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Volumn 9, Issue 5, 2016, Pages 487-499

Gastrointestinal stem cells in health and disease: From flies to humans

Author keywords

Cancer; Drosophila; Dysplasia; Intestine; Metaplasia; Regeneration; Stem cells

Indexed keywords

CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; DROSOPHILA; DYSPLASIA; EPITHELIUM DYSPLASIA; GASTROINTESTINAL TRACT; HUMAN; INTESTINAL STEM CELL; MAMMAL; METAPLASIA; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; CYTOLOGY; DISEASES; DROSOPHILA MELANOGASTER; HEALTH; PHYSIOLOGY; STEM CELL;

EID: 84966586643     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.024232     Document Type: Review
Times cited : (94)

References (168)
  • 1
    • 79958207849 scopus 로고    scopus 로고
    • Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells
    • Amcheslavsky, A., Ito, N., Jiang, J. and Ip, Y. T. (2011). Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells. J. Cell Biol. 193, 695-710.
    • (2011) J. Cell Biol. , vol.193 , pp. 695-710
    • Amcheslavsky, A.1    Ito, N.2    Jiang, J.3    Ip, Y.T.4
  • 4
    • 72849170034 scopus 로고
    • Changes in bronchial epithelium in relation to cigarette smoking and in relation to lung cancer
    • Auerbach, O., Stout, A. P., Hammond, E. C. and Garfinkel, L. (1961). Changes in bronchial epithelium in relation to cigarette smoking and in relation to lung cancer. N. Engl. J. Med. 265, 253-267.
    • (1961) N. Engl. J. Med. , vol.265 , pp. 253-267
    • Auerbach, O.1    Stout, A.P.2    Hammond, E.C.3    Garfinkel, L.4
  • 6
    • 84897928013 scopus 로고    scopus 로고
    • Intestinal inflammation and stem cell homeostasis in aging Drosophila melanogaster
    • Ayyaz, A. and Jasper, H. (2013). Intestinal inflammation and stem cell homeostasis in aging Drosophila melanogaster. Front. Cell. Infect. Microbiol. 3, 98.
    • (2013) Front. Cell. Infect. Microbiol. , vol.3 , pp. 98
    • Ayyaz, A.1    Jasper, H.2
  • 7
    • 84930160218 scopus 로고    scopus 로고
    • Haemocytes control stem cell activity in the Drosophila intestine
    • Ayyaz, A., Li, H. and Jasper, H. (2015). Haemocytes control stem cell activity in the Drosophila intestine. Nat. Cell Biol. 17, 736-748.
    • (2015) Nat. Cell Biol. , vol.17 , pp. 736-748
    • Ayyaz, A.1    Li, H.2    Jasper, H.3
  • 8
    • 84891007206 scopus 로고    scopus 로고
    • Adult intestinal stem cells: Critical drivers of epithelial homeostasis and regeneration
    • Barker, N. (2014). Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration. Nat. Rev. Mol. Cell Biol. 15, 19-33.
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , pp. 19-33
    • Barker, N.1
  • 10
    • 78649639492 scopus 로고    scopus 로고
    • Tissue-resident adult stem cell populations of rapidly self-renewing organs
    • Barker, N., Bartfeld, S. and Clevers, H. (2010a). Tissue-resident adult stem cell populations of rapidly self-renewing organs. Cell Stem Cell 7, 656-670.
    • (2010) Cell Stem Cell , vol.7 , pp. 656-670
    • Barker, N.1    Bartfeld, S.2    Clevers, H.3
  • 14
  • 15
    • 73549097743 scopus 로고    scopus 로고
    • JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage
    • Beebe, K., Lee, W.-C. and Micchelli, C. A. (2010). JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage. Dev. Biol. 338, 28-37.
    • (2010) Dev. Biol. , vol.338 , pp. 28-37
    • Beebe, K.1    Lee, W.-C.2    Micchelli, C.A.3
  • 16
    • 84922569595 scopus 로고    scopus 로고
    • Generation of enteroendocrine cell diversity in midgut stem cell lineages
    • Beehler-Evans, R. and Micchelli, C. A. (2015). Generation of enteroendocrine cell diversity in midgut stem cell lineages. Development 142, 654-664.
    • (2015) Development , vol.142 , pp. 654-664
    • Beehler-Evans, R.1    Micchelli, C.A.2
  • 17
    • 79955133184 scopus 로고    scopus 로고
    • EGF signaling regulates the proliferation of intestinal stem cells in Drosophila
    • Biteau, B. and Jasper, H. (2011). EGF signaling regulates the proliferation of intestinal stem cells in Drosophila. Development 138, 1045-1055.
    • (2011) Development , vol.138 , pp. 1045-1055
    • Biteau, B.1    Jasper, H.2
  • 18
    • 84903436454 scopus 로고    scopus 로고
    • Slit/Robo signaling regulates cell fate decisions in the intestinal stem cell lineage of Drosophila
    • Biteau, B. and Jasper, H. (2014). Slit/Robo signaling regulates cell fate decisions in the intestinal stem cell lineage of Drosophila. Cell Rep. 7, 1867-1875.
    • (2014) Cell Rep. , vol.7 , pp. 1867-1875
    • Biteau, B.1    Jasper, H.2
  • 19
    • 52949093944 scopus 로고    scopus 로고
    • JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut
    • Biteau, B., Hochmuth, C. E. and Jasper, H. (2008). JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut. Cell Stem Cell 3, 442-455.
    • (2008) Cell Stem Cell , vol.3 , pp. 442-455
    • Biteau, B.1    Hochmuth, C.E.2    Jasper, H.3
  • 20
    • 78449240115 scopus 로고    scopus 로고
    • Lifespan extension by preserving proliferative homeostasis in Drosophila
    • Biteau, B., Karpac, J., Supoyo, S., De Gennaro, M., Lehmann, R. and Jasper, H. (2010). Lifespan extension by preserving proliferative homeostasis in Drosophila. PLoS Genet. 6, e1001159.
    • (2010) PLoS Genet , vol.6 , pp. e1001159
    • Biteau, B.1    Karpac, J.2    Supoyo, S.3    De Gennaro, M.4    Lehmann, R.5    Jasper, H.6
  • 21
    • 80755174406 scopus 로고    scopus 로고
    • Maintaining tissue homeostasis: Dynamic control of somatic stem cell activity
    • Biteau, B., Hochmuth, C. E. and Jasper, H. (2011). Maintaining tissue homeostasis: dynamic control of somatic stem cell activity. Cell Stem Cell 9, 402-411.
    • (2011) Cell Stem Cell , vol.9 , pp. 402-411
    • Biteau, B.1    Hochmuth, C.E.2    Jasper, H.3
  • 22
    • 0032897996 scopus 로고    scopus 로고
    • Clonal analysis of mouse intestinal epithelial progenitors
    • Bjerknes, M. and Cheng, H. (1999). Clonal analysis of mouse intestinal epithelial progenitors. Gastroenterology 116, 7-14.
