.M. Roberts (Eds.).
-
(2015)
Mycobacteria Protocols
, pp. 151-175
-
-
Schnappinger, D.1
O'Brien, K.2
Ehrt, S.3
-
111
-
-
80053459537
-
Evaluating the sensitivity ofMycobacterium tuberculosis to biotin deprivation using regulated gene expression
-
Woong Park S., Klotzsche M., Wilson D.J., Boshoff H.I., Eoh H., Manjunatha U., Blumenthal A., Rhee K., Barry C.E., Aldrich C.C., Ehrt S., Schnappinger D. Evaluating the sensitivity ofMycobacterium tuberculosis to biotin deprivation using regulated gene expression. PLoS Pathog. 2011, 7.
-
(2011)
PLoS Pathog.
, vol.7
-
-
Woong Park, S.1
Klotzsche, M.2
Wilson, D.J.3
Boshoff, H.I.4
Eoh, H.5
Manjunatha, U.6
Blumenthal, A.7
Rhee, K.8
Barry, C.E.9
Aldrich, C.C.10
Ehrt, S.11
Schnappinger, D.12
-
112
-
-
84925236491
-
A multi-stress model for high throughput screening against non-replicating Mycobacterium tuberculosis
-
Springer, New York, T. Parish, D.M. Roberts (Eds.)
-
Gold B., Warrier T., Nathan C. A multi-stress model for high throughput screening against non-replicating Mycobacterium tuberculosis. Mycobacteria Protocols 2015, 293-315. Springer, New York. T. Parish, D.M. Roberts (Eds.).
-
(2015)
Mycobacteria Protocols
, pp. 293-315
-
-
Gold, B.1
Warrier, T.2
Nathan, C.3
-
113
-
-
84924351877
-
Novel inhibitors of cholesterol degradation inMycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment
-
VanderVen B.C., Fahey R.J., Lee W., Liu Y., Abramovitch R.B., Memmott C., Crowe A.M., Eltis L.D., Perola E., Deininger D.D., Wang T., Locher C.P., Russell D.G. Novel inhibitors of cholesterol degradation inMycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment. PLoS Pathog. 2015, 11.
-
(2015)
PLoS Pathog.
, vol.11
-
-
VanderVen, B.C.1
Fahey, R.J.2
Lee, W.3
Liu, Y.4
Abramovitch, R.B.5
Memmott, C.6
Crowe, A.M.7
Eltis, L.D.8
Perola, E.9
Deininger, D.D.10
Wang, T.11
Locher, C.P.12
Russell, D.G.13
-
114
-
-
84943664518
-
The association between sterilizing activity and drug distribution into tuberculosis lesions
-
Prideaux B., Via L.E., Zimmerman M.D., Eum S., Sarathy J., O'Brien P., Chen C., Kaya F., Weiner D.M., Chen P.Y., Song T., Lee M., Shim T.S., Cho J.S., Kim W., Cho S.N., Olivier K.N., Barry C.E., Dartois V. The association between sterilizing activity and drug distribution into tuberculosis lesions. Nat. Med. 2015, 21:1223-1227.
-
(2015)
Nat. Med.
, vol.21
, pp. 1223-1227
-
-
Prideaux, B.1
Via, L.E.2
Zimmerman, M.D.3
Eum, S.4
Sarathy, J.5
O'Brien, P.6
Chen, C.7
Kaya, F.8
Weiner, D.M.9
Chen, P.Y.10
Song, T.11
Lee, M.12
Shim, T.S.13
Cho, J.S.14
Kim, W.15
Cho, S.N.16
Olivier, K.N.17
Barry, C.E.18
Dartois, V.19
-
115
-
-
84908126151
-
Four-month moxifloxacin-based regimens for drug-sensitive tuberculosis
-
Gillespie S.H., Crook A.M., McHugh T.D., Mendel C.M., Meredith S.K., Murray S.R., Pappas F., Phillips P.P.J., Nunn A.J. Four-month moxifloxacin-based regimens for drug-sensitive tuberculosis. N. Engl. J. Med. 2014, 371:1577-1587.
