-
2
-
-
84855281420
-
Repetitive elements may comprise over two-thirds of the human genome
-
doi:10.1371/journal.pgen.1002384
-
de Koning AP, Gu W, Castoe TA, Batzer MA, Pollock DD, (2011) Repetitive elements may comprise over two-thirds of the human genome. PLoS Genet 7: e1002384 doi:10.1371/journal.pgen.1002384.
-
(2011)
PLoS Genet
, vol.7
-
-
de Koning, A.P.1
Gu, W.2
Castoe, T.A.3
Batzer, M.A.4
Pollock, D.D.5
-
3
-
-
78149432728
-
Variable tandem repeats accelerate evolution of coding and regulatory sequences
-
Gemayel R, Vinces MD, Legendre M, Verstrepen KJ, (2010) Variable tandem repeats accelerate evolution of coding and regulatory sequences. Annual Review of Genetics 44: 445-477.
-
(2010)
Annual Review of Genetics
, vol.44
, pp. 445-477
-
-
Gemayel, R.1
Vinces, M.D.2
Legendre, M.3
Verstrepen, K.J.4
-
4
-
-
0020044638
-
SINEs and LINEs: highly repeated short and long interspersed sequences in mammalian genomes
-
Singer MF, (1982) SINEs and LINEs: highly repeated short and long interspersed sequences in mammalian genomes. Cell 28: 433-434.
-
(1982)
Cell
, vol.28
, pp. 433-434
-
-
Singer, M.F.1
-
5
-
-
33745469628
-
Fitness cost of LINE-1 (L1) activity in humans
-
Boissinot S, Davis J, Entezam A, Petrov D, Furano AV, (2006) Fitness cost of LINE-1 (L1) activity in humans. Proc Natl Acad Sci U S A 103: 9590-9594.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 9590-9594
-
-
Boissinot, S.1
Davis, J.2
Entezam, A.3
Petrov, D.4
Furano, A.V.5
-
6
-
-
4544223707
-
Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L
-
Bourc'his D, Bestor TH, (2004) Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L. Nature 431: 96-99.
-
(2004)
Nature
, vol.431
, pp. 96-99
-
-
Bourc'his, D.1
Bestor, T.H.2
-
7
-
-
33947720638
-
MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline
-
Carmell MA, Girard A, van de Kant HJ, Bourc'his D, Bestor TH, et al. (2007) MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Developmental Cell 12: 503-514.
-
(2007)
Developmental Cell
, vol.12
, pp. 503-514
-
-
Carmell, M.A.1
Girard, A.2
van de Kant, H.J.3
Bourc'his, D.4
Bestor, T.H.5
-
8
-
-
0036135014
-
Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements
-
Liang G, Chan MF, Tomigahara Y, Tsai YC, Gonzales FA, et al. (2002) Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Molecular and Cellular Biology 22: 480-491.
-
(2002)
Molecular and Cellular Biology
, vol.22
, pp. 480-491
-
-
Liang, G.1
Chan, M.F.2
Tomigahara, Y.3
Tsai, Y.C.4
Gonzales, F.A.5
-
9
-
-
77955495399
-
Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells
-
Garcia-Perez JL, Morell M, Scheys JO, Kulpa DA, Morell S, et al. (2010) Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells. Nature 466: 769-773.
-
(2010)
Nature
, vol.466
, pp. 769-773
-
-
Garcia-Perez, J.L.1
Morell, M.2
Scheys, J.O.3
Kulpa, D.A.4
Morell, S.5
-
10
-
-
78549247463
-
L1 retrotransposition in neurons is modulated by MeCP2
-
Muotri AR, Marchetto MC, Coufal NG, Oefner R, Yeo G, et al. (2010) L1 retrotransposition in neurons is modulated by MeCP2. Nature 468: 443-446.
-
(2010)
Nature
, vol.468
, pp. 443-446
-
-
Muotri, A.R.1
Marchetto, M.C.2
Coufal, N.G.3
Oefner, R.4
Yeo, G.5
-
11
-
-
4644250896
-
Lsh, an epigenetic guardian of repetitive elements
-
Huang J, Fan T, Yan Q, Zhu H, Fox S, et al. (2004) Lsh, an epigenetic guardian of repetitive elements. Nucleic Acids Research 32: 5019-5028.