    • (1999) Gastroenterology , vol.116 , pp. 7-14
    • Bjerknes, M.1    Cheng, H.2
  • 23
  • 25
    • 84949626188 scopus 로고    scopus 로고
    • All for one and one for all: Regionalization of the Drosophila intestine
    • Buchon, N. and Osman, D. (2015). All for one and one for all: regionalization of the Drosophila intestine. Insect Biochem. Mol. Biol. 67, 2-8.
    • (2015) Insect Biochem. Mol. Biol. , vol.67 , pp. 2-8
    • Buchon, N.1    Osman, D.2
  • 26
    • 70349617469 scopus 로고    scopus 로고
    • Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila
    • Buchon, N., Broderick, N. A., Chakrabarti, S. and Lemaitre, B. (2009). Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes Dev. 23, 2333-2344.
    • (2009) Genes Dev. , vol.23 , pp. 2333-2344
    • Buchon, N.1    Broderick, N.A.2    Chakrabarti, S.3    Lemaitre, B.4
  • 27
    • 78650397479 scopus 로고    scopus 로고
    • Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection
    • Buchon, N., Broderick, N. A., Kuraishi, T. and Lemaitre, B. (2010). Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. BMC Biol. 8, 152.
    • (2010) BMC Biol. , vol.8 , pp. 152
    • Buchon, N.1    Broderick, N.A.2    Kuraishi, T.3    Lemaitre, B.4
  • 28
    • 84882709450 scopus 로고    scopus 로고
    • Gut homeostasis in a microbial world: Insights from Drosophila melanogaster
    • Buchon, N., Broderick, N. A. and Lemaitre, B. (2013a). Gut homeostasis in a microbial world: insights from Drosophila melanogaster. Nat. Rev. Microbiol. 11, 615-626.
    • (2013) Nat. Rev. Microbiol. , vol.11 , pp. 615-626
    • Buchon, N.1    Broderick, N.A.2    Lemaitre, B.3
  • 29
    • 84878614163 scopus 로고    scopus 로고
    • Morphological and molecular characterization of adult midgut compartmentalization in Drosophila
    • Buchon, N., Osman, D., David, F. P. A., Fang, H. Y., Boquete, J.-P., Deplancke, B. and Lemaitre, B. (2013b). Morphological and molecular characterization of adult midgut compartmentalization in Drosophila. Cell Rep. 3, 1725-1738.
    • (2013) Cell Rep. , vol.3 , pp. 1725-1738
    • Buchon, N.1    Osman, D.2    David, F.P.A.3    Fang, H.Y.4    Boquete, J.-P.5    Deplancke, B.6    Lemaitre, B.7
  • 31
    • 18844380630 scopus 로고    scopus 로고
    • Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice
    • Cai, X., Carlson, J., Stoicov, C., Li, H., Wang, T. C. and Houghton, J. (2005). Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice. Gastroenterology 128, 1937-1952.
    • (2005) Gastroenterology , vol.128 , pp. 1937-1952
    • Cai, X.1    Carlson, J.2    Stoicov, C.3    Li, H.4    Wang, T.C.5    Houghton, J.6
  • 32
    • 84910052931 scopus 로고    scopus 로고
    • Age-associated loss of lamin-B leads to systemic inflammation and gut hyperplasia
    • Chen, H., Zheng, X. and Zheng, Y. (2014). Age-associated loss of lamin-B leads to systemic inflammation and gut hyperplasia. Cell 159, 829-843.
    • (2014) Cell , vol.159 , pp. 829-843
    • Chen, H.1    Zheng, X.2    Zheng, Y.3
  • 33
    • 43449097534 scopus 로고    scopus 로고
    • Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor
    • Choi, N.-H., Kim, J.-G., Yang, D.-J., Kim, Y.-S. and Yoo, M.-A. (2008). Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor. Aging Cell 7, 318-334.
    • (2008) Aging Cell , vol.7 , pp. 318-334
    • Choi, N.-H.1    Kim, J.-G.2    Yang, D.-J.3    Kim, Y.-S.4    Yoo, M.-A.5
  • 34
    • 81755187019 scopus 로고    scopus 로고
    • Nonautonomous regulation of Drosophila midgut stem cell proliferation by the insulin-signaling pathway
    • Choi, N. H., Lucchetta, E. and Ohlstein, B. (2011). Nonautonomous regulation of Drosophila midgut stem cell proliferation by the insulin-signaling pathway. Proc. Natl. Acad. Sci. USA 108, 18702-18707.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 18702-18707
    • Choi, N.H.1    Lucchetta, E.2    Ohlstein, B.3
  • 36
    • 84883876708 scopus 로고    scopus 로고
    • A gutsy approach to stem cells and signalling: An interview with Hans Clevers
    • Clevers, H. (2013a). A gutsy approach to stem cells and signalling: an interview with Hans Clevers. Dis. Model. Mech. 6, 1053-1056.
    • (2013) Dis. Model. Mech. , vol.6 , pp. 1053-1056
    • Clevers, H.1
  • 37
    • 84880548336 scopus 로고    scopus 로고
    • The intestinal crypt, a prototype stem cell compartment
    • Clevers, H. (2013b). The intestinal crypt, a prototype stem cell compartment. Cell 154, 274-284.
    • (2013) Cell , vol.154 , pp. 274-284
    • Clevers, H.1
  • 38
    • 0027065034 scopus 로고
    • Human gastric carcinogenesis: A multistep and multifactorial process-First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention
    • Correa, P. (1992). Human gastric carcinogenesis: a multistep and multifactorial process-First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res. 52, 6735-6740.
    • (1992) Cancer Res. , vol.52 , pp. 6735-6740
    • Correa, P.1
  • 39
    • 34547549860 scopus 로고    scopus 로고
    • Carcinogenesis of Helicobacter pylori
    • Correa, P. and Houghton, J. (2007). Carcinogenesis of Helicobacter pylori. Gastroenterology 133, 659-672.
    • (2007) Gastroenterology , vol.133 , pp. 659-672
    • Correa, P.1    Houghton, J.2
  • 42
    • 33846211765 scopus 로고    scopus 로고
    • The detection, surveillance and treatment of premalignant gastric lesions related to Helicobacter pylori infection
    • de Vries, A. C., Haringsma, J. and Kuipers, E. J. (2007). The detection, surveillance and treatment of premalignant gastric lesions related to Helicobacter pylori infection. Helicobacter 12, 1-15.
    • (2007) Helicobacter , vol.12 , pp. 1-15
    • De Vries, A.C.1    Haringsma, J.2    Kuipers, E.J.3
  • 43
    • 84949798263 scopus 로고    scopus 로고
    • Signal integration by Ca(2+) regulates intestinal stem-cell activity
    • Deng, H., Gerencser, A. A. and Jasper, H. (2015). Signal integration by Ca(2+) regulates intestinal stem-cell activity. Nature 528, 212-217.
