Emergence and spread of extensively and totally drug-resistant tuberculosis, South Africa

Emerging Infectious Diseases

Volumn 19, Issue 3, 2013, Pages 449-455

  Klopper, Marisa ^a   Warren, Robin Mark ^a   Hayes, Cindy ^b   van Pittius, Nicolaas Claudius Gey ^a   Streicher, Elizabeth Maria ^a   Müller, Borna ^a,c,d   Sirgel, Frederick Adriaan ^a   Chabula Nxiweni, Mamisa ^e   Hoosain, Ebrahim ^f   Coetzee, Gerrit ^b   van Helden, Paul David ^a   Victor, Thomas Calldo ^a   Trollip, André Phillip ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b NATIONAL HEALTH LABORATORY SERVICE   (South Africa)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d UNIVERSITY OF BASEL   (Switzerland)

^e Nelson Mandela Metropolitan Municipality Department of Health   (South Africa)

^f HUMAN SCIENCES RESEARCH COUNCIL   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; CAPREOMYCIN; ETHIONAMIDE; ISONIAZID; KANAMYCIN; OFLOXACIN; RIFAMPICIN;

ANTIBIOTIC SENSITIVITY; ARTICLE; DNA FINGERPRINTING; DNA SEQUENCE; DRUG RESISTANT TUBERCULOSIS; GENOTYPING TECHNIQUE; HUMAN; MULTIDRUG RESISTANCE; MYCOBACTERIUM TUBERCULOSIS; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SOUTH AFRICA; SPUTUM ANALYSIS;

BACTERIA; EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS; MDR TB; MYCOBACTERIA; MYCOBACTERIUM TUBERCULOSIS; SOUTH AFRICA; TB; TOTALLY DRUG RESISTANT TB; TUBERCULOSIS; XDR-TB;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; CATALASE; CLUSTER ANALYSIS; COMMUNICABLE DISEASES, EMERGING; EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS; GENOTYPE; HUMANS; MICROBIAL SENSITIVITY TESTS; MUTATION, MISSENSE; MYCOBACTERIUM TUBERCULOSIS; SOUTH AFRICA; TUBERCULOSIS, PULMONARY;

EID: 84874258234     PISSN: 10806040     EISSN: 10806059     Source Type: Journal    
DOI: 10.3201/eid1903.120246     Document Type: Article

References (35)

