메뉴 건너뛰기




Volumn 4, Issue FEB, 2016, Pages

The reverse transcriptase encoded by LINE-1 retrotransposons in the genesis, progression, and therapy of cancer

Author keywords

Cancer heterogeneity; Differentiation therapy; Epigenetics; LINE 1 retrotransposons; Reverse transcriptase; Tumorigenesis

Indexed keywords


EID: 84969523755     PISSN: None     EISSN: 22962646     Source Type: Journal    
DOI: 10.3389/fchem.2016.00006     Document Type: Review
Times cited : (41)

References (118)
  • 1
    • 84861968721 scopus 로고    scopus 로고
    • Small non-coding RNAs mount a silent revolution in gene expression
    • Aalto, A. P., and Pasquinelli, A. E. (2012). Small non-coding RNAs mount a silent revolution in gene expression. Curr. Opin. Cell Biol. 24, 333-340. doi: 10.1016/j.ceb.2012.03.006
    • (2012) Curr. Opin. Cell Biol , vol.24 , pp. 333-340
    • Aalto, A.P.1    Pasquinelli, A.E.2
  • 2
    • 84954403208 scopus 로고    scopus 로고
    • LINE-1 induces hTERT and ensures telomere maintenance in tumour cell lines
    • Aschacher, T., Wolf, B., Enzmann, F., Kienzl, P., Messner, B., Sampl, S., et al. (2016). LINE-1 induces hTERT and ensures telomere maintenance in tumour cell lines. Oncogene 35, 94-104. doi: 10.1038/onc.2015.65
    • (2016) Oncogene , vol.35 , pp. 94-104
    • Aschacher, T.1    Wolf, B.2    Enzmann, F.3    Kienzl, P.4    Messner, B.5    Sampl, S.6
  • 3
    • 34248358963 scopus 로고    scopus 로고
    • Progress in understanding the biology of the human mutagen LINE-1
    • Babushok, D. V., and Kazazian, H. H. Jr. (2007). Progress in understanding the biology of the human mutagen LINE-1. Hum. Mutat. 28, 527-539. doi: 10.1002/humu.20486
    • (2007) Hum. Mutat , vol.28 , pp. 527-539
    • Babushok, D.V.1    Kazazian, H.H.2
  • 4
    • 0014964654 scopus 로고
    • RNA-dependent DNA polymerase in virions of RNA tumor viruses
    • Baltimore, D. (1970). RNA-dependent DNA polymerase in virions of RNA tumor viruses. Nature 226, 1209-1211. doi: 10.1038/2261209a0
    • (1970) Nature , vol.226 , pp. 1209-1211
    • Baltimore, D.1
  • 7
    • 77956865601 scopus 로고    scopus 로고
    • All y'all need to know'bout retroelements in cancer
    • Belancio, V. P., Roy-Engel, A. M., and Deininger, P. L. (2010). All y'all need to know'bout retroelements in cancer. Semin. Cancer Biol. 20, 200-210. doi: 10.1016/j.semcancer.2010.06.001
    • (2010) Semin. Cancer Biol , vol.20 , pp. 200-210
    • Belancio, V.P.1    Roy-Engel, A.M.2    Deininger, P.L.3
  • 8
    • 32944476464 scopus 로고    scopus 로고
    • Expression of LINE-1 retroposons is essential for murine preimplantation development
    • Beraldi, R., Pittoggi, C., Sciamanna, I., Mattei, E., and Spadafora, C. (2006). Expression of LINE-1 retroposons is essential for murine preimplantation development. Mol. Reprod. Dev. 73, 279-287. doi: 10.1002/mrd.20423
    • (2006) Mol. Reprod. Dev , vol.73 , pp. 279-287
    • Beraldi, R.1    Pittoggi, C.2    Sciamanna, I.3    Mattei, E.4    Spadafora, C.5
  • 9
    • 39749165104 scopus 로고    scopus 로고
    • Transposable elements as drivers of genomic and biological diversity in vertebrates
    • Böehne, A., Brunet, F., Galiana-Arnoux, D., Schultheis, C., and Volff, J. N. (2008). Transposable elements as drivers of genomic and biological diversity in vertebrates. Chromosome Res. 16, 203-215. doi: 10.1007/s10577-007-1202-6
    • (2008) Chromosome Res , vol.16 , pp. 203-215
    • Böehne, A.1    Brunet, F.2    Galiana-Arnoux, D.3    Schultheis, C.4    Volff, J.N.5
  • 10
    • 83455168092 scopus 로고    scopus 로고
    • Comprehensive analysis of microRNA genomic loci identifies pervasive repetitive-element origins
    • Borchert, G. M., Holton, N. W., Williams, J. D., Hernan, W. L., Bishop, I. P., Dembosky, J. A., et al. (2011). Comprehensive analysis of microRNA genomic loci identifies pervasive repetitive-element origins. Mob. Genet. Elements 1, 8-17. doi: 10.4161/mge.1.1.15766
    • (2011) Mob. Genet. Elements , vol.1 , pp. 8-17
    • Borchert, G.M.1    Holton, N.W.2    Williams, J.D.3    Hernan, W.L.4    Bishop, I.P.5    Dembosky, J.A.6
  • 11
    • 71749094924 scopus 로고    scopus 로고
    • Transposable elements in gene regulation and in the evolution of vertebrate genomes
    • Bourque, G. (2009). Transposable elements in gene regulation and in the evolution of vertebrate genomes. Curr. Opin. Genet. Dev. 19, 607-612. doi: 10.1016/j.gde.2009.10.013
    • (2009) Curr. Opin. Genet. Dev , vol.19 , pp. 607-612
    • Bourque, G.1
  • 13
    • 34247344319 scopus 로고    scopus 로고
    • Retrotransposable elements and human disease
    • Callinan, P. A., and Batzer, M. A. (2006). Retrotransposable elements and human disease. Genome Dyn. 1, 104-115. doi: 10.1159/000092503
    • (2006) Genome Dyn , vol.1 , pp. 104-115
    • Callinan, P.A.1    Batzer, M.A.2
  • 14
    • 84867867046 scopus 로고    scopus 로고
    • Prognostic value of LINE-1 retrotransposon expression and its subcellular localization in breast cancer
    • Chen, L., Dahlstrom, J. E., Chandra, A., Board, P., and Rangasamy, D. (2012a). Prognostic value of LINE-1 retrotransposon expression and its subcellular localization in breast cancer. Breast Cancer Res. Treat. 136, 129-142. doi: 10.1007/s10549-012-2246-7
    • (2012) Breast Cancer Res. Treat , vol.136 , pp. 129-142
    • Chen, L.1    Dahlstrom, J.E.2    Chandra, A.3    Board, P.4    Rangasamy, D.5
  • 15
    • 84863799077 scopus 로고    scopus 로고
    • Naturally occurring endo-siRNA silences LINE-1 retrotransposons in human cells through DNA methylation
    • Chen, L., Dahlstrom, J. E., Lee, S. H., and Rangasamy, D. (2012b). Naturally occurring endo-siRNA silences LINE-1 retrotransposons in human cells through DNA methylation. Epigenetics 7, 758-771. doi: 10.4161/epi.20706
    • (2012) Epigenetics , vol.7 , pp. 758-771
    • Chen, L.1    Dahlstrom, J.E.2    Lee, S.H.3    Rangasamy, D.4
  • 16
    • 69349096044 scopus 로고    scopus 로고
    • L1 retrotransposition in human neural progenitor cells
    • Coufal, N. G., Garcia-Perez, J. L., Peng, G. E., Yeo, G. W., Mu, Y., Lovci, M. T., et al. (2009). L1 retrotransposition in human neural progenitor cells. Nature 460, 1127-1131. doi: 10.1038/nature08248
    • (2009) Nature , vol.460 , pp. 1127-1131
    • Coufal, N.G.1    Garcia-Perez, J.L.2    Peng, G.E.3    Yeo, G.W.4    Mu, Y.5    Lovci, M.T.6
  • 17
    • 84867326265 scopus 로고    scopus 로고
    • Solid tumor differentiation therapy-is it possible?