    • (2015) Nature , vol.528 , pp. 212-217
    • Deng, H.1    Gerencser, A.A.2    Jasper, H.3
  • 44
    • 84919623629 scopus 로고    scopus 로고
    • Cellular heterogeneity in the mouse esophagus implicates the presence of a nonquiescent epithelial stem cell population
    • De Ward, A. D., Cramer, J. and Lagasse, E. (2014). Cellular heterogeneity in the mouse esophagus implicates the presence of a nonquiescent epithelial stem cell population. Cell Rep. 9, 701-711.
    • (2014) Cell Rep. , vol.9 , pp. 701-711
    • De Ward, A.D.1    Cramer, J.2    Lagasse, E.3
  • 45
    • 84865539510 scopus 로고    scopus 로고
    • A single progenitor population switches behavior to maintain and repair esophageal epithelium
    • Doupe, D. P., Alcolea, M. P., Roshan, A., Zhang, G., Klein, A. M., Simons, B. D. and Jones, P. H. (2012). A single progenitor population switches behavior to maintain and repair esophageal epithelium. Science 337, 1091-1093.
    • (2012) Science , vol.337 , pp. 1091-1093
    • Doupe, D.P.1    Alcolea, M.P.2    Roshan, A.3    Zhang, G.4    Klein, A.M.5    Simons, B.D.6    Jones, P.H.7
  • 46
    • 84899618411 scopus 로고    scopus 로고
    • Specification of regional intestinal stem cell identity during Drosophila metamorphosis
    • Driver, I. and Ohlstein, B. (2014). Specification of regional intestinal stem cell identity during Drosophila metamorphosis. Development 141, 1848-1856.
    • (2014) Development , vol.141 , pp. 1848-1856
    • Driver, I.1    Ohlstein, B.2
  • 47
    • 84949201273 scopus 로고    scopus 로고
    • Regional cell Specific RNA expression profiling of FACS isolated drosophila intestinal cell populations
    • Dutta, D., Buchon, N., Xiang, J. and Edgar, B. A. (2015a). Regional Cell Specific RNA Expression Profiling of FACS Isolated Drosophila Intestinal Cell Populations. Curr. Protoc. Stem Cell Biol. 34, 2F.2.1-2F.2.14.
    • (2015) Curr. Protoc. Stem Cell Biol. , vol.34 , pp. 1-14
    • Dutta, D.1    Buchon, N.2    Xiang, J.3    Edgar, B.A.4
  • 50
    • 0036091028 scopus 로고    scopus 로고
    • Barrett's esophagus
    • Falk, G. W. (2002). Barrett's esophagus. Gastroenterology 122, 1569-1591.
    • (2002) Gastroenterology , vol.122 , pp. 1569-1591
    • Falk, G.W.1
  • 51
    • 35648969554 scopus 로고    scopus 로고
    • Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells
    • Fevr, T., Robine, S., Louvard, D. and Huelsken, J. (2007). Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells. Mol. Cell. Biol. 27, 7551-7559.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 7551-7559
    • Fevr, T.1    Robine, S.2    Louvard, D.3    Huelsken, J.4
  • 53
    • 20544447734 scopus 로고    scopus 로고
    • Notch signals control the fate of immature progenitor cells in the intestine
    • Fre, S., Huyghe, M., Mourikis, P., Robine, S., Louvard, D. and Artavanis-Tsakonas, S. (2005). Notch signals control the fate of immature progenitor cells in the intestine. Nature 435, 964-968.
    • (2005) Nature , vol.435 , pp. 964-968
    • Fre, S.1    Huyghe, M.2    Mourikis, P.3    Robine, S.4    Louvard, D.5    Artavanis-Tsakonas, S.6
  • 54
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov, S. I., Greten, F. R. and Karin, M. (2010). Immunity, inflammation, and cancer. Cell 140, 883-899.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 55
    • 84947706087 scopus 로고    scopus 로고
    • Stem cell regulation. Bidirectional Notch signaling regulates Drosophila intestinal stem cell multipotency
    • Guo, Z. and Ohlstein, B. (2015). Stem cell regulation. Bidirectional Notch signaling regulates Drosophila intestinal stem cell multipotency. Science 350, aab0988.
    • (2015) Science , vol.350 , pp. aab0988
    • Guo, Z.1    Ohlstein, B.2
  • 56
    • 84880027871 scopus 로고    scopus 로고
    • Injury-induced BMP signaling negatively regulates Drosophila midgut homeostasis
    • Guo, Z., Driver, I. and Ohlstein, B. (2013). Injury-induced BMP signaling negatively regulates Drosophila midgut homeostasis. J. Cell Biol. 201, 945-961.
    • (2013) J. Cell Biol. , vol.201 , pp. 945-961
    • Guo, Z.1    Driver, I.2    Ohlstein, B.3
  • 57
    • 84892714390 scopus 로고    scopus 로고
    • PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan
    • Guo, L., Karpac, J., Tran, S. L. and Jasper, H. (2014). PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan. Cell 156, 109-122.
    • (2014) Cell , vol.156 , pp. 109-122
    • Guo, L.1    Karpac, J.2    Tran, S.L.3    Jasper, H.4
  • 58
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D. and Weinberg, R. A. (2011). Hallmarks of cancer: the next generation. Cell 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 61
    • 77953186500 scopus 로고    scopus 로고
    • Colorectal dysplasia in chronic inflammatory bowel disease: Pathology, clinical implications, and pathogenesis
    • Harpaz, N. and Polydorides, A. D. (2010). Colorectal dysplasia in chronic inflammatory bowel disease: pathology, clinical implications, and pathogenesis. Arch. Pathol. Lab. Med. 134, 876-895.
    • (2010) Arch. Pathol. Lab. Med. , vol.134 , pp. 876-895
    • Harpaz, N.1    Polydorides, A.D.2
  • 62
    • 38349109862 scopus 로고    scopus 로고
    • Troy binding to lymphotoxin-alpha activates NF kappa B mediated transcription
    • Hashimoto, T., Schlessinger, D. and Cui, C.-Y. (2008). Troy binding to lymphotoxin-alpha activates NF kappa B mediated transcription. Cell Cycle 7, 106-111.
    • (2008) Cell Cycle , vol.7 , pp. 106-111
    • Hashimoto, T.1    Schlessinger, D.2    Cui, C.-Y.3
  • 63
    • 6944224156 scopus 로고    scopus 로고
    • BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling
    • He, X. C., Zhang, J., Tong, W.-G., Tawfik, O., Ross, J., Scoville, D. H., Tian, Q., Zeng, X., He, X., Wiedemann, L. M. et al. (2004). BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat. Genet. 36, 1117-1121.
    • (2004) Nat. Genet , vol.36 , pp. 1117-1121
    • He, X.C.1    Zhang, J.2    Tong, W.-G.3    Tawfik, O.4    Ross, J.5    Scoville, D.H.6    Tian, Q.7    Zeng, X.8    He, X.9    Wiedemann, L.M.10
  • 64
    • 0029110835 scopus 로고
    • Organization of the crypt-villus axis and evolution of its stem cell hierarchy during intestinal development
    • Hermiston, M. L. and Gordon, J. I. (1995). Organization of the crypt-villus axis and evolution of its stem cell hierarchy during intestinal development. Am. J. Physiol. 268, G813-G822.