1. World Health Organization, WHO-IUTALD Global Project on Anti-Tuberculosis Drug Resistance Surveillance. Anti-tuberculosis drug resistance in the world (report no. 4) [cited 2008 Apr 30]. http://www.who.int/tb/publications/2008/drs_report4_26feb08.pdf
2. Cox HS, McDermid C, Azevedo V, Muller O, Coetzee D, Simpson J, et al. Epidemic levels of drug resistant tuberculosis (MDR and XDR-TB) in a high HIV prevalence setting in Khayelitsha, South Africa. PLoS ONE. 2010;5:e13901. http://dx.doi.org/10.1371/journal.pone.0013901
3. World Health Organization. Multidrug and extensively drug-resistant TB (M/XDR-TB) 2010. Global report on surveillance and response [cited 2010 Jun 26]. http://whqlibdoc.who.int/publications/2010/9789241599191_eng.pdf
4. National Health Laboratory Services. National Institute for Communicable Diseases annual report 2009 [cited 2012 Jan 26]. http://www.nicd.ac.za/assets/files/Annual_report_2009.pdf
5. Shean KP, Willcox PA, Siwendu SN, Laserson KF, Gross L, Kammerer S, et al. Treatment outcome and follow-up of multidrug-resistant tuberculosis patients, West Coast/Winelands, South Africa, 1992-2002. Int J Tuberc Lung Dis. 2008;12:1182-9.
6. Dheda K, Shean K, Zumla A, Badri M, Streicher EM, Page-Shipp L, et al. Early treatment outcomes and HIV status of patients with extensively drug-resistant tuberculosis in South Africa: a retrospective cohort study. Lancet. 2010;375:1798-807. http://dx.doi.org/10.1016/S0140-6736(10)60492-8
7. Van Rie A, Warren R, Richardson M, Gie RP, Enarson DA, Beyers N, et al. Classification of drug-resistant tuberculosis in an epidemic area. Lancet. 2000;356:22-5. http://dx.doi.org/10.1016/S0140-6736(00)02429-6
8. Johnson R, Warren RM, van der Spuy GD, Gey Van Pittius NC, Theron D, Streicher EM, et al. Drug-resistant tuberculosis epidemic in the Western Cape driven by a virulent Beijing genotype strain. Int J Tuberc Lung Dis. 2010;14:119-21.
9. Johnson R, Warren R, Strauss OJ, Jordaan AM, Falmer AA, Beyers N, et al. An outbreak of drug-resistant tuberculosis caused by a Beijing strain in the Western Cape, South Africa. Int J Tuberc Lung Dis. 2006;10:1412-4.
10. Strauss OJ, Warren RM, Jordaan A, Streicher EM, Hanekom M, Falmer AA, et al. Spread of a low-fitness drug-resistant Mycobacterium tuberculosis strain in a setting of high human immunodeficiency virus prevalence. J Clin Microbiol. 2008;46:1514-6. http://dx.doi.org/10.1128/JCM.01938-07
11. Gagneux S, Long CD, Small PM, Van T, Schoolnik GK, Bohannan BJ. The competitive cost of antibiotic resistance in Mycobacterium tuberculosis. Science. 2006;312:1944-6. http://dx.doi.org/10.1126/science.1124410
12. Kvasnovsky CL, Cegielski JP, Erasmus R, Siwisa NO, Thomas K, der Walt ML. Extensively drug-resistant TB in Eastern Cape, South Africa: high mortality in HIV-negative and HIV-positive patients. J Acquir Immune Defic Syndr. 2011;57:146-52. http://dx.doi.org/10.1097/QAI.0b013e31821190a3
13. Gandhi NR, Moll A, Sturm AW, Pawinski R, Govender T, Lalloo U, et al. Extensively drug resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet. 2006;368:1575-80. http://dx.doi.org/10.1016/S0140-6736(06)69573-1
14. Van Rie A, Enarson D. XDR tuberculosis: an indicator of public-health negligence. Lancet. 2006;368:1554-6. http://dx.doi.org/10.1016/S0140-6736(06)69575-5
15. Sharma M, Thibert L, Chedore P, Shandro C, Jamieson F, Tyrrell G, et al. Canadian multicenter laboratory study for standardized second-line antimicrobial susceptibility testing of Mycobacterium tuberculosis. J Clin Microbiol. 2011;49:4112-6. http://dx.doi.org/10.1128/JCM.05195-11
16. Warren RM, Victor TC, Streicher EM, Richardson M, Beyers N, van Pittius NC, et al. Patients with active tuberculosis often have different strains in the same sputum specimen. Am J Respi Crit Care Med. 2004;169:610-4. http://dx.doi.org/10.1164/rccm.200305-714OC
17. Kamerbeek J, Schouls L, Kolk A, van Agterveld M, van Soolingen D, Kuijper S, et al. Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology. J Clin Microbiol. 1997;35:907-14.