    • Cruz, F. D., and Matushansky, I. (2012). Solid tumor differentiation therapy-is it possible? Oncotarget 3, 559-567. doi: 10.18632/oncotarget.512
    • (2012) Oncotarget , vol.3 , pp. 559-567
    • Cruz, F.D.1    Matushansky, I.2
  • 18
    • 79955552036 scopus 로고    scopus 로고
    • Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition
    • Dai, L., Huang, Q., and Boeke, J. D. (2011). Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition. BMC Biochem. 2:18. doi: 10.1186/1471-2091-12-18
    • (2011) BMC Biochem , vol.2 , pp. 18
    • Dai, L.1    Huang, Q.2    Boeke, J.D.3
  • 19
    • 4243937106 scopus 로고    scopus 로고
    • A highly selective telomerase inhibitor limiting human cancer cell proliferation
    • Damm, K., Hemmann, U., Garin-Chesa, P., Hauel, N., Kauffmann, I., Priepke, H., et al. (2001). A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J. 20, 6958-6968. doi: 10.1093/emboj/20.24.6958
    • (2001) EMBO J , vol.20 , pp. 6958-6968
    • Damm, K.1    Hemmann, U.2    Garin-Chesa, P.3    Hauel, N.4    Kauffmann, I.5    Priepke, H.6
  • 20
    • 0041353551 scopus 로고    scopus 로고
    • LINE-mediated retrotransposition of marked Alu sequences
    • Dewannieux, M., Esnault, C., and Heidmann, T. (2003). LINE-mediated retrotransposition of marked Alu sequences. Nat. Genet. 35, 41-48. doi: 10.1038/ng1223
    • (2003) Nat. Genet , vol.35 , pp. 41-48
    • Dewannieux, M.1    Esnault, C.2    Heidmann, T.3
  • 22
    • 84936882178 scopus 로고    scopus 로고
    • U6 snRNA Pseudogenes: markers of retrotransposition dynamics in mammals
    • Doucet, A. J., Droc, G., Siol, O., Audoux, J., and Gilbert, N. (2015). U6 snRNA Pseudogenes: markers of retrotransposition dynamics in mammals. Mol. Biol. Evol. 32, 1815-1832. doi: 10.1093/molbev/msv062
    • (2015) Mol. Biol. Evol , vol.32 , pp. 1815-1832
    • Doucet, A.J.1    Droc, G.2    Siol, O.3    Audoux, J.4    Gilbert, N.5
  • 23
    • 84940979605 scopus 로고    scopus 로고
    • LINE-1 expression and retrotransposition in Barrett's esophagus and esophageal carcinoma
    • Doucet-O'Hare, T. T., Rodic, N., Sharma, R., Darbari, I., Abril, G., Choi, J. A., et al. (2015). LINE-1 expression and retrotransposition in Barrett's esophagus and esophageal carcinoma. Proc. Natl. Acad. Sci. U.S.A. 112, E4894-E900. doi: 10.1073/pnas.1502474112
    • (2015) Proc. Natl. Acad. Sci. U.S.A , vol.112 , pp. E4894-E4900
    • Doucet-O'Hare, T.T.1    Rodic, N.2    Sharma, R.3    Darbari, I.4    Abril, G.5    Choi, J.A.6
  • 24
    • 0034079713 scopus 로고    scopus 로고
    • Human LINE retrotransposons generate processed pseudogenes
    • Esnault, C., Maestre, J., and Heidmann, T. (2000). Human LINE retrotransposons generate processed pseudogenes. Nat. Genet. 24, 363-367. doi: 10.1038/74184
    • (2000) Nat. Genet , vol.24 , pp. 363-367
    • Esnault, C.1    Maestre, J.2    Heidmann, T.3
  • 25
    • 81355142141 scopus 로고    scopus 로고
    • Non-coding RNAs in human disease
    • Esteller, M. (2011). Non-coding RNAs in human disease. Nat. Rev. Genet. 12, 861-874. doi: 10.1038/nrg3074
    • (2011) Nat. Rev. Genet , vol.12 , pp. 861-874
    • Esteller, M.1
  • 26
    • 84941923663 scopus 로고    scopus 로고
    • Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution
    • Ewing, A. D., Gacita, A., Wood, L. D., Ma, F., Xing, D., Kim, M. S., et al. (2015). Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution. Genome Res. 25, 1536-1545. doi: 10.1101/gr.196238.115
    • (2015) Genome Res , vol.25 , pp. 1536-1545
    • Ewing, A.D.1    Gacita, A.2    Wood, L.D.3    Ma, F.4    Xing, D.5    Kim, M.S.6
  • 27
    • 84890559595 scopus 로고    scopus 로고
    • Long non-coding RNAs: new players in cell differentiation and development
    • Fatica, A., and Bozzoni, I. (2014). Long non-coding RNAs: new players in cell differentiation and development. Nat. Rev. 15, 7-21. doi: 10.1038/nrg3606
    • (2014) Nat. Rev , vol.15 , pp. 7-21
    • Fatica, A.1    Bozzoni, I.2
  • 28
    • 42349096534 scopus 로고    scopus 로고
    • Transposable elements and the evolution of regulatory networks
    • Feschotte, C. (2008). Transposable elements and the evolution of regulatory networks. Nat Rev. Genet. 9, 397-405. doi: 10.1038/nrg2337
    • (2008) Nat Rev. Genet , vol.9 , pp. 397-405
    • Feschotte, C.1
  • 30
    • 34047270440 scopus 로고    scopus 로고
    • Characterization of microRNA expression levels and their biological correlates in human cancer cell lines
    • Gaur, A., Jewell, D. A., Liang, Y., Ridzon, D., Moore, J. H., and Chen, C., et al. (2007). Characterization of microRNA expression levels and their biological correlates in human cancer cell lines. Cancer Res. 67, 2456-2468. doi: 10.1158/0008-5472.CAN-06-2698
    • (2007) Cancer Res , vol.67 , pp. 2456-2468
    • Gaur, A.1    Jewell, D.A.2    Liang, Y.3    Ridzon, D.4    Moore, J.H.5    Chen, C.6
  • 32
    • 52949095077 scopus 로고    scopus 로고
    • Retrotransposons revisited: the restraint and rehabilitation of parasites
    • Goodier, J. L., and Kazazian, H. H. Jr. (2008). Retrotransposons revisited: the restraint and rehabilitation of parasites. Cell 135, 23-35. doi: 10.1016/j.cell.2008.09.022
    • (2008) Cell , vol.135 , pp. 23-35
    • Goodier, J.L.1    Kazazian, H.H.2
  • 33
    • 84890159577 scopus 로고    scopus 로고
    • Increased expression and copy number amplification of LINE-1 and SINE B1 retrotransposable elements in murine mammary carcinoma progression
    • Gualtieri, A., Andreola, F., Sciamanna, I., Sinibaldi-Vallebona, P., Serafino, A., and Spadafora, C. (2013). Increased expression and copy number amplification of LINE-1 and SINE B1 retrotransposable elements in murine mammary carcinoma progression. Oncotarget 4, 1882-1893. doi: 10.18632/oncotarget.1188
    • (2013) Oncotarget , vol.4 , pp. 1882-1893
    • Gualtieri, A.1    Andreola, F.2    Sciamanna, I.3    Sinibaldi-Vallebona, P.4    Serafino, A.5    Spadafora, C.6