-
(2014)
N. Engl. J. Med.
, vol.371
, pp. 1577-1587
-
-
Gillespie, S.H.1
Crook, A.M.2
McHugh, T.D.3
Mendel, C.M.4
Meredith, S.K.5
Murray, S.R.6
Pappas, F.7
Phillips, P.P.J.8
Nunn, A.J.9
-
116
-
-
84455169868
-
Pharmacokinetic evaluation of the penetration of antituberculosis agents in rabbit pulmonary lesions
-
Kjellsson M.C., Via L.E., Goh A., Weiner D., Low K.M., Kern S., Pillai G., Barry C.E., Dartois V. Pharmacokinetic evaluation of the penetration of antituberculosis agents in rabbit pulmonary lesions. Antimicrob. Agents Chemother. 2012, 56:446-457.
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 446-457
-
-
Kjellsson, M.C.1
Via, L.E.2
Goh, A.3
Weiner, D.4
Low, K.M.5
Kern, S.6
Pillai, G.7
Barry, C.E.8
Dartois, V.9
-
117
-
-
19544390531
-
Influence of efflux transporters on the accumulation and efflux of four quinolones (ciprofloxacin, levofloxacin, garenoxacin, and moxifloxacin) in J774 macrophages
-
Michot J.-M., Seral C., Van Bambeke F., Mingeot-Leclercq M.-P., Tulkens P.M. Influence of efflux transporters on the accumulation and efflux of four quinolones (ciprofloxacin, levofloxacin, garenoxacin, and moxifloxacin) in J774 macrophages. Antimicrob. Agents Chemother. 2005, 49:2429-2437.
-
(2005)
Antimicrob. Agents Chemother.
, vol.49
, pp. 2429-2437
-
-
Michot, J.-M.1
Seral, C.2
Van Bambeke, F.3
Mingeot-Leclercq, M.-P.4
Tulkens, P.M.5
-
118
-
-
0006750564
-
Distribution and excretion of radioactive isoniazid in tuberculous patients
-
Barclay W.R., Ebert R.H., Le Roy G.V., Manthei R.W., Roth L.J. Distribution and excretion of radioactive isoniazid in tuberculous patients. J. Am. Med. Assoc. 1953, 151:1384-1388.
-
(1953)
J. Am. Med. Assoc.
, vol.151
, pp. 1384-1388
-
-
Barclay, W.R.1
Ebert, R.H.2
Le Roy, G.V.3
Manthei, R.W.4
Roth, L.J.5
-
119
-
-
0014620387
-
Rifomycin levels in the lung and tuberculous lesions in man
-
Canetti G., Parrot R., Porven G., Le Lirzin M. Rifomycin levels in the lung and tuberculous lesions in man. Acta Tuberc. Pneumol. Belg. 1969, 60:315-322.
-
(1969)
Acta Tuberc. Pneumol. Belg.
, vol.60
, pp. 315-322
-
-
Canetti, G.1
Parrot, R.2
Porven, G.3
Le Lirzin, M.4
-
120
-
-
0027258934
-
Cerebrospinal fluid drug concentrations and the treatment of tuberculous meningitis
-
Ellard G.A., Humphries M.J., Allen B.W. Cerebrospinal fluid drug concentrations and the treatment of tuberculous meningitis. Am. Rev. Respir. Dis. 1993, 148:650-655.
-
(1993)
Am. Rev. Respir. Dis.
, vol.148
, pp. 650-655
-
-
Ellard, G.A.1
Humphries, M.J.2
Allen, B.W.3
-
121
-
-
0023099883
-
Penetration of pyrazinamide into the cerebrospinal fluid in tuberculous meningitis
-
Ellard G.A., Humphries M.J., Gabriel M., Teoh R. Penetration of pyrazinamide into the cerebrospinal fluid in tuberculous meningitis. Br. Med. J. (Clin. Res. Ed.) 1987, 294:284-285.
-
(1987)
Br. Med. J. (Clin. Res. Ed.)
