SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 267-270

5- and 6-Membered (thio)lactones are prodrug type carbonic anhydrase inhibitors

(4) Carta, Fabrizio a Maresca, Alfonso a Scozzafava, Andrea a Supuran, Claudiu T a

a UNIVERSITY OF FLORENCE (Italy)

Author keywords

Carbonic anhydrase; Coumarin; Esterase activity; Isoform selective inhibitor; Lactone; Prodrug; Thiolactone

Indexed keywords

5,6 DIHYDRO 2H PYRAN 2 ONE; 6 (1S HYDROXY 3 METHYLBUTYL) 7 METHOXY 2H CHROMEN 2 ONE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; COUMARIN DERIVATIVE; ESTERASE; GAMMA VALEROLACTONE; HYDROXYACID; LACTONE; NATURAL PRODUCT; PRODRUG; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROLYSIS;

ANTINEOPLASTIC AGENTS; CARBONIC ANHYDRASE INHIBITORS; CHEMISTRY, PHARMACEUTICAL; COUMARINS; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; KINETICS; LACTONES; MODELS, CHEMICAL; NEOPLASMS; PRODRUGS; PROTEIN ISOFORMS;

EID: 84655175049 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.11.018 Document Type: Article

Times cited : (60)

References (26)

1
- 38849143765
- C.T. Supuran Nat. Rev. Drug Disc. 7 2008 168
- (2008) Nat. Rev. Drug Disc. , vol.7 , pp. 168
- Supuran, C.T.¹

2
- 77954218410
- C.T. Supuran Bioorg. Med. Chem. Lett. 20 2010 3467
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 3467
- Supuran, C.T.¹

3
- 0037369153
- C.T. Supuran, A. Scozzafava, and A. Casini Med. Res. Rev. 23 2003 146
- (2003) Med. Res. Rev. , vol.23 , pp. 146
- Supuran, C.T.¹ Scozzafava, A.² Casini, A.³

4
- 78649857406
- C.T. Supuran Curr. Pharm. Des. 16 2010 3233
- (2010) Curr. Pharm. Des. , vol.16 , pp. 3233
- Supuran, C.T.¹

5
- 41149115712
- H. Vu, N.B. Pham, and R.J. Quinn J. Biomol. Screen. 13 2008 265
- (2008) J. Biomol. Screen. , vol.13 , pp. 265
- Vu, H.¹ Pham, N.B.² Quinn, R.J.³

6
- 67749116253
- A. Maresca, C. Temperini, H. Vu, N.B. Pham, S.A. Poulsen, A. Scozzafava, R.J. Quinn, and C.T. Supuran J. Am. Chem. Soc. 131 2009 3057
- (2009) J. Am. Chem. Soc. , vol.131 , pp. 3057
- Maresca, A.¹ Temperini, C.² Vu, H.³ Pham, N.B.⁴ Poulsen, S.A.⁵ Scozzafava, A.⁶ Quinn, R.J.⁷ Supuran, C.T.⁸

7
- 74849118851
- A. Maresca, C. Temperini, L. Pochet, B. Masereel, A. Scozzafava, and C.T. Supuran J. Med. Chem. 53 2010 335
- (2010) J. Med. Chem. , vol.53 , pp. 335
- Maresca, A.¹ Temperini, C.² Pochet, L.³ Masereel, B.⁴ Scozzafava, A.⁵ Supuran, C.T.⁶

8
- 66549090944
- P. Ebbesen, E.O. Pettersen, T.A. Gorr, G. Jobst, K. Williams, J. Kienninger, R.H. Wenger, S. Pastorekova, L. Dubois, P. Lambin, B.G. Wouters, C.T. Supuran, L. Poellinger, P. Ratcliffe, A. Kanopka, A. Görlach, M. Gasmann, A.L. Harris, P. Maxwell, and A. Scozzafava J. Enzyme Inhib. Med. Chem. 24 2009 1
- (2009) J. Enzyme Inhib. Med. Chem. , vol.24 , pp. 1
- Ebbesen, P.¹ Pettersen, E.O.² Gorr, T.A.³ Jobst, G.⁴ Williams, K.⁵ Kienninger, J.⁶ Wenger, R.H.⁷ Pastorekova, S.⁸ Dubois, L.⁹ Lambin, P.¹⁰ Wouters, B.G.¹¹ Supuran, C.T.¹² Poellinger, L.¹³ Ratcliffe, P.¹⁴ Kanopka, A.¹⁵ Görlach, A.¹⁶ Gasmann, M.¹⁷ Harris, A.L.¹⁸ Maxwell, P.¹⁹ Scozzafava, A.²⁰ more..