  • 34
    • 0026587657 scopus 로고
    • Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease
    • Guy, C. T., Cardiff, R. D., and Muller, W. J. (1992). Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol. Cell. Biol. 12, 954-961. doi: 10.1128/MCB.12.3.954
    • (1992) Mol. Cell. Biol , vol.12 , pp. 954-961
    • Guy, C.T.1    Cardiff, R.D.2    Muller, W.J.3
  • 35
    • 0036053548 scopus 로고    scopus 로고
    • Mobile genetic element activation and genotoxic cancer therapy potential clinical implications
    • Hagan, C. R., and Rudin, C. M. (2002). Mobile genetic element activation and genotoxic cancer therapy potential clinical implications. Am. J. Pharmacogenomics 2, 25-35. doi: 10.2165/00129785-200202010-00003
    • (2002) Am. J. Pharmacogenomics , vol.2 , pp. 25-35
    • Hagan, C.R.1    Rudin, C.M.2
  • 36
    • 84895909846 scopus 로고    scopus 로고
    • Rethinking the war on cancer
    • Hanahan, D. (2014). Rethinking the war on cancer. Lancet 383, 558-563. doi: 10.1016/S0140-6736(13)62226-6
    • (2014) Lancet , vol.383 , pp. 558-563
    • Hanahan, D.1
  • 37
    • 84862507347 scopus 로고    scopus 로고
    • Active human retrotransposons: variation and disease
    • Hancks, D. C., and Kazazian, H. H. Jr. (2012). Active human retrotransposons: variation and disease. Curr. Opin. Genet. Dev. 22, 191-203. doi: 10.1016/j.gde.2012.02.006
    • (2012) Curr. Opin. Genet. Dev , vol.22 , pp. 191-203
    • Hancks, D.C.1    Kazazian, H.H.2
  • 38
    • 84939223990 scopus 로고    scopus 로고
    • Efavirenz has the highest anti-proliferative effect of non-nucleoside reverse transcriptase pnhibitors against pancreatic cancer cells
    • Hecht, M., Erber, S., Harrer, T., Klinker, H., Roth, T., Parsch, H., et al. (2015). Efavirenz has the highest anti-proliferative effect of non-nucleoside reverse transcriptase pnhibitors against pancreatic cancer cells. PLoS ONE 10:e0130277. doi: 10.1371/journal.pone.0130277
    • (2015) PLoS ONE , vol.10
    • Hecht, M.1    Erber, S.2    Harrer, T.3    Klinker, H.4    Roth, T.5    Parsch, H.6
  • 39
    • 77955702253 scopus 로고    scopus 로고
    • Retroviral reverse transcriptases
    • Herschhorn, A., and Hizi, A. (2010). Retroviral reverse transcriptases. Cell. Mol. Life Sci. 67, 2717-2747. doi: 10.1007/s00018-010-0346-2
    • (2010) Cell. Mol. Life Sci , vol.67 , pp. 2717-2747
    • Herschhorn, A.1    Hizi, A.2
  • 40
    • 84919393196 scopus 로고    scopus 로고
    • A phase II trial evaluating the efficacy and safety of efavirenz in metastatic castration-resistant prostate cancer
    • Houédé, N., Pulido, M., Mourey, L., Joly, F., Ferrero, J. M., Bellera, C., et al. (2014). A phase II trial evaluating the efficacy and safety of efavirenz in metastatic castration-resistant prostate cancer. Oncologist 19, 1227-1228. doi: 10.1634/theoncologist.2014-0345
    • (2014) Oncologist , vol.19 , pp. 1227-1228
    • Houédé, N.1    Pulido, M.2    Mourey, L.3    Joly, F.4    Ferrero, J.M.5    Bellera, C.6
  • 41
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome
    • International Human Genome Sequencing Consortium (2001). Initial sequencing and analysis of the human genome. Nature 409, 860-921. doi: 10.1038/35057062
    • (2001) Nature , vol.409 , pp. 860-921
  • 42
    • 77953889472 scopus 로고    scopus 로고
    • Natural mutagenesis of human genomes by endogenous retrotransposons
    • Iskow, R. C., McCabe, M. T., Mills, R. E., Torene, S., Pittard, W. S., Neuwald, A. F., et al. (2010). Natural mutagenesis of human genomes by endogenous retrotransposons. Cell 141, 1253-1261. doi: 10.1016/j.cell.2010.05.020
    • (2010) Cell , vol.141 , pp. 1253-1261
    • Iskow, R.C.1    McCabe, M.T.2    Mills, R.E.3    Torene, S.4    Pittard, W.S.5    Neuwald, A.F.6
  • 43
    • 84869866890 scopus 로고    scopus 로고
    • MicroRNA and cancer
    • Jansson, M. D., and Lund, A. H. (2012). MicroRNA and cancer. Mol. Oncol. 6, 590-610. doi: 10.1016/j.molonc.2012.09.006
    • (2012) Mol. Oncol , vol.6 , pp. 590-610
    • Jansson, M.D.1    Lund, A.H.2
  • 44
    • 0026621858 scopus 로고
    • The first human genes for tRNA(ArgICG), tRNA(GlyUCC), and tRNA(ThrIGU) and more tRNA(Val) pseudogenes: expression and pre-tRNA maturation in HeLa cell-free extracts
    • Kaçar, Y., Thomann, H. U., and Gross, H. J. (1992). The first human genes for tRNA(ArgICG), tRNA(GlyUCC), and tRNA(ThrIGU) and more tRNA(Val) pseudogenes: expression and pre-tRNA maturation in HeLa cell-free extracts. DNA Cell Biol. 11, 781-790. doi: 10.1089/dna.1992.11.781
    • (1992) DNA Cell Biol , vol.11 , pp. 781-790
    • Kaçar, Y.1    Thomann, H.U.2    Gross, H.J.3
  • 45
    • 84875377539 scopus 로고    scopus 로고
    • Retroelements in human disease
    • Kaer, K., and Speek, M. (2013). Retroelements in human disease. Gene 518, 231-241. doi: 10.1016/j.gene.2013.01.008
    • (2013) Gene , vol.518 , pp. 231-241
    • Kaer, K.1    Speek, M.2
  • 46
    • 39749137048 scopus 로고    scopus 로고
    • Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer
    • Kaiser, S., Park, Y. K., Franklin, J. L., Halberg, R. B., Yu, M., Jessen, W. J., et al. (2007). Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol. 8:R131. doi: 10.1186/gb-2007-8-7-r131
    • (2007) Genome Biol , vol.8 , pp. R131
    • Kaiser, S.1    Park, Y.K.2    Franklin, J.L.3    Halberg, R.B.4    Yu, M.5    Jessen, W.J.6
  • 47
    • 84885735554 scopus 로고    scopus 로고
    • Mutational landscape and significance across 12 major cancer types
    • Kandoth, C., McLellan, M. D., Vandin, F., Ye, K., Niu, B., Lu, C., et al. (2013). Mutational landscape and significance across 12 major cancer types. Nature 502, 333-339. doi: 10.1038/nature12634
    • (2013) Nature , vol.502 , pp. 333-339
    • Kandoth, C.1    McLellan, M.D.2    Vandin, F.3    Ye, K.4    Niu, B.5    Lu, C.6
  • 48
    • 66149168927 scopus 로고    scopus 로고
