Combinatorial lead optimization of [1,2]-diamines based on ethambutol as potential antituberculosis preclinical candidates

Journal of Combinatorial Chemistry

Volumn 5, Issue 2, 2003, Pages 172-187

  Lee, Richard E ^a,b   Protopopova, Marina ^c   Crooks, Emma ^c   Slayden, Richard A ^d   Terrot, Marianne ^a,c   Barry III, Clifton E ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c SEQUELLA INC   (United States)

^d Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIAMINE DERIVATIVE; ETHAMBUTOL; ISOENZYME; N (1 ADAMANTYL) N' (2 PHENYLCYCLOPROPYL)ETHANE 1,2 DIAMINE; N (1 ADAMANTYLMETHYL) N (3,3 DIPHENYLPROPYL)ETHANE 1,2 DIAMINE; N (2,2 DIPHENYLETHYL) N' (MYRTANYL)ETHANE 1,2 DIAMINE; N (2,2 DIPHENYLETHYL) N' BORNYLETHANE 1,2 DIAMINE; N (2,2 DIPHENYLETHYL) N' ISOPINOCAMPHEYLETHANE 1,2 DIAMINE; N (2,2 DIPHENYLETHYL) N'(1 METHYLADAMANTYL)ETHANE 1,2 DIAMINE; N (3,3 DIPHENYLPROPYL) N' (1 ETHYLCYCLOHEXANE)ETHANE 1,2 DIAMINE; N (3,3 DIPHENYLPROPYL) N' (2 NORBORNYL)ETHANE 1,2 DIAMINE; N (3,3 DIPHENYLPROPYL) N' ISOPINOCAMPHEYLETHANE 1,2 DIAMINE; N (CYCLOOCTYL) N' (1 METHYLADAMANTYL)ETHANE 1,2 DIAMINE; N (CYCLOOCTYL) N' (2 ADAMANTYL)ETHANE 1,2 DIAMINE; N (CYCLOOCTYL) N' (3,3 DIPHENYLPROPYL)ETHANE 1,2 DIAMINE; N (CYCLOOCTYL) N' ISOPINOCAMPHEYLETHANE 1,2 DIAMINE; N (MYRTANYL) N' (2,2 DIPHENYLETHYL)PROPYL 1,2 DIAMINE; N [[2 (N' GERANYL)AMINOETHYL] 2 ETHYL] 2 ETHYLPIPERIDINE; N GERANYL N' (1,1 DIPHENYLMETHYL)ETHANE 1,2 DIAMINE; N GERANYL N' (2 ADAMANTHYL)ETHANE 1,2 DIAMINE; N GERANYL N' (2 ADAMANTYL)ETHANE 1,2 DIAMINE; N GERANYL N' ALLYL N' (CYCLOPENTYL)ETHANE 1,2 DIAMINE; N MYRTANYL N' (1 ETHYLCYCLOHEXANE)ETHANE 1,2 DIAMINE; N MYRTANYL N' (3,3 DIPHENYLPROPYL)ETHANE 1,2 DIAMINE; N MYRTANYL N' (CYCLOOCTYL)ETHANE 1,2 DIAMINE; N MYRTANYL N' ISOPINOCAMPHEYLETHANE 1,2 DIAMINE; N,N' BIS(MYRTANYL)PROPANE 1,2 DIAMINE; TRANSFERASE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG; DIAMINE; DRUG DERIVATIVE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; RESIN;

ACYLATION; ARTICLE; BINDING SITE; COMBINATORIAL CHEMISTRY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HYDROPHOBICITY; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULE; MYCOBACTERIUM TUBERCULOSIS; PURIFICATION; REDUCTION; SOLID; ANTIBIOTIC RESISTANCE; CELL WALL; DRUG EFFECT; DRUG SCREENING; MASS SPECTROMETRY; METABOLISM; MICROBIOLOGICAL EXAMINATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANTITUBERCULAR AGENTS; CELL WALL; COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLOGRAPHY, X-RAY; DIAMINES; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, BACTERIAL; ETHAMBUTOL; INDICATORS AND REAGENTS; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; RESINS, SYNTHETIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0038700567     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc020071p     Document Type: Article

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