, vol.294
, pp. 284-285
-
-
Ellard, G.A.1
Humphries, M.J.2
Gabriel, M.3
Teoh, R.4
-
122
-
-
79954595692
-
High-sensitivity MALDI-MRM-MS imaging of moxifloxacin distribution in tuberculosis-infected rabbit lungs and granulomatous lesions
-
Prideaux B., Dartois V., Staab D., Weiner D.M., Goh A., Via L.E., Barry C.E., Stoeckli M. High-sensitivity MALDI-MRM-MS imaging of moxifloxacin distribution in tuberculosis-infected rabbit lungs and granulomatous lesions. Anal. Chem. 2011, 83:2112-2118.
-
(2011)
Anal. Chem.
, vol.83
, pp. 2112-2118
-
-
Prideaux, B.1
Dartois, V.2
Staab, D.3
Weiner, D.M.4
Goh, A.5
Via, L.E.6
Barry, C.E.7
Stoeckli, M.8
-
123
-
-
84865200761
-
Mass spectrometry imaging for drug distribution studies
-
Prideaux B., Stoeckli M. Mass spectrometry imaging for drug distribution studies. J. Proteome 2012, 75:4999-5013.
-
(2012)
J. Proteome
, vol.75
, pp. 4999-5013
-
-
Prideaux, B.1
Stoeckli, M.2
-
124
-
-
0032508046
-
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
-
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E., Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L., Oliver K., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J., Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 1998, 393:537-544.
-
(1998)
Nature
, vol.393
, pp. 537-544
-
-
Cole, S.T.1
Brosch, R.2
Parkhill, J.3
Garnier, T.4
Churcher, C.5
Harris, D.6
Gordon, S.V.7
Eiglmeier, K.8
Gas, S.9
Barry, C.E.10
Tekaia, F.11
Badcock, K.12
Basham, D.13
Brown, D.14
Chillingworth, T.15
Connor, R.16
Davies, R.17
Devlin, K.18
Feltwell, T.19
Gentles, S.20
Hamlin, N.21
Holroyd, S.22
Hornsby, T.23
Jagels, K.24
Krogh, A.25
McLean, J.26
Moule, S.27
Murphy, L.28
Oliver, K.29
Osborne, J.30
Quail, M.A.31
Rajandream, M.A.32
Rogers, J.33
Rutter, S.34
Seeger, K.35
Skelton, J.36
Squares, R.37
Squares, S.38
Sulston, J.E.39
Taylor, K.40
Whitehead, S.41
Barrell, B.G.42
more..
-
125
-
-
14944375311
-
New targets and screening approaches in antimicrobial drug discovery
-
Brown E.D., Wright G.D. New targets and screening approaches in antimicrobial drug discovery. Chem. Rev. 2005, 105:759-774.
-
(2005)
Chem. Rev.
, vol.105
, pp. 759-774
-
-
Brown, E.D.1
Wright, G.D.2
-
126
-
-
33644867602
-
Improving the hit-to-lead process: data-driven assessment of drug-like and lead-like screening hits
-
Wunberg T., Hendrix M., Hillisch A., Lobell M., Meier H., Schmeck C., Wild H., Hinzen B. Improving the hit-to-lead process: data-driven assessment of drug-like and lead-like screening hits. Drug Discov. Today 2006, 11:175-180.
-
(2006)
Drug Discov. Today
, vol.11
, pp. 175-180
-
-
Wunberg, T.1
Hendrix, M.2
Hillisch, A.3
Lobell, M.4
Meier, H.5
Schmeck, C.6
Wild, H.7
Hinzen, B.8
-
127
-
-
78951492035
-
Experimental validation of a fragment library for lead discovery using SPR biosensor technology
-
Elinder M., Geitmann M., Gossas T., Källblad P., Winquist J., Nordström H., Hämäläinen M., Danielson U.H. Experimental validation of a fragment library for lead discovery using SPR biosensor technology. J. Biomol. Screen. 2011, 16:15-25.