    • L1 retrotransposition occurs mainly in embryogenesis and creates somatic mosaicism
    • Kano, H., Godoy, I., Courtney, C., Vetter, M. R., Gerton, G. L., Ostertag, E. M., et al. (2009). L1 retrotransposition occurs mainly in embryogenesis and creates somatic mosaicism. Genes Dev. 23, 1303-1312. doi: 10.1101/gad.1803909
    • (2009) Genes Dev , vol.23 , pp. 1303-1312
    • Kano, H.1    Godoy, I.2    Courtney, C.3    Vetter, M.R.4    Gerton, G.L.5    Ostertag, E.M.6
  • 49
    • 84876864345 scopus 로고    scopus 로고
    • Transposable elements are major contributors to the origin, diversification, and regulation of vertebrate long noncoding RNAs
    • Kapusta, A., Kronenberg, Z., Lynch, V. J., Zhuo, X., Ramsay, L. A., Bourque, G., et al. (2013). Transposable elements are major contributors to the origin, diversification, and regulation of vertebrate long noncoding RNAs. PLoS Genet. 9:e1003470. doi: 10.1371/journal.pgen.1003470
    • (2013) PLoS Genet , vol.9
    • Kapusta, A.1    Kronenberg, Z.2    Lynch, V.J.3    Zhuo, X.4    Ramsay, L.A.5    Bourque, G.6
  • 50
    • 84869881863 scopus 로고    scopus 로고
    • Transposable elements reveal a stem cell-specific class of long noncoding RNAs
    • Kelley, D., and Rinn, J. (2012). Transposable elements reveal a stem cell-specific class of long noncoding RNAs. Genome Biol. 13:R107. doi: 10.1186/gb-2012-13-11-r107
    • (2012) Genome Biol , vol.13 , pp. R107
    • Kelley, D.1    Rinn, J.2
  • 51
    • 58849112575 scopus 로고    scopus 로고
    • Biogenesis of small RNAs in animals
    • Kim, V. N., Han, J., and Siomi, M. C. (2009). Biogenesis of small RNAs in animals. Nat. Rev. Mol. Cell Biol. 10, 126-139. doi: 10.1038/nrm2632
    • (2009) Nat. Rev. Mol. Cell Biol , vol.10 , pp. 126-139
    • Kim, V.N.1    Han, J.2    Siomi, M.C.3
  • 52
    • 63049102497 scopus 로고    scopus 로고
    • Parallel progression of primary tumours and metastases
    • Klein, C. A. (2009). Parallel progression of primary tumours and metastases. Nat. Rev. Cancer 9, 302-312. doi: 10.1038/nrc2627
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 302-312
    • Klein, C.A.1
  • 53
    • 33745864020 scopus 로고    scopus 로고
    • Cis-preferential LINE-1 reverse transcriptase activity in ribonucleoprotein particles
    • Kulpa, D. A., and Moran, J. V. (2006). Cis-preferential LINE-1 reverse transcriptase activity in ribonucleoprotein particles. Nat. Struc. Mol. Biol. 13, 655-660. doi: 10.1038/nsmb1107
    • (2006) Nat. Struc. Mol. Biol , vol.13 , pp. 655-660
    • Kulpa, D.A.1    Moran, J.V.2
  • 54
    • 26244437260 scopus 로고    scopus 로고
    • Reverse transcriptase inhibitors downregulate cell proliferation in vitro and in vivo and restore TSH signaling and iodine uptake in human thyroid anaplastic carcinoma
    • Landriscina, M., Fabiano, A., Altamura, S., Bagala, C., Piscazzi, A., Cassano, A., et al. (2005). Reverse transcriptase inhibitors downregulate cell proliferation in vitro and in vivo and restore TSH signaling and iodine uptake in human thyroid anaplastic carcinoma. J. Clin. Endocrinol. Metab. 90, 5663-5671. doi: 10.1210/jc.2005-0367
    • (2005) J. Clin. Endocrinol. Metab , vol.90 , pp. 5663-5671
    • Landriscina, M.1    Fabiano, A.2    Altamura, S.3    Bagala, C.4    Piscazzi, A.5    Cassano, A.6
  • 55
    • 84865285978 scopus 로고    scopus 로고
    • Landscape of somatic retrotransposition in human cancers
    • Lee, E., Iskow, R., Yang, L., Gokcumen, O., Haseley, P., Luquette, L. J. III., et al. (2012). Landscape of somatic retrotransposition in human cancers. Science 337, 967-971. doi: 10.1126/science.1222077
    • (2012) Science , vol.337 , pp. 967-971
    • Lee, E.1    Iskow, R.2    Yang, L.3    Gokcumen, O.4    Haseley, P.5    Luquette, L.J.6
  • 57
    • 0034816040 scopus 로고    scopus 로고
    • Differentiation therapy of human cancer: basic science and clinical applications
    • Leszczyniecka, M., Roberts, T., Dent, P., Grant, S., and Fisher, P. B. (2001). Differentiation therapy of human cancer: basic science and clinical applications. Pharmacol. Ther. 90, 105-196. doi: 10.1016/S0163-7258(01)00132-2
    • (2001) Pharmacol. Ther , vol.90 , pp. 105-196
    • Leszczyniecka, M.1    Roberts, T.2    Dent, P.3    Grant, S.4    Fisher, P.B.5
  • 58
    • 80051997952 scopus 로고    scopus 로고
    • Dynamic interactions between transposable elements and their hosts
    • Levin, H. L., and Moran, J. V. (2011). Dynamic interactions between transposable elements and their hosts. Nat. Rev. Genet. 12, 615-627. doi: 10.1038/nrg3030
    • (2011) Nat. Rev. Genet , vol.12 , pp. 615-627
    • Levin, H.L.1    Moran, J.V.2
  • 59
    • 84891930123 scopus 로고    scopus 로고
    • Chromatin remodeling by the small RNA machinery in mammalian cells
    • Li, L. C. (2014). Chromatin remodeling by the small RNA machinery in mammalian cells. Epigenetics 9, 1-8. doi: 10.4161/epi.26830
    • (2014) Epigenetics , vol.9 , pp. 1-8
    • Li, L.C.1
  • 60
    • 0036392034 scopus 로고    scopus 로고
    • Epigenetics wins over genetics: induction of differentiation in tumor cells
    • Lotem, J., and Sachs, L. (2002). Epigenetics wins over genetics: induction of differentiation in tumor cells. Semin. Cancer Biol. 12, 339-346. doi: 10.1016/S1044-579X(02)00054-8
    • (2002) Semin. Cancer Biol , vol.12 , pp. 339-346
    • Lotem, J.1    Sachs, L.2
  • 61
    • 84865415008 scopus 로고    scopus 로고
    • 29 Mammalian genomes reveal novel exaptations of mobile elements for likely regulatory functions in the human genome
    • Lowe, C. B., and Haussler, D. (2012). 29 Mammalian genomes reveal novel exaptations of mobile elements for likely regulatory functions in the human genome. PLoS ONE 7:e43128. doi: 10.1371/journal.pone.0043128
    • (2012) PLoS ONE , vol.7
    • Lowe, C.B.1    Haussler, D.2
  • 62
    • 20444460289 scopus 로고    scopus 로고
    • MicroRNA expression profiles classify human cancers