    • (1995) Am. J. Physiol. , vol.268 , pp. G813-G822
    • Hermiston, M.L.1    Gordon, J.I.2
  • 65
    • 79551610653 scopus 로고    scopus 로고
    • Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila
    • Hochmuth, C. E., Biteau, B., Bohmann, D. and Jasper, H. (2011). Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila. Cell Stem Cell 8, 188-199.
    • (2011) Cell Stem Cell , vol.8 , pp. 188-199
    • Hochmuth, C.E.1    Biteau, B.2    Bohmann, D.3    Jasper, H.4
  • 68
    • 2442600137 scopus 로고    scopus 로고
    • Diagnosis and management of dysplasia in patients with inflammatory bowel diseases
    • Itzkowitz, S. H. and Harpaz, N. (2004). Diagnosis and management of dysplasia in patients with inflammatory bowel diseases. Gastroenterology 126, 1634-1648.
    • (2004) Gastroenterology , vol.126 , pp. 1634-1648
    • Itzkowitz, S.H.1    Harpaz, N.2
  • 70
    • 84939500222 scopus 로고    scopus 로고
    • Identification and genetic manipulation of human and mouse oesophageal stem cells
    • Jeong, Y., Rhee, H., Martin, S., Klass, D., Lin, Y., Nguyen, L. X. T., Feng, W. and Diehn, M. (2015). Identification and genetic manipulation of human and mouse oesophageal stem cells. Gut 309, G216-G228.
    • (2015) Gut , vol.309 , pp. G216-G228
    • Jeong, Y.1    Rhee, H.2    Martin, S.3    Klass, D.4    Lin, Y.5    Nguyen, L.X.T.6    Feng, W.7    Diehn, M.8
  • 71
    • 64549110803 scopus 로고    scopus 로고
    • EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors
    • Jiang, H. and Edgar, B. A. (2009). EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors. Development 136, 483-493.
    • (2009) Development , vol.136 , pp. 483-493
    • Jiang, H.1    Edgar, B.A.2
  • 72
    • 80455173895 scopus 로고    scopus 로고
    • Intestinal stem cells in the adult Drosophila midgut
    • Jiang, H. and Edgar, B. A. (2011). Intestinal stem cells in the adult Drosophila midgut. Exp. Cell Res. 317, 2780-2788.
    • (2011) Exp. Cell Res. , vol.317 , pp. 2780-2788
    • Jiang, H.1    Edgar, B.A.2
  • 73
    • 67549133157 scopus 로고    scopus 로고
    • Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut
    • Jiang, H., Patel, P. H., Kohlmaier, A., Grenley, M. O., McEwen, D. G. and Edgar, B. A. (2009). Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell 137, 1343-1355.
    • (2009) Cell , vol.137 , pp. 1343-1355
    • Jiang, H.1    Patel, P.H.2    Kohlmaier, A.3    Grenley, M.O.4    McEwen, D.G.5    Edgar, B.A.6
  • 74
    • 78650977190 scopus 로고    scopus 로고
    • EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila
    • Jiang, H., Grenley, M. O., Bravo, M.-J., Blumhagen, R. Z. and Edgar, B. A. (2011). EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila. Cell Stem Cell 8, 84-95.
    • (2011) Cell Stem Cell , vol.8 , pp. 84-95
    • Jiang, H.1    Grenley, M.O.2    Bravo, M.-J.3    Blumhagen, R.Z.4    Edgar, B.A.5
  • 77
    • 84930576826 scopus 로고    scopus 로고
    • Barrett's esophagus: Recent insights into pathogenesis and cellular ontogeny
    • Kapoor, H., Agrawal, D. K. and Mittal, S. K. (2015). Barrett's esophagus: recent insights into pathogenesis and cellular ontogeny. Transl. Res. 166, 28-40.
    • (2015) Transl. Res. , vol.166 , pp. 28-40
    • Kapoor, H.1    Agrawal, D.K.2    Mittal, S.K.3
  • 78
    • 84870700189 scopus 로고    scopus 로고
    • Notchmediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage
    • Kapuria, S., Karpac, J., Biteau, B., Hwangbo, D. and Jasper, H. (2012). Notchmediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage. PLoS Genet. 8, e1003045.
    • (2012) PLoS Genet , vol.8 , pp. e1003045
    • Kapuria, S.1    Karpac, J.2    Biteau, B.3    Hwangbo, D.4    Jasper, H.5
  • 79
    • 78650202455 scopus 로고    scopus 로고
    • The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration
    • Karpowicz, P., Perez, J. and Perrimon, N. (2010). The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. Development 137, 4135-4145.
    • (2010) Development , vol.137 , pp. 4135-4145
    • Karpowicz, P.1    Perez, J.2    Perrimon, N.3
  • 80
    • 79959216005 scopus 로고    scopus 로고
    • Genetics and pathogenesis of inflammatory bowel disease
    • Khor, B., Gardet, A. and Xavier, R. J. (2011). Genetics and pathogenesis of inflammatory bowel disease. Nature 474, 307-317.
    • (2011) Nature , vol.474 , pp. 307-317
    • Khor, B.1    Gardet, A.2    Xavier, R.J.3
  • 81
    • 79955724664 scopus 로고    scopus 로고
    • Notch signaling in stomach epithelial stem cell homeostasis
    • Kim, T.-H. and Shivdasani, R. A. (2011). Notch signaling in stomach epithelial stem cell homeostasis. J. Exp. Med. 208, 677-688.
    • (2011) J. Exp. Med. , vol.208 , pp. 677-688
    • Kim, T.-H.1    Shivdasani, R.A.2
  • 82
    • 0031848068 scopus 로고    scopus 로고
    • Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
    • Korinek, V., Barker, N., Moerer, P., van Donselaar, E., Huls, G., Peters, P. J. and Clevers, H. (1998). Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat. Genet. 19, 379-383.
    • (1998) Nat. Genet , vol.19 , pp. 379-383
    • Korinek, V.1    Barker, N.2    Moerer, P.3    Van Donselaar, E.4    Huls, G.5    Peters, P.J.6    Clevers, H.7
  • 85
    • 0346458662 scopus 로고    scopus 로고
    • Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1
    • Kuhnert, F., Davis, C. R., Wang, H.-T., Chu, P., Lee, M., Yuan, J., Nusse, R. and Kuo, C. J. (2004). Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc. Natl. Acad. Sci. USA 101, 266-271.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 266-271
    • Kuhnert, F.1    Davis, C.R.2    Wang, H.-T.3    Chu, P.4    Lee, M.5    Yuan, J.6    Nusse, R.7    Kuo, C.J.8
  • 86
    • 0021957288 scopus 로고
    • Dynamic histology of the antral epithelium in the mouse stomach: II. Ultrastructure and renewal of isthmal cells
    • Lee, E. R. and Leblond, C. P. (1985). Dynamic histology of the antral epithelium in the mouse stomach: II. Ultrastructure and renewal of isthmal cells. Am. J. Anat. 172, 205-224.
