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Volumn 348, Issue 6239, 2015, Pages 1106-1112
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Targeting DnaN for tuberculosis therapy using novel griselimycins
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Author keywords
[No Author keywords available]
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Indexed keywords
DNA POLYMERASE;
GRISELIMYCIN;
ISONIAZID;
PYRAZINAMIDE;
RIFAMPICIN;
TUBERCULOSTATIC AGENT;
UNCLASSIFIED DRUG;
BACTERIAL PROTEIN;
CYCLOHEXYLGRISELIMYCIN;
CYCLOPEPTIDE;
DNA DIRECTED DNA POLYMERASE;
DNAN PROTEIN, BACTERIA;
METHYLGRISELIMYCIN;
ANTIBIOTICS;
ANTIMICROBIAL ACTIVITY;
BACTERIUM;
DISEASE TREATMENT;
DNA;
DRUG DEVELOPMENT;
DRUG RESISTANCE;
ENZYME;
INHIBITION;
METABOLITE;
PRIORITIZATION;
TUBERCULOSIS;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
ANIMAL TISSUE;
ANTIBACTERIAL ACTIVITY;
AREA UNDER THE CURVE;
ARTICLE;
BACTERIAL GROWTH;
BINDING KINETICS;
CHEMICAL STRUCTURE;
COLONY FORMING UNIT;
COMPARATIVE STUDY;
CONTROLLED STUDY;
DNA REPAIR;
DNA REPLICATION;
DNA STRAND BREAKAGE;
DNAN GENE;
DOSE RESPONSE;
DRUG BIOAVAILABILITY;
DRUG DEGRADATION;
DRUG HALF LIFE;
DRUG STRUCTURE;
GENE;
GENE AMPLIFICATION;
GENE TARGETING;
HUMAN;
HUMAN CELL;
HYDROGEN BOND;
IN VITRO STUDY;
IN VIVO STUDY;
KINETIC PARAMETERS;
LUNG LESION;
MAXIMUM PLASMA CONCENTRATION;
METABOLIC STABILITY;
MICROSOME;
MINIMUM INHIBITORY CONCENTRATION;
MOUSE;
MYCOBACTERIUM TUBERCULOSIS;
NONHUMAN;
PRIORITY JOURNAL;
PROTEIN CONFORMATION;
SINGLE DRUG DOSE;
STREPTOMYCES;
STRUCTURE ACTIVITY RELATION;
TUBERCULOSIS;
UNBOUND FRACTION;
VOLUME OF DISTRIBUTION;
ANIMAL;
ANTAGONISTS AND INHIBITORS;
CHEMISTRY;
DISEASE MODEL;
DRUG DESIGN;
DRUG EFFECTS;
ENZYMOLOGY;
METABOLISM;
MICROBIAL SENSITIVITY TEST;
MICROBIOLOGY;
MOLECULAR GENETICS;
MOLECULARLY TARGETED THERAPY;
MYCOBACTERIUM SMEGMATIS;
PROTEIN SECONDARY STRUCTURE;
TUBERCULOSIS, MULTIDRUG-RESISTANT;
TUMOR CELL LINE;
X RAY CRYSTALLOGRAPHY;
MYCOBACTERIUM TUBERCULOSIS;
STREPTOMYCES;
ANIMALS;
ANTITUBERCULAR AGENTS;
BACTERIAL PROTEINS;
CELL LINE, TUMOR;
CRYSTALLOGRAPHY, X-RAY;
DISEASE MODELS, ANIMAL;
DNA-DIRECTED DNA POLYMERASE;
DRUG DESIGN;
HUMANS;
MICE;
MICROBIAL SENSITIVITY TESTS;
MOLECULAR SEQUENCE DATA;
MOLECULAR TARGETED THERAPY;
MYCOBACTERIUM SMEGMATIS;
MYCOBACTERIUM TUBERCULOSIS;
PEPTIDES, CYCLIC;
PROTEIN STRUCTURE, SECONDARY;
STREPTOMYCES;
TUBERCULOSIS, MULTIDRUG-RESISTANT;
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EID: 84930647575
PISSN: 00368075
EISSN: 10959203
Source Type: Journal
DOI: 10.1126/science.aaa4690 Document Type: Article |
Times cited : (256)
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References (33)
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