High-sensitivity MALDI-MRM-MS imaging of moxifloxacin distribution in tuberculosis-infected rabbit lungs and granulomatous lesions

Analytical Chemistry

Volumn 83, Issue 6, 2011, Pages 2112-2118

  Prideaux, Brendan ^a   ́roniqueDartois, Ve ^c   Staab, Dieter ^a   Weiner, Danielle M ^b   Goh, Anne ^c   Via, Laura E ^b   Barry III, Clifton E ^b   Stoeckli, Markus ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-TB COMPOUNDS; BIOLOGICAL TISSUES; DRUG DISTRIBUTION; DRUG EFFICACY; GRANULOMATOUS LESIONS; HIGH-SENSITIVITY; ION TRANSITION; LC/MS/MS; LOW LEVEL; LUNG BIOPSY; LUNG TISSUE; MATRIX; MOXIFLOXACIN; REFERENCE STANDARD; SENSITIVE METHOD; SPRAYING PROCESS; SUPPRESSING EFFECTS; TIME POINTS; TISSUE SECTIONS;

ANIMALS; BIOLOGICAL ORGANS; BIOPSY; EXPERIMENTS;

TISSUE;

ANTIINFECTIVE AGENT; HETEROCYCLIC COMPOUND; MOXIFLOXACIN; QUINOLINE DERIVATIVE;

ANIMAL; ARTICLE; FEMALE; LUNG; LUNG GRANULOMA; LUNG TUBERCULOSIS; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; MICROBIOLOGY; MOLECULAR IMAGING; PATHOLOGY; RABBIT; STANDARD;

ANIMALS; ANTI-BACTERIAL AGENTS; AZA COMPOUNDS; FEMALE; GRANULOMA, RESPIRATORY TRACT; LUNG; MOLECULAR IMAGING; QUINOLINES; RABBITS; REFERENCE STANDARDS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TUBERCULOSIS, PULMONARY;

EID: 79954595692     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac1029049     Document Type: Article

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