-
(2011)
J. Biomol. Screen.
, vol.16
, pp. 15-25
-
-
Elinder, M.1
Geitmann, M.2
Gossas, T.3
Källblad, P.4
Winquist, J.5
Nordström, H.6
Hämäläinen, M.7
Danielson, U.H.8
-
128
-
-
80052588394
-
The structure-activity relationship of urea derivatives as anti-tuberculosis agents
-
Brown J.R., North E.J., Hurdle J.G., Morisseau C., Scarborough J.S., Sun D., Kordulakova J., Scherman M.S., Jones V., Grzegorzewicz A., Crew R.M., Jackson M., McNeil M.R., Lee R.E. The structure-activity relationship of urea derivatives as anti-tuberculosis agents. Bioorg. Med. Chem. 2011, 19:5585-5595.
-
(2011)
Bioorg. Med. Chem.
, vol.19
, pp. 5585-5595
-
-
Brown, J.R.1
North, E.J.2
Hurdle, J.G.3
Morisseau, C.4
Scarborough, J.S.5
Sun, D.6
Kordulakova, J.7
Scherman, M.S.8
Jones, V.9
Grzegorzewicz, A.10
Crew, R.M.11
Jackson, M.12
McNeil, M.R.13
Lee, R.E.14
-
129
-
-
61649109015
-
The influence of lead discovery strategies on the properties of drug candidates
-
Keseru G.M., Makara G.M. The influence of lead discovery strategies on the properties of drug candidates. Nat. Rev. Drug Discov. 2009, 8:203-212.
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 203-212
-
-
Keseru, G.M.1
Makara, G.M.2
-
130
-
-
0031024171
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski C. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 1997, 23:3-25.
-
(1997)
Adv. Drug Deliv. Rev.
, vol.23
, pp. 3-25
-
-
Lipinski, C.1
-
131
-
-
0034461768
-
Drug-like properties and the causes of poor solubility and poor permeability
-
Lipinski C. Drug-like properties and the causes of poor solubility and poor permeability. J. Pharmacol. Toxicol. Methods 2000, 44:235-249.
-
(2000)
J. Pharmacol. Toxicol. Methods
, vol.44
, pp. 235-249
-
-
Lipinski, C.1
-
132
-
-
84925251163
-
Repurposing-a ray of hope in tackling extensively drug resistance in tuberculosis
-
Maitra A., Bates S., Kolvekar T., Devarajan P.V., Guzman J.D., Bhakta S. Repurposing-a ray of hope in tackling extensively drug resistance in tuberculosis. Int. J. Infect. Dis. 2015, 32:50-55.
-
(2015)
Int. J. Infect. Dis.
, vol.32
, pp. 50-55
-
-
Maitra, A.1
Bates, S.2
Kolvekar, T.3
Devarajan, P.V.4
Guzman, J.D.5
Bhakta, S.6
-
133
-
-
84957878463
-
In vitro activity of β-lactams in combination with β-lactamase inhibitors against multidrug-resistant Mycobacterium tuberculosis isolates
-
Zhang D., Wang Y., Lu J., Pang Y. In vitro activity of β-lactams in combination with β-lactamase inhibitors against multidrug-resistant Mycobacterium tuberculosis isolates. Antimicrob. Agents Chemother. 2015, 60:393-399.
-
(2015)
Antimicrob. Agents Chemother.
, vol.60
, pp. 393-399
-
-
Zhang, D.1
Wang, Y.2
Lu, J.3
Pang, Y.4
-
134
-
-
84902160791
-
Tebipenem, a new carbapenem antibiotic, Is a Slow Substrate That Inhibits the β-Lactamase from Mycobacterium tuberculosis
-
Hazra S., Xu H., Blanchard J.S. Tebipenem, a new carbapenem antibiotic, Is a Slow Substrate That Inhibits the β-Lactamase from Mycobacterium tuberculosis. Biochemistry 2014, 53:3671-3678.
-
(2014)
Biochemistry
, vol.53
, pp. 3671-3678
-
-
Hazra, S.1
Xu, H.2
Blanchard, J.S.3
|