-
(2004)
Nucleic Acids Research
, vol.32
, pp. 5019-5028
-
-
Huang, J.1
Fan, T.2
Yan, Q.3
Zhu, H.4
Fox, S.5
-
12
-
-
2442564700
-
Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG
-
Sun LQ, Lee DW, Zhang Q, Xiao W, Raabe EH, et al. (2004) Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. Genes & Development 18: 1035-1046.
-
(2004)
Genes & Development
, vol.18
, pp. 1035-1046
-
-
Sun, L.Q.1
Lee, D.W.2
Zhang, Q.3
Xiao, W.4
Raabe, E.H.5
-
13
-
-
49249126168
-
DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development
-
Fan T, Schmidtmann A, Xi S, Briones V, Zhu H, et al. (2008) DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development. Epigenetics: Official Journal of the DNA Methylation Society 3: 134-142.
-
(2008)
Epigenetics: Official Journal of the DNA Methylation Society
, vol.3
, pp. 134-142
-
-
Fan, T.1
Schmidtmann, A.2
Xi, S.3
Briones, V.4
Zhu, H.5
-
14
-
-
67349209262
-
Epigenetic control of mammalian LINE-1 retrotransposon by retinoblastoma proteins
-
Montoya-Durango DE, Liu Y, Teneng I, Kalbfleisch T, Lacy ME, et al. (2009) Epigenetic control of mammalian LINE-1 retrotransposon by retinoblastoma proteins. Mutation Research 665: 20-28.
-
(2009)
Mutation Research
, vol.665
, pp. 20-28
-
-
Montoya-Durango, D.E.1
Liu, Y.2
Teneng, I.3
Kalbfleisch, T.4
Lacy, M.E.5
-
15
-
-
49549100511
-
Trex1 prevents cell-intrinsic initiation of autoimmunity
-
Stetson DB, Ko JS, Heidmann T, Medzhitov R, (2008) Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 134: 587-598.
-
(2008)
Cell
, vol.134
, pp. 587-598
-
-
Stetson, D.B.1
Ko, J.S.2
Heidmann, T.3
Medzhitov, R.4
-
17
-
-
33745044396
-
Cellular inhibitors of long interspersed element 1 and Alu retrotransposition
-
Bogerd HP, Wiegand HL, Hulme AE, Garcia-Perez JL, O'Shea KS, et al. (2006) Cellular inhibitors of long interspersed element 1 and Alu retrotransposition. Proc Natl Acad Sci U S A 103: 8780-8785.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 8780-8785
-
-
Bogerd, H.P.1
Wiegand, H.L.2
Hulme, A.E.3
Garcia-Perez, J.L.4
O'Shea, K.S.5
-
18
-
-
80052206764
-
Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons
-
Ikeda T, Abd El Galil KH, Tokunaga K, Maeda K, Sata T, et al. (2011) Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons. Nucleic Acids Research 39: 5538-5554.
-
(2011)
Nucleic Acids Research
, vol.39
, pp. 5538-5554
-
-
Ikeda, T.1
Abd El Galil, K.H.2
Tokunaga, K.3
Maeda, K.4
Sata, T.5
-
19
-
-
20544466648
-
Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition
-
Muotri AR, Chu VT, Marchetto MC, Deng W, Moran JV, et al. (2005) Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. Nature 435: 903-910.
-
(2005)
Nature
, vol.435
, pp. 903-910
-
-
Muotri, A.R.1
Chu, V.T.2
Marchetto, M.C.3
Deng, W.4
Moran, J.V.5
-
20
-
-
81855178276
-
Somatic retrotransposition alters the genetic landscape of the human brain
-
Baillie JK, Barnett MW, Upton KR, Gerhardt DJ, Richmond TA, et al. (2011) Somatic retrotransposition alters the genetic landscape of the human brain. Nature 479: 534-537.
-
(2011)
Nature
, vol.479
, pp. 534-537
-
-
Baillie, J.K.1
Barnett, M.W.2
Upton, K.R.3
Gerhardt, D.J.4
Richmond, T.A.5
-
21
-
-
0023947487
-
Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma
-
Morse B, Rotherg PG, South VJ, Spandorfer JM, Astrin SM, (1988) Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma. Nature 333: 87-90.
-
(1988)
Nature
, vol.333
, pp. 87-90
-
-
Morse, B.1
Rotherg, P.G.2
South, V.J.3
Spandorfer, J.M.4
Astrin, S.M.5
-
22
-
-
0026503996
-
Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer
-
Miki Y, Nishisho I, Horii A, Miyoshi Y, Utsunomiya J, et al. (1992) Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer. Cancer Research 52: 643-645.
