Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria

Antimicrobial Agents and Chemotherapy

Volumn 57, Issue 3, 2013, Pages 1394-1403

  Hernandez, Vincent ^a   Crépin, Thibaut ^b   Palencia, Andrés ^b   Cusack, Stephen ^b   Akama, Tsutomu ^a   Baker, Stephen J ^a   Bu, Wei ^a   Feng, Lisa ^a   Freund, Yvonne R ^a   Liu, Liang ^a   Meewan, Maliwan ^a   Mohan, Manisha ^a   Mao, Weimin ^a   Rock, Fernando L ^a   Sexton, Holly ^a   Sheoran, Anita ^a   Zhang, Yanchen ^a   Zhang, Yong Kang ^a   Zhou, Yasheen ^a   Nieman, James A ^c   Anugula, Mahipal Reddy ^c   Keramane, El Mehdi ^c   Savariraj, Kingsley ^c   Shekhar Reddy, D ^c   Sharma, Rashmi ^c   Subedi, Rajendra ^c   Singh, Rajeshwar ^c   O'Leary, Ann ^d   Simon, Nerissa L ^e   De Marsh, Peter L ^e   Mushtaq, Shazad ^f   Warner, Marina ^f   Livermore, David M ^f,g   Alley, M R K ^a   Plattner, Jacob J ^a   more..

^a PFIZER INC   (United States)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

^c NAEJA Pharmaceuticals Inc   (Canada)

^d Ricerca Inc   (United States)

^e GLAXOSMITHKLINE   (United States)

^f PUBLIC HEALTH ENGLAND   (United Kingdom)

^g UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAPENEMASE; GSK 2251052; LEUCINE TRANSFER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; ESCHERICHIA COLI; FEMALE; GRAM NEGATIVE BACTERIUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

AMINO ACYL-TRNA SYNTHETASES; ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; BORON COMPOUNDS; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ESCHERICHIA COLI; FEMALE; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; LEUCINE; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; PSEUDOMONAS AERUGINOSA; STRUCTURE-ACTIVITY RELATIONSHIP; THIGH;

EID: 84874038233     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.02058-12     Document Type: Article

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