    • Lu, J., Getz, G., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., and Peck, D., et al. (2005). MicroRNA expression profiles classify human cancers. Nature 435, 834-838. doi: 10.1038/nature03702
    • (2005) Nature , vol.435 , pp. 834-838
    • Lu, J.1    Getz, G.2    Miska, E.A.3    Alvarez-Saavedra, E.4    Lamb, J.5    Peck, D.6
  • 63
    • 78650074133 scopus 로고    scopus 로고
    • The relationship between early embryo development and tumourigenesis
    • Ma, Y., Zhang P., Wang, F., Yang, J., Yang, Z., and Qin, H. (2010). The relationship between early embryo development and tumourigenesis. J. Cell. Mol. Med. 14, 2697-2701. doi: 10.1111/j.1582-4934.2010.01191.x
    • (2010) J. Cell. Mol. Med , vol.14 , pp. 2697-2701
    • Ma, Y.1    Zhang, P.2    Wang, F.3    Yang, J.4    Yang, Z.5    Qin, H.6
  • 64
    • 60149098474 scopus 로고    scopus 로고
    • Small RNAs as guardians of the genome
    • Malone, C. D., and Hannon, G. J. (2009). Small RNAs as guardians of the genome. Cell 136, 656-668. doi: 10.1016/j.cell.2009.01.045
    • (2009) Cell , vol.136 , pp. 656-668
    • Malone, C.D.1    Hannon, G.J.2
  • 65
    • 0037955469 scopus 로고    scopus 로고
    • Exposure of normal and transformed cells to nevirapine, a reverse transcriptase inhibitor, reduces cell growth and promotes differentiation
    • Mangiacasale, R., Pittoggi, C., Sciamanna, I., Careddu, A., Mattei, E., Lorenzini, R., et al. (2003). Exposure of normal and transformed cells to nevirapine, a reverse transcriptase inhibitor, reduces cell growth and promotes differentiation. Oncogene 22, 2750-2761. doi: 10.1038/sj.onc.1206354
    • (2003) Oncogene , vol.22 , pp. 2750-2761
    • Mangiacasale, R.1    Pittoggi, C.2    Sciamanna, I.3    Careddu, A.4    Mattei, E.5    Lorenzini, R.6
  • 66
    • 84884377472 scopus 로고    scopus 로고
    • Tumour heterogeneity and cancer cell plasticity
    • Meachem, C. E., and Morrison, S. J. (2013). Tumour heterogeneity and cancer cell plasticity. Nature 501, 328-337. doi: 10.1038/nature12624
    • (2013) Nature , vol.501 , pp. 328-337
    • Meachem, C.E.1    Morrison, S.J.2
  • 67
    • 0026503996 scopus 로고
    • Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer
    • Miki, Y., Nishisho, I., Horii, A., Miyoshi, Y., Utsunomiya, J., Kinzler, K. W., et al. (1992). Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer. Cancer Res. 52, 643-645.
    • (1992) Cancer Res , vol.52 , pp. 643-645
    • Miki, Y.1    Nishisho, I.2    Horii, A.3    Miyoshi, Y.4    Utsunomiya, J.5    Kinzler, K.W.6
  • 68
    • 84939469319 scopus 로고    scopus 로고
    • The Fine LINE: methylation drawing the cancer landscape
    • Miousse, I. R., and Koturbash, I. (2015). The Fine LINE: methylation drawing the cancer landscape. Biomed Res. Int. 2015:131547. doi: 10.1155/2015/131547
    • (2015) Biomed Res. Int , vol.2015
    • Miousse, I.R.1    Koturbash, I.2
  • 69
    • 0023947487 scopus 로고
    • Insertional mutagenesis of the myc locus by a LINE-1 sequence in a hu-man breast carcinoma
    • Morse, B., Rotherg, P. G., South, V. J., Spandorfer, J. M., and Astrin, S. M. (1988). Insertional mutagenesis of the myc locus by a LINE-1 sequence in a hu-man breast carcinoma. Nature 333, 87-90. doi: 10.1038/333087a0
    • (1988) Nature , vol.333 , pp. 87-90
    • Morse, B.1    Rotherg, P.G.2    South, V.J.3    Spandorfer, J.M.4    Astrin, S.M.5
  • 70
    • 77950394199 scopus 로고    scopus 로고
    • DNA Transposons: Nature and application in Genomics
    • Muñoz-López, M., and García-Pérez, J. L. (2010). DNA Transposons: Nature and application in Genomics. Curr. Biol. 11, 115-128. doi: 10.2174/138920210790886871
    • (2010) Curr. Biol , vol.11 , pp. 115-128
    • Muñoz-López, M.1    García-Pérez, J.L.2
  • 71
    • 4444292985 scopus 로고    scopus 로고
    • Highly penetrant hereditary cancer syndromes
    • Nagy, R., Sweet, K., and Eng, C. (2004). Highly penetrant hereditary cancer syndromes. Oncogene 23, 6445-6470. doi: 10.1038/sj.onc.1207714
    • (2004) Oncogene , vol.23 , pp. 6445-6470
    • Nagy, R.1    Sweet, K.2    Eng, C.3
  • 73
    • 84875082455 scopus 로고    scopus 로고
    • Conserved non-coding elements and cis regulation: actions speak louder than words
    • Nelson, A. C., and Wardle, F. C. (2013). Conserved non-coding elements and cis regulation: actions speak louder than words. Development 140, 1385-1395. doi: 10.1242/dev.084459
    • (2013) Development , vol.140 , pp. 1385-1395
    • Nelson, A.C.1    Wardle, F.C.2
  • 74
    • 33745620751 scopus 로고    scopus 로고
    • Functional noncoding sequences derived from SINEs in the mammalian genome
    • Nishihara, H., Smit, A. F. A., and Okada, N. (2006). Functional noncoding sequences derived from SINEs in the mammalian genome. Genome Res. 16, 864-874. doi: 10.1101/gr.5255506
    • (2006) Genome Res , vol.16 , pp. 864-874
    • Nishihara, H.1    Smit, A.F.A.2    Okada, N.3
  • 75
    • 84917683573 scopus 로고    scopus 로고
    • LINE-1 retrotransposons and let-7 miRNA: partners in the pathogenesis of cancer?
    • Ohms, S., Lee, S. H., and Rangasamy, D. (2014). LINE-1 retrotransposons and let-7 miRNA: partners in the pathogenesis of cancer? Front Genet. 5:338. doi: 10.3389/fgene.2014.00338
    • (2014) Front Genet , vol.5 , pp. 338
    • Ohms, S.1    Lee, S.H.2    Rangasamy, D.3
  • 76
    • 84905096226 scopus 로고    scopus 로고
    • Silencing of LINE-1 retrotransposons contributes to variation in small noncoding RNA expression in human cancer cells
    • Ohms, S., and Rangasamy, D. (2014). Silencing of LINE-1 retrotransposons contributes to variation in small noncoding RNA expression in human cancer cells. Oncotarget 5, 4103-4117. doi: 10.18632/oncotarget.1822
    • (2014) Oncotarget , vol.5 , pp. 4103-4117
    • Ohms, S.1    Rangasamy, D.2
  • 77
    • 0015271630 scopus 로고
    • So much "junk" DNA in our genome
    • Ohno, S. (1972). So much "junk" DNA in our genome. Brookhaven Symp. Biol. 23, 366-370.
