Carbonic anhydrase and matrix metalloproteinase inhibitors: Sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes

Journal of Medicinal Chemistry

Volumn 43, Issue 20, 2000, Pages 3677-3687

  Scozzafava, A ^a   Supuran, C T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID HYDROXAMATE DERIVATIVE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE IV; CLOSTRIDIOPEPTIDASE A; COLLAGENASE; GELATINASE A; GELATINASE B; HYDROXAMIC ACID DERIVATIVE; MATRIX METALLOPROTEINASE INHIBITOR; N HYDROXYSULFONAMIDE DERIVATIVE; NEUTROPHIL COLLAGENASE; SULFONAMIDE; UNCLASSIFIED DRUG; ZINC ION;

ARTICLE; CANCER INVASION; CARCINOGENESIS; CLOSTRIDIUM HISTOLYTICUM; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; HUMAN; HUMAN CELL;

AMINO ACIDS; ANIMALS; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CATTLE; CLOSTRIDIUM; COBALT; COLLAGENASES; HUMANS; HYDROXAMIC ACIDS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 8; MATRIX METALLOPROTEINASE 9; PROTEASE INHIBITORS; SPECTROPHOTOMETRY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; SULFONES; ZINC;

EID: 0034609778     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000027t     Document Type: Article

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