    • (1985) Am. J. Anat. , vol.172 , pp. 205-224
    • Lee, E.R.1    Leblond, C.P.2
  • 87
    • 69549113488 scopus 로고    scopus 로고
    • Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation
    • Lee, W.-C., Beebe, K., Sudmeier, L. and Micchelli, C. A. (2009). Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation. Development 136, 2255-2264.
    • (2009) Development , vol.136 , pp. 2255-2264
    • Lee, W.-C.1    Beebe, K.2    Sudmeier, L.3    Micchelli, C.A.4
  • 89
    • 84888602564 scopus 로고    scopus 로고
    • The digestive tract of Drosophila melanogaster
    • Lemaitre, B. and Miguel-Aliaga, I. (2013). The digestive tract of Drosophila melanogaster. Annu. Rev. Genet. 47, 377-404.
    • (2013) Annu. Rev. Genet , vol.47 , pp. 377-404
    • Lemaitre, B.1    Miguel-Aliaga, I.2
  • 90
    • 4344626065 scopus 로고    scopus 로고
    • Factors predicting progression of gastric intestinal metaplasia: Results of a randomised trial on Helicobacter pylori eradication
    • Leung, W. K., Lin, S.-R., Ching, J. Y. L., To, K.-F., Ng, E. K.W., Chan, F. K. L., Lau, J. Y. W. and Sung, J. J. Y. (2004). Factors predicting progression of gastric intestinal metaplasia: results of a randomised trial on Helicobacter pylori eradication. Gut 53, 1244-1249.
    • (2004) Gut , vol.53 , pp. 1244-1249
    • Leung, W.K.1    Lin, S.-R.2    Ching, J.Y.L.3    To, K.-F.4    Ng, E.K.W.5    Chan, F.K.L.6    Lau, J.Y.W.7    Sung, J.J.Y.8
  • 91
    • 0030024841 scopus 로고    scopus 로고
    • Diphtheria toxin-mediated ablation of parietal cells in the stomach of transgenic mice
    • Li, Q., Karam, S. M. and Gordon, J. I. (1996). Diphtheria toxin-mediated ablation of parietal cells in the stomach of transgenic mice. J. Biol. Chem. 271, 3671-3676.
    • (1996) J. Biol. Chem. , vol.271 , pp. 3671-3676
    • Li, Q.1    Karam, S.M.2    Gordon, J.I.3
  • 92
    • 84892441178 scopus 로고    scopus 로고
    • Dpp signaling determines regional stem cell identity in the regenerating adult Drosophila gastrointestinal tract
    • Li, H., Qi, Y. and Jasper, H. (2013a). Dpp signaling determines regional stem cell identity in the regenerating adult Drosophila gastrointestinal tract. Cell Rep. 4, 10-18.
    • (2013) Cell Rep. , vol.4 , pp. 10-18
    • Li, H.1    Qi, Y.2    Jasper, H.3
  • 93
    • 84873838480 scopus 로고    scopus 로고
    • Trachea-derived dpp controls adult midgut homeostasis in Drosophila
    • Li, Z., Zhang, Y., Han, L., Shi, L. and Lin, X. (2013b). Trachea-derived dpp controls adult midgut homeostasis in Drosophila. Dev. Cell 24, 133-143.
    • (2013) Dev. Cell , vol.24 , pp. 133-143
    • Li, Z.1    Zhang, Y.2    Han, L.3    Shi, L.4    Lin, X.5
  • 94
    • 84922542256 scopus 로고    scopus 로고
    • Single-cell analysis of proxy reporter allele-marked epithelial cells establishes intestinal stem cell hierarchy
    • Li, N., Yousefi, M., Nakauka-Ddamba, A., Jain, R., Tobias, J., Epstein, J. A., Jensen, S. T. and Lengner, C. J. (2014). Single-cell analysis of proxy reporter allele-marked epithelial cells establishes intestinal stem cell hierarchy. Stem Cell Rep. 3, 876-891.
    • (2014) Stem Cell Rep. , vol.3 , pp. 876-891
    • Li, N.1    Yousefi, M.2    Nakauka-Ddamba, A.3    Jain, R.4    Tobias, J.5    Epstein, J.A.6    Jensen, S.T.7    Lengner, C.J.8
  • 95
    • 85011945190 scopus 로고    scopus 로고
    • Preventing age-related decline of gut compartmentalization limits microbiota dysbiosis and extends lifespan
    • Li, H., Qi, Y. and Jasper, H. (2016). Preventing age-related decline of gut compartmentalization limits microbiota dysbiosis and extends lifespan. Cell Host Microbe 19, 240-253.
    • (2016) Cell Host Microbe , vol.19 , pp. 240-253
    • Li, H.1    Qi, Y.2    Jasper, H.3
  • 96
    • 54549104587 scopus 로고    scopus 로고
    • Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells
    • Lin, G., Xu, N. and Xi, R. (2008). Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells. Nature 455, 1119-1123.
    • (2008) Nature , vol.455 , pp. 1119-1123
    • Lin, G.1    Xu, N.2    Xi, R.3
  • 97
    • 77950367306 scopus 로고    scopus 로고
    • Paracrine unpaired signaling through the JAK/STAT pathway controls self-renewal and lineage differentiation of drosophila intestinal stem cells
    • Lin, G., Xu, N. and Xi, R. (2010). Paracrine unpaired signaling through the JAK/STAT pathway controls self-renewal and lineage differentiation of drosophila intestinal stem cells. J. Mol. Cell Biol. 2, 37-49.
    • (2010) J. Mol. Cell Biol. , vol.2 , pp. 37-49
    • Lin, G.1    Xu, N.2    Xi, R.3
  • 98
    • 84875129324 scopus 로고    scopus 로고
    • Sox2 cooperates with inflammation-mediated Stat3 activation in the malignant transformation of foregut basal progenitor cells
    • Liu, K., Jiang, M., Lu, Y., Chen, H., Sun, J., Wu, S., Ku, W.-Y., Nakagawa, H., Kita, Y., Natsugoe, S. et al. (2013). Sox2 cooperates with inflammation-mediated Stat3 activation in the malignant transformation of foregut basal progenitor cells. Cell Stem Cell 12, 304-315.
    • (2013) Cell Stem Cell , vol.12 , pp. 304-315
    • Liu, K.1    Jiang, M.2    Lu, Y.3    Chen, H.4    Sun, J.5    Wu, S.6    Ku, W.-Y.7    Nakagawa, H.8    Kita, Y.9    Natsugoe, S.10
  • 99
    • 84918832933 scopus 로고    scopus 로고
    • Regulation of Drosophila intestinal stem cell maintenance and differentiation by the transcription factor Escargot
    • Loza-Coll, M. A., Southall, T. D., Sandall, S. L., Brand, A. H. and Jones, D. L. (2014). Regulation of Drosophila intestinal stem cell maintenance and differentiation by the transcription factor Escargot. EMBO J. 33, 2983-2996.