    • (1972) Brookhaven Symp. Biol , vol.23 , pp. 366-370
    • Ohno, S.1
  • 78
    • 80053266481 scopus 로고    scopus 로고
    • Mobile DNA and the TE-Thrust hypothesis: supporting evidence from the primates
    • Oliver, K. R., and Greene, W. K. (2011). Mobile DNA and the TE-Thrust hypothesis: supporting evidence from the primates. Mob. DNA 2:8. doi: 10.1186/1759-8753-2-8
    • (2011) Mob. DNA , vol.2 , pp. 8
    • Oliver, K.R.1    Greene, W.K.2
  • 79
    • 0018857680 scopus 로고
    • Selfish DNA: the ultimate parasite
    • Orgel, L. E., and Crick, F. H. (1980). Selfish DNA: the ultimate parasite. Nature 284, 604-607. doi: 10.1038/284604a0
    • (1980) Nature , vol.284 , pp. 604-607
    • Orgel, L.E.1    Crick, F.H.2
  • 80
    • 34250803852 scopus 로고    scopus 로고
    • Distinct roles for LINE-1 and Herv-K retroelements in cell proliferation, differentiation and tumor progression
    • Oricchio, E., Beraldi, R., Sciamanna, I., Tolstonog, G. V., Schumann, G. G., and Spadafora, C. (2007). Distinct roles for LINE-1 and Herv-K retroelements in cell proliferation, differentiation and tumor progression. Oncogene 26, 4226-4233. doi: 10.1038/sj.onc.1210214
    • (2007) Oncogene , vol.26 , pp. 4226-4233
    • Oricchio, E.1    Beraldi, R.2    Sciamanna, I.3    Tolstonog, G.V.4    Schumann, G.G.5    Spadafora, C.6
  • 81
    • 0345636604 scopus 로고    scopus 로고
    • SVA elements are nonautonomous retrotransposons that cause disease in humans
    • Ostertag, E. M., Goodier, J. L., Zhang, Y., and Kazazain, H. H. Jr. (2003). SVA elements are nonautonomous retrotransposons that cause disease in humans. Am. J. Hum. Genet. 73, 1444-1451. doi: 10.1086/380207
    • (2003) Am. J. Hum. Genet , vol.73 , pp. 1444-1451
    • Ostertag, E.M.1    Goodier, J.L.2    Zhang, Y.3    Kazazain, H.H.4
  • 82
    • 84893093139 scopus 로고    scopus 로고
    • Inhibition of LINE-1 retrotransposon-encoded reverse transcriptase modulates the expression of cell differentiation genes in breast cancer cells
    • Patnala, R., Lee, S. H., Dahlstrom, J. E., Ohms, S., Chen, L., Dheen, S. T., et al. (2013). Inhibition of LINE-1 retrotransposon-encoded reverse transcriptase modulates the expression of cell differentiation genes in breast cancer cells. Breast. Cancer Res. Treat 143, 239-253. doi: 10.1007/s10549-013-2812-7
    • (2013) Breast. Cancer Res. Treat , vol.143 , pp. 239-253
    • Patnala, R.1    Lee, S.H.2    Dahlstrom, J.E.3    Ohms, S.4    Chen, L.5    Dheen, S.T.6
  • 83
    • 84887995915 scopus 로고    scopus 로고
    • Gene regulation by antisense transcription
    • Pelechano, V., and Steinmetz, L. M. (2013). Gene regulation by antisense transcription. Nat Rev. 14, 880-893. doi: 10.1038/nrg3594
    • (2013) Nat Rev , vol.14 , pp. 880-893
    • Pelechano, V.1    Steinmetz, L.M.2
  • 84
    • 17144393758 scopus 로고    scopus 로고
    • Retropseudogenes derived from the human Ro/SS-A autoantigen-associated hY RNAs
    • Perreault, J., Noël, J. F., Brière, F., Cousineau, B., Lucier, J. F., et al. (2005). Retropseudogenes derived from the human Ro/SS-A autoantigen-associated hY RNAs. Nucleic Acids Res. 33, 2032-2041. doi: 10.1093/nar/gki504
    • (2005) Nucleic Acids Res , vol.33 , pp. 2032-2041
    • Perreault, J.1    Noël, J.F.2    Brière, F.3    Cousineau, B.4    Lucier, J.F.5
  • 85
    • 84905860997 scopus 로고    scopus 로고
    • Endogenous siRNAs: regulators of internal affairs
    • Piatek, M. J., and Werner, A. (2014). Endogenous siRNAs: regulators of internal affairs. Biochem. Soc. Trans. 42, 1174-1179. doi: 10.1042/BST20140068
    • (2014) Biochem. Soc. Trans , vol.42 , pp. 1174-1179
    • Piatek, M.J.1    Werner, A.2
  • 86
    • 79955035120 scopus 로고    scopus 로고
    • Pseudogenes: Pseudo-functional or key regulators in health and disease?
    • Pink, R. C., Wicks, K., Caley, D. P., Punch, E. K., Jacobs, L., and Carter, D. R. F. (2011). Pseudogenes: Pseudo-functional or key regulators in health and disease? RNA 17, 792-798. doi: 10.1261/rna.2658311
    • (2011) RNA , vol.17 , pp. 792-798
    • Pink, R.C.1    Wicks, K.2    Caley, D.P.3    Punch, E.K.4    Jacobs, L.5    Carter, D.R.F.6
  • 87
    • 0141571160 scopus 로고    scopus 로고
    • Role of endogenous reverse transcriptase in murine early embryo development
    • Pittoggi, C., Sciamanna, I., Mattei, E., Beraldi, R., Lobascio, A. M., Mai, A., et al. (2003). Role of endogenous reverse transcriptase in murine early embryo development. Mol. Reprod. Dev. 66, 225-236. doi: 10.1002/mrd.10349
    • (2003) Mol. Reprod. Dev , vol.66 , pp. 225-236
    • Pittoggi, C.1    Sciamanna, I.2    Mattei, E.3    Beraldi, R.4    Lobascio, A.M.5    Mai, A.6
  • 88
    • 84867050577 scopus 로고    scopus 로고
    • Transposable elements: an abundant and natural source of regulatory sequences for host genes
    • Rebollo, R., Romanish, M. T., and Mager, D. L. (2012). Transposable elements: an abundant and natural source of regulatory sequences for host genes. Annu. Rev. Genet. 46, 21-42. doi: 10.1146/annurev-genet-110711-155621
    • (2012) Annu. Rev. Genet , vol.46 , pp. 21-42
    • Rebollo, R.1    Romanish, M.T.2    Mager, D.L.3
  • 89
    • 84875999688 scopus 로고    scopus 로고
    • Long interspersed element-1 (LINE-1): passenger or driver in human neoplasms?