9
- 69949128698
- L. Dubois, N.G. Lieuwes, A. Maresca, A. Thiry, C.T. Supuran, A. Scozzafava, B.G. Wouters, and P. Lambin Radiother. Oncol. 92 2009 423
- (2009) Radiother. Oncol. , vol.92 , pp. 423
- Dubois, L.¹ Lieuwes, N.G.² Maresca, A.³ Thiry, A.⁴ Supuran, C.T.⁵ Scozzafava, A.⁶ Wouters, B.G.⁷ Lambin, P.⁸

10
- 67651091693
- J.K.J. Ahlskog, C.E. Dumelin, S. Trüssel, J. Marlind, and D. Neri Bioorg. Med. Chem. Lett. 19 2009 4851
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 4851
- Ahlskog, J.K.J.¹ Dumelin, C.E.² Trüssel, S.³ Marlind, J.⁴ Neri, D.⁵

11
- 68749119336
- J.K. Ahlskog, C. Schliemann, J. Mrlind, U. Qureshi, A. Ammar, R.B. Pedleym, and D. Neri Br. J. Cancer 101 2009 645
- (2009) Br. J. Cancer , vol.101 , pp. 645
- Ahlskog, J.K.¹ Schliemann, C.² Mrlind, J.³ Qureshi, U.⁴ Ammar, A.⁵ Pedleym, R.B.⁶ Neri, D.⁷

12
- 77955391402
- F. Carta, C. Temperini, A. Innocenti, A. Scozzafava, K. Kaila, and C.T. Supuran J. Med.Chem. 53 2010 5511
- (2010) J. Med.Chem. , vol.53 , pp. 5511
- Carta, F.¹ Temperini, C.² Innocenti, A.³ Scozzafava, A.⁴ Kaila, K.⁵ Supuran, C.T.⁶

13
- 84889476926
- X-Ray Crystallography of CA Inhibitors and its Importance in Drug Design
- C.T. Supuran, J.Y. Winum, Wiley Hoboken
- V. Alterio, A. Di Fiore, K. D'Ambrosio, C.T. Supuran, and G. De Simone X-Ray Crystallography of CA Inhibitors and its Importance in Drug Design C.T. Supuran, J.Y. Winum, Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural and Disease Applications 2009 Wiley Hoboken 73 138
- (2009) Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural and Disease Applications , pp. 73-138
- Alterio, V.¹ Di Fiore, A.² D'Ambrosio, K.³ Supuran, C.T.⁴ De Simone, G.⁵

14
- 8844249356
- E. Švastová, A. Hulíkova, M. Rafajová, M. Zat'ovi čová, A. Gibadulinova, A. Casini, A. Cecchi, A. Scozzafava, C. Supuran, and J. Pastorek FEBS Lett. 577 2004 439
- (2004) FEBS Lett. , vol.577 , pp. 439
- Švastová, E.¹ Hulíkova, A.² Rafajová, M.³ Zat'ovi Čová, M.⁴ Gibadulinova, A.⁵ Casini, A.⁶ Cecchi, A.⁷ Scozzafava, A.⁸ Supuran, C.⁹ Pastorek, J.¹⁰

15
- 50649105780
- P. Swietach, S. Wigfield, P. Cobden, C.T. Supuran, A.L. Harris, and R.D. Vaughan-Jones J. Biol. Chem. 283 2008 20473
- (2008) J. Biol. Chem. , vol.283 , pp. 20473
- Swietach, P.¹ Wigfield, S.² Cobden, P.³ Supuran, C.T.⁴ Harris, A.L.⁵ Vaughan-Jones, R.D.⁶

16
- 79952808077
- F. Pacchiano, F. Carta, P.C. McDonald, Y. Lou, D. Vullo, A. Scozzafava, S. Dedhar, and C.T. Supuran J. Med. Chem. 54 2011 1896
- (2011) J. Med. Chem. , vol.54 , pp. 1896
- Pacchiano, F.¹ Carta, F.² McDonald, P.C.³ Lou, Y.⁴ Vullo, D.⁵ Scozzafava, A.⁶ Dedhar, S.⁷ Supuran, C.T.⁸

17
- 77955424195
- A. Maresca, and C.T. Supuran Bioorg. Med. Chem. Lett. 20 2010 4511
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 4511
- Maresca, A.¹ Supuran, C.T.²

18
- 78449303755
- A. Maresca, A. Scozzafava, and C.T. Supuran Bioorg. Med. Chem. Lett. 20 2010 7255
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 7255
- Maresca, A.¹ Scozzafava, A.² Supuran, C.T.³

