Regional Cell-Specific Transcriptome Mapping Reveals Regulatory Complexity in the Adult Drosophila Midgut

Cell Reports

Volumn 12, Issue 2, 2015, Pages 346-358

  Dutta, Devanjali ^a   Dobson, Adam J ^b,c   Houtz, Philip L ^b   Gläßer, Christine ^a   Revah, Jonathan ^b   Korzelius, Jerome ^a   Patel, Parthive H ^a   Edgar, Bruce A ^a   Buchon, Nicolas ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Department of Obstetrics Gynecology   (United States)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; PROTEIN PTX1; PROTEIN SMVT; PROTEIN SNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GAL4; TRANSCRIPTION FACTOR GATAE; TRANSCRIPTOME; UNCLASSIFIED DRUG; BIOTIN TRANSPORTER; COTRANSPORTER; DROSOPHILA PROTEIN; GATAE PROTEIN, DROSOPHILA; KAYAK PROTEIN, DROSOPHILA; SMALL INTERFERING RNA; SNAIL FAMILY TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR GATA;

ABDOMINAL WALL MUSCULATURE; ADULT; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL INTERACTION; CELL SPECIFICITY; CONTROLLED STUDY; DROSOPHILA; ENTEROENDOCRINE CELL; FLUORESCENCE ACTIVATED CELL SORTING; GENE MAPPING; GENETIC DATABASE; GENETIC VARIABILITY; HOMEOSTASIS; IMAGO; IMMUNITY; INFECTION; INTESTINAL STEM CELL; INTESTINE CELL; MIDGUT; MULTIPOTENT STEM CELL; NONHUMAN; PRIORITY JOURNAL; RNA SEQUENCE; STEM CELL; TRANSCRIPTION REGULATION; TRANSCRIPTOMICS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CELL SURVIVAL; CYTOLOGY; GENETICS; INTESTINE; METABOLISM; PRINCIPAL COMPONENT ANALYSIS; RNA INTERFERENCE;

ABDOMINAL MUSCLES; ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; DROSOPHILA; DROSOPHILA PROTEINS; ENTEROCYTES; ENTEROENDOCRINE CELLS; GATA TRANSCRIPTION FACTORS; INTESTINES; PRINCIPAL COMPONENT ANALYSIS; RNA INTERFERENCE; RNA, SMALL INTERFERING; STEM CELLS; SYMPORTERS; TRANSCRIPTION FACTORS; TRANSCRIPTOME;

EID: 84937512699     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.06.009     Document Type: Article

References (39)