    • Rodic, N., and Burns, K. H. (2013). Long interspersed element-1 (LINE-1): passenger or driver in human neoplasms? PLoS Genet. 9:e1003402. doi: 10.1371/journal.pgen.1003402
    • (2013) PLoS Genet , vol.9
    • Rodic, N.1    Burns, K.H.2
  • 90
    • 84899548825 scopus 로고    scopus 로고
    • Long Interspersed Element-1 protein expression is a hallmark of many human cancers
    • Rodic, N., Sharma, R., Sharma, R., Zampella, J., Dai, L., Taylor, M. S., et al. (2014). Long Interspersed Element-1 protein expression is a hallmark of many human cancers. Am. J. Pathol. 184, 1280-1286. doi: 10.1016/j.ajpath.2014.01.007
    • (2014) Am. J. Pathol , vol.184 , pp. 1280-1286
    • Rodic, N.1    Sharma, R.2    Sharma, R.3    Zampella, J.4    Dai, L.5    Taylor, M.S.6
  • 91
    • 84941024427 scopus 로고    scopus 로고
    • Retrotransposon insertions in the clonal evolution of pancreatic ductal adenocarcinoma
    • Rodic, N., Steranka, J. P., Makohon-Moore, A., Moyer, A., Shen, P., Sharma, R., et al. (2015). Retrotransposon insertions in the clonal evolution of pancreatic ductal adenocarcinoma. Nat. Med. 21, 1060-1064. doi: 10.1038/nm.3919
    • (2015) Nat. Med , vol.21 , pp. 1060-1064
    • Rodic, N.1    Steranka, J.P.2    Makohon-Moore, A.3    Moyer, A.4    Shen, P.5    Sharma, R.6
  • 92
    • 84891928406 scopus 로고    scopus 로고
    • A tumor-promoting mechanism mediated by retrotransposon-encoded reverse transcriptase is active in human transformed cell lines
    • Sciamanna, I., Gualtieri, A., Cossetti, C., Osimo, E. F., Ferracin, M., Macchia, G., et al. (2013). A tumor-promoting mechanism mediated by retrotransposon-encoded reverse transcriptase is active in human transformed cell lines. Oncotarget 4, 2271-2287. doi: 10.18632/oncotarget.1403
    • (2013) Oncotarget , vol.4 , pp. 2271-2287
    • Sciamanna, I.1    Gualtieri, A.2    Cossetti, C.3    Osimo, E.F.4    Ferracin, M.5    Macchia, G.6
  • 93
    • 84907994611 scopus 로고    scopus 로고
    • Regulatory roles of LINE-1-encoded reverse transcriptase in cancer onset and progression
    • Sciamanna, I., Gualtieri, A., Piazza, P. V., and Spadafora, C. (2014). Regulatory roles of LINE-1-encoded reverse transcriptase in cancer onset and progression. Oncotarget 5, 8039-8051. doi: 10.18632/oncotarget.2504
    • (2014) Oncotarget , vol.5 , pp. 8039-8051
    • Sciamanna, I.1    Gualtieri, A.2    Piazza, P.V.3    Spadafora, C.4
  • 94
    • 20544437829 scopus 로고    scopus 로고
    • Inhibition of endogenous reverse transcriptase antagonizes human tumor growth
    • Sciamanna, I., Landriscina, M., Pittoggi, C., Quirino, M., Marelli, C., Beraldi, R., et al. (2005). Inhibition of endogenous reverse transcriptase antagonizes human tumor growth. Oncogene 24, 3923-3931. doi: 10.1038/sj.onc.1208562
    • (2005) Oncogene , vol.24 , pp. 3923-3931
    • Sciamanna, I.1    Landriscina, M.2    Pittoggi, C.3    Quirino, M.4    Marelli, C.5    Beraldi, R.6
  • 95
    • 79959691959 scopus 로고    scopus 로고
    • A reverse transcriptase-dependent mechanism is essential for murine preimplantation development
    • Sciamanna, I., Vitullo, P., Curatolo, A., and Spadafora, C. (2011). A reverse transcriptase-dependent mechanism is essential for murine preimplantation development. Genes 2, 360-373. doi: 10.3390/genes2020360
    • (2011) Genes , vol.2 , pp. 360-373
    • Sciamanna, I.1    Vitullo, P.2    Curatolo, A.3    Spadafora, C.4
  • 96
    • 84875698271 scopus 로고    scopus 로고
    • Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma
    • Shukla, R., Upton, K. R., Muñoz-Lopez, M., Gerhardt, D. J., Fisher, M. E., Nguyen, T., et al. (2013). Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma. Cell 153, 101-111. doi: 10.1016/j.cell.2013.02.032
    • (2013) Cell , vol.153 , pp. 101-111
    • Shukla, R.1    Upton, K.R.2    Muñoz-Lopez, M.3    Gerhardt, D.J.4    Fisher, M.E.5    Nguyen, T.6
  • 97
    • 79953691143 scopus 로고    scopus 로고
    • Retrotransposon-encoded reverse transcriptase in the genesis, progression and cellular plasticity of human cancer
    • Sinibaldi-Vallebona, P., Matteucci, C., and Spadafora, C. (2011). Retrotransposon-encoded reverse transcriptase in the genesis, progression and cellular plasticity of human cancer. Cancers 3, 1141-1157. doi: 10.3390/cancers3011141
    • (2011) Cancers , vol.3 , pp. 1141-1157
    • Sinibaldi-Vallebona, P.1    Matteucci, C.2    Spadafora, C.3
  • 98
    • 33947303168 scopus 로고    scopus 로고
    • Transposable elements and the epigenetic regulation of the genome
    • Slotkin, R. K., and Martienssen, R. (2007). Transposable elements and the epigenetic regulation of the genome. Nat. Rev. Genet. 8, 272-285. doi: 10.1038/nrg2072
    • (2007) Nat. Rev. Genet , vol.8 , pp. 272-285
    • Slotkin, R.K.1    Martienssen, R.2
  • 99
    • 84870482898 scopus 로고    scopus 로고
    • Extensive somatic L1 retrotransposition in colorectal tumors
    • Solyom, S., Ewing, A. D., Rahrmann, E. P., Doucet, T., Nelson, H. H., Burns, M. B., et al. (2012). Extensive somatic L1 retrotransposition in colorectal tumors. Genome Res. 22, 2328-2338. doi: 10.1101/gr.145235.112
    • (2012) Genome Res , vol.22 , pp. 2328-2338
    • Solyom, S.1    Ewing, A.D.2    Rahrmann, E.P.3    Doucet, T.4    Nelson, H.H.5    Burns, M.B.6
  • 100
    • 84923952286 scopus 로고    scopus 로고
    • A Big Bang model of human colorectal tumor growth
    • Sottoriva, A., Kang, H., Ma, Z., Graham, T. A., Salomon, M. P., Zhao, J., et al. (2015). A Big Bang model of human colorectal tumor growth. Nat. Genet. 47, 209-216. doi: 10.1038/ng.3214
    • (2015) Nat. Genet , vol.47 , pp. 209-216
    • Sottoriva, A.1    Kang, H.2    Ma, Z.3    Graham, T.A.4    Salomon, M.P.5    Zhao, J.6
  • 101
    • 44249124060 scopus 로고    scopus 로고
    • Sperm-mediated 'reverse' gene transfer: a role of reverse transcriptase in the generation of new genetic information
    • Spadafora, C. (2008). Sperm-mediated 'reverse' gene transfer: a role of reverse transcriptase in the generation of new genetic information. Hum. Reprod. 23, 735-740. doi: 10.1093/humrep/dem425
    • (2008) Hum. Reprod , vol.23 , pp. 735-740
    • Spadafora, C.1
  • 102
    • 84926197939 scopus 로고    scopus 로고
    • A LINE-1-encoded reverse transcriptase-dependent regulatory mechanism is active in embryogenesis and tumorigenesis
    • Spadafora, C. (2015). A LINE-1-encoded reverse transcriptase-dependent regulatory mechanism is active in embryogenesis and tumorigenesis. Ann. N.Y. Acad. Sci. 1341, 164-171. doi: 10.1111/nyas.12637
    • (2015) Ann. N.Y. Acad. Sci , vol.1341 , pp. 164-171
    • Spadafora, C.1
  • 103
    • 84856071488 scopus 로고    scopus 로고
    • Cancers of unknown primary origin: current perspectives and future therapeutic strategies
    • Stella, G. M., Senetta, R., Cassenti, A., Ronco, M., and Cassoni, P. (2012). Cancers of unknown primary origin: current perspectives and future therapeutic strategies. J. Translat. Med. 10:12. doi: 10.1186/1479-5876-10-12
    • (2012) J. Translat. Med , vol.10 , pp. 12
    • Stella, G.M.1    Senetta, R.2    Cassenti, A.3    Ronco, M.4    Cassoni, P.5
  • 104
    • 75749098853 scopus 로고    scopus 로고
    • MicroRNA function is globally suppressed in mouse oocytes and early embryos
    • Suh, N., Baehner, L., Moltzahn, F., Melton, C., Shenoy, A., Chen, J., et al. (2010). MicroRNA function is globally suppressed in mouse oocytes and early embryos. Curr. Biol. 20, 271-277. doi: 10.1016/j.cub.2009.12.044
    • (2010) Curr. Biol , vol.20 , pp. 271-277
    • Suh, N.1    Baehner, L.2    Moltzahn, F.3    Melton, C.4    Shenoy, A.5    Chen, J.6
  • 105
    • 78649668597 scopus 로고    scopus 로고
    • Retinoids, retinoic acid receptors, and cancer
    • Tang, X. H., and Gudas, L. J. (2011). Retinoids, retinoic acid receptors, and cancer. Annu. Rev. Pathol. 6, 345-364. doi: 10.1146/annurev-pathol-011110-130303
    • (2011) Annu. Rev. Pathol , vol.6 , pp. 345-364
    • Tang, X.H.1    Gudas, L.J.2
  • 106
    • 0015008372 scopus 로고
    • Guest editorial. The protovirus hypothesis: speculations on the significance of RNA-directed DNA synthesis for normal development and for carcinogenesis
    • Temin, H. M. (1971). Guest editorial. The protovirus hypothesis: speculations on the significance of RNA-directed DNA synthesis for normal development and for carcinogenesis. J. Natl. Cancer Inst. 46, III-VI.