    • (2014) EMBO J. , vol.33 , pp. 2983-2996
    • Loza-Coll, M.A.1    Southall, T.D.2    Sandall, S.L.3    Brand, A.H.4    Jones, D.L.5
  • 103
    • 84883398166 scopus 로고    scopus 로고
    • Physiological and stem cell compartmentalization within the Drosophila midgut
    • Marianes, A. and Spradling, A. C. (2013). Physiological and stem cell compartmentalization within the Drosophila midgut. Elife 2, e00886.
    • (2013) Elife , vol.2 , pp. e00886
    • Marianes, A.1    Spradling, A.C.2
  • 105
    • 31444452338 scopus 로고    scopus 로고
    • Evidence that stem cells reside in the adult Drosophila midgut epithelium
    • Micchelli, C. A. and Perrimon, N. (2006). Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature 439, 475-479.
    • (2006) Nature , vol.439 , pp. 475-479
    • Micchelli, C.A.1    Perrimon, N.2
  • 106
    • 8444247084 scopus 로고    scopus 로고
    • Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation
    • Milano, J., McKay, J., Dagenais, C., Foster-Brown, L., Pognan, F., Gadient, R., Jacobs, R. T., Zacco, A., Greenberg, B. and Ciaccio, P. J. (2004). Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation. Toxicol. Sci. 82, 341-358.
    • (2004) Toxicol. Sci. , vol.82 , pp. 341-358
    • Milano, J.1    McKay, J.2    Dagenais, C.3    Foster-Brown, L.4    Pognan, F.5    Gadient, R.6    Jacobs, R.T.7    Zacco, A.8    Greenberg, B.9    Ciaccio, P.J.10
  • 107
    • 79251547698 scopus 로고    scopus 로고
    • Gastric epithelial stem cells
    • Mills, J. C. and Shivdasani, R. A. (2011). Gastric epithelial stem cells. Gastroenterology 140, 412-424.
    • (2011) Gastroenterology , vol.140 , pp. 412-424
    • Mills, J.C.1    Shivdasani, R.A.2
  • 111
    • 84966666529 scopus 로고    scopus 로고
    • Stem-cell-specific endocytic degradation defects lead to intestinal dysplasia in Drosophila
    • Nagy, P., Kovács, L., Sándor, G. O. and Juhász, G. (2016). Stem-cell-specific endocytic degradation defects lead to intestinal dysplasia in Drosophila. Dis. Model Mech. 9, 501-512.
    • (2016) Dis. Model Mech. , vol.9 , pp. 501-512
    • Nagy, P.1    Kovács, L.2    Sándor, G.O.3    Juhász, G.4
  • 112
    • 25144456045 scopus 로고    scopus 로고
    • Functional specification in the Drosophila endoderm
    • Nakagoshi, H. (2005). Functional specification in the Drosophila endoderm. Dev. Growth Differ. 47, 383-392.
    • (2005) Dev. Growth Differ. , vol.47 , pp. 383-392
    • Nakagoshi, H.1
  • 113
    • 84899639879 scopus 로고    scopus 로고
    • Cytokines in inflammatory bowel disease
    • Neurath, M. F. (2014). Cytokines in inflammatory bowel disease. Nat. Rev. Immunol. 14, 329-342.
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 329-342
    • Neurath, M.F.1
  • 114
    • 80155123827 scopus 로고    scopus 로고
    • Altered modes of stem cell division drive adaptive intestinal growth
    • O'Brien, L. E., Soliman, S. S., Li, X. and Bilder, D. (2011). Altered modes of stem cell division drive adaptive intestinal growth. Cell 147, 603-614.
    • (2011) Cell , vol.147 , pp. 603-614
    • O'Brien, L.E.1    Soliman, S.S.2    Li, X.3    Bilder, D.4
  • 115
    • 31444444485 scopus 로고    scopus 로고
    • The adult Drosophila posterior midgut is maintained by pluripotent stem cells
    • Ohlstein, B. and Spradling, A. (2006). The adult Drosophila posterior midgut is maintained by pluripotent stem cells. Nature 439, 470-474.
    • (2006) Nature , vol.439 , pp. 470-474
    • Ohlstein, B.1    Spradling, A.2
  • 116
    • 33847168133 scopus 로고    scopus 로고
    • Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling
    • Ohlstein, B. and Spradling, A. (2007). Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling. Science 315, 988-992.
    • (2007) Science , vol.315 , pp. 988-992
    • Ohlstein, B.1    Spradling, A.2
  • 117
  • 118
    • 84940591073 scopus 로고    scopus 로고
    • Niche appropriation by Drosophila intestinal stem cell tumours
    • Patel, P. H., Dutta, D. and Edgar, B. A. (2015). Niche appropriation by Drosophila intestinal stem cell tumours. Nat. Cell Biol. 17, 1182-1192.
    • (2015) Nat. Cell Biol. , vol.17 , pp. 1182-1192
    • Patel, P.H.1    Dutta, D.2    Edgar, B.A.3
  • 119
    • 3042602815 scopus 로고    scopus 로고
    • Phenotypic differences between esophageal and gastric intestinal metaplasia
    • Piazuelo, M. B., Haque, S., Delgado, A., Du, J. X., Rodriguez, F. and Correa, P. (2004). Phenotypic differences between esophageal and gastric intestinal metaplasia. Mod. Pathol. 17, 62-74.
    • (2004) Mod. Pathol. , vol.17 , pp. 62-74
    • Piazuelo, M.B.1    Haque, S.2    Delgado, A.3    Du, J.X.4    Rodriguez, F.5    Correa, P.6
  • 120
    • 0037829660 scopus 로고    scopus 로고
    • Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
    • Pinto, D., Gregorieff, A., Begthel, H. and Clevers, H. (2003). Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev. 17, 1709-1713.
    • (2003) Genes Dev. , vol.17 , pp. 1709-1713
    • Pinto, D.1    Gregorieff, A.2    Begthel, H.3    Clevers, H.4
  • 121
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Podolsky, D. K. (2002). Inflammatory bowel disease. N. Engl. J. Med. 347, 417-429.
    • (2002) N. Engl. J. Med. , vol.347 , pp. 417-429
    • Podolsky, D.K.1
  • 122
    • 0022001046 scopus 로고
    • Derivation of mouse intestinal crypts from single progenitor cells
    • Ponder, B. A. J., Schmidt, G. H., Wilkinson, M. M., Wood, M. J., Monk, M. and Reid, A. (1985). Derivation of mouse intestinal crypts from single progenitor cells. Nature 313, 689-691.