-
(1992)
Cancer Research
, vol.52
, pp. 643-645
-
-
Miki, Y.1
Nishisho, I.2
Horii, A.3
Miyoshi, Y.4
Utsunomiya, J.5
-
23
-
-
84870482898
-
Extensive somatic L1 retrotransposition in colorectal tumors
-
Solyom S, Ewing AD, Rahrmann EP, Doucet T, Nelson HH, et al. (2012) Extensive somatic L1 retrotransposition in colorectal tumors. Genome Res 22: 2328-2338.
-
(2012)
Genome Res
, vol.22
, pp. 2328-2338
-
-
Solyom, S.1
Ewing, A.D.2
Rahrmann, E.P.3
Doucet, T.4
Nelson, H.H.5
-
24
-
-
84865285978
-
Landscape of somatic retrotransposition in human cancers
-
Lee E, Iskow R, Yang L, Gokcumen O, Haseley P, et al. (2012) Landscape of somatic retrotransposition in human cancers. Science 337: 967-971.
-
(2012)
Science
, vol.337
, pp. 967-971
-
-
Lee, E.1
Iskow, R.2
Yang, L.3
Gokcumen, O.4
Haseley, P.5
-
25
-
-
77953889472
-
Natural mutagenesis of human genomes by endogenous retrotransposons
-
Iskow RC, McCabe MT, Mills RE, Torene S, Pittard WS, et al. (2010) Natural mutagenesis of human genomes by endogenous retrotransposons. Cell 141: 1253-1261.
-
(2010)
Cell
, vol.141
, pp. 1253-1261
-
-
Iskow, R.C.1
McCabe, M.T.2
Mills, R.E.3
Torene, S.4
Pittard, W.S.5
-
26
-
-
79952822096
-
Association of nuclear localization of a long interspersed nuclear element-1 protein in breast tumors with poor prognostic outcomes
-
Harris CR, Normart R, Yang Q, Stevenson E, Haffty BG, et al. (2010) Association of nuclear localization of a long interspersed nuclear element-1 protein in breast tumors with poor prognostic outcomes. Genes Cancer 1: 115-124.
-
(2010)
Genes Cancer
, vol.1
, pp. 115-124
-
-
Harris, C.R.1
Normart, R.2
Yang, Q.3
Stevenson, E.4
Haffty, B.G.5
-
27
-
-
33846923647
-
Expression of LINE-1 p40 protein in pediatric malignant germ cell tumors and its association with clinicopathological parameters: a report from the Children's Oncology Group
-
Su Y, Davies S, Davis M, Lu H, Giller R, et al. (2007) Expression of LINE-1 p40 protein in pediatric malignant germ cell tumors and its association with clinicopathological parameters: a report from the Children's Oncology Group. Cancer Lett 247: 204-212.
-
(2007)
Cancer Lett
, vol.247
, pp. 204-212
-
-
Su, Y.1
Davies, S.2
Davis, M.3
Lu, H.4
Giller, R.5
-
28
-
-
77955065411
-
Somatic expression of LINE-1 elements in human tissues
-
Belancio VP, Roy-Engel AM, Pochampally RR, Deininger P, (2010) Somatic expression of LINE-1 elements in human tissues. Nucleic Acids Research 38: 3909-3922.
-
(2010)
Nucleic Acids Research
, vol.38
, pp. 3909-3922
-
-
Belancio, V.P.1
Roy-Engel, A.M.2
Pochampally, R.R.3
Deininger, P.4
-
29
-
-
79551642322
-
Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers
-
Ting DT, Lipson D, Paul S, Brannigan BW, Akhavanfard S, et al. (2011) Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers. Science 331: 593-596.
-
(2011)
Science
, vol.331
, pp. 593-596
-
-
Ting, D.T.1
Lipson, D.2
Paul, S.3
Brannigan, B.W.4
Akhavanfard, S.5
-
30
-
-
69449085661
-
Differential repetitive DNA methylation in multiple myeloma molecular subgroups
-
Bollati V, Fabris S, Pegoraro V, Ronchetti D, Mosca L, et al. (2009) Differential repetitive DNA methylation in multiple myeloma molecular subgroups. Carcinogenesis 30: 1330-1335.