1. Amcheslavsky A., Jiang J., Ip Y.T. Tissue damage-induced intestinal stem cell division in Drosophila. Cell Stem Cell 2009, 4:49-61.
2. Anders S., Huber W. Differential expression analysis for sequence count data. Genome Biol. 2010, 11:R106.
3. Bardin A.J., Perdigoto C.N., Southall T.D., Brand A.H., Schweisguth F. Transcriptional control of stem cell maintenance in the Drosophila intestine. Development 2010, 137:705-714.
4. Beehler-Evans R., Micchelli C.A. Generation of enteroendocrine cell diversity in midgut stem cell lineages. Development 2015, 142:654-664.
5. Beuling E., Aronson B.E., Tran L.M.D., Stapleton K.A., ter Horst E.N., Vissers L.A., Verzi M.P., Krasinski S.D. GATA6 is required for proliferation, migration, secretory cell maturation, and gene expression in the mature mouse colon. Mol. Cell. Biol. 2012, 32:3392-3402.
6. Biteau B., Jasper H. EGF signaling regulates the proliferation of intestinal stem cells in Drosophila. Development 2011, 138:1045-1055.
7. Biteau B., Jasper H. Slit/Robo signaling regulates cell fate decisions in the intestinal stem cell lineage of Drosophila. Cell Rep. 2014, 7:1867-1875.
8. Buchon N., Broderick N.A., Chakrabarti S., Lemaitre B. Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes Dev. 2009, 23:2333-2344.
9. Buchon N., Broderick N.A., Kuraishi T., Lemaitre B. Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. BMC Biol. 2010, 8:152.
10. Buchon N., Osman D., David F.P.A., Fang H.Y., Boquete J.-P., Deplancke B., Lemaitre B. Morphological and molecular characterization of adult midgut compartmentalization in Drosophila. Cell Rep. 2013, 3:1725-1738.
11. Buchon N., Broderick N.A., Lemaitre B. Gut homeostasis in a microbial world: insights from Drosophila melanogaster. Nat. Rev. Microbiol. 2013, 11:615-626.
12. Camporeale G., Zempleni J., Eissenberg J.C. Susceptibility to heat stress and aberrant gene expression patterns in holocarboxylase synthetase-deficient Drosophila melanogaster are caused by decreased biotinylation of histones, not of carboxylases. J. Nutr. 2007, 137:885-889.
13. Cordero J.B., Stefanatos R.K., Scopelliti A., Vidal M., Sansom O.J. Inducible progenitor-derived Wingless regulates adult midgut regeneration in Drosophila. EMBO J. 2012, 31:3901-3917.
14. Dimitriadis V.K. Fine structure of the midgut of adult Drosophila auraria and its relationship to the sites of acidophilic secretion. J. Insect Physiol. 1991, 37:167-177.
15. Dutta D., Xiang J., Edgar B.A. RNA expression profiling from FACS-isolated cells of the Drosophila intestine. Curr. Protoc. Stem Cell Biol. 2013, 27. Unit 2F.2.
16. Goulas S., Conder R., Knoblich J.A. The Par complex and integrins direct asymmetric cell division in adult intestinal stem cells. Cell Stem Cell 2012, 11:529-540.
17. Guo Z., Driver I., Ohlstein B. Injury-induced BMP signaling negatively regulates Drosophila midgut homeostasis. J. Cell Biol. 2013, 201:945-961.
18. Herrmann C., Van de Sande B., Potier D., Aerts S. i-cisTarget: an integrative genomics method for the prediction of regulatory features and cis-regulatory modules. Nucleic Acids Res. 2012, 40:e114.
19. Jiang H., Edgar B.A. EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors. Development 2009, 136:483-493.
20. Jiang H., Patel P.H., Kohlmaier A., Grenley M.O., McEwen D.G., Edgar B.A. Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell 2009, 137:1343-1355.
21. Jiang H., Grenley M.O., Bravo M.-J., Blumhagen R.Z., Edgar B.A. EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila. Cell Stem Cell 2011, 8:84-95.
22. Korzelius J., Naumann S.K., Loza-Coll M.A., Chan J.S., Dutta D., Oberheim J., Gläßer C., Southall T.D., Brand A.H., Jones D.L., Edgar B.A. Escargot maintains stemness and suppresses differentiation in Drosophila intestinal stem cells. EMBO J. 2014, 33:2967-2982.
23. Li H., Qi Y., Jasper H. Dpp signaling determines regional stem cell identity in the regenerating adult Drosophila gastrointestinal tract. Cell Rep. 2013, 4:10-18.
24. Lin G., Xu N., Xi R. Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells. Nature 2008, 455:1119-1123.
25. Marianes A., Spradling A.C. Physiological and stem cell compartmentalization within the Drosophila midgut. eLife 2013, 2:e00886.
26. Martorell Ò., Merlos-Suárez A., Campbell K., Barriga F.M., Christov C.P., Miguel-Aliaga I., Batlle E., Casanova J., Casali A. Conserved mechanisms of tumorigenesis in the Drosophila adult midgut. PLoS ONE 2014, 9:e88413.
27. Micchelli C.A., Perrimon N. Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature 2006, 439:475-479.
28. Miron N., Cristea V. Enterocytes: active cells in tolerance to food and microbial antigens in the gut. Clin. Exp. Immunol. 2012, 167:405-412.
29. Ohlstein B., Spradling A. The adult Drosophila posterior midgut is maintained by pluripotent stem cells. Nature 2006, 439:470-474.
30. Ohlstein B., Spradling A. Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling. Science 2007, 315:988-992.
31. Peterson L.W., Artis D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat. Rev. Immunol. 2014, 14:141-153.
32. Scopelliti A., Cordero J.B., Diao F., Strathdee K., White B.H., Sansom O.J., Vidal M. Local control of intestinal stem cell homeostasis by enteroendocrine cells in the adult Drosophila midgut. Curr. Biol. 2014, 24:1199-1211.
33. Shaw R.L., Kohlmaier A., Polesello C., Veelken C., Edgar B.A., Tapon N. The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration. Development 2010, 137:4147-4158.
34. Singh S.R., Zeng X., Zheng Z., Hou S.X. The adult Drosophila gastric and stomach organs are maintained by a multipotent stem cell pool at the foregut/midgut junction in the cardia (proventriculus). Cell Cycle 2011, 10:1109-1120.
35. Strand M., Micchelli C.A. Quiescent gastric stem cells maintain the adult Drosophila stomach. Proc. Natl. Acad. Sci. USA 2011, 108:17696-17701.
36. Tian A., Jiang J. Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut. eLife 2014, 3:e01857.
37. Veenstra J.A., Agricola H.-J., Sellami A. Regulatory peptides in fruit fly midgut. Cell Tissue Res. 2008, 334:499-516.
38. Whissell G., Montagni E., Martinelli P., Hernando-Momblona X., Sevillano M., Jung P., Cortina C., Calon A., Abuli A., Castells A., et al. The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression. Nat. Cell Biol. 2014, 16:695-707.
39. Zeng X., Hou S.X. Enteroendocrine cells are generated from stem cells through a distinct progenitor in the adult Drosophila posterior midgut. Development 2015, 142:644-653.