    • (1971) J. Natl. Cancer Inst , vol.46 , pp. III-VI
    • Temin, H.M.1
  • 107
    • 0014964695 scopus 로고
    • RNA-dependent DNA polymerase in virions of Rous sarcoma virus
    • Temin, H. M., and Mizutani, S. (1970). RNA-dependent DNA polymerase in virions of Rous sarcoma virus. Nature 226, 1211-1213. doi: 10.1038/2261211a0
    • (1970) Nature , vol.226 , pp. 1211-1213
    • Temin, H.M.1    Mizutani, S.2
  • 108
    • 84903675449 scopus 로고    scopus 로고
    • In vitro screening for compounds that enhance human L1 mobilization
    • Terasaki, N., Goodier, J. L., Cheung, L. E., Wang, Y. J., Kajikawa, M., Kazazian, H. H. Jr., et al. (2013). In vitro screening for compounds that enhance human L1 mobilization. PLoS ONE 8:e74629. doi: 10.1371/journal.pone.0074629
    • (2013) PLoS ONE , vol.8
    • Terasaki, N.1    Goodier, J.L.2    Cheung, L.E.3    Wang, Y.J.4    Kajikawa, M.5    Kazazian, H.H.6
  • 109
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • The ENCODE and Project Consortium (2012). An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57-74. doi: 10.1038/nature11247
    • (2012) Nature , vol.489 , pp. 57-74
  • 110
    • 0021767937 scopus 로고
    • Human genes and pseudogenes for the 7SL RNA component of signal recognition particle
    • Ullu, E., and Weiner, A. M. (1984). Human genes and pseudogenes for the 7SL RNA component of signal recognition particle. EMBO J. 3, 3303-3310
    • (1984) EMBO J , vol.3 , pp. 3303-3310
    • Ullu, E.1    Weiner, A.M.2
  • 112
    • 84855926569 scopus 로고    scopus 로고
    • LINE-1 retrotransposon copies are amplified during murine early embryo development
    • Vitullo, P., Sciamanna, I., Baiocchi, M., Sinibaldi-Vallebona, P., and Spadafora, C. (2012). LINE-1 retrotransposon copies are amplified during murine early embryo development. Mol. Reprod. Dev. 79, 118-127. doi: 10.1002/mrd.22003
    • (2012) Mol. Reprod. Dev , vol.79 , pp. 118-127
    • Vitullo, P.1    Sciamanna, I.2    Baiocchi, M.3    Sinibaldi-Vallebona, P.4    Spadafora, C.5
  • 114
    • 79956052873 scopus 로고    scopus 로고
    • Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus
    • Watanabe, T., Tomizawa, S., Mitsuya, K., Totoki, Y., Yamamoto, Y., et al. (2011). Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus. Science 332, 848-852. doi: 10.1126/science.1203919
    • (2011) Science , vol.332 , pp. 848-852
    • Watanabe, T.1    Tomizawa, S.2    Mitsuya, K.3    Totoki, Y.4    Yamamoto, Y.5
  • 115
    • 0035144498 scopus 로고    scopus 로고
    • Human L1 retrotransposition: cis preference versus trans complementation
    • Wei, W., Gilbert, N., Ooi, S. L., Lawler, J. F., Ostertag, E. M., Kazazian, H. H., et al. (2001). Human L1 retrotransposition: cis preference versus trans complementation. Mol. Cell. Biol. 21, 1429-1439. doi: 10.1128/MCB.21.4.1429-1439.2001
    • (2001) Mol. Cell. Biol , vol.21 , pp. 1429-1439
    • Wei, W.1    Gilbert, N.2    Ooi, S.L.3    Lawler, J.F.4    Ostertag, E.M.5    Kazazian, H.H.6
  • 116
    • 20044366725 scopus 로고    scopus 로고
    • Highly conserved non-coding sequences are associated with vertebrate development
    • Woolfe, A., Goodson, M., Goode, D. K., Snell, P., McEwen, G. K., Vavouri, T., et al. (2005). Highly conserved non-coding sequences are associated with vertebrate development. PLoS Biol. 3:e7. doi: 10.1371/journal.pbio.0030007
    • (2005) PLoS Biol , vol.3
    • Woolfe, A.1    Goodson, M.2    Goode, D.K.3    Snell, P.4    McEwen, G.K.5    Vavouri, T.6
  • 117
    • 33748363713 scopus 로고    scopus 로고
    • L1 retrotransposition is suppressed by endogenously encoded small interfering RNAs in human cultured cells
    • Yang, N., and Kazazian, H. H. Jr. (2006). L1 retrotransposition is suppressed by endogenously encoded small interfering RNAs in human cultured cells. Nat. Struc. Mol. Biol. 13, 763-771. doi: 10.1038/nsmb1141
    • (2006) Nat. Struc. Mol. Biol , vol.13 , pp. 763-771
    • Yang, N.1    Kazazian, H.H.2
  • 118
    • 84878376400 scopus 로고    scopus 로고
    • Long non-coding RNA: a new player in cancer
    • Zhang, H., Chen, Z., Wang, X., Huang, Z., He, Z., and Chen, Y. (2013). Long non-coding RNA: a new player in cancer. J. Hemat. Oncol. 6:37. doi: 10.1186/1756-8722-6-37
    • (2013) J. Hemat. Oncol , vol.6 , pp. 37
    • Zhang, H.1    Chen, Z.2    Wang, X.3    Huang, Z.4    He, Z.5    Chen, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.