-
(2009)
Carcinogenesis
, vol.30
, pp. 1330-1335
-
-
Bollati, V.1
Fabris, S.2
Pegoraro, V.3
Ronchetti, D.4
Mosca, L.5
-
31
-
-
27944504788
-
Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia
-
Roman-Gomez J, Jimenez-Velasco A, Agirre X, Cervantes F, Sanchez J, et al. (2005) Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia. Oncogene 24: 7213-7223.
-
(2005)
Oncogene
, vol.24
, pp. 7213-7223
-
-
Roman-Gomez, J.1
Jimenez-Velasco, A.2
Agirre, X.3
Cervantes, F.4
Sanchez, J.5
-
32
-
-
79951499200
-
Biological and clinical relevance of quantitative global methylation of repetitive DNA sequences in chronic lymphocytic leukemia
-
Fabris S, Bollati V, Agnelli L, Morabito F, Motta V, et al. (2011) Biological and clinical relevance of quantitative global methylation of repetitive DNA sequences in chronic lymphocytic leukemia. Epigenetics 6: 188-194.
-
(2011)
Epigenetics
, vol.6
, pp. 188-194
-
-
Fabris, S.1
Bollati, V.2
Agnelli, L.3
Morabito, F.4
Motta, V.5
-
34
-
-
46149113196
-
L1 mobile element expression causes multiple types of toxicity
-
Wallace NA, Belancio VP, Deininger PL, (2008) L1 mobile element expression causes multiple types of toxicity. Gene 419: 75-81.
-
(2008)
Gene
, vol.419
, pp. 75-81
-
-
Wallace, N.A.1
Belancio, V.P.2
Deininger, P.L.3
-
35
-
-
33645068168
-
The human LINE-1 retrotransposon creates DNA double-strand breaks
-
Gasior SL, Wakeman TP, Xu B, Deininger PL, (2006) The human LINE-1 retrotransposon creates DNA double-strand breaks. Journal of Molecular Biology 357: 1383-1393.
-
(2006)
Journal of Molecular Biology
, vol.357
, pp. 1383-1393
-
-
Gasior, S.L.1
Wakeman, T.P.2
Xu, B.3
Deininger, P.L.4
-
36
-
-
0037047396
-
Human l1 retrotransposition is associated with genetic instability in vivo
-
Symer DE, Connelly C, Szak ST, Caputo EM, Cost GJ, et al. (2002) Human l1 retrotransposition is associated with genetic instability in vivo. Cell 110: 327-338.
-
(2002)
Cell
, vol.110
, pp. 327-338
-
-
Symer, D.E.1
Connelly, C.2
Szak, S.T.3
Caputo, E.M.4
Cost, G.J.5
-
37
-
-
71249101060
-
Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer
-
Lin C, Yang L, Tanasa B, Hutt K, Ju BG, et al. (2009) Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell 139: 1069-1083.
-
(2009)
Cell
, vol.139
, pp. 1069-1083
-
-
Lin, C.1
Yang, L.2
Tanasa, B.3
Hutt, K.4
Ju, B.G.5
-
38
-
-
79955552036
-
Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition
-
Dai L, Huang Q, Boeke JD, (2011) Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition. BMC Biochemistry 12: 18.
-
(2011)
BMC Biochemistry
, vol.12
, pp. 18
-
-
Dai, L.1
Huang, Q.2
Boeke, J.D.3
-
39
-
-
45249124072
-
Nucleoside analogue reverse transcriptase inhibitors differentially inhibit human LINE-1 retrotransposition
-
doi:10.1371/journal.pone.0001547
-
Jones RB, Garrison KE, Wong JC, Duan EH, Nixon DF, et al. (2008) Nucleoside analogue reverse transcriptase inhibitors differentially inhibit human LINE-1 retrotransposition. PLoS One 3: e1547 doi:10.1371/journal.pone.0001547.
-
(2008)
PLoS One
, vol.3
-
-
Jones, R.B.1
Garrison, K.E.2
Wong, J.C.3
Duan, E.H.4
Nixon, D.F.5
-
40
-
-
78649910640
-
The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines
-
doi:10.1371/journal.pone.0014221
-
Carlini F, Ridolfi B, Molinari A, Parisi C, Bozzuto G, et al. (2010) The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines. PloS One 5: e14221 doi:10.1371/journal.pone.0014221.
