The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: Adduct affinity and drug resistance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue SUPPL. 2, 2003, Pages 13881-13886

  Rawat, Richa ^a   Whitty, Adrian ^b   Tonge, Peter J ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b BIOGEN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCIDE; CATALASE; ISONIAZID; NICOTINAMIDE ADENINE DINUCLEOTIDE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; TRICLOSAN;

ARTICLE; BACTERIAL GENE; CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG BINDING; DRUG MECHANISM; ENZYME INHIBITION; GENE MUTATION; INHA GENE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; DRUG RESISTANCE, BACTERIAL; ENZYME INHIBITORS; ISONIAZID; KINETICS; MUTATION; MYCOBACTERIUM TUBERCULOSIS; NAD; OXIDOREDUCTASES; THERMODYNAMICS;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); MYCOBACTERIUM; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; UNCULTURED ACTINOMYCETE;

EID: 0345133299     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.2235848100     Document Type: Article

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