L1 retrotransposition in human neural progenitor cells

Nature

Volumn 460, Issue 7259, 2009, Pages 1127-1131

  Coufal, Nicole G ^a   Garcia Perez, José L ^b,c   Peng, Grace E ^a   Yeo, Gene W ^a,e   Mu, Yangling ^a   Lovci, Michael T ^a,e   Morell, Maria ^b   O'Shea, K Sue ^b   Moran, John V ^b,d   Gage, Fred H ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF GRANADA   (Spain)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA;

BIOENGINEERING; BRAIN; CARDIOVASCULAR SYSTEM; DNA; EVOLUTIONARY BIOLOGY; GERM CELL; HOMINID; POLYMERASE CHAIN REACTION; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; DNA TRANSPOSITION; EMBRYONIC STEM CELL; EVOLUTION; FEMALE; FETUS; GERM LINE; HEART; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN GENOME; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER; LONG INTERSPERSED ELEMENT 1; LONG INTERSPERSED REPEAT; MALE; NERVE CELL; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; RETROPOSON; SOMATIC CELL;

5' UNTRANSLATED REGIONS; BRAIN; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; DNA METHYLATION; EMBRYONIC STEM CELLS; FETUS; GENE DOSAGE; HUMANS; NEURONS; POLYMERASE CHAIN REACTION; RETROELEMENTS;

RATTUS;

EID: 69349096044     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature08248     Document Type: Article

References (28)

1. Muotri, A. R. et al. Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. Nature 435, 903-910 (2005).
2. Tang, Y., Nyengaard, J. R., De Groot, D. M. & Gundersen, H. J. Total regional and global number of synapses in the human brain neocortex. Synapse 41, 258-273 (2001). (Pubitemid 32691509)
3. Uchida, N. et al. Direct isolation of human central nervous system stem cells. Proc. Natl Acad. Sci. USA 97, 14720-14725 (2000).
4. Brouha, B. et al. Hot L1s account for the bulk of retrotransposition in the human population. Proc. Natl Acad. Sci. USA 100, 5280-5285 (2003).
5. Moran, J. V. et al. High frequency retrotransposition in cultured mammalian cells. Cell 87, 917-927 (1996).
6. Ostertag, E. M. et al. Amouse model of human L1 retrotransposition. Nature Genet. 32, 655-660 (2002).
7. Ostertag, E. M., Prak, E. T., DeBerardinis, R. J., Moran, J. V. & Kazazian, H. H. Jr. Determination of L1 retrotransposition kinetics in cultured cells. Nucleic Acids Res. 28, 1418-1423 (2000).
8. Kulpa, D. A. & Moran, J. V. Ribonucleoprotein particle formation is necessary but not sufficient for LINE-1 retrotransposition. Hum. Mol. Genet. 14, 3237-3248 (2005).
9. Moran, J. & Gilbert, N. Mammalian LINE-1 Retrotransposons and Related Elements (ASM Press, 2002).
10. Myers, J. S. et al. A comprehensive analysis of recently integrated human Ta L1 elements. Am. J. Hum. Genet. 71, 312-326 (2002).
11. Morrish, T. A. et al. DNA repair mediated by endonuclease-independent LINE-1 retrotransposition. Nature Genet. 31, 159-165 (2002).
12. Gilbert, N., Lutz, S., Morrish, T. A. & Moran, J. V. Multiple fates of L1 retrotransposition intermediates in cultured human cells. Mol. Cell. Biol. 25, 7780-7795 (2005).
13. Symer, D. E. et al. Human L1 retrotransposition is associated with genetic instability in vivo. Cell 110, 327-338 (2002).
14. Yeo, G. W. et al. Alternative splicing events identified in human embryonic stem cells and neural progenitors. PLoS Comput. Biol. 3, e196 (2007).
15. Bourc'his, D. & Bestor, T. H. Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L. Nature 431, 96-99 (2004).
16. Takai, D. & Jones, P. A. The CpG island searcher: a new WWW resource. In Silico Biol. 3, 235-240 (2003). (Pubitemid 37493047)
17. Yu, F., Zingler, N., Schumann, G. & Stratling, W. H. Methyl-CpG-binding protein 2 represses LINE-1 expression and retrotransposition but not Alu transcription. Nucleic Acids Res. 29, 4493-4501 (2001). (Pubitemid 33064789)
18. Tchenio, T., Casella, J. F. & Heidmann, T. Members of the SRY family regulate the human LINE retrotransposons. Nucleic Acids Res. 28, 411-415 (2000). (Pubitemid 30057978)
19. Lee, C., Wevrick, R., Fisher, R. B., Ferguson-Smith, M. A. & Lin, C. C. Human centromeric DNAs. Hum. Genet. 100, 291-304 (1997).
20. Pavlicek, A., Paces, J., Zika, R. & Hejnar, J. Length distribution of long interspersed nucleotide elements (LINEs) and processed pseudogenes of human endogenous retroviruses: implications for retrotransposition and pseudogene detection. Gene 300, 189-194 (2002). (Pubitemid 35441174)
21. Grimaldi, G., Skowronski, J. & Singer, M. F. Defining the beginning and end of KpnI family segments. EMBO J. 3, 1753-1759 (1984).
22. Gage, F. H. Mammalian neural stem cells. Science 287, 1433-1438 (2000).
23. Prak, E. T., Dodson, A. W., Farkash, E. A. & Kazazian, H. H. Jr. Tracking an embryonic L1 retrotransposition event. Proc. Natl Acad. Sci. USA 100, 1832-1837 (2003).
24. Garcia-Perez, J. L. et al. LINE-1 retrotransposition in human embryonic stem cells. Hum. Mol. Genet. 16, 1569-1577 (2007).
25. van den Hurk, J. A. et al. L1 retrotransposition can occur early in human embryonic development. Hum. Mol. Genet. 16, 1587-1592 (2007).
26. Thomson, J. A. et al. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145-1147 (1998).
27. Zhang, S. C., Wernig, M., Duncan, I. D., Brustle, O. & Thomson, J. A. In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nature Biotechnol. 19, 1129-1133 (2001).
28. Forslund, O. et al. Nucleotide sequence and phylogenetic classification of candidate human papilloma virus type 92. Virology 312, 255-260 (2003). (Pubitemid 36960003)