-
(2010)
PloS One
, vol.5
-
-
Carlini, F.1
Ridolfi, B.2
Molinari, A.3
Parisi, C.4
Bozzuto, G.5
-
41
-
-
20544437829
-
Inhibition of endogenous reverse transcriptase antagonizes human tumor growth
-
Sciamanna I, Landriscina M, Pittoggi C, Quirino M, Mearelli C, et al. (2005) Inhibition of endogenous reverse transcriptase antagonizes human tumor growth. Oncogene 24: 3923-3931.
-
(2005)
Oncogene
, vol.24
, pp. 3923-3931
-
-
Sciamanna, I.1
Landriscina, M.2
Pittoggi, C.3
Quirino, M.4
Mearelli, C.5
-
42
-
-
0037955469
-
Exposure of normal and transformed cells to nevirapine, a reverse transcriptase inhibitor, reduces cell growth and promotes differentiation
-
Mangiacasale R, Pittoggi C, Sciamanna I, Careddu A, Mattei E, et al. (2003) Exposure of normal and transformed cells to nevirapine, a reverse transcriptase inhibitor, reduces cell growth and promotes differentiation. Oncogene 22: 2750-2761.
-
(2003)
Oncogene
, vol.22
, pp. 2750-2761
-
-
Mangiacasale, R.1
Pittoggi, C.2
Sciamanna, I.3
Careddu, A.4
Mattei, E.5
-
43
-
-
67349173665
-
The regulated retrotransposon transcriptome of mammalian cells
-
Faulkner GJ, Kimura Y, Daub CO, Wani S, Plessy C, et al. (2009) The regulated retrotransposon transcriptome of mammalian cells. Nature Genetics 41: 563-571.
-
(2009)
Nature Genetics
, vol.41
, pp. 563-571
-
-
Faulkner, G.J.1
Kimura, Y.2
Daub, C.O.3
Wani, S.4
Plessy, C.5
-
44
-
-
77952414230
-
Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer
-
doi:10.1371/journal.pgen.1000917
-
Wolff EM, Byun HM, Han HF, Sharma S, Nichols PW, et al. (2010) Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer. PLoS Genet 6: e1000917 doi:10.1371/journal.pgen.1000917.
-
(2010)
PLoS Genet
, vol.6
-
-
Wolff, E.M.1
Byun, H.M.2
Han, H.F.3
Sharma, S.4
Nichols, P.W.5
-
45
-
-
33644755464
-
Multiple forms of genetic instability within a 2-Mb chromosomal segment of 3q26.3-q27 are associated with development of esophageal adenocarcinoma
-
Lin L, Wang Z, Prescott MS, van Dekken H, Thomas DG, et al. (2006) Multiple forms of genetic instability within a 2-Mb chromosomal segment of 3q26.3-q27 are associated with development of esophageal adenocarcinoma. Genes, Chromosomes & Cancer 45: 319-331.
-
(2006)
Genes, Chromosomes & Cancer
, vol.45
, pp. 319-331
-
-
Lin, L.1
Wang, Z.2
Prescott, M.S.3
van Dekken, H.4
Thomas, D.G.5
-
46
-
-
70449107061
-
Isolation of cancer-specific chimeric transcripts induced by hypomethylation of the LINE-1 antisense promoter
-
Cruickshanks HA, Tufarelli C, (2009) Isolation of cancer-specific chimeric transcripts induced by hypomethylation of the LINE-1 antisense promoter. Genomics 94: 397-406.
-
(2009)
Genomics
, vol.94
, pp. 397-406
-
-
Cruickshanks, H.A.1
Tufarelli, C.2
-
47
-
-
78049349212
-
Demethylation of a LINE-1 antisense promoter in the cMet locus impairs Met signalling through induction of illegitimate transcription
-
Weber B, Kimhi S, Howard G, Eden A, Lyko F, (2010) Demethylation of a LINE-1 antisense promoter in the cMet locus impairs Met signalling through induction of illegitimate transcription. Oncogene 29: 5775-5784.
-
(2010)
Oncogene
, vol.29
, pp. 5775-5784
-
-
Weber, B.1
Kimhi, S.2
Howard, G.3
Eden, A.4
Lyko, F.5
-
48
-
-
78649274945
-
Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer
-
Estecio MR, Gallegos J, Vallot C, Castoro RJ, Chung W, et al. (2010) Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer. Genome Research 20: 1369-1382.
-
(2010)
Genome Research
, vol.20
, pp. 1369-1382
-
-
Estecio, M.R.1
Gallegos, J.2
Vallot, C.3
Castoro, R.J.4
Chung, W.5
|