    • (1985) Nature , vol.313 , pp. 689-691
    • Ponder, B.A.J.1    Schmidt, G.H.2    Wilkinson, M.M.3    Wood, M.J.4    Monk, M.5    Reid, A.6
  • 124
    • 84883300053 scopus 로고    scopus 로고
    • TSC1/2 regulates intestinal stem cell maintenance and lineage differentiation through Rheb-TORC1-S6K but independently of nutritional status or Notch regulation
    • Quan, Z., Sun, P., Lin, G. and Xi, R. (2013). TSC1/2 regulates intestinal stem cell maintenance and lineage differentiation through Rheb-TORC1-S6K but independently of nutritional status or Notch regulation. J. Cell Sci. 126, 3884-3892.
    • (2013) J. Cell Sci. , vol.126 , pp. 3884-3892
    • Quan, Z.1    Sun, P.2    Lin, G.3    Xi, R.4
  • 125
    • 84870930962 scopus 로고    scopus 로고
    • Barrett esophagus: What a mouse model can teach us about human disease
    • Quante, M., Abrams, J. A., Lee, Y. and Wang, T. C. (2012a). Barrett esophagus: what a mouse model can teach us about human disease. Cell Cycle 11, 4328-4338.
    • (2012) Cell Cycle , vol.11 , pp. 4328-4338
    • Quante, M.1    Abrams, J.A.2    Lee, Y.3    Wang, T.C.4
  • 127
    • 78650471357 scopus 로고    scopus 로고
    • Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways
    • Ren, F., Wang, B., Yue, T., Yun, E.-Y., Ip, Y. T. and Jiang, J. (2010). Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. Proc. Natl. Acad. Sci. USA 107, 21064-21069.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 21064-21069
    • Ren, F.1    Wang, B.2    Yue, T.3    Yun, E.-Y.4    Ip, Y.T.5    Jiang, J.6
  • 129
    • 84871830937 scopus 로고    scopus 로고
    • Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila
    • Rera, M., Clark, R. I. and Walker, D. W. (2012). Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila. Proc. Natl. Acad. Sci. USA 109, 21528-21533.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 21528-21533
    • Rera, M.1    Clark, R.I.2    Walker, D.W.3
  • 131
    • 46249128798 scopus 로고    scopus 로고
    • Bmi1 is expressed in vivo in intestinal stem cells
    • Sangiorgi, E. and Capecchi, M. R. (2008). Bmi1 is expressed in vivo in intestinal stem cells. Nat. Genet. 40, 915-920.
    • (2008) Nat. Genet , vol.40 , pp. 915-920
    • Sangiorgi, E.1    Capecchi, M.R.2
  • 132
    • 0022003991 scopus 로고
    • Barrett's esophagus: Its prevalence and association with adenocarcinoma in patients with symptoms of gastroesophageal reflux
    • Sarr, M. G., Hamilton, S. R., Marrone, G. C. and Cameron, J. L. (1985). Barrett's esophagus: its prevalence and association with adenocarcinoma in patients with symptoms of gastroesophageal reflux. Am. J. Surg. 149, 187-193.
    • (1985) Am. J. Surg. , vol.149 , pp. 187-193
    • Sarr, M.G.1    Hamilton, S.R.2    Marrone, G.C.3    Cameron, J.L.4
  • 133
    • 84863756127 scopus 로고    scopus 로고
    • Wnt signaling, stem cells, and cancer of the gastrointestinal tract
    • Schepers, A. and Clevers, H. (2012). Wnt signaling, stem cells, and cancer of the gastrointestinal tract. Cold Spring Harb. Perspect. Biol. 4, a007989.
    • (2012) Cold Spring Harb. Perspect. Biol. , vol.4 , pp. a007989
    • Schepers, A.1    Clevers, H.2
  • 135
    • 0030795415 scopus 로고    scopus 로고
    • CDX1 protein expression in normal, metaplastic, and neoplastic human alimentary tract epithelium
    • Silberg, D. G., Furth, E. E., Taylor, J. K., Schuck, T., Chiou, T. and Traber, P. G. (1997). CDX1 protein expression in normal, metaplastic, and neoplastic human alimentary tract epithelium. Gastroenterology 113, 478-486.
    • (1997) Gastroenterology , vol.113 , pp. 478-486
    • Silberg, D.G.1    Furth, E.E.2    Taylor, J.K.3    Schuck, T.4    Chiou, T.5    Traber, P.G.6
  • 139
    • 34247350842 scopus 로고    scopus 로고
    • Metaplasia and transdifferentiation: From pure biology to the clinic
    • Slack, J. M. W. (2007). Metaplasia and transdifferentiation: from pure biology to the clinic. Nat. Rev. Mol. Cell Biol. 8, 369-378.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 369-378
    • Slack, J.M.W.1
  • 140
    • 77956507262 scopus 로고    scopus 로고
    • Warts and Yorkie mediate intestinal regeneration by influencing stem cell proliferation
    • Staley, B. K. and Irvine, K. D. (2010). Warts and Yorkie mediate intestinal regeneration by influencing stem cell proliferation. Curr. Biol. 20, 1580-1587.
    • (2010) Curr. Biol. , vol.20 , pp. 1580-1587
    • Staley, B.K.1    Irvine, K.D.2
  • 142
    • 80055094597 scopus 로고    scopus 로고
    • Quiescent gastric stem cells maintain the adult Drosophila stomach
    • Strand, M. and Micchelli, C. A. (2011). Quiescent gastric stem cells maintain the adult Drosophila stomach. Proc. Natl. Acad. Sci. USA 108, 17696-17701.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 17696-17701
    • Strand, M.1    Micchelli, C.A.2
  • 143
    • 84893368647 scopus 로고    scopus 로고
    • Regional control of Drosophila gut stem cell proliferation: EGF establishes GSSC proliferative set point & controls emergence from quiescence
    • Strand, M. and Micchelli, C. A. (2013). Regional control of Drosophila gut stem cell proliferation: EGF establishes GSSC proliferative set point & controls emergence from quiescence. PLoS ONE 8, e80608.
    • (2013) PLoS ONE , vol.8 , pp. e80608
    • Strand, M.1    Micchelli, C.A.2
  • 144
    • 48349135915 scopus 로고    scopus 로고
    • The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling
    • Takashima, S., Mkrtchyan, M., Younossi-Hartenstein, A., Merriam, J. R. and Hartenstein, V. (2008). The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling. Nature 454, 651-655.
    • (2008) Nature , vol.454 , pp. 651-655
    • Takashima, S.1    Mkrtchyan, M.2    Younossi-Hartenstein, A.3    Merriam, J.R.4    Hartenstein, V.5
  • 145
    • 84898762338 scopus 로고    scopus 로고
    • Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut
    • Tian, A. and Jiang, J. (2014). Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut. Elife 3, e01857.
    • (2014) Elife , vol.3 , pp. e01857
    • Tian, A.1    Jiang, J.2
  • 146
    • 80054041585 scopus 로고    scopus 로고
    • A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
    • Tian, H., Biehs, B., Warming, S., Leong, K. G., Rangell, L., Klein, O. D. and de Sauvage, F. J. (2011). A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature 478, 255-259.