19
- 79955490807
- Y. Lou, P.C. McDonald, A. Oloumi, S.K. Chia, C. Ostlund, A. Ahmadi, A. Kyle, U. Auf dem Keller, S. Leung, D.G. Huntsman, B. Clarke, B.W. Sutherland, D. Waterhouse, M.B. Bally, C.D. Roskelley, C.M. Overall, A. Minchinton, F. Pacchiano, F. Carta, A. Scozzafava, N. Touisni, J.Y. Winum, C.T. Supuran, and S. Dedhar Cancer Res. 71 2011 3364
- (2011) Cancer Res. , vol.71 , pp. 3364
- Lou, Y.¹ McDonald, P.C.² Oloumi, A.³ Chia, S.K.⁴ Ostlund, C.⁵ Ahmadi, A.⁶ Kyle, A.⁷ Auf Dem Keller, U.⁸ Leung, S.⁹ Huntsman, D.G.¹⁰ Clarke, B.¹¹ Sutherland, B.W.¹² Waterhouse, D.¹³ Bally, M.B.¹⁴ Roskelley, C.D.¹⁵ Overall, C.M.¹⁶ Minchinton, A.¹⁷ Pacchiano, F.¹⁸ Carta, F.¹⁹ Scozzafava, A.²⁰ more..

20
- 70349490906
- V. Alterio, M. Hilvo, A. Di Fiore, C.T. Supuran, P. Pan, S. Parkkila, A. Scaloni, J. Pastorek, S. Pastorekova, C. Pedone, A. Scozzafava, S.M. Monti, and G. De Simone Proc. Natl. Acad. Sci. U.S.A. 106 2009 16233
- (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 16233
- Alterio, V.¹ Hilvo, M.² Di Fiore, A.³ Supuran, C.T.⁴ Pan, P.⁵ Parkkila, S.⁶ Scaloni, A.⁷ Pastorek, J.⁸ Pastorekova, S.⁹ Pedone, C.¹⁰ Scozzafava, A.¹¹ Monti, S.M.¹² De Simone, G.¹³

21
- 80053563164
- D. Neri, and C.T. Supuran Nat. Rev. Drug Disc. 10 2011 767
- (2011) Nat. Rev. Drug Disc. , vol.10 , pp. 767
- Neri, D.¹ Supuran, C.T.²

22
- 0015239422
- 3b,4 and represent the mean from at least three different determinations. CA isoforms were recombinant ones obtained in house as reported earlier.
- (1971) J. Biol. Chem. , vol.246 , pp. 2561
- Khalifah, R.G.¹

23
- 77249175356
- C. Temperini, A. Innocenti, A. Scozzafava, S. Parkkila, and C.T. Supuran J. Med. Chem. 53 2010 850
- (2010) J. Med. Chem. , vol.53 , pp. 850
- Temperini, C.¹ Innocenti, A.² Scozzafava, A.³ Parkkila, S.⁴ Supuran, C.T.⁵

24
- 58949104942
- A. Di Fiore, S.M. Monti, M. Hilvo, S. Parkkila, V. Romano, A. Scaloni, C. Pedone, A. Scozzafava, C.T. Supuran, and G. De Simone Proteins 74 2009 164
- (2009) Proteins , vol.74 , pp. 164
- Di Fiore, A.¹ Monti, S.M.² Hilvo, M.³ Parkkila, S.⁴ Romano, V.⁵ Scaloni, A.⁶ Pedone, C.⁷ Scozzafava, A.⁸ Supuran, C.T.⁹ De Simone, G.¹⁰

25
- 84655161255
- WO Pat. 025620 A2
- Manning, P.T.; Misko, T.P. Preparation of amino acid derivatives as inhibitors of inducible nitric oxide synthase for use in combination therapy with alkylating agents. WO Pat. 2005, 025620 A2.
- (2005) Preparation of Amino Acid Derivatives As Inhibitors of Inducible Nitric Oxide Synthase for Use in Combination Therapy with Alkylating Agents
- Manning, P.T.¹ Misko, T.P.²

26
- 1542768447
- A. Defoin, G. Augelmann, H. Fritz, G. Geffroy, C. Schmidlin, and J. Streith Helv. Chim. Acta 1985 1998
- (1985) Helv. Chim. Acta , pp. 1998
- Defoin, A.¹ Augelmann, G.² Fritz, H.³ Geffroy, G.⁴ Schmidlin, C.⁵ Streith, J.⁶

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.