18. Streicher EM, Victor TC, van der SG, Sola C, Rastogi N, van Helden PD, et al. Spoligotype signatures in the Mycobacterium tuberculosis complex. J Clin Microbiol. 2007;45:237-40. http://dx.doi.org/10.1128/JCM.01429-06
19. Mokrousov I, Narvskaya O, Otten T, Vyazovaya A, Limeschenko E, Steklova L, et al. Phylogenetic reconstruction within Mycobacterium tuberculosis Beijing genotype in northwestern Russia. Res Microbiol. 2002;153:629-37. http://dx.doi.org/10.1016/S0923-2508(02)01374-8
20. Plikaytis BB, Marden JL, Crawford JT, Woodley CL, Butler WR, Shinnick TM. Multiplex PCR assay specific for the multidrug-resistant strain W of Mycobacterium tuberculosis. J Clin Microbiol. 1994;32:1542-6.
21. Warren R, de Kock M, Engelke E, Myburgh R, Gey van Pittius NC, Victor T, et al. Safe Mycobacterium tuberculosis DNA extraction method that does not compromise integrity. J Clin Microbiol. 2006;44:254-6. http://dx.doi.org/10.1128/JCM.44.1.254-256.2006
22. Calver AD, Falmer AA, Murray M, Strauss OJ, Streicher EM, Hanekom M, et al. Emergence of increased resistance and extensively drug-resistant tuberculosis despite treatment adherence, South Africa. Emerg Infect Dis. 2010;16:264-71. http://dx.doi.org/10.3201/eid1602.090968
23. Sirgel FA, Tait M, Warren RM, Streicher EM, Bottger EC, van Helden PD, et al. Mutations in the rrs A1401G gene and phenotypic resistance to amikacin and capreomycin in Mycobacterium tuberculosis. Microb Drug Resist. 2012;18:193-7.
24. Mlambo CK, Warren RM, Poswa X, Victor TC, Duse AG, Marais E. Genotypic diversity of extensively drug-resistant tuberculosis (XDR-TB) in South Africa. Int J Tuberc Lung Dis. 2008;12:99-104.
25. Pillay M, Sturm AW. Evolution of the extensively drug-resistant F15/LAM4/KZN strain of Mycobacterium tuberculosis in KwaZulu-Natal, South Africa. Clin Infect Dis. 2007;45:1409-14. http://dx.doi.org/10.1086/522987
26. Porteous JB. The treatment of pulmonary tuberculosis. S Afr Med J. 1959;33:265-7.
27. Ioerger TR, Koo S, No EG, Chen X, Larsen MH, Jacobs WR Jr, et al. Genome analysis of multi-and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa. PLoS ONE. 2009;4:e7778. http://dx.doi.org/10.1371/journal.pone.0007778
28. Streicher EM, Muller B, Chihota V, Mlambo C, Tait M, Pillay M, et al. Emergence and treatment of multidrug resistant (MDR) and extensively drug-resistant (XDR) tuberculosis in South Africa. Infect Genet Evol. 2012;12:686-94 http://dx.doi.org/10.1016/j.meegid.2011.07.019
29. Hillemann D, Rusch-Gerdes S, Richter E. Feasibility of the GenoType MTBDRsl assay for fluoroquinolone, amikacin-capreomycin, and ethambutol resistance testing of Mycobacterium tuberculosis strains and clinical specimens. J Clin Microbiol. 2009;47:1767-72. http://dx.doi.org/10.1128/JCM.00081-09
30. Velayati AA, Masjedi MR, Farnia P, Tabarsi P, Ghanavi J, Ziazarifi AH, et al. Emergence of new forms of totally drug-resistant tuberculosis bacilli: super extensively drug-resistant tuberculosis or totally drug-resistant strains in Iran. Chest. 2009;136:420-5. http://dx.doi.org/10.1378/chest.08-2427
31. World Health Organization Stop TB Department. Drug-resistant tuberculosis: frequently asked questions, January 26, 2012 [cited 2012 Feb 8]. http://www.who.int/tb/challenges/mdr/TDRFAQs160112final.pdf
32. Chihota VN, Muller B, Mlambo CK, Pillay M, Tait M, Streicher EM, et al. The population structure of multi-and extensively drug-resistant tuberculosis in South Africa. J Clin Microbiol. 2012;50:995-1002. http://dx.doi.org/10.1128/JCM.05832-11
33. Sandgren A, Strong M, Muthukrishnan P, Weiner BK, Church GM, Murray MB. Tuberculosis drug resistance mutation database. 2009. PLoS Med. 2009;6:e2. http://dx.doi.org/10.1371/journal.pmed.1000002
34. Müller B, Streicher EM, Hoek KG, Tait M, Trollip A, Bosman ME, et al. inhA promoter mutations: a gateway to extensively drug-resistant tuberculosis in South Africa? Int J Tuberc Lung Dis. 2011;15:344-51.
35. Barnard M, Albert H, Coetzee G, O'Brien R, Bosman ME. Rapid molecular screening for multidrug-resistant tuberculosis in a high-volume public health laboratory in South Africa. 2008. Am J Respi Crit Care Med. 2008;177:787-92. http://dx.doi.org/10.1164/rccm.200709-1436OC