    • (2011) Nature , vol.478 , pp. 255-259
    • Tian, H.1    Biehs, B.2    Warming, S.3    Leong, K.G.4    Rangell, L.5    Klein, O.D.6    De Sauvage, F.J.7
  • 147
    • 84927696737 scopus 로고    scopus 로고
    • Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis
    • Tian, H., Biehs, B., Chiu, C., Siebel, C. W., Wu, Y., Costa, M., de Sauvage, F. J. and Klein, O. D. (2015). Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis. Cell Rep. 11, 33-42.
    • (2015) Cell Rep. , vol.11 , pp. 33-42
    • Tian, H.1    Biehs, B.2    Chiu, C.3    Siebel, C.W.4    Wu, Y.5    Costa, M.6    De Sauvage, F.J.7    Klein, O.D.8
  • 149
    • 67650121080 scopus 로고    scopus 로고
    • Diagnosis and management of dysplasia in patients with ulcerative colitis and Crohn's disease of the colon
    • Ullman, T., Odze, R. and Farraye, F. A. (2009). Diagnosis and management of dysplasia in patients with ulcerative colitis and Crohn's disease of the colon. Inflamm. Bowel Dis. 15, 630-638.
    • (2009) Inflamm. Bowel Dis. , vol.15 , pp. 630-638
    • Ullman, T.1    Odze, R.2    Farraye, F.A.3
  • 150
    • 67650299380 scopus 로고    scopus 로고
    • Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility
    • Uronis, J. M., Muhlbauer, M., Herfarth, H. H., Rubinas, T. C., Jones, G. S. and Jobin, C. (2009). Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility. PLoS ONE 4, e6026.
    • (2009) PLoS ONE , vol.4 , pp. e6026
    • Uronis, J.M.1    Muhlbauer, M.2    Herfarth, H.H.3    Rubinas, T.C.4    Jones, G.S.5    Jobin, C.6
  • 152
    • 67651159312 scopus 로고    scopus 로고
    • Stem cells, self-renewal, and differentiation in the intestinal epithelium
    • van der Flier, L. G. and Clevers, H. (2009). Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu. Rev. Physiol. 71, 241-260.
    • (2009) Annu. Rev. Physiol. , vol.71 , pp. 241-260
    • Van-Der-Flier, L.G.1    Clevers, H.2
  • 157
    • 79951850400 scopus 로고    scopus 로고
    • LgR5 expression and cancer stem cell hypothesis: Clue to define the true origin of esophageal adenocarcinomas with and without Barrett's esophagus?
    • von Rahden, B. H. A., Kircher, S., Lazariotou, M., Reiber, C., Stuermer, L., Otto, C., Germer, C. T. and Grimm, M. (2011). LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett's esophagus? J. Exp. Clin. Cancer Res. 30, 23.
    • (2011) J. Exp. Clin. Cancer Res. , vol.30 , pp. 23
    • Von Rahden, B.H.A.1    Kircher, S.2    Lazariotou, M.3    Reiber, C.4    Stuermer, L.5    Otto, C.6    Germer, C.T.7    Grimm, M.8
  • 160
    • 84899934624 scopus 로고    scopus 로고
    • EGFR and Notch signaling respectively regulate proliferative activity and multiple cell lineage differentiation of Drosophila gastric stem cells
    • Wang, C., Guo, X. and Xi, R. (2014). EGFR and Notch signaling respectively regulate proliferative activity and multiple cell lineage differentiation of Drosophila gastric stem cells. Cell Res. 24, 610-627.
    • (2014) Cell Res. , vol.24 , pp. 610-627
    • Wang, C.1    Guo, X.2    Xi, R.3
  • 161
    • 84943529076 scopus 로고    scopus 로고
    • Ttk69 acts as a master repressor of enteroendocrine cell specification in Drosophila intestinal stem cell lineages
    • Wang, C., Guo, X., Dou, K., Chen, H. and Xi, R. (2015a). Ttk69 acts as a master repressor of enteroendocrine cell specification in Drosophila intestinal stem cell lineages. Development 142, 3321-3331.
    • (2015) Development , vol.142 , pp. 3321-3331
    • Wang, C.1    Guo, X.2    Dou, K.3    Chen, H.4    Xi, R.5
  • 162
    • 84930787599 scopus 로고    scopus 로고
    • PERK limits Drosophila lifespan by promoting intestinal stem cell proliferation in response to ER stress
    • Wang, L., Ryoo, H. D., Qi, Y. and Jasper, H. (2015b). PERK limits Drosophila lifespan by promoting intestinal stem cell proliferation in response to ER stress. PLoS Genet. 11, e1005220.
    • (2015) PLoS Genet , vol.11 , pp. e1005220
    • Wang, L.1    Ryoo, H.D.2    Qi, Y.3    Jasper, H.4
  • 163
    • 34447092208 scopus 로고    scopus 로고
    • Immunology of Helicobacter pylori: Insights into the failure of the immune response and perspectives on vaccine studies
    • Wilson, K. T. and Crabtree, J. E. (2007). Immunology of Helicobacter pylori: insights into the failure of the immune response and perspectives on vaccine studies. Gastroenterology 133, 288-308.
    • (2007) Gastroenterology , vol.133 , pp. 288-308
    • Wilson, K.T.1    Crabtree, J.E.2
  • 165
    • 11144355129 scopus 로고    scopus 로고
    • Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation
    • Wong, G. T., Manfra, D., Poulet, F. M., Zhang, Q., Josien, H., Bara, T., Engstrom, L., Pinzon-Ortiz, M., Fine, J. S., Lee, H.-J. J. et al. (2004). Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J. Biol. Chem. 279, 12876-12882.
    • (2004) J. Biol. Chem. , vol.279 , pp. 12876-12882
    • Wong, G.T.1    Manfra, D.2    Poulet, F.M.3    Zhang, Q.4    Josien, H.5    Bara, T.6    Engstrom, L.7    Pinzon-Ortiz, M.8    Fine, J.S.9    Lee, H.-J.J.10
  • 167
    • 85027935285 scopus 로고    scopus 로고
    • Regulation of selfrenewal and differentiation by the intestinal stem cell niche
    • Yeung, T. M., Chia, L. A., Kosinski, C. M. and Kuo, C. J. (2011). Regulation of selfrenewal and differentiation by the intestinal stem cell niche. Cell. Mol. Life Sci. 68, 2513-2523.
    • (2011) Cell. Mol. Life Sci. , vol.68 , pp. 2513-2523
    • Yeung, T.M.1    Chia, L.A.2    Kosinski, C.M.3    Kuo, C.J.4
  • 168
    • 84922553419 scopus 로고    scopus 로고
    • Enteroendocrine cells are generated from stem cells through a distinct progenitor in the adult Drosophila posterior midgut
    • Zeng, X. and Hou, S. X. (2015). Enteroendocrine cells are generated from stem cells through a distinct progenitor in the adult Drosophila posterior midgut. Development 142, 644-653.
    • (2015) Development , vol.142 , pp. 644-653
    • Zeng, X.1    Hou, S.X.2


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