Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): A class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases

Journal of Medicinal Chemistry

Volumn 56, Issue 1, 2013, Pages 293-300

  Tars, Kaspars ^a   Vullo, Daniela ^b   Kazaks, Andris ^a   Leitans, Janis ^a   Lends, Alons ^c   Grandane, Aiga ^c   Zalubovskis, Raivis ^c   Scozzafava, Andrea ^b   Supuran, Claudiu T ^b  

^a LATVIAN BIOMEDICAL RESEARCH AND STUDY CENTRE   (Latvia)

^b UNIVERSITY OF FLORENCE   (Italy)

^c LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,2 DIOXIDO 1,2 BENZOXATHIIN 6 YL) 4 PHENYL 1H 1,2,3 TRITRIAZOLE; 1,2 BENZOXATHIINE 2,2 DIOXIDE DERIVATIVE; 6 AZIDO 1,2 BENZOXATHIINE 2,2 DIOXIDE; ACETAZOLAMIDE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; COUMARIN DERIVATIVE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; HYDROLYSIS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; X RAY;

ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CATALYTIC DOMAIN; CLICK CHEMISTRY; COUMARINS; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROLYSIS; ISOENZYMES; MOLECULAR STRUCTURE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84872343989     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301625s     Document Type: Article

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